The impact of colony‐stimulating factor‐1 on fracture healing: An experimental study
Identifieur interne : 005A32 ( Main/Exploration ); précédent : 005A31; suivant : 005A33The impact of colony‐stimulating factor‐1 on fracture healing: An experimental study
Auteurs : Kambiz Sarahrudi [Autriche] ; Mehdi Mousavi [Autriche] ; Karl Grossschmidt [Autriche] ; Nezir Sela [Autriche] ; Franz König [Autriche] ; Vilmos Vécsei [Autriche] ; Seyedhossein Aharinejad [Autriche]Source :
- Journal of Orthopaedic Research [ 0736-0266 ] ; 2009-01.
English descriptors
- KwdEn :
- Adobe photoshop, Bone defects, Bone formation, Bone healing, Bone miner, Callus, Cell biochem, Cell number, Clin, Clin orthop, Complete consolidation, Control animal, Control animals, Control group, Cytokine, Defect, Defect bridged, Defect healing, Defect zone, Early phase, Femur, Femur diaphysis, Femur shaft, Fracture, Fracture callus, Fracture healing, Fracture healing process, Fracture repair, Growth factor, Growth factor beta, Healing, Healing process, Higher number, Important role, Long bones, Medical statistics, Medical university, Mineralized bone, Observation period, Orthop, Orthopaedic, Orthopaedic research january, Orthopaedic research society, Osmotic mini pumps, Osteoclast, Osteoclast production, Osteoclast proliferation, Osteoprotegerin ligand, Osteotomy, Postoperative days, Potential role, Present study, Radiologic examination, Radiological healing, Receptor activator, Right femur, Soft tissue, Statistical analysis, Supine position, Treatment group, Wiley periodicals, Zeeland rabbits.
- Teeft :
- Adobe photoshop, Bone defects, Bone formation, Bone healing, Bone miner, Callus, Cell biochem, Cell number, Clin, Clin orthop, Complete consolidation, Control animal, Control animals, Control group, Cytokine, Defect, Defect bridged, Defect healing, Defect zone, Early phase, Femur, Femur diaphysis, Femur shaft, Fracture, Fracture callus, Fracture healing, Fracture healing process, Fracture repair, Growth factor, Growth factor beta, Healing, Healing process, Higher number, Important role, Long bones, Medical statistics, Medical university, Mineralized bone, Observation period, Orthop, Orthopaedic, Orthopaedic research january, Orthopaedic research society, Osmotic mini pumps, Osteoclast, Osteoclast production, Osteoclast proliferation, Osteoprotegerin ligand, Osteotomy, Postoperative days, Potential role, Present study, Radiologic examination, Radiological healing, Receptor activator, Right femur, Soft tissue, Statistical analysis, Supine position, Treatment group, Wiley periodicals, Zeeland rabbits.
Abstract
The role of colony stimulating factor‐1 (CSF‐1) in the regulation of osteoclasts and bone remodeling suggests that CSF‐1 may also be involved in regulation of bone healing. The ability of CSF‐1 to promote healing of bone defects was tested in a rabbit model. Twenty‐four New Zeeland rabbits were included in the study. Animals were assigned to two groups: the control group (n = 12) was treated by plate fixation. The animals in the second group (n = 12) were also stabilized by conventional plating and received additionally CSF‐1 for 2 weeks systemically. Histologic, histomorphometric, and radiologic examinations were performed to evaluate the healing process at 4, 8, and 12 weeks following surgery. Animals that were treated by CSF‐1 produced a significantly higher amount of mineralized bone over the first 8 weeks after fracture compared to the control animals. Furthermore, a higher number of osteoclasts was found in CSF‐1‐treated animals within the first 8 weeks, compared to the controls. The present data emphasize for the first time the importance of CSF‐1 in the bone healing. The use of CSF‐1 in addition to conventional fixation might be a novel approach for the treatment of bone defects. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:36–41, 2009
Url:
DOI: 10.1002/jor.20680
Affiliations:
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type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName><wicri:orgArea>Department of Traumatology and Sporttraumatology, Danube Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Grossschmidt, Karl" sort="Grossschmidt, Karl" uniqKey="Grossschmidt K" first="Karl" last="Grossschmidt">Karl Grossschmidt</name><affiliation wicri:level="3"><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName><wicri:orgArea>Department of Histology</wicri:orgArea></affiliation></author><author><name sortKey="Sela, Nezir" sort="Sela, Nezir" uniqKey="Sela N" first="Nezir" last="Sela">Nezir Sela</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Laboratory for Cardiovascular Research, Center of Anatomy and Cell Biology, Medical University of Vienna, Waehringerstrasse 13, A‐1090 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unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-01">2009-01</date></imprint><idno type="ISSN">0736-0266</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0736-0266</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adobe photoshop</term><term>Bone defects</term><term>Bone formation</term><term>Bone healing</term><term>Bone miner</term><term>Callus</term><term>Cell biochem</term><term>Cell number</term><term>Clin</term><term>Clin orthop</term><term>Complete consolidation</term><term>Control animal</term><term>Control animals</term><term>Control group</term><term>Cytokine</term><term>Defect</term><term>Defect bridged</term><term>Defect healing</term><term>Defect