Effect on bone formation of the autogenous tooth graft in the treatment of peri-implant vertical bone defects in the minipigs
Identifieur interne : 001195 ( Main/Exploration ); précédent : 001194; suivant : 001196Effect on bone formation of the autogenous tooth graft in the treatment of peri-implant vertical bone defects in the minipigs
Auteurs : Seok Kon Kim [Corée du Sud] ; Sae Woong Kim ; Kyung Wook KimSource :
- Maxillofacial Plastic and Reconstructive Surgery [ 2288-8101 ] ; 2015.
Abstract
The aim of this study was to evaluate the effect of autogenous tooth bone as a graft material for regeneration of bone in vertical bony defects of the minipigs.
Six minipigs were used in this study. Four molars were extracted in the right mandibular dentition and sent to the Korea Tooth Bank for fabrication of autogenous tooth bone. Ten days later, each extraction site was implanted with MS Implant Narrow Ridge 3.0x10mm fixture (Osstem, Seoul, Korea) after standardized 2mm-sized artificial vertical bony defect formation. Pineappleshaped Root-On type autogenous tooth bones were applied to the vertical defects around the neck area of the posterior three fixtures and the fore-most one was not applied with autogenous bone as a control group. Each minipig was sacrificed at 4, 8, 12 weeks after fixture installation and examined radiologically and histologically. Histological evaluation was done under light microscope with Villanueva osteochrome bone staining with semi-quantitative histomorphometric study. Percentage of new bone over total area (NBF) and bone to implant contact (BIC) ratio were evaluated using digital software for area calculation.
NBF were 48.15 ± 18.02%, 45.50 ± 28.37%, and 77.13 ± 15.30% in 4, 8, and 12 weeks, respectively for experimental groups. The control group showed 37.00 ± 11.53%, 32.25 ± 26.99%, and 1.33 ± 2.31% in 4,8,12 weeks, respectively. BIC ratio were 53.08 ± 19.82%, 45.00 ± 28.37%, and 75.13 ± 16.55% in 4,8,12 weeks, respectively. Those for the control groups were 38.33 ± 6.43%, 33.50 ± 29.51 %, and 1.33 ± 2.31% in 4, 8, 12 weeks, respectively.
Autogenous tooth bone showed higher score than control group in NBF and BIC in all the data encompassing 4,8,12 weeks specimens, but statistically significant only 12 weeks data in both NBF and BIC.
Url:
DOI: 10.1186/s40902-015-0002-8
PubMed: 25750910
PubMed Central: 4343263
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect on bone formation of the autogenous tooth graft in the treatment of peri-implant vertical bone defects in the minipigs</title><author><name sortKey="Kim, Seok Kon" sort="Kim, Seok Kon" uniqKey="Kim S" first="Seok Kon" last="Kim">Seok Kon Kim</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Anesthesiology and Pain Medicine, Dankook University College of Medicine, Cheonan, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Anesthesiology and Pain Medicine, Dankook University College of Medicine, Cheonan</wicri:regionArea><wicri:noRegion>Cheonan</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Sae Woong" sort="Kim, Sae Woong" uniqKey="Kim S" first="Sae Woong" last="Kim">Sae Woong Kim</name><affiliation><nlm:aff id="Aff1">Department of OMFS, College of Dentistry, Dankook University, 29 Anseodong, Cheonan, Chungnam 330-714 Korea</nlm:aff><wicri:noCountry code="subfield">Chungnam 330-714 Korea</wicri:noCountry></affiliation></author><author><name sortKey="Kim, Kyung Wook" sort="Kim, Kyung Wook" uniqKey="Kim K" first="Kyung Wook" last="Kim">Kyung Wook Kim</name><affiliation><nlm:aff id="Aff1">Department of OMFS, College of Dentistry, Dankook University, 29 Anseodong, Cheonan, Chungnam 330-714 Korea</nlm:aff><wicri:noCountry code="subfield">Chungnam 330-714 Korea</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25750910</idno><idno type="pmc">4343263</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343263</idno><idno type="RBID">PMC:4343263</idno><idno type="doi">10.1186/s40902-015-0002-8</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000D26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D26</idno><idno type="wicri:Area/Pmc/Curation">000D26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D26</idno><idno type="wicri:Area/Pmc/Checkpoint">000E43</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E43</idno><idno type="wicri:Area/Ncbi/Merge">005925</idno><idno