Periodontal microbiota and phospholipases: The Oral Infections and Vascular Disease Epidemiology Study (INVEST)
Identifieur interne : 000E39 ( Main/Curation ); précédent : 000E38; suivant : 000E40Periodontal microbiota and phospholipases: The Oral Infections and Vascular Disease Epidemiology Study (INVEST)
Auteurs : Adrien Boillot [France] ; Ryan T. Demmer [États-Unis] ; Ziad Mallat [France, Royaume-Uni] ; Ralph L. Sacco [États-Unis] ; David R. Jacobs [États-Unis, Norvège] ; Joelle Benessiano [France] ; Alain Tedgui [France] ; Tatjana Rundek [États-Unis] ; Panos N. Papapanou [États-Unis] ; Moïse Desvarieux [États-Unis, France]Source :
- Atherosclerosis [ 0021-9150 ] ; 2015.
Abstract
Periodontal infections have been linked to cardiovascular disease, including atherosclerosis, and systemic inflammation has been proposed as a possible mediator. Secretory phospholipase A2 (s-PLA2) and Lipoprotein-associated PLA2 (Lp-PLA2) are inflammatory enzymes associated with athero-sclerosis. No data are available on the association between oral microbiota and PLA2s. We studied whether a relationship exists between periodontal microbiota and the activities of these enzymes.
The Oral Infection and Vascular Disease Epidemiology Study (INVEST) collected subgingival biofilms and serum samples from 593 dentate men and women (age 68.7 ± 8.6 years). 4561 biofilm samples were collected in the two most posterior teeth of each quadrant (average 7/participant) for quantitative assessment of 11 bacterial species using DNA–DNA checkerboard hybridization. Mean concentration of s-PLA2 and activities of s-PLA2 and Lp-PLA2 were regressed on tertiles of etiologic dominance (ED). ED is defined as the level of presumed periodontopathic species/combined level of all eleven species measured, and represents the relative abundance of periodontopathic organisms. Analyses were adjusted for age, sex, race/ethnicity, education, smoking, BMI, diabetes, LDL cholesterol and HDL cholesterol, and systolic blood pressure.
Higher levels of s-PLA2 activity were observed across increasing tertiles of etiologic dominance (0.66 ± 0.04 nmol ml−1 min−1, 0.73 ± 0.04 nmol ml−1 min−1, 0.89 ± 0.04 nmol ml−1 min−1; p < 0.001), with also a trend of association between Lp-PLA2 activity and ED (p = 0.07), while s-PLA2 concentration was unrelated to ED.
Increasingly greater s-PLA2 activity at higher tertiles of etiologic dominance may provide a mechanistic explanatory link of the relationship between periodontal microbiota and vascular diseases. Additional studies investigating the role of s-PLA2 are needed.
Url:
DOI: 10.1016/j.atherosclerosis.2015.07.039
PubMed: 26282947
PubMed Central: 4862208
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002589
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :002589
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000B70
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :005E54
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :005E54
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :005E54
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000E41
Links to Exploration step
PMC:4862208Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Periodontal microbiota and phospholipases: The Oral Infections and Vascular Disease Epidemiology Study (INVEST)</title>
<author><name sortKey="Boillot, Adrien" sort="Boillot, Adrien" uniqKey="Boillot A" first="Adrien" last="Boillot">Adrien Boillot</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Department of Periodontology, Rothschild Hospital (AP-HP); University Paris 7, 5 Rue Santerre, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Department of Periodontology, Rothschild Hospital (AP-HP); University Paris 7, 5 Rue Santerre, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2"> INSERM U1018, University of Versailles St Quentin. Centre for research in Epidemiology and Population Health, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM U1018, University of Versailles St Quentin. Centre for research in Epidemiology and Population Health, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demmer, Ryan T" sort="Demmer, Ryan T" uniqKey="Demmer R" first="Ryan T." last="Demmer">Ryan T. Demmer</name>
<affiliation wicri:level="4"><nlm:aff id="A3"> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Mallat, Ziad" sort="Mallat, Ziad" uniqKey="Mallat Z" first="Ziad" last="Mallat">Ziad Mallat</name>
<affiliation wicri:level="3"><nlm:aff id="A4"> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A5"> Department of Medicine, University of Cambridge, Cambridge, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Department of Medicine, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L." last="Sacco">Ralph L. Sacco</name>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jacobs, David R" sort="Jacobs, David R" uniqKey="Jacobs D" first="David R." last="Jacobs">David R. Jacobs</name>
<affiliation wicri:level="2"><nlm:aff id="A7"> Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A8"> Department of Nutrition, University of Oslo, Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea> Department of Nutrition, University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benessiano, Joelle" sort="Benessiano, Joelle" uniqKey="Benessiano J" first="Joelle" last="Benessiano">Joelle Benessiano</name>
<affiliation wicri:level="3"><nlm:aff id="A9"> Service de Biochimie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Service de Biochimie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tedgui, Alain" sort="Tedgui, Alain" uniqKey="Tedgui A" first="Alain" last="Tedgui">Alain Tedgui</name>
<affiliation wicri:level="3"><nlm:aff id="A4"> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rundek, Tatjana" sort="Rundek, Tatjana" uniqKey="Rundek T" first="Tatjana" last="Rundek">Tatjana Rundek</name>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name>
