Effects of oestrogen deficiency on the alveolar bone of rats with experimental periodontitis
Identifieur interne : 001187 ( Main/Exploration ); précédent : 001186; suivant : 001188Effects of oestrogen deficiency on the alveolar bone of rats with experimental periodontitis
Auteurs : Xin-Chen Xu [République populaire de Chine] ; Hui Chen [République populaire de Chine] ; Xi Zhang [République populaire de Chine] ; Zan-Jing Zhai [République populaire de Chine] ; Xu-Qiang Liu [République populaire de Chine] ; Xin-Yi Zheng [République populaire de Chine] ; Jun Zhang [République populaire de Chine] ; An Qin [République populaire de Chine] ; Er-Yi Lu [République populaire de Chine]Source :
- Molecular Medicine Reports [ 1791-2997 ] ; 2015.
Abstract
Periodontitis is an inflammatory disease characterized by loss of connective tissue and alveolar bone, and osteoporosis is a common disease characterized by a systemic impairment of bone mass and microarchitecture. To date, the association between periodontitis and osteoporosis has remained to be fully elucidated. In the present study, an experimental rat model of periodontitis was used to explore the effects of oestrogen deficiency-induced osteoporosis on the maxillary alveolar bone. Forty-four female, six-month-old Sprague-Dawley rats were randomly divided into four groups: Control, ligature, ovariectomized (OVX), and OVX + ligature. One month after ovariectomy, rats in the ligature and OVX + ligature groups received ligatures on their first and second maxillary molars for 1 month. Fluorescent labelling was performed prior to sacrificing the animals. At the end of the experiment, the maxillae and serum were collected and subjected to micro-computed tomography analysis, confocal laser-scanning microscopic observation, Van Gieson's fuchsin staining, tartrate-resistant acid phosphatase staining and ELISA. Ligatures slightly reduced the alveolar bone mineral density (BMD) and bone formation rate, but significantly reduced alveolar crest height (ACH). Ovariectomy reduced the alveolar BMD, impaired the trabecular structure, reduced the bone formation rate and increased the serum levels of bone resorption markers. Animals in the OVX + ligature group exhibited a lower alveolar BMD, a poorer trabecular structure, a reduced ACH, a lower bone formation rate and higher serum levels of bone resorption markers compared with those in the control group. The results of the present study showed that ovariectomy enhanced alveolar bone loss and reduced the ACH of rats with experimental periodontitis. Thus, post-menopausal osteoporosis may influence the progression of periodontitis.
Url:
DOI: 10.3892/mmr.2015.3875
PubMed: 26035209
PubMed Central: 4526094
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011</wicri:regionArea><wicri:noRegion>Shanghai 200011</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Er Yi" sort="Lu, Er Yi" uniqKey="Lu E" first="Er-Yi" last="Lu">Er-Yi Lu</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-12-03-3494">Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011</wicri:regionArea><wicri:noRegion>Shanghai 200011</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26035209</idno><idno type="pmc">4526094</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526094</idno><idno type="RBID">PMC:4526094</idno><idno type="doi">10.3892/mmr.2015.3875</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000399</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000399</idno><idno type="wicri:Area/Pmc/Curation">000399</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000399</idno><idno type="wicri:Area/Pmc/Checkpoint">000E35</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E35</idno><idno type="wicri:Area/Ncbi/Merge">005C16</idno><idno type="wicri:Area/Ncbi/Curation">005C16</idno><idno type="wicri:Area/Ncbi/Checkpoint">005C16</idno><idno type="wicri:doubleKey">1791-2997:2015:Xu X:effects:of:oestrogen</idno><idno type="wicri:Area/Main/Merge">001189</idno><idno type="wicri:Area/Main/Curation">001187</idno><idno type="wicri:Area/Main/Exploration">001187</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of oestrogen deficiency on the alveolar bone of rats with experimental periodontitis</title><author><name sortKey="Xu, Xin Chen" sort="Xu, Xin Chen" uniqKey="Xu X" first="Xin-Chen" last="Xu">Xin-Chen Xu</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-12-03-3494">Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011</wicri:regionArea><wicri:noRegion>Shanghai 200011</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hui" sort="Chen, Hui" uniqKey="Chen H" first="Hui" last="Chen">Hui Chen</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-12-03-3494">Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011</wicri:regionArea><wicri:noRegion>Shanghai 200011</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xi" sort="Zhang, Xi" uniqKey="Zhang X" first="Xi" last="Zhang">Xi Zhang</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-12-03-3494">Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011</wicri:regionArea><wicri:noRegion>Shanghai 200011</wicri:noRegion></affiliation></author><author><name sortKey="Zhai, Zan Jing" sort="Zhai, Zan Jing" uniqKey="Zhai Z" first="Zan-Jing" last="Zhai">Zan-Jing Zhai</name><affiliation wicri:level="1"><nlm:aff