Effect of a Particulate and a Putty-Like Tricalcium Phosphate-Based Bone-grafting Material on Bone Formation, Volume Stability and Osteogenic Marker Expression after Bilateral Sinus Floor Augmentation in Humans
Identifieur interne : 000272 ( Main/Exploration ); précédent : 000271; suivant : 000273Effect of a Particulate and a Putty-Like Tricalcium Phosphate-Based Bone-grafting Material on Bone Formation, Volume Stability and Osteogenic Marker Expression after Bilateral Sinus Floor Augmentation in Humans
Auteurs : Christine Knabe ; Doaa Adel Khattab ; Esther Kluk ; Rainer Struck ; Michael StillerSource :
- Journal of Functional Biomaterials [ 2079-4983 ] ; 2017.
Abstract
This study examines the effect of a hyaluronic acid (HyAc) containing tricalcium phosphate putty scaffold material (TCP-P) and of a particulate tricalcium phosphate (TCP-G) graft on bone formation, volume stability and osteogenic marker expression in biopsies sampled 6 months after bilateral sinus floor augmentation (SFA) in 7 patients applying a split-mouth design. 10% autogenous bone chips were added to the grafting material during surgery. The grain size of the TCP granules was 700 to 1400 µm for TCP-G and 125 to 250 µm and 500 to 700 µm (ratio 1:1) for TCP-P. Biopsies were processed for immunohistochemical analysis of resin-embedded sections. Sections were stained for collagen type I (Col I), alkaline phosphatase (ALP), osteocalcin (OC) and bone sialoprotein (BSP). Furthermore, the bone area and biomaterial area fraction were determined histomorphometrically. Cone-beam CT data recorded after SFA and 6 months later were used for calculating the graft volume at these two time points. TCP-P displayed more advantageous surgical handling properties and a significantly greater bone area fraction and smaller biomaterial area fraction. This was accompanied by significantly greater expression of Col I and BSP and in osteoblasts and osteoid and a less pronounced reduction in grafting volume with TCP-P. SFA using both types of materials resulted in formation of sufficient bone volume for facilitating stable dental implant placement with all dental implants having been in function without any complications for 6 years. Since TCP-P displayed superior surgical handling properties and greater bone formation than TCP-G, without the HyAc hydrogel matrix having any adverse effect on bone formation or graft volume stability, TCP-P can be regarded as excellent grafting material for SFA in a clinical setting. The greater bone formation observed with TCP-P may be related to the difference in grain size of the TCP granules and/or the addition of the HyAc.
Url:
DOI: 10.3390/jfb8030031
PubMed: 28758916
PubMed Central: 5618282
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of a Particulate and a Putty-Like Tricalcium Phosphate-Based Bone-grafting Material on Bone Formation, Volume Stability and Osteogenic Marker Expression after Bilateral Sinus Floor Augmentation in Humans</title><author><name sortKey="Knabe, Christine" sort="Knabe, Christine" uniqKey="Knabe C" first="Christine" last="Knabe">Christine Knabe</name><affiliation><nlm:aff id="af1-jfb-08-00031">Department of Experimental Orofacial Medicine, Philipps University; 35039 Marburg, Germany;<email>estherkluk@aol.com</email> (E.K.);<email>stiller@implant-consult.de</email> (M.S.)</nlm:aff></affiliation></author><author><name sortKey="Adel Khattab, Doaa" sort="Adel Khattab, Doaa" uniqKey="Adel Khattab D" first="Doaa" last="Adel Khattab">Doaa Adel Khattab</name><affiliation><nlm:aff id="af2-jfb-08-00031">Department of Oral Periodontology, School of Dentistry, Ain Shams University, Cairo 11772, Egypt;<email>doaadel12345@yahoo.com</email></nlm:aff></affiliation></author><author><name sortKey="Kluk, Esther" sort="Kluk, Esther" uniqKey="Kluk E" first="Esther" last="Kluk">Esther Kluk</name><affiliation><nlm:aff id="af1-jfb-08-00031">Department of Experimental Orofacial Medicine, Philipps University; 35039 Marburg, Germany;<email>estherkluk@aol.com</email> (E.K.);<email>stiller@implant-consult.de</email> (M.S.)