Phenotype and cell proliferation activity of duct-like structures in human sublingual glands: a histological and immunohistochemical study
Identifieur interne : 000E33 ( Main/Exploration ); précédent : 000E32; suivant : 000E34Phenotype and cell proliferation activity of duct-like structures in human sublingual glands: a histological and immunohistochemical study
Auteurs : Elen De Souza Tolentino [Brésil] ; Cleverson Soares Teixeira [Brésil] ; Luciana Reis Azevedo-Alanis [Brésil] ; Heitor Marques Hon Rio [Brésil] ; José Humberto Damante [Brésil]Source :
- Journal of Applied Oral Science [ 1678-7757 ] ; 2015.
Abstract
There are several age-related microscopic changes in the salivary glands, including the increase in the number of duct-like structures (DLS). However, the true origin and the phenotype of the DLS are not known.
To evaluate the phenotype and the cell proliferation index of the DLS of human sublingual glands.
Sixty sublingual glands obtained from human cadavers were divided into two groups - 0-30 and 61-90 years old. The phenotype was estimated by immunostaining for cytokeratin 19 (CK 19) and the S-100 protein as well as by the presence of mucin and glycogen. The cell proliferation index was determined by the Ki-67 antibody. The histochemical techniques used periodic acid-Schiff (PAS) and Alcian Blue. In each captured microscopic field, the DLS were counted to establish a percentage for the staining profile. The statistical analysis was accomplished using Student’s t-test, the Mann-Whitney test and Pearson’s correlation coefficient (p<0.05).
Comparing both groups, only CK 19 showed a statistically significant difference (p=0.033), with the strongest expression in the elderly group. There was no significant difference between PAS and Alcian Blue (p=0.270). In both groups, the immunostaining for CK 19 was stronger than that for S-100 (p=0.004;p<0.001), but there was no correlation between the two immunomarkers (ρ=-0.163; p=0.315). There was no immunostaining for Ki-67.
DLS demonstrate a ductal phenotypic profile and do not present cell proliferation activity. DLS may represent a regressive process arising from acini or represent the result of metaplasia.
Url:
DOI: 10.1590/1678-775720140349
PubMed: 26221919
PubMed Central: 4510659
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Phenotype and cell proliferation activity of duct-like structures in human sublingual glands: a histological and immunohistochemical study</title><author><name sortKey="Tolentino, Elen De Souza" sort="Tolentino, Elen De Souza" uniqKey="Tolentino E" first="Elen De Souza" last="Tolentino">Elen De Souza Tolentino</name><affiliation wicri:level="2"><nlm:aff id="aff1">- Department of Dentistry, Maringá State University, Maringá, PR, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>- Department of Dentistry, Maringá State University, Maringá, PR</wicri:regionArea><placeName><region type="state">Paraná (État)</region></placeName></affiliation></author><author><name sortKey="Teixeira, Cleverson Soares" sort="Teixeira, Cleverson Soares" uniqKey="Teixeira C" first="Cleverson Soares" last="Teixeira">Cleverson Soares Teixeira</name><affiliation wicri:level="2"><nlm:aff id="aff2">Lauro de Souza Lima Institute, Bauru, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Lauro de Souza Lima Institute, Bauru, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Azevedo Alanis, Luciana Reis" sort="Azevedo Alanis, Luciana Reis" uniqKey="Azevedo Alanis L" first="Luciana Reis" last="Azevedo-Alanis">Luciana Reis Azevedo-Alanis</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Dentistry, Pontifical Catholic University of Paraná, Curitiba, PR, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Department of Dentistry, Pontifical Catholic University of Paraná, Curitiba, PR</wicri:regionArea><placeName><region type="state">Paraná (État)</region></placeName></affiliation></author><author><name sortKey="Hon Rio, Heitor Marques" sort="Hon Rio, Heitor Marques" uniqKey="Hon Rio H" first="Heitor Marques" last="Hon Rio">Heitor Marques Hon Rio</name><affiliation wicri:level="4"><nlm:aff id="aff4">Department of Pediatric Dentistry, Orthodontics and Community Health, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Department of Pediatric Dentistry, Orthodontics and Community Health, Bauru School of Dentistry, University of São Paulo, Bauru, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Damante, Jose Humberto" sort="Damante, Jose Humberto" uniqKey="Damante J" first="José Humberto" last="Damante">José Humberto Damante</name><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26221919</idno><idno type="pmc">4510659</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510659</idno><idno type="RBID">PMC:4510659</idno><idno type="doi">10.1590/1678-775720140349</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000315</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000315</idno><idno type="wicri:Area/Pmc/Curation">000315</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000315</idno><idno type="wicri:Area/Pmc/Checkpoint">000B64</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B64</idno><idno type="wicri:Area/Ncbi/Merge">005D77</idno><idno type="wicri:Area/Ncbi/Curation">005D77</idno><idno type="wicri:Area/Ncbi/Checkpoint">005D77</idno><idno type="wicri:doubleKey">1678-7757:2015:Tolentino E:phenotype:and:cell</idno><idno type="wicri:Area/Main/Merge">000E35</idno><idno type="wicri:Area/Main/Curation">000E33</idno><idno