Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement
Identifieur interne : 000223 ( Main/Exploration ); précédent : 000222; suivant : 000224Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement
Auteurs : Alberto Ortiz-Vig N ; Sergio Martinez-Villa ; I Aki Suarez ; Fabio Vignoletti ; Mariano SanzSource :
- International Journal of Implant Dentistry [ 2198-4034 ] ; 2017.
Abstract
The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures.
In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed using CCXBB as bone replacement grafts. Twenty-six weeks postoperatively, a re-entry procedure was performed to evaluate the bone width for adequate implant placement and two histological specimens were retrieved from each patient, one being processed for ground sectioning and the other for decalcified paraffin-included sections. In non-decalcified sections, the relative proportions occupied by bone, biomaterials, and connective tissue present in the biopsies were identified. In de-calcified sections, structures and cells positive for osteopontin (OPN), tartrate-resistant acid phosphatase activity (TRAP), osteocalcin (OSC), and alkaline phosphatase (ALP) were assessed.
Soft tissue dehiscence occurred during the follow-up in 5 out of 15 patients (33.3%). The mean crest width at baseline was 2.78 mm (SD 0.57) and the mean crest width at re-entry was 6.90 mm (SD 1.22), with a mean ridge width increase of 4.12 mm (SD 1.32). Twenty-six bone biopsies were obtained from 13 patients. Histomorphometric analysis showed a mean of 26.90% (SD 12.21) of mineralized vital bone (MVB), 21.37% (SD 7.36) of residual CCXBB, 47.13% (SD 19.15) of non-mineralized tissue, and 0.92% of DBBM. The immunohistochemical analysis revealed a large number of OPN-positive cells 8.12% (SD 4.73), a lower proportion of TRAP positive multinuclear cells 5.09% (SD 4.91), OSC-positive cells 4.09% (SD 4.34), and a limited amount of ALP positive cells 1.63% (SD 2).
CCXBB achieved significant horizontal crestal width allowing for staged implant placement in most of the patients. In light of the histological outcomes and implant failures, special attention must be placed to prevent soft tissue dehiscence when CCXBB is used in severe atrophic alveolar crests.
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DOI: 10.1186/s40729-017-0087-1
PubMed: 28634845
PubMed Central: 5478548
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement</title><author><name sortKey="Ortiz Vig N, Alberto" sort="Ortiz Vig N, Alberto" uniqKey="Ortiz Vig N A" first="Alberto" last="Ortiz-Vig N">Alberto Ortiz-Vig N</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Martinez Villa, Sergio" sort="Martinez Villa, Sergio" uniqKey="Martinez Villa S" first="Sergio" last="Martinez-Villa">Sergio Martinez-Villa</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Suarez, I Aki" sort="Suarez, I Aki" uniqKey="Suarez I" first="I Aki" last="Suarez">I Aki Suarez</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Vignoletti, Fabio" sort="Vignoletti, Fabio" uniqKey="Vignoletti F" first="Fabio" last="Vignoletti">Fabio Vignoletti</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Sanz, Mariano" sort="Sanz, Mariano" uniqKey="Sanz M" first="Mariano" last="Sanz">Mariano Sanz</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28634845</idno><idno type="pmc">5478548</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478548</idno><idno type="RBID">PMC:5478548</idno><idno type="doi">10.1186/s40729-017-0087-1</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000C97</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C97</idno><idno type="wicri:Area/Pmc/Curation">000C97</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C97</idno><idno type="wicri:Area/Pmc/Checkpoint">000204</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000204</idno><idno type="wicri:Area/Ncbi/Merge">007049</idno><idno type="wicri:Area/Ncbi/Curation">007049</idno><idno type="wicri:Area/Ncbi/Checkpoint">007049</idno><idno type="wicri:Area/Main/Merge">000223</idno><idno type="wicri:Area/Main/Curation">000223</idno><idno type="wicri:Area/Main/Exploration">000223</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement</title><author><name sortKey="Ortiz Vig N, Alberto" sort="Ortiz Vig N, Alberto" uniqKey="Ortiz Vig N A" first="Alberto" last="Ortiz-Vig N">Alberto Ortiz-Vig N</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Martinez Villa, Sergio" sort="Martinez Villa, Sergio" uniqKey="Martinez Villa S" first="Sergio" last="Martinez-Villa">Sergio Martinez-Villa</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Suarez, I Aki" sort="Suarez, I Aki" uniqKey="Suarez I" first="I Aki" last="Suarez">I Aki Suarez</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Vignoletti, Fabio" sort="Vignoletti, Fabio" uniqKey="Vignoletti F" first="Fabio" last="Vignoletti">Fabio Vignoletti</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Sanz, Mariano" sort="Sanz, Mariano" uniqKey="Sanz M" first="Mariano" last="Sanz">Mariano Sanz</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Implant Dentistry</title><idno type="eISSN">2198-4034</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures.