Giant Keratocystic Odontogenic Tumor: Three Cases and Literature Review
Identifieur interne : 002469 ( Main/Exploration ); précédent : 002468; suivant : 002470Giant Keratocystic Odontogenic Tumor: Three Cases and Literature Review
Auteurs : Alexandre Caixeta Guimarães ; Mariana Dutra De Cassia Ferreira Santos ; Guilherme Machado De Carvalho ; Carlos Takahiro Chone ; Leopoldo Nizam PfeilstickerSource :
- Iranian Journal of Otorhinolaryngology [ 2251-7251 ] ; 2013.
Abstract
A keratocystic odontogenic tumor is a benign intra-bone mass originating from dental lamina or its residue. It represents 2–11% of jaw cysts, and has a slow but aggressive growth. The evaluation of molecular characteristics, immunohistochemistry, and genetic expression currently have no established classification regarding the evolution and pathophysiologic pattern of these lesions.
This is a clinical retrospective study with a full analysis of patient history regarding physical evaluation, radiologic images, pathology results, and surgical resection. We performed a major literature review concerning current concepts relating to its biological characterization. Three cases of keratocystic odontogenic tumor were identified. Two of the cases were large, with aggressive behavior and significant bone destruction and recurrence, which had been overlooked for more than a decade. The third case had an early diagnosis, and the treatment led to full recovery and complete healing.
The keratocystic odontogenic tumor is a benign lesion with slow growth, which lends itself to a more conservative treatment, even in cases of large lesions. A better understanding of these tumors, both at the biological and molecular level, could lead to guidelines for treatment and prognosis of such patients.
Url:
PubMed: 24303448
PubMed Central: 3846250
Affiliations:
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Brazil.</italic></nlm:aff></affiliation></author><author><name sortKey="Machado De Carvalho, Guilherme" sort="Machado De Carvalho, Guilherme" uniqKey="Machado De Carvalho G" first="Guilherme" last="Machado De Carvalho">Guilherme Machado De Carvalho</name><affiliation><nlm:aff id="aff1"><italic>Department of Otorhinolaryngology, University of Campinas (UNICAMP), School of Medical Sciences (FCM), São Paulo, Brazil.</italic></nlm:aff></affiliation></author><author><name sortKey="Takahiro Chone, Carlos" sort="Takahiro Chone, Carlos" uniqKey="Takahiro Chone C" first="Carlos" last="Takahiro Chone">Carlos Takahiro Chone</name><affiliation><nlm:aff id="aff1"><italic>Department of Otorhinolaryngology, University of Campinas (UNICAMP), School of Medical Sciences (FCM), São Paulo, Brazil.</italic></nlm:aff></affiliation></author><author><name sortKey="Nizam Pfeilsticker, Leopoldo" sort="Nizam Pfeilsticker, Leopoldo" uniqKey="Nizam Pfeilsticker L" first="Leopoldo" last="Nizam Pfeilsticker">Leopoldo Nizam Pfeilsticker</name><affiliation><nlm:aff id="aff1"><italic>Department of Otorhinolaryngology, University of Campinas (UNICAMP), School of Medical Sciences (FCM), São Paulo, Brazil.</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24303448</idno><idno type="pmc">3846250</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846250</idno><idno type="RBID">PMC:3846250</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001D26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D26</idno><idno type="wicri:Area/Pmc/Curation">001D26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D26</idno><idno type="wicri:Area/Pmc/Checkpoint">001990</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001990</idno><idno type="wicri:Area/Ncbi/Merge">004B96</idno><idno 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sort="Dutra De Cassia Ferreira Santos, Mariana" uniqKey="Dutra De Cassia Ferreira Santos M" first="Mariana" last="Dutra De Cassia Ferreira Santos">Mariana Dutra De Cassia Ferreira Santos</name><affiliation><nlm:aff id="aff1"><italic>Department of Otorhinolaryngology, University of Campinas (UNICAMP), School of Medical Sciences (FCM), São Paulo, Brazil.</italic></nlm:aff></affiliation></author><author><name sortKey="Machado De Carvalho, Guilherme" sort="Machado De Carvalho, Guilherme" uniqKey="Machado De Carvalho G" first="Guilherme" last="Machado De Carvalho">Guilherme Machado De Carvalho</name><affiliation><nlm:aff id="aff1"><italic>Department of Otorhinolaryngology, University of Campinas (UNICAMP), School of Medical Sciences (FCM), São Paulo, Brazil.