Effects of antiepileptic drugs on the serum folate and vitamin B12 in various epileptic patients
Identifieur interne : 000864 ( Main/Exploration ); précédent : 000863; suivant : 000865Effects of antiepileptic drugs on the serum folate and vitamin B12 in various epileptic patients
Auteurs : Hong-Li Huang [République populaire de Chine] ; Hao Zhou [République populaire de Chine] ; Nuan Wang [République populaire de Chine] ; Chun-Yu Yu [République populaire de Chine]Source :
- Biomedical Reports [ 2049-9434 ] ; 2016.
Abstract
Epilepsy is a common neurodegenerative disease with an increasing morbidity. Clinical treatment of epilepsy includes symptomatic treatment, etiological treatment, surgery and prevention. The aim of the present study was to determine the effects of antiepileptic drugs (AEDs) on serum folate and vitamin B12 in various epileptic patients, and to examine the correlation between these effects and secondary cerebrovascular events. A total of 68 epileptic patients, diagnosed between May 2012 and May 2014, were included in the present study. The study included 8 cases of autonomic seizures, 10 cases of absence seizures, 13 cases of complex partial seizures, 28 cases of generalized tonic-clonic seizures, and 9 cases of simple partial seizures. The patients received appropriate AED treatment according to the characteristics of epileptic seizure and the treatment guidance. The differences in the serum levels of folate and vitamin B12 in these patients, and the differences in the secondary cerebrovascular events in these patients after 1 year follow-up were analyzed. The difference in the AEDs used by various epileptic patients was statistically significant (P<0.05). The proportion of AED monotherapy in the autonomic seizure group and petit mal group was highest, and the proportion of two AED in combination with the psychomotor seizure, grand mal and simple partial seizure groups was highest. The serum levels of folate and vitamin B12 in these patients following treatment were significantly lower than those prior to treatment (P<0.05). The differences in the serum levels of folate and vitamin B12 in these groups following treatment were not statistically significant (P>0.05). The difference in the incidence of cerebrovascular events in these groups at follow up was not statistically significant (P>0.05). The multifactorial logistic regression analysis revealed that the serum levels of folate and vitamin B12 were the independent risk factors for epilepsy with secondary cerebrovascular events [folate: odds ratio (OR)=0.536, P=0.039; vitamin: OR=0.382, P=0.041]. In conclusion, various AEDs may decrease the serum levels of folate and vitamin B12 and affect the secondary cerebrovascular events in various epileptic patients. Thus, regular supplementation of folate and vitamin B12 may be an option.
Url:
DOI: 10.3892/br.2016.737
PubMed: 27699007
PubMed Central: 5038598
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Neurology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000</wicri:regionArea><wicri:noRegion>Jiangsu 221000</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27699007</idno><idno type="pmc">5038598</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038598</idno><idno type="RBID">PMC:5038598</idno><idno type="doi">10.3892/br.2016.737</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002876</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002876</idno><idno type="wicri:Area/Pmc/Curation">002876</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002876</idno><idno type="wicri:Area/Pmc/Checkpoint">000730</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000730</idno><idno type="wicri:Area/Ncbi/Merge">006A82</idno><idno type="wicri:Area/Ncbi/Curation">006A82</idno><idno type="wicri:Area/Ncbi/Checkpoint">006A82</idno><idno type="wicri:doubleKey">2049-9434:2016:Huang H:effects:of:antiepileptic</idno><idno type="wicri:Area/Main/Merge">000864</idno><idno type="wicri:Area/Main/Curation">000864</idno><idno type="wicri:Area/Main/Exploration">000864</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of antiepileptic drugs on the serum folate and vitamin B12 in various epileptic patients</title><author><name sortKey="Huang, Hong Li" sort="Huang, Hong Li" uniqKey="Huang H" first="Hong-Li" last="Huang">Hong-Li Huang</name><affiliation wicri:level="1"><nlm:aff id="af1-br-0-0-737">Department of Neurology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Neurology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000</wicri:regionArea><wicri:noRegion>Jiangsu 221000</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Hao" sort="Zhou, Hao" uniqKey="Zhou H" first="Hao" last="Zhou">Hao Zhou</name><affiliation wicri:level="1"><nlm:aff id="af1-br-0-0-737">Department of Neurology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Neurology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000</wicri:regionArea><wicri:noRegion>Jiangsu 221000</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Nuan" sort="Wang, Nuan" uniqKey="Wang N" first="Nuan" last="Wang">Nuan Wang</name><affiliation wicri:level="1"><nlm:aff