Human immune responses to oral micro-organisms. I. Association of localized juvenile periodontitis (LJP) with serum antibody responses to Actinobacillus actinomycetemcomitans.
Identifieur interne : 00D441 ( Main/Curation ); précédent : 00D440; suivant : 00D442Human immune responses to oral micro-organisms. I. Association of localized juvenile periodontitis (LJP) with serum antibody responses to Actinobacillus actinomycetemcomitans.
Auteurs : J L Ebersole ; M A Taubman ; D J Smith ; R J Genco ; D E FreySource :
- Clinical and Experimental Immunology [ 0009-9104 ] ; 1982.
Abstract
The association between periodontal disease in humans and serum and salivary antibody to Actinobacillus actinomycetemcomitans strain Y4 was determined. An Elisa was used to examine anti-Y4 antibody of the IgM, IgG, IgA and IgE isotypes in serum from 127 individuals and IgA in parotid saliva. Patients diagnosed as having localized juvenile periodontitis (n = 37) had significantly higher levels and frequency of serum IgG antibodies to Y4 than all other groups. Serum and salivary IgA and serum IgE antibody levels were significantly increased in patients with both localized and generalized types of juvenile periodontitis (n = 48) when compared to all other patient groups. Specificity studies suggested that the antigenic determinants that were differentiating the group responses were unique to the Y4 organism. These results indicate that serum antibodies to Y4 may reflect an infectious process with this micro-organism and that these responses may provide some diagnostic value in delineating different types of periodontal diseases.
Url:
PubMed: 7094425
PubMed Central: 1536378
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