</nlm:aff></affiliation><affiliation><nlm:aff id="af3-jfb-08-00031">European Center of Dental Implantology (ECDI), 14193 Berlin, Germany;<email>info@implant-consult.de</email></nlm:aff></affiliation></author><author><name sortKey="Struck, Rainer" sort="Struck, Rainer" uniqKey="Struck R" first="Rainer" last="Struck">Rainer Struck</name><affiliation><nlm:aff id="af3-jfb-08-00031">European Center of Dental Implantology (ECDI), 14193 Berlin, Germany;<email>info@implant-consult.de</email></nlm:aff></affiliation></author><author><name sortKey="Stiller, Michael" sort="Stiller, Michael" uniqKey="Stiller M" first="Michael" last="Stiller">Michael Stiller</name><affiliation><nlm:aff id="af1-jfb-08-00031">Department of Experimental Orofacial Medicine, Philipps University; 35039 Marburg, Germany;<email>estherkluk@aol.com</email> (E.K.);<email>stiller@implant-consult.de</email> (M.S.)</nlm:aff></affiliation><affiliation><nlm:aff id="af3-jfb-08-00031">European Center of Dental Implantology (ECDI), 14193 Berlin, Germany;<email>info@implant-consult.de</email></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28758916</idno><idno type="pmc">5618282</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618282</idno><idno type="RBID">PMC:5618282</idno><idno type="doi">10.3390/jfb8030031</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">003151</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003151</idno><idno type="wicri:Area/Pmc/Curation">003151</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003151</idno><idno type="wicri:Area/Pmc/Checkpoint">000251</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000251</idno><idno type="wicri:Area/Ncbi/Merge">007122</idno><idno type="wicri:Area/Ncbi/Curation">007122</idno><idno type="wicri:Area/Ncbi/Checkpoint">007122</idno><idno type="wicri:Area/Main/Merge">000272</idno><idno type="wicri:Area/Main/Curation">000272</idno><idno type="wicri:Area/Main/Exploration">000272</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of a Particulate and a Putty-Like Tricalcium Phosphate-Based Bone-grafting Material on Bone Formation, Volume Stability and Osteogenic Marker Expression after Bilateral Sinus Floor Augmentation in Humans</title><author><name sortKey="Knabe, Christine" sort="Knabe, Christine" uniqKey="Knabe C" first="Christine" last="Knabe">Christine Knabe</name><affiliation><nlm:aff id="af1-jfb-08-00031">Department of Experimental Orofacial Medicine, Philipps University; 35039 Marburg, Germany;<email>estherkluk@aol.com</email> (E.K.);<email>stiller@implant-consult.de</email> (M.S.)</nlm:aff></affiliation></author><author><name sortKey="Adel Khattab, Doaa" sort="Adel Khattab, Doaa" uniqKey="Adel Khattab D" first="Doaa" last="Adel Khattab">Doaa Adel Khattab</name><affiliation><nlm:aff id="af2-jfb-08-00031">Department of Oral Periodontology, School of Dentistry, Ain Shams University, Cairo 11772, Egypt;<email>doaadel12345@yahoo.com</email></nlm:aff></affiliation></author><author><name sortKey="Kluk, Esther" sort="Kluk, Esther" uniqKey="Kluk E" first="Esther" last="Kluk">Esther Kluk</name><affiliation><nlm:aff id="af1-jfb-08-00031">Department of Experimental Orofacial Medicine, Philipps University; 35039 Marburg, Germany;<email>estherkluk@aol.com</email> (E.K.);<email>stiller@implant-consult.de</email> (M.S.)