Serveur d'exploration sur le patient édenté

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Lessons learned and unlearned in periodontal microbiology

Identifieur interne : 002A99 ( Main/Exploration ); précédent : 002A98; suivant : 002B00

Lessons learned and unlearned in periodontal microbiology

Auteurs : Ricardo Teles ; Flavia Teles ; Jorge Frias-Lopez ; Bruce Paster ; Anne Haffajee

Source :

RBID : ISTEX:DA9B4902E04CD956EB79ACAE35803A265617CF3F

Descripteurs français

English descriptors

Abstract

Periodontal diseases are initiated by bacterial species living in polymicrobial biofilms at or below the gingival margin and progress largely as a result of the inflammation elicited by specific subgingival species. In the past few decades, efforts to understand the periodontal microbiota have led to an exponential increase in information about biofilms associated with periodontal health and disease. In fact, the oral microbiota is one of the best‐characterized microbiomes that colonize the human body. Despite this increased knowledge, one has to ask if our fundamental concepts of the etiology and pathogenesis of periodontal diseases have really changed. In this article we will review how our comprehension of the structure and function of the subgingival microbiota has evolved over the years in search of lessons learned and unlearned in periodontal microbiology. More specifically, this review focuses on: (i) how the data obtained through molecular techniques have impacted our knowledge of the etiology of periodontal infections; (ii) the potential role of viruses in the etiopathogenesis of periodontal diseases; (iii) how concepts of microbial ecology have expanded our understanding of host–microbe interactions that might lead to periodontal diseases; (iv) the role of inflammation in the pathogenesis of periodontal diseases; and (v) the impact of these evolving concepts on therapeutic and preventive strategies to periodontal infections. We will conclude by reviewing how novel systems‐biology approaches promise to unravel new details of the pathogenesis of periodontal diseases and hopefully lead to a better understanding of their mechanisms.

Url:
DOI: 10.1111/prd.12010


Affiliations:


