Selective laser melting of titanium alloy enables osseointegration of porous multi-rooted implants in a rabbit model
Identifieur interne : 000524 ( Main/Exploration ); précédent : 000523; suivant : 000525Selective laser melting of titanium alloy enables osseointegration of porous multi-rooted implants in a rabbit model
Auteurs : Wei Peng ; Liangwei Xu ; Jia You ; Lihua Fang ; Qing ZhangSource :
- BioMedical Engineering OnLine [ 1475-925X ] ; 2016.
Abstract
Osseointegration refers to the direct connection between living bone and the surface of a load-bearing artificial implant. Porous implants with well-controlled porosity and pore size can enhance osseointegration. However, until recently implants were produced by machining solid core titanium rods. The aim of this study was to develop a multi-rooted dental implant (MRI) with a connected porous surface structure to facilitate osseointegration.
MRIs manufactured by selective laser melting (SLM) and commercial implants with resorbable blasting media (RBM)-treated surfaces were inserted into the hind limbs of New Zealand white rabbits. Osseointegration was evaluated periodically over 12 weeks by micro-computerized tomography (CT) scanning, histological analysis, mechanical push-out tests, and torque tests.
Bone volume densities were consistently higher in the MRI group than in the RBM group throughout the study period, ultimately resulting in a peak value of 48.41 % for the MRI group. Histological analysis revealed denser surrounding bone growth in the MRIs; after 4 and 8 weeks, bone tissue had grown into the pore structures and root bifurcation areas, respectively. Biomechanics tests indicated binding of the porous MRIs to the neobone tissues, as push-out forces strengthened from 294.7 to 446.5 N and maximum mean torque forces improved from 81.15 to 289.57 N (MRI), versus 34.79 to 87.8 N in the RBM group.
MRIs manufactured by SLM possess a connected porous surface structure that improves the osteogenic characteristics of the implant surface.
Url:
DOI: 10.1186/s12938-016-0207-9
PubMed: 27439427
PubMed Central: 4955147
Affiliations:
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China</wicri:noCountry></affiliation></author><author><name sortKey="You, Jia" sort="You, Jia" uniqKey="You J" first="Jia" last="You">Jia You</name><affiliation><nlm:aff id="Aff1">Key Laboratory of E&M, Ministry of Education & Zhejiang Province, Zhejiang University of Technology, Hangzhou, Zhe Jiang People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">Zhe Jiang People’s Republic of China</wicri:noCountry></affiliation></author><author><name sortKey="Fang, Lihua" sort="Fang, Lihua" uniqKey="Fang L" first="Lihua" last="Fang">Lihua Fang</name><affiliation><nlm:aff id="Aff2">Department of Stomatology, Zhejiang University of Huzhou Hospital, Huzhou, Zhe Jiang People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">Zhe Jiang People’s Republic of China</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Qing" sort="Zhang, Qing" uniqKey="Zhang Q" first="Qing" last="Zhang">Qing Zhang</name><affiliation><nlm:aff id="Aff2">Department of Stomatology, 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Xu</name><affiliation><nlm:aff id="Aff1">Key Laboratory of E&M, Ministry of Education & Zhejiang Province, Zhejiang University of Technology, Hangzhou, Zhe Jiang People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">Zhe Jiang People’s Republic of China</wicri:noCountry></affiliation></author><author><name sortKey="You, Jia" sort="You, Jia" uniqKey="You J" first="Jia" last="You">Jia You</name><affiliation><nlm:aff id="Aff1">Key Laboratory of E&M, Ministry of Education & Zhejiang Province, Zhejiang University of Technology, Hangzhou, Zhe Jiang People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">Zhe Jiang People’s Republic of China</wicri:noCountry></affiliation></author><author><name sortKey="Fang, Lihua" sort="Fang, Lihua" uniqKey="Fang L" first="Lihua" last="Fang">Lihua Fang</name><affiliation><nlm:aff id="Aff2">Department of Stomatology, Zhejiang University of Huzhou Hospital, Huzhou, Zhe Jiang People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">Zhe Jiang People’s Republic of China</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Qing" sort="Zhang, Qing" uniqKey="Zhang Q" first="Qing" last="Zhang">Qing Zhang</name><affiliation><nlm:aff id="Aff2">Department of Stomatology, Zhejiang University of Huzhou Hospital, Huzhou, Zhe Jiang People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">Zhe Jiang People’s Republic of China</wicri:noCountry></affiliation></author></analytic><series><title level="j">BioMedical Engineering OnLine</title><idno type="eISSN">1475-925X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Osseointegration refers to the direct connection between living bone and the surface of a load-bearing artificial implant. Porous implants with well-controlled porosity and pore size can enhance osseointegration. However, until recently implants were produced by machining solid core titanium rods. The aim of this study was to develop a multi-rooted dental implant (MRI) with a connected porous surface structure to facilitate osseointegration.</p></sec><sec><title>Methods</title><p>MRIs manufactured by selective laser melting (SLM) and commercial implants with resorbable blasting media (RBM)-treated surfaces were inserted into the hind limbs of New Zealand white rabbits. Osseointegration was evaluated periodically over 12 weeks by micro-computerized tomography (CT) scanning, histological analysis, mechanical push-out tests, and torque tests.</p></sec><sec><title>Results</title><p>Bone volume densities were consistently higher in the MRI group than in the RBM group throughout the study period, ultimately resulting in a peak value of 48.41 % for the MRI group. Histological analysis revealed denser surrounding bone growth in the MRIs; after 4 and 8 weeks, bone tissue had grown into the pore structures and root bifurcation areas, respectively. Biomechanics tests indicated binding of the porous MRIs to the neobone tissues, as push-out forces strengthened from 294.7 to 446.5 N and maximum mean torque forces improved from 81.15 to 289.57 N (MRI), versus 34.79 to 87.8 N in the RBM group.</p></sec><sec><title>Conclusions</title><p>MRIs manufactured by SLM possess a connected porous surface structure that improves the osteogenic characteristics of the implant surface.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chappuis, V" uniqKey="Chappuis V">V Chappuis</name></author><author><name sortKey="Buser, R" uniqKey="Buser R">R Buser</name></author><author><name sortKey="Br Gger, U" uniqKey="Br Gger U">U Brägger</name></author><author><name sortKey="Bornstein, Mm" uniqKey="Bornstein M">MM Bornstein</name></author><author><name sortKey="Salvi, Ge" uniqKey="Salvi G">GE Salvi</name></author><author><name sortKey="Buser, D" uniqKey="Buser D">D 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sortKey="You, Jia" sort="You, Jia" uniqKey="You J" first="Jia" last="You">Jia You</name><name sortKey="Zhang, Qing" sort="Zhang, Qing" uniqKey="Zhang Q" first="Qing" last="Zhang">Qing Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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