Radiographic Periodontal Bone Loss in Chronic Kidney Disease
Identifieur interne : 003E58 ( Main/Exploration ); précédent : 003E57; suivant : 003E59Radiographic Periodontal Bone Loss in Chronic Kidney Disease
Auteurs : Marie-Danielle Messier [États-Unis] ; Karin Emde [États-Unis] ; Leonard Stern [États-Unis] ; Jai Radhakrishnan [États-Unis] ; Linda Vernocchi [États-Unis] ; BIN CHENG [États-Unis] ; Christos Angelopoulos [États-Unis] ; Panos N. Papapanou [États-Unis]Source :
- Journal of periodontology : (1970) [ 0022-3492 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Background: We examined the extent and severity of radiographic periodontal bone loss in patients with different stages of chronic kidney disease (CKD) and explored a potential dose- response relationship between bone loss and CKD-related biomarkers. Methods: Panoramic radiographs were obtained from 129 CKD patients (78 males and 51 females; mean age: 63.5 years, range: 24 to 91 years), including 63 patients undergoing dialysis for an average of 3.3 years (range: 0.5 to 14 years). Glomerular filtration rate (GFR), dialysis dose, and levels of serum biomarkers were obtained through a hospital database. Interproximal bone loss was assessed as a percentage of root length. Results: Twenty-nine participants were edentulous (23.8% of those on dialysis versus 21.2% of those with residual kidney function; X2 test, P= 0.724). The extent of bone loss was higher among dialysis patients (analysis of variance [ANOVA], P = 0.007), but no clear dose-response association between CKD stage and extent was evident. GFR, dialysis dose, and levels of serum biomarkers did not differ between edentulous and dentate individuals, and only serum albumin was lower in patients with extensive bone loss (ANOVA, P= 0.030). After adjusting for dialysis status, the severity of bone loss was positively associated with glucose levels (multiple regression, P= 0.019) and white blood cell count (P= 0.032), whereas the number of teeth present was positively associated with plasma phosphorus (P= 0.008) and negatively with glucose levels (P= 0.011). Conclusion: Despite a higher extent of bone loss in dialysis patients, the lack of a dose-response association between bone loss and CKD stage or the levels of CKD-related serum biomarkers underscores the complex relationship between the two conditions.
Affiliations:
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York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Emde, Karin" sort="Emde, Karin" uniqKey="Emde K" first="Karin" last="Emde">Karin Emde</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Stern, Leonard" sort="Stern, Leonard" uniqKey="Stern L" first="Leonard" last="Stern">Leonard Stern</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia 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first="Linda" last="Vernocchi">Linda Vernocchi</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University</s1><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Bin Cheng" sort="Bin Cheng" uniqKey="Bin Cheng" last="Bin Cheng">BIN CHENG</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Biostatistics, Mailman School of Public Health, Columbia University</s1><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Angelopoulos, Christos" sort="Angelopoulos, Christos" uniqKey="Angelopoulos C" first="Christos" last="Angelopoulos">Christos Angelopoulos</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Division of Oral Radiology, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University</s1><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author></analytic><series><title level="j" type="main">Journal of periodontology : (1970)</title><title level="j" type="abbreviated">J. periodontol. : (1970)</title><idno type="ISSN">0022-3492</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of periodontology : (1970)</title><title level="j" type="abbreviated">J. periodontol. : (1970)</title><idno type="ISSN">0022-3492</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar bone</term><term>Chronic</term><term>Chronic kidney disease</term><term>Dentistry</term><term>Dialysis</term><term>Epidemiology</term><term>Inflammation</term><term>Osteopenia</term><term>Periodontitis</term><term>Radiography</term><term>Renal failure</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Ostéopénie</term><term>Néphropathie chronique</term><term>Parodontite</term><term>Radiographie</term><term>Dialyse</term><term>Os alvéolaire</term><term>Chronique</term><term>Epidémiologie</term><term>Inflammation</term><term>Insuffisance rénale</term><term>Dentisterie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: We examined the extent and severity of radiographic periodontal bone loss in patients with different stages of chronic kidney disease (CKD) and explored a potential dose- response relationship between bone loss and CKD-related biomarkers. Methods: Panoramic radiographs were obtained from 129 CKD patients (78 males and 51 females; mean age: 63.5 years, range: 24 to 91 years), including 63 patients undergoing dialysis for an average of 3.3 years (range: 0.5 to 14 years). Glomerular filtration rate (GFR), dialysis dose, and levels of serum biomarkers were obtained through a hospital database. Interproximal bone loss was assessed as a percentage of root length. Results: Twenty-nine participants were edentulous (23.8% of those on dialysis versus 21.2% of those with residual kidney function; X<sup>2</sup> test, P= 0.724). The extent of bone loss was higher among dialysis patients (analysis of variance [ANOVA], P = 0.007), but no clear dose-response association between CKD stage and extent was evident. GFR, dialysis dose, and levels of serum biomarkers did not differ between edentulous and dentate individuals, and only serum albumin was lower in patients with extensive bone loss (ANOVA, P= 0.030). After adjusting for dialysis status, the severity of bone loss was positively associated with glucose levels (multiple regression, P= 0.019) and white blood cell count (P= 0.032), whereas the number of teeth present was positively associated with plasma phosphorus (P= 0.008) and negatively with glucose levels (P= 0.011). Conclusion: Despite a higher extent of bone loss in dialysis patients, the lack of a dose-response association between bone loss and CKD stage or the levels of CKD-related serum biomarkers underscores the complex relationship between the two conditions.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Messier, Marie Danielle" sort="Messier, Marie Danielle" uniqKey="Messier M" first="Marie-Danielle" last="Messier">Marie-Danielle Messier</name></region><name sortKey="Angelopoulos, Christos" sort="Angelopoulos, Christos" uniqKey="Angelopoulos C" first="Christos" last="Angelopoulos">Christos Angelopoulos</name><name sortKey="Bin Cheng" sort="Bin Cheng" uniqKey="Bin Cheng" last="Bin Cheng">BIN CHENG</name><name sortKey="Emde, Karin" sort="Emde, Karin" uniqKey="Emde K" first="Karin" last="Emde">Karin Emde</name><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name><name sortKey="Radhakrishnan, Jai" sort="Radhakrishnan, Jai" uniqKey="Radhakrishnan J" first="Jai" last="Radhakrishnan">Jai Radhakrishnan</name><name sortKey="Stern, Leonard" sort="Stern, Leonard" uniqKey="Stern L" first="Leonard" last="Stern">Leonard Stern</name><name sortKey="Vernocchi, Linda" sort="Vernocchi, Linda" uniqKey="Vernocchi L" first="Linda" last="Vernocchi">Linda Vernocchi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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