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<term>Actinomyces</term>
<term>Actinomycetemcomitans</term>
<term>Amoxicillin</term>
<term>Antibiotic</term>
<term>Antimicrobial</term>
<term>Appl</term>
<term>Appl environ microbiol</term>
<term>Attachment loss</term>
<term>Bacterial species</term>
<term>Bacteroidetes</term>
<term>Biol</term>
<term>Capnocytophaga</term>
<term>Caries</term>
<term>Checkerboard</term>
<term>Checkerboard hybridization</term>
<term>Chronic periodontitis</term>
<term>Clin</term>
<term>Clin microbiol</term>
<term>Clin periodontol</term>
<term>Clonal</term>
<term>Clone</term>
<term>Coli</term>
<term>Colonization</term>
<term>Crevicular</term>
<term>Cytokine</term>
<term>Cytomegalovirus</term>
<term>Database</term>
<term>Dental plaque</term>
<term>Denticola</term>
<term>Denture</term>
<term>Dewhirst</term>
<term>Disease progression</term>
<term>Ecology</term>
<term>Ecosystem</term>
<term>Environ</term>
<term>Etiological</term>
<term>Etiological agents</term>
<term>Etiology</term>
<term>Eubacterium</term>
<term>Experimental gingivitis</term>
<term>Forsythia</term>
<term>Fusobacterium</term>
<term>Genome</term>
<term>Genomic</term>
<term>Gingival</term>
<term>Gingival crevicular</term>
<term>Gingivalis</term>
<term>Gingivitis</term>
<term>Haffajee</term>
<term>Hasturk</term>
<term>Herpesvirus</term>
<term>Herpesviruses</term>
<term>Horizontal gene transfer</term>
<term>Human cytomegalovirus</term>
<term>Hybridization</term>
<term>Immunol</term>
<term>Intermedia</term>
<term>Lymphotropic</term>
<term>Metronidazole</term>
<term>Microarray</term>
<term>Microbial</term>
<term>Microbial complexes</term>
<term>Microbial diversity</term>
<term>Microbial microarray</term>
<term>Microbiol</term>
<term>Microbiological</term>
<term>Microbiologist</term>
<term>Microbiology</term>
<term>Microbiome</term>
<term>Microbiome database</term>
<term>Microbiota</term>
<term>Molecular techniques</term>
<term>Natural teeth</term>
<term>Ndings</term>
<term>Nigrescens</term>
<term>Nucleatum</term>
<term>Oral cavity</term>
<term>Oral microbiol immunol</term>
<term>Paster</term>
<term>Pathogen</term>
<term>Pathogenesis</term>
<term>Periodontal</term>
<term>Periodontal disease</term>
<term>Periodontal disease progression</term>
<term>Periodontal diseases</term>
<term>Periodontal health</term>
<term>Periodontal infections</term>
<term>Periodontal lesions</term>
<term>Periodontal microbiology</term>
<term>Periodontal pathogens</term>
<term>Periodontal therapy</term>
<term>Periodontal tissue destruction</term>
<term>Periodontally</term>
<term>Periodontitis</term>
<term>Periodontitis patients</term>
<term>Periodontol</term>
<term>Phenotypic</term>
<term>Phylotypes</term>
<term>Phylum</term>
<term>Plaque</term>
<term>Plaque accumulation</term>
<term>Plo</term>
<term>Pocket depth</term>
<term>Polymerase</term>
<term>Porphyromonas</term>
<term>Porphyromonas gingivalis</term>
<term>Potential role</term>
<term>Prevotella</term>
<term>Primer</term>
<term>Progression</term>
<term>Putative</term>
<term>Pyrosequencing</term>
<term>Recent years</term>
<term>Resolvin</term>
<term>Ribosomal</term>
<term>Rrna</term>
<term>Selenomonas</term>
<term>Sequencing</term>
<term>Socransky</term>
<term>Spirochete</term>
<term>Streptococcus</term>
<term>Subgingival</term>
<term>Subgingival microbiota</term>
<term>Subgingival samples</term>
<term>Subset</term>
<term>Supragingival</term>
<term>Synergistetes</term>
<term>Tannerella</term>
<term>Taxon</term>
<term>Teles</term>
<term>Tissue destruction</term>
<term>Treponema</term>
<term>Unculturable</term>
<term>Uncultured</term>
<term>Unlearned</term>
<term>Viral</term>
<term>Winkelhoff</term>
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<term>Actinomyces</term>
<term>Actinomycetemcomitans</term>
<term>Amoxicillin</term>
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<term>Antimicrobial</term>
<term>Appl</term>
<term>Appl environ microbiol</term>
<term>Attachment loss</term>
<term>Bacterial species</term>
<term>Bacteroidetes</term>
<term>Biol</term>
<term>Capnocytophaga</term>
<term>Caries</term>
<term>Checkerboard</term>
<term>Checkerboard hybridization</term>
<term>Chronic periodontitis</term>
<term>Clin</term>
<term>Clin microbiol</term>
<term>Clin periodontol</term>
<term>Clonal</term>
<term>Clone</term>
<term>Coli</term>
<term>Colonization</term>
<term>Crevicular</term>
<term>Cytokine</term>
<term>Cytomegalovirus</term>
<term>Database</term>
<term>Dental plaque</term>
<term>Denticola</term>
<term>Denture</term>
<term>Dewhirst</term>
<term>Disease progression</term>
<term>Ecology</term>
<term>Ecosystem</term>
<term>Environ</term>
<term>Etiological</term>
<term>Etiological agents</term>
<term>Etiology</term>