zone</term><term>Early phase</term><term>Femur</term><term>Femur diaphysis</term><term>Femur shaft</term><term>Fracture</term><term>Fracture callus</term><term>Fracture healing</term><term>Fracture healing process</term><term>Fracture repair</term><term>Growth factor</term><term>Growth factor beta</term><term>Healing</term><term>Healing process</term><term>Higher number</term><term>Important role</term><term>Long bones</term><term>Medical statistics</term><term>Medical university</term><term>Mineralized bone</term><term>Observation period</term><term>Orthop</term><term>Orthopaedic</term><term>Orthopaedic research january</term><term>Orthopaedic research society</term><term>Osmotic mini pumps</term><term>Osteoclast</term><term>Osteoclast production</term><term>Osteoclast proliferation</term><term>Osteoprotegerin ligand</term><term>Osteotomy</term><term>Postoperative days</term><term>Potential role</term><term>Present study</term><term>Radiologic examination</term><term>Radiological healing</term><term>Receptor activator</term><term>Right femur</term><term>Soft tissue</term><term>Statistical analysis</term><term>Supine position</term><term>Treatment group</term><term>Wiley periodicals</term><term>Zeeland rabbits</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adobe photoshop</term><term>Bone defects</term><term>Bone formation</term><term>Bone healing</term><term>Bone miner</term><term>Callus</term><term>Cell biochem</term><term>Cell number</term><term>Clin</term><term>Clin orthop</term><term>Complete consolidation</term><term>Control animal</term><term>Control animals</term><term>Control group</term><term>Cytokine</term><term>Defect</term><term>Defect bridged</term><term>Defect healing</term><term>Defect zone</term><term>Early phase</term><term>Femur</term><term>Femur diaphysis</term><term>Femur shaft</term><term>Fracture</term><term>Fracture callus</term><term>Fracture healing</term><term>Fracture healing process</term><term>Fracture repair</term><term>Growth factor</term><term>Growth factor beta</term><term>Healing</term><term>Healing process</term><term>Higher number</term><term>Important role</term><term>Long bones</term><term>Medical statistics</term><term>Medical university</term><term>Mineralized bone</term><term>Observation period</term><term>Orthop</term><term>Orthopaedic</term><term>Orthopaedic research january</term><term>Orthopaedic research society</term><term>Osmotic mini pumps</term><term>Osteoclast</term><term>Osteoclast production</term><term>Osteoclast proliferation</term><term>Osteoprotegerin ligand</term><term>Osteotomy</term><term>Postoperative days</term><term>Potential role</term><term>Present study</term><term>Radiologic examination</term><term>Radiological healing</term><term>Receptor activator</term><term>Right femur</term><term>Soft tissue</term><term>Statistical analysis</term><term>Supine position</term><term>Treatment group</term><term>Wiley periodicals</term><term>Zeeland rabbits</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of colony stimulating factor‐1 (CSF‐1) in the regulation of osteoclasts and bone remodeling suggests that CSF‐1 may also be involved in regulation of bone healing. The ability of CSF‐1 to promote healing of bone defects was tested in a rabbit model. Twenty‐four New Zeeland rabbits were included in the study. Animals were assigned to two groups: the control group (n = 12) was treated by plate fixation. The animals in the second group (n = 12) were also stabilized by conventional plating and received additionally CSF‐1 for 2 weeks systemically. Histologic, histomorphometric, and radiologic examinations were performed to evaluate the healing process at 4, 8, and 12 weeks following surgery. Animals that were treated by CSF‐1 produced a significantly higher amount of mineralized bone over the first 8 weeks after fracture compared to the control animals. Furthermore, a higher number of osteoclasts was found in CSF‐1‐treated animals within the first 8 weeks, compared to the controls. The present data emphasize for the first time the importance of CSF‐1 in the bone healing. The use of CSF‐1 in addition to conventional fixation might be a novel approach for the treatment of bone defects. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:36–41, 2009</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Sarahrudi, Kambiz" sort="Sarahrudi, Kambiz" uniqKey="Sarahrudi K" first="Kambiz" last="Sarahrudi">Kambiz Sarahrudi</name></region><name sortKey="Aharinejad, Seyedhossein" sort="Aharinejad, Seyedhossein" uniqKey="Aharinejad S" first="Seyedhossein" last="Aharinejad">Seyedhossein Aharinejad</name><name sortKey="Aharinejad, Seyedhossein" sort="Aharinejad, Seyedhossein" uniqKey="Aharinejad S" first="Seyedhossein" last="Aharinejad">Seyedhossein Aharinejad</name><name sortKey="Grossschmidt, Karl" sort="Grossschmidt, Karl" uniqKey="Grossschmidt K" first="Karl" last="Grossschmidt">Karl Grossschmidt</name><name sortKey="Konig, Franz" sort="Konig, Franz" uniqKey="Konig F" first="Franz" last="König">Franz König</name><name sortKey="Mousavi, Mehdi" sort="Mousavi, Mehdi" uniqKey="Mousavi M" first="Mehdi" last="Mousavi">Mehdi Mousavi</name><name sortKey="Sela, Nezir" sort="Sela, Nezir" uniqKey="Sela N" first="Nezir" last="Sela">Nezir Sela</name><name sortKey="Vecsei, Vilmos" sort="Vecsei, Vilmos" uniqKey="Vecsei V" first="Vilmos" last="Vécsei">Vilmos Vécsei</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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