</nlm:aff></affiliation><affiliation><nlm:aff id="af3-jfb-08-00031">European Center of Dental Implantology (ECDI), 14193 Berlin, Germany;<email>info@implant-consult.de</email></nlm:aff></affiliation></author><author><name sortKey="Struck, Rainer" sort="Struck, Rainer" uniqKey="Struck R" first="Rainer" last="Struck">Rainer Struck</name><affiliation><nlm:aff id="af3-jfb-08-00031">European Center of Dental Implantology (ECDI), 14193 Berlin, Germany;<email>info@implant-consult.de</email></nlm:aff></affiliation></author><author><name sortKey="Stiller, Michael" sort="Stiller, Michael" uniqKey="Stiller M" first="Michael" last="Stiller">Michael Stiller</name><affiliation><nlm:aff id="af1-jfb-08-00031">Department of Experimental Orofacial Medicine, Philipps University; 35039 Marburg, Germany;<email>estherkluk@aol.com</email> (E.K.);<email>stiller@implant-consult.de</email> (M.S.)</nlm:aff></affiliation><affiliation><nlm:aff id="af3-jfb-08-00031">European Center of Dental Implantology (ECDI), 14193 Berlin, Germany;<email>info@implant-consult.de</email></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Functional Biomaterials</title><idno type="eISSN">2079-4983</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study examines the effect of a hyaluronic acid (HyAc) containing tricalcium phosphate putty scaffold material (TCP-P) and of a particulate tricalcium phosphate (TCP-G) graft on bone formation, volume stability and osteogenic marker expression in biopsies sampled 6 months after bilateral sinus floor augmentation (SFA) in 7 patients applying a split-mouth design. 10% autogenous bone chips were added to the grafting material during surgery. The grain size of the TCP granules was 700 to 1400 µm for TCP-G and 125 to 250 µm and 500 to 700 µm (ratio 1:1) for TCP-P. Biopsies were processed for immunohistochemical analysis of resin-embedded sections. Sections were stained for collagen type I (Col I), alkaline phosphatase (ALP), osteocalcin (OC) and bone sialoprotein (BSP). Furthermore, the bone area and biomaterial area fraction were determined histomorphometrically. Cone-beam CT data recorded after SFA and 6 months later were used for calculating the graft volume at these two time points. TCP-P displayed more advantageous surgical handling properties and a significantly greater bone area fraction and smaller biomaterial area fraction. This was accompanied by significantly greater expression of Col I and BSP and in osteoblasts and osteoid and a less pronounced reduction in grafting volume with TCP-P. SFA using both types of materials resulted in formation of sufficient bone volume for facilitating stable dental implant placement with all dental implants having been in function without any complications for 6 years. Since TCP-P displayed superior surgical handling properties and greater bone formation than TCP-G, without the HyAc hydrogel matrix having any adverse effect on bone formation or graft volume stability, TCP-P can be regarded as excellent grafting material for SFA in a clinical setting. The greater bone formation observed with TCP-P may be related to the difference in grain size of the TCP granules and/or the addition of the HyAc.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aghaloo, T L" uniqKey="Aghaloo T">T.L. Aghaloo</name></author><author><name sortKey="Moy, P K" uniqKey="Moy P">P.K. Moy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knabe, C" uniqKey="Knabe C">C. 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Stiller</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Adel Khattab, Doaa" sort="Adel Khattab, Doaa" uniqKey="Adel Khattab D" first="Doaa" last="Adel Khattab">Doaa Adel Khattab</name><name sortKey="Kluk, Esther" sort="Kluk, Esther" uniqKey="Kluk E" first="Esther" last="Kluk">Esther Kluk</name><name sortKey="Knabe, Christine" sort="Knabe, Christine" uniqKey="Knabe C" first="Christine" last="Knabe">Christine Knabe</name><name sortKey="Stiller, Michael" sort="Stiller, Michael" uniqKey="Stiller M" first="Michael" last="Stiller">Michael Stiller</name><name sortKey="Struck, Rainer" sort="Struck, Rainer" uniqKey="Struck R" first="Rainer" last="Struck">Rainer Struck</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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