</italic></nlm:aff></affiliation></author><author><name sortKey="Takahiro Chone, Carlos" sort="Takahiro Chone, Carlos" uniqKey="Takahiro Chone C" first="Carlos" last="Takahiro Chone">Carlos Takahiro Chone</name><affiliation><nlm:aff id="aff1"><italic>Department of Otorhinolaryngology, University of Campinas (UNICAMP), School of Medical Sciences (FCM), São Paulo, Brazil.</italic></nlm:aff></affiliation></author><author><name sortKey="Nizam Pfeilsticker, Leopoldo" sort="Nizam Pfeilsticker, Leopoldo" uniqKey="Nizam Pfeilsticker L" first="Leopoldo" last="Nizam Pfeilsticker">Leopoldo Nizam Pfeilsticker</name><affiliation><nlm:aff id="aff1"><italic>Department of Otorhinolaryngology, University of Campinas (UNICAMP), School of Medical Sciences (FCM), São Paulo, Brazil.</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Iranian Journal of Otorhinolaryngology</title><idno type="ISSN">2251-7251</idno><idno type="eISSN">2251-726X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction:</title><p>A keratocystic odontogenic tumor is a benign intra-bone mass originating from dental lamina or its residue. It represents 2–11% of jaw cysts, and has a slow but aggressive growth. The evaluation of molecular characteristics, immunohistochemistry, and genetic expression currently have no established classification regarding the evolution and pathophysiologic pattern of these lesions. </p></sec><sec><title>Case Report:</title><p>This is a clinical retrospective study with a full analysis of patient history regarding physical evaluation, radiologic images, pathology results, and surgical resection. We performed a major literature review concerning current concepts relating to its biological characterization. Three cases of keratocystic odontogenic tumor were identified. Two of the cases were large, with aggressive behavior and significant bone destruction and recurrence, which had been overlooked for more than a decade. The third case had an early diagnosis, and the treatment led to full recovery and complete healing. </p></sec><sec><title>Conclusion: </title><p>The keratocystic odontogenic tumor is a benign lesion with slow growth, which lends itself to a more conservative treatment, even in cases of large lesions. A better understanding of these tumors, both at the biological and molecular level, could lead to guidelines for treatment and prognosis of such patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mendes, Ra" uniqKey="Mendes R">RA Mendes</name></author><author><name sortKey="Carvalho, Jf" uniqKey="Carvalho J">JF Carvalho</name></author><author><name sortKey="Van, Der Waal I" uniqKey="Van D">der Waal I Van</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Sun, Zj" uniqKey="Sun Z">ZJ Sun</name></author><author><name sortKey="Zhao, Yf" uniqKey="Zhao Y">YF Zhao</name></author><author><name sortKey="Bian, Z" uniqKey="Bian Z">Z Bian</name></author><author><name sortKey="Fan, Mw" uniqKey="Fan M">MW Fan</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z 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Guimaraes, Alexandre" uniqKey="Caixeta Guimaraes A" first="Alexandre" last="Caixeta Guimarães">Alexandre Caixeta Guimarães</name><name sortKey="Dutra De Cassia Ferreira Santos, Mariana" sort="Dutra De Cassia Ferreira Santos, Mariana" uniqKey="Dutra De Cassia Ferreira Santos M" first="Mariana" last="Dutra De Cassia Ferreira Santos">Mariana Dutra De Cassia Ferreira Santos</name><name sortKey="Machado De Carvalho, Guilherme" sort="Machado De Carvalho, Guilherme" uniqKey="Machado De Carvalho G" first="Guilherme" last="Machado De Carvalho">Guilherme Machado De Carvalho</name><name sortKey="Nizam Pfeilsticker, Leopoldo" sort="Nizam Pfeilsticker, Leopoldo" uniqKey="Nizam Pfeilsticker L" first="Leopoldo" last="Nizam Pfeilsticker">Leopoldo Nizam Pfeilsticker</name><name sortKey="Takahiro Chone, Carlos" sort="Takahiro Chone, Carlos" uniqKey="Takahiro Chone C" first="Carlos" last="Takahiro Chone">Carlos Takahiro Chone</name></noCountry></tree></affiliations></record>Pour manipuler ce document 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