type="wicri:Area/Main/Exploration">000E33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Phenotype and cell proliferation activity of duct-like structures in human sublingual glands: a histological and immunohistochemical study</title><author><name sortKey="Tolentino, Elen De Souza" sort="Tolentino, Elen De Souza" uniqKey="Tolentino E" first="Elen De Souza" last="Tolentino">Elen De Souza Tolentino</name><affiliation wicri:level="2"><nlm:aff id="aff1">- Department of Dentistry, Maringá State University, Maringá, PR, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>- Department of Dentistry, Maringá State University, Maringá, PR</wicri:regionArea><placeName><region type="state">Paraná (État)</region></placeName></affiliation></author><author><name sortKey="Teixeira, Cleverson Soares" sort="Teixeira, Cleverson Soares" uniqKey="Teixeira C" first="Cleverson Soares" last="Teixeira">Cleverson Soares Teixeira</name><affiliation wicri:level="2"><nlm:aff id="aff2">Lauro de Souza Lima Institute, Bauru, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Lauro de Souza Lima Institute, Bauru, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Azevedo Alanis, Luciana Reis" sort="Azevedo Alanis, Luciana Reis" uniqKey="Azevedo Alanis L" first="Luciana Reis" last="Azevedo-Alanis">Luciana Reis Azevedo-Alanis</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Dentistry, Pontifical Catholic University of Paraná, Curitiba, PR, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Department of Dentistry, Pontifical Catholic University of Paraná, Curitiba, PR</wicri:regionArea><placeName><region type="state">Paraná (État)</region></placeName></affiliation></author><author><name sortKey="Hon Rio, Heitor Marques" sort="Hon Rio, Heitor Marques" uniqKey="Hon Rio H" first="Heitor Marques" last="Hon Rio">Heitor Marques Hon Rio</name><affiliation wicri:level="4"><nlm:aff id="aff4">Department of Pediatric Dentistry, Orthodontics and Community Health, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Department of Pediatric Dentistry, Orthodontics and Community Health, Bauru School of Dentistry, University of São Paulo, Bauru, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Damante, Jose Humberto" sort="Damante, Jose Humberto" uniqKey="Damante J" first="José Humberto" last="Damante">José Humberto Damante</name><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author></analytic><series><title level="j">Journal of Applied Oral Science</title><idno type="ISSN">1678-7757</idno><idno type="eISSN">1678-7765</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>There are several age-related microscopic changes in the salivary glands, including the increase in the number of duct-like structures (DLS). However, the true origin and the phenotype of the DLS are not known. </p><sec><title>Objective</title><p> To evaluate the phenotype and the cell proliferation index of the DLS of human sublingual glands.</p></sec><sec><title>Material and Methods</title><p> Sixty sublingual glands obtained from human cadavers were divided into two groups - 0-30 and 61-90 years old. The phenotype was estimated by immunostaining for cytokeratin 19 (CK 19) and the S-100 protein as well as by the presence of mucin and glycogen. The cell proliferation index was determined by the Ki-67 antibody. The histochemical techniques used periodic acid-Schiff (PAS) and Alcian Blue. In each captured microscopic field, the DLS were counted to establish a percentage for the staining profile. The statistical analysis was accomplished using Student’s t-test, the Mann-Whitney test and Pearson’s correlation coefficient (p<0.05).</p></sec><sec><title>Results</title><p> Comparing both groups, only CK 19 showed a statistically significant difference (p=0.033), with the strongest expression in the elderly group. There was no significant difference between PAS and Alcian Blue (p=0.270). In both groups, the immunostaining for CK 19 was stronger than that for S-100 (p=0.004;p<0.001), but there was no correlation between the two immunomarkers (ρ=-0.163; p=0.315). There was no immunostaining for Ki-67.</p></sec><sec><title>Conclusions</title><p> DLS demonstrate a ductal phenotypic profile and do not present cell proliferation activity. 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Patel</name></author><author><name sortKey="Yale, Rs" uniqKey="Yale R">RS Yale</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Brésil</li></country><region><li>Paraná (État)</li><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Brésil"><region name="Paraná (État)"><name sortKey="Tolentino, Elen De Souza" sort="Tolentino, Elen De Souza" uniqKey="Tolentino E" first="Elen De Souza" last="Tolentino">Elen De Souza Tolentino</name></region><name sortKey="Azevedo Alanis, Luciana Reis" sort="Azevedo Alanis, Luciana Reis" uniqKey="Azevedo Alanis L" first="Luciana Reis" last="Azevedo-Alanis">Luciana Reis Azevedo-Alanis</name><name sortKey="Damante, Jose Humberto" sort="Damante, Jose Humberto" uniqKey="Damante J" first="José Humberto" last="Damante">José Humberto Damante</name><name sortKey="Hon Rio, Heitor Marques" sort="Hon Rio, Heitor Marques" uniqKey="Hon Rio H" first="Heitor Marques" last="Hon Rio">Heitor Marques Hon Rio</name><name sortKey="Teixeira, Cleverson Soares" sort="Teixeira, Cleverson Soares" uniqKey="Teixeira C" first="Cleverson Soares" last="Teixeira">Cleverson Soares Teixeira</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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