Photofunctionalization of TiO2 for Optimal Bone-titanium Integration: A Novel Phenomenon of Super Osseointegration
Identifieur interne : 005110 ( Main/Exploration ); précédent : 005109; suivant : 005111Photofunctionalization of TiO2 for Optimal Bone-titanium Integration: A Novel Phenomenon of Super Osseointegration
Auteurs : Takahiro Ogawa [États-Unis]Source :
- Nanostructure Science and Technology [ 1571-5744 ] ; 2010.
Abstract
Abstract: Osteoporotic fractures, degenerative changes in joints, and edentulous jaws are quite common clinical problems. Owing to its bone bonding property, the so-called osseointegration or bone-titanium integration, titanium implants are used as a reconstructive anchor in such diseases and disorders, despite unsolved concerns of medical and societal concerns and cost issues. Here, we present ultraviolet (UV) light-treated titanium surfaces with markedly increased bone-forming and bonding capacity. The UV-treated surface offers an osteoblast-affinity environment, as demonstrated by enhanced attachment, spread, proliferation, and functional differentiation of bone-forming cells (osteoblasts). New bone formation spreads extensively onto the UV-treated titanium implants with virtually no intervention by soft tissue, maximizing the bone-implant contact up to nearly 100% compared with 55% of untreated titanium. The UV treatment accelerates the establishment of implant biomechanical fixation by fourfold. These cell-affinity properties strongly correlated with UV-catalytic removal of hydrocarbons from the TiO2 surface. The data suggest that this photofunctionalization converts bioinert titanium to bioactive titanium, enabling more rapid and complete establishment of bone-titanium integration. We propose to define the unique biological phenomenon specifically induced around this novel titanium surface as “super osseointegration” and expect it to have immediate and broad applications in dental and orthopedic fields because it is simple, highly effective, and inexpensive.
Url:
DOI: 10.1007/978-0-387-48444-0_29
Affiliations:
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