id="af1-br-0-0-737">Department of Neurology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Neurology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000</wicri:regionArea><wicri:noRegion>Jiangsu 221000</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Chun Yu" sort="Yu, Chun Yu" uniqKey="Yu C" first="Chun-Yu" last="Yu">Chun-Yu Yu</name><affiliation wicri:level="1"><nlm:aff id="af1-br-0-0-737">Department of Neurology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Neurology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000</wicri:regionArea><wicri:noRegion>Jiangsu 221000</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biomedical Reports</title><idno type="ISSN">2049-9434</idno><idno type="eISSN">2049-9442</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Epilepsy is a common neurodegenerative disease with an increasing morbidity. Clinical treatment of epilepsy includes symptomatic treatment, etiological treatment, surgery and prevention. The aim of the present study was to determine the effects of antiepileptic drugs (AEDs) on serum folate and vitamin B12 in various epileptic patients, and to examine the correlation between these effects and secondary cerebrovascular events. A total of 68 epileptic patients, diagnosed between May 2012 and May 2014, were included in the present study. The study included 8 cases of autonomic seizures, 10 cases of absence seizures, 13 cases of complex partial seizures, 28 cases of generalized tonic-clonic seizures, and 9 cases of simple partial seizures. The patients received appropriate AED treatment according to the characteristics of epileptic seizure and the treatment guidance. The differences in the serum levels of folate and vitamin B12 in these patients, and the differences in the secondary cerebrovascular events in these patients after 1 year follow-up were analyzed. The difference in the AEDs used by various epileptic patients was statistically significant (P<0.05). The proportion of AED monotherapy in the autonomic seizure group and petit mal group was highest, and the proportion of two AED in combination with the psychomotor seizure, grand mal and simple partial seizure groups was highest. The serum levels of folate and vitamin B12 in these patients following treatment were significantly lower than those prior to treatment (P<0.05). The differences in the serum levels of folate and vitamin B12 in these groups following treatment were not statistically significant (P>0.05). The difference in the incidence of cerebrovascular events in these groups at follow up was not statistically significant (P>0.05). The multifactorial logistic regression analysis revealed that the serum levels of folate and vitamin B12 were the independent risk factors for epilepsy with secondary cerebrovascular events [folate: odds ratio (OR)=0.536, P=0.039; vitamin: OR=0.382, P=0.041]. In conclusion, various AEDs may decrease the serum levels of folate and vitamin B12 and affect the secondary cerebrovascular events in various epileptic patients. Thus, regular supplementation of folate and vitamin B12 may be an option.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alvim, Mk" uniqKey="Alvim M">MK Alvim</name></author><author><name sortKey="Coan, Ac" uniqKey="Coan A">AC Coan</name></author><author><name sortKey="Campos, Bm" uniqKey="Campos B">BM Campos</name></author><author><name sortKey="Yasuda, Cl" uniqKey="Yasuda C">CL Yasuda</name></author><author><name sortKey="Oliveira, Mc" uniqKey="Oliveira M">MC Oliveira</name></author><author><name sortKey="Morita, Me" uniqKey="Morita M">ME Morita</name></author><author><name sortKey="Cendes, F" uniqKey="Cendes F">F Cendes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, F" uniqKey="Zhu F">F Zhu</name></author><author><name sortKey="Lang, Sy" uniqKey="Lang S">SY Lang</name></author><author><name sortKey="Wang, Xq" uniqKey="Wang X">XQ Wang</name></author><author><name sortKey="Shi, Xb" 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sortKey="Sarda, Mp" uniqKey="Sarda M">MP Sardà</name></author><author><name sortKey="Queralt, Jm" uniqKey="Queralt J">JM Queraltó</name></author><author><name sortKey="Marti Fabregas, J" uniqKey="Marti Fabregas J">J Martí-Fabregas</name></author><author><name sortKey="Garcia Moll, X" uniqKey="Garcia Moll X">X García-Moll</name></author><author><name sortKey="Fernandez, C" uniqKey="Fernandez C">C Férnandez</name></author><author><name sortKey="Rodriguez, A" uniqKey="Rodriguez A">A Rodriguez</name></author><author><name sortKey="Cuesta, J" uniqKey="Cuesta J">J Cuesta</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Huang, Hong Li" sort="Huang, Hong Li" uniqKey="Huang H" first="Hong-Li" last="Huang">Hong-Li Huang</name></noRegion><name sortKey="Wang, Nuan" sort="Wang, Nuan" uniqKey="Wang N" first="Nuan" last="Wang">Nuan Wang</name><name sortKey="Yu, Chun Yu" sort="Yu, Chun Yu" uniqKey="Yu C" first="Chun-Yu" last="Yu">Chun-Yu Yu</name><name sortKey="Zhou, Hao" sort="Zhou, Hao" uniqKey="Zhou H" first="Hao" last="Zhou">Hao Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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