type="wicri:Area/Ncbi/Curation">005925</idno><idno type="wicri:Area/Ncbi/Checkpoint">005925</idno><idno type="wicri:doubleKey">2288-8101:2015:Kim S:effect:on:bone</idno><idno type="wicri:Area/Main/Merge">001198</idno><idno type="wicri:Area/Main/Curation">001195</idno><idno type="wicri:Area/Main/Exploration">001195</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect on bone formation of the autogenous tooth graft in the treatment of peri-implant vertical bone defects in the minipigs</title><author><name sortKey="Kim, Seok Kon" sort="Kim, Seok Kon" uniqKey="Kim S" first="Seok Kon" last="Kim">Seok Kon Kim</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Anesthesiology and Pain Medicine, Dankook University College of Medicine, Cheonan, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Anesthesiology and Pain Medicine, Dankook University College of Medicine, Cheonan</wicri:regionArea><wicri:noRegion>Cheonan</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Sae Woong" sort="Kim, Sae Woong" uniqKey="Kim S" first="Sae Woong" last="Kim">Sae Woong Kim</name><affiliation><nlm:aff id="Aff1">Department of OMFS, College of Dentistry, Dankook University, 29 Anseodong, Cheonan, Chungnam 330-714 Korea</nlm:aff><wicri:noCountry code="subfield">Chungnam 330-714 Korea</wicri:noCountry></affiliation></author><author><name sortKey="Kim, Kyung Wook" sort="Kim, Kyung Wook" uniqKey="Kim K" first="Kyung Wook" last="Kim">Kyung Wook Kim</name><affiliation><nlm:aff id="Aff1">Department of OMFS, College of Dentistry, Dankook University, 29 Anseodong, Cheonan, Chungnam 330-714 Korea</nlm:aff><wicri:noCountry code="subfield">Chungnam 330-714 Korea</wicri:noCountry></affiliation></author></analytic><series><title level="j">Maxillofacial Plastic and Reconstructive Surgery</title><idno type="ISSN">2288-8101</idno><idno type="eISSN">2288-8586</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The aim of this study was to evaluate the effect of autogenous tooth bone as a graft material for regeneration of bone in vertical bony defects of the minipigs.</p></sec><sec><title>Material and Methods</title><p>Six minipigs were used in this study. Four molars were extracted in the right mandibular dentition and sent to the Korea Tooth Bank for fabrication of autogenous tooth bone. Ten days later, each extraction site was implanted with MS Implant Narrow Ridge 3.0x10mm fixture (Osstem, Seoul, Korea) after standardized 2mm-sized artificial vertical bony defect formation. Pineappleshaped Root-On type autogenous tooth bones were applied to the vertical defects around the neck area of the posterior three fixtures and the fore-most one was not applied with autogenous bone as a control group. Each minipig was sacrificed at 4, 8, 12 weeks after fixture installation and examined radiologically and histologically. Histological evaluation was done under light microscope with Villanueva osteochrome bone staining with semi-quantitative histomorphometric study. Percentage of new bone over total area (NBF) and bone to implant contact (BIC) ratio were evaluated using digital software for area calculation.</p></sec><sec><title>Result</title><p>NBF were 48.15 ± 18.02%, 45.50 ± 28.37%, and 77.13 ± 15.30% in 4, 8, and 12 weeks, respectively for experimental groups. The control group showed 37.00 ± 11.53%, 32.25 ± 26.99%, and 1.33 ± 2.31% in 4,8,12 weeks, respectively. BIC ratio were 53.08 ± 19.82%, 45.00 ± 28.37%, and 75.13 ± 16.55% in 4,8,12 weeks, respectively. Those for the control groups were 38.33 ± 6.43%, 33.50 ± 29.51 %, and 1.33 ± 2.31% in 4, 8, 12 weeks, respectively.</p></sec><sec><title>Conclusion</title><p>Autogenous tooth bone showed higher score than control group in NBF and BIC in all the data encompassing 4,8,12 weeks specimens, but statistically significant only 12 weeks data in both NBF and BIC.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hiatt, Wh" uniqKey="Hiatt W">WH Hiatt</name></author><author><name sortKey="Schallhorn, Rg" uniqKey="Schallhorn R">RG Schallhorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellegaard, B" uniqKey="Ellegaard B">B Ellegaard</name></author><author><name sortKey="Karring, T" uniqKey="Karring T">T Karring</name></author><author><name sortKey="Davies, R" uniqKey="Davies R">R Davies</name></author><author><name sortKey="Le, H" uniqKey="Le H">H 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