Association of Periodontal Diseases and Liver Fibrosis in Patients With HCV and/or HBV infection
Identifieur interne : 001C69 ( Main/Exploration ); précédent : 001C68; suivant : 001C70Association of Periodontal Diseases and Liver Fibrosis in Patients With HCV and/or HBV infection
Auteurs : Yumiko Nagao [Japon] ; Yuji Kawahigashi [Japon] ; Michio Sata [Japon]Source :
- Hepatitis Monthly [ 1735-143X ] ; 2014.
Abstract
Periodontal disease and systemic health are closely associated. However, there is no data supporting the association between periodontal disease and patients with liver diseases associated with hepatitis C virus (HCV) and/or hepatitis B virus (HBV) infection.
The aim of this study was to evaluate the association between periodontitis and progression of liver diseases in patients with HCV and/or HBV infection.
In this retrospective study, 351 patients with HCV- and/or HBV-related liver diseases underwent screening for periodontal disease using the Salivaster® salivary occult blood test from February 2010 to June 2014. Furthermore, we examined the prevalence of fimbrillin (
Of 351 patients, 76 patients (group 1) had a strong positive result for salivary occult blood test and 275 patients (group 2) had weak positive or negative test results. Significant factors between the groups were obesity, level of AST, ALT, LDH, ALP, Alb, D.Bil, T.cho, AFP, platelets (Plt), IRI, HOMA-IR, current interferon (IFN) treatment and the daily frequency of tooth brushing. Between-groups analysis indicated that total protein (T.pro) level and liver fibrosis were significant factors. According to multivariate analysis, five factors were associated with periodontal disease as Plt count below 80000, brushing teeth only once a day, current IFN treatment, aged 65 years or older and obesity. The adjusted odds ratios for these five factors were 5.80, 3.46, 2.87, 2.50 and 2.33, respectively, and each was statistically significant. Twenty-eight saliva specimens had positive results for
Periodontitis might be associated with progression of viral liver disease; hence, controlling oral disease is essential for the prevention and management of liver fibrosis.
Url:
DOI: 10.5812/hepatmon.23264
PubMed: 25737729
PubMed Central: 4329233
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of Periodontal Diseases and Liver Fibrosis in Patients With HCV and/or HBV infection</title><author><name sortKey="Nagao, Yumiko" sort="Nagao, Yumiko" uniqKey="Nagao Y" first="Yumiko" last="Nagao">Yumiko Nagao</name><affiliation wicri:level="1"><nlm:aff id="aff47907">Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Fukuoka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Kawahigashi, Yuji" sort="Kawahigashi, Yuji" uniqKey="Kawahigashi Y" first="Yuji" last="Kawahigashi">Yuji Kawahigashi</name><affiliation wicri:level="1"><nlm:aff id="aff47907">Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Fukuoka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Sata, Michio" sort="Sata, Michio" uniqKey="Sata M" first="Michio" last="Sata">Michio Sata</name><affiliation wicri:level="1"><nlm:aff id="aff47909">Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Fukuoka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25737729</idno><idno type="pmc">4329233</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329233</idno><idno type="RBID">PMC:4329233</idno><idno type="doi">10.5812/hepatmon.23264</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002C73</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C73</idno><idno type="wicri:Area/Pmc/Curation">002C73</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C73</idno><idno type="wicri:Area/Pmc/Checkpoint">001602</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001602</idno><idno type="wicri:Area/Ncbi/Merge">005899</idno><idno type="wicri:Area/Ncbi/Curation">005899</idno><idno type="wicri:Area/Ncbi/Checkpoint">005899</idno><idno type="wicri:doubleKey">1735-143X:2014:Nagao Y:association:of:periodontal</idno><idno type="wicri:Area/Main/Merge">001C76</idno><idno type="wicri:Area/Main/Curation">001C69</idno><idno type="wicri:Area/Main/Exploration">001C69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of Periodontal Diseases and Liver Fibrosis in Patients With HCV and/or HBV infection</title><author><name sortKey="Nagao, Yumiko" sort="Nagao, Yumiko" uniqKey="Nagao Y" first="Yumiko" last="Nagao">Yumiko Nagao</name><affiliation wicri:level="1"><nlm:aff