id="af2-mmr-12-03-3494">Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011</wicri:regionArea><wicri:noRegion>Shanghai 200011</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Xu Qiang" sort="Liu, Xu Qiang" uniqKey="Liu X" first="Xu-Qiang" last="Liu">Xu-Qiang Liu</name><affiliation wicri:level="1"><nlm:aff id="af2-mmr-12-03-3494">Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011</wicri:regionArea><wicri:noRegion>Shanghai 200011</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Xin Yi" sort="Zheng, Xin Yi" uniqKey="Zheng X" first="Xin-Yi" last="Zheng">Xin-Yi Zheng</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-12-03-3494">Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011</wicri:regionArea><wicri:noRegion>Shanghai 200011</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name><affiliation wicri:level="1"><nlm:aff id="af2-mmr-12-03-3494">Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011</wicri:regionArea><wicri:noRegion>Shanghai 200011</wicri:noRegion></affiliation></author><author><name sortKey="Qin, An" sort="Qin, An" uniqKey="Qin A" first="An" last="Qin">An Qin</name><affiliation wicri:level="1"><nlm:aff id="af2-mmr-12-03-3494">Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011</wicri:regionArea><wicri:noRegion>Shanghai 200011</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Er Yi" sort="Lu, Er Yi" uniqKey="Lu E" first="Er-Yi" last="Lu">Er-Yi Lu</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-12-03-3494">Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011</wicri:regionArea><wicri:noRegion>Shanghai 200011</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular Medicine Reports</title><idno type="ISSN">1791-2997</idno><idno type="eISSN">1791-3004</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Periodontitis is an inflammatory disease characterized by loss of connective tissue and alveolar bone, and osteoporosis is a common disease characterized by a systemic impairment of bone mass and microarchitecture. To date, the association between periodontitis and osteoporosis has remained to be fully elucidated. In the present study, an experimental rat model of periodontitis was used to explore the effects of oestrogen deficiency-induced osteoporosis on the maxillary alveolar bone. Forty-four female, six-month-old Sprague-Dawley rats were randomly divided into four groups: Control, ligature, ovariectomized (OVX), and OVX + ligature. One month after ovariectomy, rats in the ligature and OVX + ligature groups received ligatures on their first and second maxillary molars for 1 month. Fluorescent labelling was performed prior to sacrificing the animals. At the end of the experiment, the maxillae and serum were collected and subjected to micro-computed tomography analysis, confocal laser-scanning microscopic observation, Van Gieson's fuchsin staining, tartrate-resistant acid phosphatase staining and ELISA. Ligatures slightly reduced the alveolar bone mineral density (BMD) and bone formation rate, but significantly reduced alveolar crest height (ACH). Ovariectomy reduced the alveolar BMD, impaired the trabecular structure, reduced the bone formation rate and increased the serum levels of bone resorption markers. Animals in the OVX + ligature group exhibited a lower alveolar BMD, a poorer trabecular structure, a reduced ACH, a lower bone formation rate and higher serum levels of bone resorption markers compared with those in the control group. The results of the present study showed that ovariectomy enhanced alveolar bone loss and reduced the ACH of rats with experimental periodontitis. Thus, post-menopausal osteoporosis may influence the progression of periodontitis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Di Benedetto, A" uniqKey="Di Benedetto A">A Di Benedetto</name></author><author><name sortKey="Gigante, I" uniqKey="Gigante I">I Gigante</name></author><author><name sortKey="Colucci, S" uniqKey="Colucci S">S Colucci</name></author><author><name sortKey="Grano, M" uniqKey="Grano M">M Grano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pihlstrom, Bl" uniqKey="Pihlstrom B">BL Pihlstrom</name></author><author><name sortKey="Michalowicz, Bs" uniqKey="Michalowicz B">BS Michalowicz</name></author><author><name sortKey="Johnson, Nw" uniqKey="Johnson N">NW Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eke, Pi" uniqKey="Eke P">PI Eke</name></author><author><name sortKey="Dye, Ba" uniqKey="Dye B">BA 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last="Chen">Hui Chen</name><name sortKey="Liu, Xu Qiang" sort="Liu, Xu Qiang" uniqKey="Liu X" first="Xu-Qiang" last="Liu">Xu-Qiang Liu</name><name sortKey="Lu, Er Yi" sort="Lu, Er Yi" uniqKey="Lu E" first="Er-Yi" last="Lu">Er-Yi Lu</name><name sortKey="Qin, An" sort="Qin, An" uniqKey="Qin A" first="An" last="Qin">An Qin</name><name sortKey="Zhai, Zan Jing" sort="Zhai, Zan Jing" uniqKey="Zhai Z" first="Zan-Jing" last="Zhai">Zan-Jing Zhai</name><name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name><name sortKey="Zhang, Xi" sort="Zhang, Xi" uniqKey="Zhang X" first="Xi" last="Zhang">Xi Zhang</name><name sortKey="Zheng, Xin Yi" sort="Zheng, Xin Yi" uniqKey="Zheng X" first="Xin-Yi" last="Zheng">Xin-Yi Zheng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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