Bone Reconstruction following Application of Bone Matrix Gelatin to Alveolar Defects: A Randomized Clinical Trial
Identifieur interne : 001372 ( Main/Exploration ); précédent : 001371; suivant : 001373Bone Reconstruction following Application of Bone Matrix Gelatin to Alveolar Defects: A Randomized Clinical Trial
Auteurs : M. Bayat [Iran] ; F. Momen Heravi [États-Unis] ; M. Mahmoudi [États-Unis] ; N. Bahrami [Iran]Source :
- International Journal of Organ Transplantation Medicine [ 2008-6482 ] ; 2015.
Abstract
Conventional dentoalveolar osseous reconstruction often involves the use of graft materials with or without barrier membranes.
To evaluate the efficacy of bone induction by bone matrix gelatin (BMG), delivered on an absorbable collagen sponge (ACS), compared to a placebo (ACS alone) in human alveolar socket defects.
20 alveolar sockets from 10 healthy adults were studied. In all cases, both the mandibular premolar area and the contralateral premolar area (as the control site) were involved. In each of the 10 patients, the extraction sites were filled randomly with BMG and ACS. The repair response was examined on day 90. Qualitative histological and quantitative histometric analysis, including the percentage of new-formed bone fill and density were done.
Assessment of the alveolar bone indicated that patients treated with BMG had significantly (p<0.05) better bone quality and quantity compared to the controls. In addition, bone density and histology revealed no differences between the newly induced and native bone.
The data from this single-blind clinical trial demonstrated that the novel combination of BMG had a striking effect on
Url:
PubMed: 26576263
PubMed Central: 4644570
Affiliations:
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Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Momen Heravi, F" sort="Momen Heravi, F" uniqKey="Momen Heravi F" first="F." last="Momen Heravi">F. Momen Heravi</name><affiliation wicri:level="2"><nlm:aff id="aff2">Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mahmoudi, M" sort="Mahmoudi, M" uniqKey="Mahmoudi M" first="M." last="Mahmoudi">M. Mahmoudi</name><affiliation wicri:level="2"><nlm:aff id="aff2">Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Bahrami, N" sort="Bahrami, N" uniqKey="Bahrami N" first="N." last="Bahrami">N. Bahrami</name><affiliation wicri:level="1"><nlm:aff id="aff1">Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. 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Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation><affiliation><nlm:aff id="aff3"><italic>Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26576263</idno><idno type="pmc">4644570</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644570</idno><idno type="RBID">PMC:4644570</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000300</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000300</idno><idno type="wicri:Area/Pmc/Curation">000300</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000300</idno><idno type="wicri:Area/Pmc/Checkpoint">000F80</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F80</idno><idno type="wicri:Area/Ncbi/Merge">006145</idno><idno type="wicri:Area/Ncbi/Curation">006145</idno><idno type="wicri:Area/Ncbi/Checkpoint">006145</idno><idno type="wicri:doubleKey">2008-6482:2015:Bayat M:bone:reconstruction:following</idno><idno type="wicri:Area/Main/Merge">001375</idno><idno type="wicri:Area/Main/Curation">001372</idno><idno type="wicri:Area/Main/Exploration">001372</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bone Reconstruction following Application of Bone Matrix Gelatin to Alveolar Defects: A Randomized Clinical Trial</title><author><name sortKey="Bayat, M" sort="Bayat, M" uniqKey="Bayat M" first="M." last="Bayat">M. Bayat</name><affiliation wicri:level="1"><nlm:aff id="aff1">Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran,</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Momen Heravi, F" sort="Momen Heravi, F" uniqKey="Momen Heravi F" first="F." last="Momen Heravi">F. Momen Heravi</name><affiliation wicri:level="2"><nlm:aff id="aff2">Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mahmoudi, M" sort="Mahmoudi, M" uniqKey="Mahmoudi M" first="M." last="Mahmoudi">M. Mahmoudi</name><affiliation wicri:level="2"><nlm:aff id="aff2">Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Bahrami, N" sort="Bahrami, N" uniqKey="Bahrami N" first="N." last="Bahrami">N. Bahrami</name><affiliation wicri:level="1"><nlm:aff id="aff1">Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran,</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation><affiliation><nlm:aff id="aff3"><italic>Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran</italic></nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Organ Transplantation Medicine</title><idno type="ISSN">2008-6482</idno><idno type="eISSN">2008-6490</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Conventional dentoalveolar osseous reconstruction often involves the use of graft materials with or without barrier membranes. </p></sec><sec><title>Objective:</title><p>To evaluate the efficacy of bone induction by bone matrix gelatin (BMG), delivered on an absorbable collagen sponge (ACS), compared to a placebo (ACS alone) in human alveolar socket defects.