<term>Eubacterium</term>
<term>Experimental gingivitis</term>
<term>Forsythia</term>
<term>Fusobacterium</term>
<term>Genome</term>
<term>Genomic</term>
<term>Gingival</term>
<term>Gingival crevicular</term>
<term>Gingivalis</term>
<term>Gingivitis</term>
<term>Haffajee</term>
<term>Hasturk</term>
<term>Herpesvirus</term>
<term>Herpesviruses</term>
<term>Horizontal gene transfer</term>
<term>Human cytomegalovirus</term>
<term>Hybridization</term>
<term>Immunol</term>
<term>Intermedia</term>
<term>Lymphotropic</term>
<term>Metronidazole</term>
<term>Microarray</term>
<term>Microbial</term>
<term>Microbial complexes</term>
<term>Microbial diversity</term>
<term>Microbial microarray</term>
<term>Microbiol</term>
<term>Microbiological</term>
<term>Microbiologist</term>
<term>Microbiology</term>
<term>Microbiome</term>
<term>Microbiome database</term>
<term>Microbiota</term>
<term>Molecular techniques</term>
<term>Natural teeth</term>
<term>Ndings</term>
<term>Nigrescens</term>
<term>Nucleatum</term>
<term>Oral cavity</term>
<term>Oral microbiol immunol</term>
<term>Paster</term>
<term>Pathogen</term>
<term>Pathogenesis</term>
<term>Periodontal</term>
<term>Periodontal disease</term>
<term>Periodontal disease progression</term>
<term>Periodontal diseases</term>
<term>Periodontal health</term>
<term>Periodontal infections</term>
<term>Periodontal lesions</term>
<term>Periodontal microbiology</term>
<term>Periodontal pathogens</term>
<term>Periodontal therapy</term>
<term>Periodontal tissue destruction</term>
<term>Periodontally</term>
<term>Periodontitis</term>
<term>Periodontitis patients</term>
<term>Periodontol</term>
<term>Phenotypic</term>
<term>Phylotypes</term>
<term>Phylum</term>
<term>Plaque</term>
<term>Plaque accumulation</term>
<term>Plo</term>
<term>Pocket depth</term>
<term>Polymerase</term>
<term>Porphyromonas</term>
<term>Porphyromonas gingivalis</term>
<term>Potential role</term>
<term>Prevotella</term>
<term>Primer</term>
<term>Progression</term>
<term>Putative</term>
<term>Pyrosequencing</term>
<term>Recent years</term>
<term>Resolvin</term>
<term>Ribosomal</term>
<term>Rrna</term>
<term>Selenomonas</term>
<term>Sequencing</term>
<term>Socransky</term>
<term>Spirochete</term>
<term>Streptococcus</term>
<term>Subgingival</term>
<term>Subgingival microbiota</term>
<term>Subgingival samples</term>
<term>Subset</term>
<term>Supragingival</term>
<term>Synergistetes</term>
<term>Tannerella</term>
<term>Taxon</term>
<term>Teles</term>
<term>Tissue destruction</term>
<term>Treponema</term>
<term>Unculturable</term>
<term>Uncultured</term>
<term>Unlearned</term>
<term>Viral</term>
<term>Winkelhoff</term>
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<term>écologie</term>
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<front>
<div type="abstract" xml:lang="en">Periodontal diseases are initiated by bacterial species living in polymicrobial biofilms at or below the gingival margin and progress largely as a result of the inflammation elicited by specific subgingival species. In the past few decades, efforts to understand the periodontal microbiota have led to an exponential increase in information about biofilms associated with periodontal health and disease. In fact, the oral microbiota is one of the best‐characterized microbiomes that colonize the human body. Despite this increased knowledge, one has to ask if our fundamental concepts of the etiology and pathogenesis of periodontal diseases have really changed. In this article we will review how our comprehension of the structure and function of the subgingival microbiota has evolved over the years in search of lessons learned and unlearned in periodontal microbiology. More specifically, this review focuses on: (i) how the data obtained through molecular techniques have impacted our knowledge of the etiology of periodontal infections; (ii) the potential role of viruses in the etiopathogenesis of periodontal diseases; (iii) how concepts of microbial ecology have expanded our understanding of host–microbe interactions that might lead to periodontal diseases; (iv) the role of inflammation in the pathogenesis of periodontal diseases; and (v) the impact of these evolving concepts on therapeutic and preventive strategies to periodontal infections. We will conclude by reviewing how novel systems‐biology approaches promise to unravel new details of the pathogenesis of periodontal diseases and hopefully lead to a better understanding of their mechanisms.</div>
</front>
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<name sortKey="Paster, Bruce" sort="Paster, Bruce" uniqKey="Paster B" first="Bruce" last="Paster">Bruce Paster</name>
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