id="aff47907">Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Fukuoka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Kawahigashi, Yuji" sort="Kawahigashi, Yuji" uniqKey="Kawahigashi Y" first="Yuji" last="Kawahigashi">Yuji Kawahigashi</name><affiliation wicri:level="1"><nlm:aff id="aff47907">Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Fukuoka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Sata, Michio" sort="Sata, Michio" uniqKey="Sata M" first="Michio" last="Sata">Michio Sata</name><affiliation wicri:level="1"><nlm:aff id="aff47909">Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Fukuoka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author></analytic><series><title level="j">Hepatitis Monthly</title><idno type="ISSN">1735-143X</idno><idno type="eISSN">1735-3408</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Periodontal disease and systemic health are closely associated. However, there is no data supporting the association between periodontal disease and patients with liver diseases associated with hepatitis C virus (HCV) and/or hepatitis B virus (HBV) infection.</p></sec><sec><title>Objectives:</title><p>The aim of this study was to evaluate the association between periodontitis and progression of liver diseases in patients with HCV and/or HBV infection.</p></sec><sec><title>Patients and Methods:</title><p>In this retrospective study, 351 patients with HCV- and/or HBV-related liver diseases underwent screening for periodontal disease using the Salivaster® salivary occult blood test from February 2010 to June 2014. Furthermore, we examined the prevalence of fimbrillin (<italic>fimA</italic>) genotype of <italic>Porphyromonas gingivalis</italic> (P. gingivalis) in 28 HCV-infected patients visited at our hospital between January 2013 and June 2014. <italic>P. gingivalis</italic> with <italic>fimA</italic> genotype with types I to V was further detected using a PCR method.</p></sec><sec><title>Results:</title><p>Of 351 patients, 76 patients (group 1) had a strong positive result for salivary occult blood test and 275 patients (group 2) had weak positive or negative test results. Significant factors between the groups were obesity, level of AST, ALT, LDH, ALP, Alb, D.Bil, T.cho, AFP, platelets (Plt), IRI, HOMA-IR, current interferon (IFN) treatment and the daily frequency of tooth brushing. Between-groups analysis indicated that total protein (T.pro) level and liver fibrosis were significant factors. According to multivariate analysis, five factors were associated with periodontal disease as Plt count below 80000, brushing teeth only once a day, current IFN treatment, aged 65 years or older and obesity. The adjusted odds ratios for these five factors were 5.80, 3.46, 2.87, 2.50 and 2.33, respectively, and each was statistically significant. Twenty-eight saliva specimens had positive results for <italic>P. gingivalis</italic> with <italic>fimA</italic> genotype types I to V. The prevalence of <italic>fimA</italic> genotype II was higher in 14 patients with liver cirrhosis or a history of hepatocellular carcinoma treatment (group B, 50.00%) than 14 patients with only hepatitis C (group A, 21.43%).</p></sec><sec><title>Conclusions:</title><p>Periodontitis might be associated with progression of viral liver disease; hence, controlling oral disease is essential for the prevention and management of liver fibrosis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Umemura, T" uniqKey="Umemura T">T Umemura</name></author><author><name sortKey="Ichijo, T" uniqKey="Ichijo T">T Ichijo</name></author><author><name sortKey="Yoshizawa, K" uniqKey="Yoshizawa K">K Yoshizawa</name></author><author><name sortKey="Tanaka, E" uniqKey="Tanaka E">E Tanaka</name></author><author><name sortKey="Kiyosawa, K" uniqKey="Kiyosawa K">K Kiyosawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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uniqKey="Persson G">GR Persson</name></author><author><name sortKey="Derouen, Ta" uniqKey="Derouen T">TA DeRouen</name></author><author><name sortKey="Page, Rc" uniqKey="Page R">RC Page</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Nagao, Yumiko" sort="Nagao, Yumiko" uniqKey="Nagao Y" first="Yumiko" last="Nagao">Yumiko Nagao</name></noRegion><name sortKey="Kawahigashi, Yuji" sort="Kawahigashi, Yuji" uniqKey="Kawahigashi Y" first="Yuji" last="Kawahigashi">Yuji Kawahigashi</name><name sortKey="Sata, Michio" sort="Sata, Michio" uniqKey="Sata M" first="Michio" last="Sata">Michio Sata</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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