</p></sec><sec><title>Methods:</title><p> 20 alveolar sockets from 10 healthy adults were studied. In all cases, both the mandibular premolar area and the contralateral premolar area (as the control site) were involved. In each of the 10 patients, the extraction sites were filled randomly with BMG and ACS. The repair response was examined on day 90. Qualitative histological and quantitative histometric analysis, including the percentage of new-formed bone fill and density were done.</p></sec><sec><title>Results:</title><p>Assessment of the alveolar bone indicated that patients treated with BMG had significantly (p<0.05) better bone quality and quantity compared to the controls. In addition, bone density and histology revealed no differences between the newly induced and native bone.</p></sec><sec><title>Conclusion:</title><p>The data from this single-blind clinical trial demonstrated that the novel combination of BMG had a striking effect on <italic>de novo</italic> osseous formation for the bone regeneration.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Moghadam, Hg" uniqKey="Moghadam H">HG Moghadam</name></author><author><name sortKey="Sandor, Gk" uniqKey="Sandor G">GK Sandor</name></author><author><name sortKey="Holmes, Hh" uniqKey="Holmes H">HH Holmes</name></author><author><name sortKey="Clokie, Cm" uniqKey="Clokie C">CM Clokie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buser, D" uniqKey="Buser D">D Buser</name></author><author><name sortKey="Ingimarsson, S" uniqKey="Ingimarsson S">S Ingimarsson</name></author><author><name sortKey="Dula, K" 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Shapira-Schweitzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shahoon, H" uniqKey="Shahoon H">H Shahoon</name></author><author><name sortKey="Azimi, Hr" uniqKey="Azimi H">HR Azimi</name></author><author><name sortKey="Kianbakht, C" uniqKey="Kianbakht C">C Kianbakht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yan, Wq" uniqKey="Yan W">WQ Yan</name></author><author><name sortKey="Oka, M" uniqKey="Oka M">M Oka</name></author><author><name sortKey="Nakamura, T" uniqKey="Nakamura T">T Nakamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szpalski, M" uniqKey="Szpalski M">M Szpalski</name></author><author><name sortKey="Gunzburg, R" uniqKey="Gunzburg R">R Gunzburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rahman, Cv" uniqKey="Rahman C">CV Rahman</name></author><author><name sortKey="Ben David, D" uniqKey="Ben David D">D Ben-David</name></author><author><name sortKey="Dhillon, A" uniqKey="Dhillon A">A Dhillon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Putney, Sd" uniqKey="Putney S">SD Putney</name></author><author><name sortKey="Burke, Pa" uniqKey="Burke P">PA Burke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bayat, M" uniqKey="Bayat M">M Bayat</name></author><author><name sortKey="Momen Heravi, F" uniqKey="Momen Heravi F">F Momen-Heravi</name></author><author><name sortKey="Marjani, M" uniqKey="Marjani M">M Marjani</name></author><author><name sortKey="Motahhary, P" uniqKey="Motahhary P">P Motahhary</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Jin, L" uniqKey="Jin L">L Jin</name></author><author><name sortKey="Balian, G" uniqKey="Balian G">G Balian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Wj" uniqKey="Chen W">WJ Chen</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name></author><author><name sortKey="Mustain, Wc" uniqKey="Mustain W">WC Mustain</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Iran</li><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="Iran"><noRegion><name sortKey="Bayat, M" sort="Bayat, M" uniqKey="Bayat M" first="M." last="Bayat">M. Bayat</name></noRegion><name sortKey="Bahrami, N" sort="Bahrami, N" uniqKey="Bahrami N" first="N." last="Bahrami">N. Bahrami</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Momen Heravi, F" sort="Momen Heravi, F" uniqKey="Momen Heravi F" first="F." last="Momen Heravi">F. Momen Heravi</name></region><name sortKey="Mahmoudi, M" sort="Mahmoudi, M" uniqKey="Mahmoudi M" first="M." last="Mahmoudi">M. Mahmoudi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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