Histological and histomorphometric evaluation of the synthetic biomaterial Natix® in horizontal reconstruction of alveolar ridge
Identifieur interne : 000226 ( Main/Exploration ); précédent : 000225; suivant : 000227Histological and histomorphometric evaluation of the synthetic biomaterial Natix® in horizontal reconstruction of alveolar ridge
Auteurs : Javad Mehrani Sabet [Iran] ; Babak Amoian [Iran] ; Maryam Seyedmajidi [Iran]Source :
- Dental Research Journal [ 1735-3327 ] ; 2017.
Abstract
Following loss of teeth, atrophy of alveolar ridge of the jaws is a substantial problem and unintended outcome that compels clinicians to perform bone reconstruction ahead of implant placement. Although autogenous bone is recommended as the gold standard in bone reconstruction, aninvasive second surgery harvestinga limited volume of bone (from intraoral source) has led a significant approachingthe use of synthetic bone substitute materials. The aim of this study was to evaluate the histologic and histomorphometric properties of porous titanium granules (Natix®) used in horizontal reconstruction of alveolar ridge before implant placement.
In the present quasi-experimental clinical trial, four patients (three females and one male) needed horizontal bone augmentation on ten areas of edentulous mandibular ridge before implant treatment. During surgery, the buccal aspect of edentulous ridge was augmented by Natix®, covered by resorbable membrane (Cytoplast®). After 8 months, 10 core biopsies were obtained.
In histological study, no foreign body reaction at the site of the newly formed bone or around the biomaterial residue was observed. Newly formed bone was fully vital with large lacunae containing osteocytes. In 60% of cases, connective tissue was observed at the biomaterial – new bone interface. In histomorphometric study, mean percentage of bone formation was 40.56% ± 19.83% and mean bone trabecular thickness was 39.98 ± 17.54 μ.
Despite acceptable histological and histomorphometric bone formation findings, in clinical terms, no increase was created in the horizontal dimension. Thus, it seems that application of this biomaterial in horizontal reconstruction of alveolar ridges with noncontained defects is inappropriate.
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PubMed: 28584532
PubMed Central: 5443015
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Medical Sciences, Babol, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Periodontics, School of Dentistry, Babol University of Medical Sciences, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author><author><name sortKey="Seyedmajidi, Maryam" sort="Seyedmajidi, Maryam" uniqKey="Seyedmajidi M" first="Maryam" last="Seyedmajidi">Maryam Seyedmajidi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28584532</idno><idno type="pmc">5443015</idno><idno 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type="wicri:Area/Main/Exploration">000226</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Histological and histomorphometric evaluation of the synthetic biomaterial Natix<sup>®</sup> in horizontal reconstruction of alveolar ridge</title><author><name sortKey="Sabet, Javad Mehrani" sort="Sabet, Javad Mehrani" uniqKey="Sabet J" first="Javad Mehrani" last="Sabet">Javad Mehrani Sabet</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Periodontics, School of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Periodontics, School of Dentistry, Mazandaran University of Medical Sciences, Sari</wicri:regionArea><wicri:noRegion>Sari</wicri:noRegion></affiliation></author><author><name sortKey="Amoian, Babak" sort="Amoian, Babak" uniqKey="Amoian B" first="Babak" last="Amoian">Babak Amoian</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Periodontics, School of Dentistry, Babol University of Medical Sciences, Babol, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Periodontics, School of Dentistry, Babol University of Medical Sciences, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author><author><name sortKey="Seyedmajidi, Maryam" sort="Seyedmajidi, Maryam" uniqKey="Seyedmajidi M" first="Maryam" last="Seyedmajidi">Maryam Seyedmajidi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol</wicri:regionArea><wicri:noRegion>Babol</wicri:noRegion></affiliation></author></analytic><series><title level="j">Dental Research Journal</title><idno type="ISSN">1735-3327</idno><idno type="eISSN">2008-0255</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>Following loss of teeth, atrophy of alveolar ridge of the jaws is a substantial problem and unintended outcome that compels clinicians to perform bone reconstruction ahead of implant placement. Although autogenous bone is recommended as the gold standard in bone reconstruction, aninvasive second surgery harvestinga limited volume of bone (from intraoral source) has led a significant approachingthe use of synthetic bone substitute materials. The aim of this study was to evaluate the histologic and histomorphometric properties of porous titanium granules (Natix<sup>®</sup>) used in horizontal reconstruction of alveolar ridge before implant placement.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>In the present quasi-experimental clinical trial, four patients (three females and one male) needed horizontal bone augmentation on ten areas of edentulous mandibular ridge before implant treatment. During surgery, the buccal aspect of edentulous ridge was augmented by Natix<sup>®</sup>, covered by resorbable membrane (Cytoplast<sup>®</sup>). After 8 months, 10 core biopsies were obtained.</p></sec><sec id="st3"><title>Results:</title><p>In histological study, no foreign body reaction at the site of the newly formed bone or around the biomaterial residue was observed. Newly formed bone was fully vital with large lacunae containing osteocytes. In 60% of cases, connective tissue was observed at the biomaterial – new bone interface. In histomorphometric study, mean percentage of bone formation was 40.56% ± 19.83% and mean bone trabecular thickness was 39.98 ± 17.54 μ.</p></sec><sec id="st4"><title>Conclusion:</title><p>Despite acceptable histological and histomorphometric bone formation findings, in clinical terms, no increase was created in the horizontal dimension. 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last="Sabet">Javad Mehrani Sabet</name></noRegion><name sortKey="Amoian, Babak" sort="Amoian, Babak" uniqKey="Amoian B" first="Babak" last="Amoian">Babak Amoian</name><name sortKey="Seyedmajidi, Maryam" sort="Seyedmajidi, Maryam" uniqKey="Seyedmajidi M" first="Maryam" last="Seyedmajidi">Maryam Seyedmajidi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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