</p></sec><sec><title>Methods</title><p>In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed using CCXBB as bone replacement grafts. Twenty-six weeks postoperatively, a re-entry procedure was performed to evaluate the bone width for adequate implant placement and two histological specimens were retrieved from each patient, one being processed for ground sectioning and the other for decalcified paraffin-included sections. In non-decalcified sections, the relative proportions occupied by bone, biomaterials, and connective tissue present in the biopsies were identified. In de-calcified sections, structures and cells positive for osteopontin (OPN), tartrate-resistant acid phosphatase activity (TRAP), osteocalcin (OSC), and alkaline phosphatase (ALP) were assessed.</p></sec><sec><title>Results</title><p>Soft tissue dehiscence occurred during the follow-up in 5 out of 15 patients (33.3%). The mean crest width at baseline was 2.78 mm (SD 0.57) and the mean crest width at re-entry was 6.90 mm (SD 1.22), with a mean ridge width increase of 4.12 mm (SD 1.32). Twenty-six bone biopsies were obtained from 13 patients. Histomorphometric analysis showed a mean of 26.90% (SD 12.21) of mineralized vital bone (MVB), 21.37% (SD 7.36) of residual CCXBB, 47.13% (SD 19.15) of non-mineralized tissue, and 0.92% of DBBM. The immunohistochemical analysis revealed a large number of OPN-positive cells 8.12% (SD 4.73), a lower proportion of TRAP positive multinuclear cells 5.09% (SD 4.91), OSC-positive cells 4.09% (SD 4.34), and a limited amount of ALP positive cells 1.63% (SD 2).</p></sec><sec><title>Conclusions</title><p>CCXBB achieved significant horizontal crestal width allowing for staged implant placement in most of the patients. 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Lindhe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindhe, J" uniqKey="Lindhe J">J Lindhe</name></author><author><name sortKey="Araujo, Mg" uniqKey="Araujo M">MG Araujo</name></author><author><name sortKey="Bufler, M" uniqKey="Bufler M">M Bufler</name></author><author><name sortKey="Liljenberg, B" uniqKey="Liljenberg B">B Liljenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galindo Moreno, P" uniqKey="Galindo Moreno P">P Galindo-Moreno</name></author><author><name sortKey="Hernandez Cortes, P" uniqKey="Hernandez Cortes P">P Hernandez-Cortes</name></author><author><name sortKey="Aneiros Fernandez, J" uniqKey="Aneiros Fernandez J">J Aneiros-Fernandez</name></author><author><name sortKey="Camara, M" uniqKey="Camara M">M Camara</name></author><author><name sortKey="Mesa, F" uniqKey="Mesa F">F Mesa</name></author><author><name sortKey="Wallace, S" uniqKey="Wallace S">S 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uniqKey="Patti A">A Patti</name></author><author><name sortKey="Gennari, L" uniqKey="Gennari L">L Gennari</name></author><author><name sortKey="Merlotti, D" uniqKey="Merlotti D">D Merlotti</name></author><author><name sortKey="Dotta, F" uniqKey="Dotta F">F Dotta</name></author><author><name sortKey="Nuti, R" uniqKey="Nuti R">R Nuti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwarz, F" uniqKey="Schwarz F">F Schwarz</name></author><author><name sortKey="Herten, M" uniqKey="Herten M">M Herten</name></author><author><name sortKey="Sager, M" uniqKey="Sager M">M Sager</name></author><author><name sortKey="Wieland, M" uniqKey="Wieland M">M Wieland</name></author><author><name sortKey="Dard, M" uniqKey="Dard M">M Dard</name></author><author><name sortKey="Becker, J" uniqKey="Becker J">J Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Becker, K" uniqKey="Becker K">K Becker</name></author><author><name sortKey="Drescher, D" uniqKey="Drescher D">D Drescher</name></author><author><name sortKey="Honscheid, R" uniqKey="Honscheid R">R Honscheid</name></author><author><name sortKey="Golubovic, V" uniqKey="Golubovic V">V Golubovic</name></author><author><name sortKey="Mihatovic, I" uniqKey="Mihatovic I">I Mihatovic</name></author><author><name sortKey="Schwarz, F" uniqKey="Schwarz F">F Schwarz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berglundh, T" uniqKey="Berglundh T">T Berglundh</name></author><author><name sortKey="Giannobile, Wv" uniqKey="Giannobile W">WV Giannobile</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Martinez Villa, Sergio" sort="Martinez Villa, Sergio" uniqKey="Martinez Villa S" first="Sergio" last="Martinez-Villa">Sergio Martinez-Villa</name><name sortKey="Ortiz Vig N, Alberto" sort="Ortiz Vig N, Alberto" uniqKey="Ortiz Vig N A" first="Alberto" last="Ortiz-Vig N">Alberto Ortiz-Vig N</name><name sortKey="Sanz, Mariano" sort="Sanz, Mariano" uniqKey="Sanz M" first="Mariano" last="Sanz">Mariano Sanz</name><name sortKey="Suarez, I Aki" sort="Suarez, I Aki" uniqKey="Suarez I" first="I Aki" last="Suarez">I Aki Suarez</name><name sortKey="Vignoletti, Fabio" sort="Vignoletti, Fabio" uniqKey="Vignoletti F" first="Fabio" last="Vignoletti">Fabio Vignoletti</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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