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Oral Microbial Profile Discriminates Breastfed from Formula-Fed Infants

Identifieur interne : 002345 ( Main/Exploration ); précédent : 002344; suivant : 002346

Oral Microbial Profile Discriminates Breastfed from Formula-Fed Infants

Auteurs : Pernilla Lif Holgerson [Suède] ; Nelly Romani Vestman [Suède] ; Rolf Claesson [Suède] ; Carina Öhman [Suède] ; Magnus Domellöf [Suède] ; Anne Cr Tanner [États-Unis] ; Olle Hernell [Suède] ; Ingegerd Johansson [Suède]

Source :

Journal of pediatric gastroenterology and nutrition [ 0277-2116 ] ; 2013.

RBID : PMC:3548038

Abstract

Objectives

Little is known about the impact of diet on the oral microbiota of infants although diet is known to affect the gut microbiota. The aims of the present study were to compare the oral microbiota in breastfed and formula-fed infants, and investigate growth inhibition of streptococci by infant-isolated lactobacilli.

Subjects and Methods

207 mothers consented to participation of their three-month old infants. 146 (70.5%) infants were exclusively and 38 (18.4%) partially breastfed, and 23 (11.1%) were exclusively formula-fed. Saliva from all infants was cultured for Lactobacillus species, with isolate identifications from 21 infants. Lactobacillus isolates were tested for their ability to supress Streptococcus mutans and Streptococcus sanguinis. Oral swabs from 73 infants were analysed by the Human Oral Microbe Identification Microarray (HOMIM) and by q-PCR for Lactobacilius gasseri.

Results

Lactobacilli were cultured from 27.8% of exclusively and partially breastfed infants, but not from formula-fed infants. The prevalence of 14 HOMIM detected taxa, and total salivary lactobacilli counts differed by feeding method. Multivariate modelling of HOMIM detected bacteria and possible confounders clustered samples from breastfed infants separately from formula-fed infants. The microbiota of breastfed infants differed based on vaginal or C-section delivery. Isolates of Lactobacillus plantarum, L. gasseri and Lactobacillus vaginalis inhibited growth of the cariogenic S. mutans and the commensal S. sanguinis: L. plantarum > L. gasseri > L. vaginalis.

Conclusion

The microbiota of the mouth differs between breastfed and formula-fed three-month-old infants. Possible mechanisms for microbial differences observed include species suppression by lactobacilli indigenous to breast milk.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548038

DOI: 10.1097/MPG.0b013e31826f2bc6
PubMed: 22955450
PubMed Central: 3548038

Affiliations:

Suède, États-Unis

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
<p id="P1">Little is known about the impact of diet on the oral microbiota of infants although diet is known to affect the gut microbiota. The aims of the present study were to compare the oral microbiota in breastfed and formula-fed infants, and investigate growth inhibition of streptococci by infant-isolated lactobacilli.</p>
</sec>
<sec id="S2"><title>Subjects and Methods</title>
<p id="P2">207 mothers consented to participation of their three-month old infants. 146 (70.5%) infants were exclusively and 38 (18.4%) partially breastfed, and 23 (11.1%) were exclusively formula-fed. Saliva from all infants was cultured for <italic>Lactobacillus</italic>
 species, with isolate identifications from 21 infants. <italic>Lactobacillus</italic>
 isolates were tested for their ability to supress <italic>Streptococcus mutans</italic>
 and <italic>Streptococcus sanguinis.</italic>
 Oral swabs from 73 infants were analysed by the Human Oral Microbe Identification Microarray (HOMIM) and by q-PCR for <italic>Lactobacilius gasseri.</italic>
</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Lactobacilli were cultured from 27.8% of exclusively and partially breastfed infants, but not from formula-fed infants. The prevalence of 14 HOMIM detected taxa, and total salivary lactobacilli counts differed by feeding method. Multivariate modelling of HOMIM detected bacteria and possible confounders clustered samples from breastfed infants separately from formula-fed infants. The microbiota of breastfed infants differed based on vaginal or C-section delivery. Isolates of <italic>Lactobacillus plantarum, L. gasseri</italic>
 and <italic>Lactobacillus vaginalis</italic>
 inhibited growth of the cariogenic <italic>S. mutans</italic>
 and the commensal <italic>S. sanguinis: L. plantarum > L. gasseri > L. vaginalis</italic>
.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">The microbiota of the mouth differs between breastfed and formula-fed three-month-old infants. Possible mechanisms for microbial differences observed include species suppression by lactobacilli indigenous to breast milk.</p>
</sec>
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Oral Microbial Profile Discriminates Breastfed from Formula-Fed Infants

Oral Microbial Profile Discriminates Breastfed from Formula-Fed Infants

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