<affiliation wicri:level="4"><nlm:aff id="A10"> Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Desvarieux, Moise" sort="Desvarieux, Moise" uniqKey="Desvarieux M" first="Moïse" last="Desvarieux">Moïse Desvarieux</name>
<affiliation wicri:level="4"><nlm:aff id="A3"> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A11"> INSERM Epidemiology and Biostatistics Research Center, Sorbonne Paris Cité, INSERM UMR 1153, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM Epidemiology and Biostatistics Research Center, Sorbonne Paris Cité, INSERM UMR 1153, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26282947</idno>
<idno type="pmc">4862208</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862208</idno>
<idno type="RBID">PMC:4862208</idno>
<idno type="doi">10.1016/j.atherosclerosis.2015.07.039</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">002589</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002589</idno>
<idno type="wicri:Area/Pmc/Curation">002589</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002589</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000B70</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B70</idno>
<idno type="wicri:Area/Ncbi/Merge">005E54</idno>
<idno type="wicri:Area/Ncbi/Curation">005E54</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">005E54</idno>
<idno type="wicri:doubleKey">0021-9150:2015:Boillot A:periodontal:microbiota:and</idno>
<idno type="wicri:Area/Main/Merge">000E41</idno>
<idno type="wicri:Area/Main/Curation">000E39</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Periodontal microbiota and phospholipases: The Oral Infections and Vascular Disease Epidemiology Study (INVEST)</title>
<author><name sortKey="Boillot, Adrien" sort="Boillot, Adrien" uniqKey="Boillot A" first="Adrien" last="Boillot">Adrien Boillot</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Department of Periodontology, Rothschild Hospital (AP-HP); University Paris 7, 5 Rue Santerre, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Department of Periodontology, Rothschild Hospital (AP-HP); University Paris 7, 5 Rue Santerre, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2"> INSERM U1018, University of Versailles St Quentin. Centre for research in Epidemiology and Population Health, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM U1018, University of Versailles St Quentin. Centre for research in Epidemiology and Population Health, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demmer, Ryan T" sort="Demmer, Ryan T" uniqKey="Demmer R" first="Ryan T." last="Demmer">Ryan T. Demmer</name>
<affiliation wicri:level="4"><nlm:aff id="A3"> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Mallat, Ziad" sort="Mallat, Ziad" uniqKey="Mallat Z" first="Ziad" last="Mallat">Ziad Mallat</name>
<affiliation wicri:level="3"><nlm:aff id="A4"> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A5"> Department of Medicine, University of Cambridge, Cambridge, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea> Department of Medicine, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L." last="Sacco">Ralph L. Sacco</name>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jacobs, David R" sort="Jacobs, David R" uniqKey="Jacobs D" first="David R." last="Jacobs">David R. Jacobs</name>
<affiliation wicri:level="2"><nlm:aff id="A7"> Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A8"> Department of Nutrition, University of Oslo, Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea> Department of Nutrition, University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benessiano, Joelle" sort="Benessiano, Joelle" uniqKey="Benessiano J" first="Joelle" last="Benessiano">Joelle Benessiano</name>
<affiliation wicri:level="3"><nlm:aff id="A9"> Service de Biochimie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Service de Biochimie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tedgui, Alain" sort="Tedgui, Alain" uniqKey="Tedgui A" first="Alain" last="Tedgui">Alain Tedgui</name>
<affiliation wicri:level="3"><nlm:aff id="A4"> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rundek, Tatjana" sort="Rundek, Tatjana" uniqKey="Rundek T" first="Tatjana" last="Rundek">Tatjana Rundek</name>
<affiliation wicri:level="2"><nlm:aff id="A6"> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name>
<affiliation wicri:level="4"><nlm:aff id="A10"> Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Desvarieux, Moise" sort="Desvarieux, Moise" uniqKey="Desvarieux M" first="Moïse" last="Desvarieux">Moïse Desvarieux</name>
<affiliation wicri:level="4"><nlm:aff id="A3"> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A11"> INSERM Epidemiology and Biostatistics Research Center, Sorbonne Paris Cité, INSERM UMR 1153, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM Epidemiology and Biostatistics Research Center, Sorbonne Paris Cité, INSERM UMR 1153, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Atherosclerosis</title>
<idno type="ISSN">0021-9150</idno>
<idno type="eISSN">1879-1484</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Periodontal infections have been linked to cardiovascular disease, including atherosclerosis, and systemic inflammation has been proposed as a possible mediator. Secretory phospholipase A2 (s-PLA2) and Lipoprotein-associated PLA2 (Lp-PLA2) are inflammatory enzymes associated with athero-sclerosis. No data are available on the association between oral microbiota and PLA2s. We studied whether a relationship exists between periodontal microbiota and the activities of these enzymes.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">The Oral Infection and Vascular Disease Epidemiology Study (INVEST) collected subgingival biofilms and serum samples from 593 dentate men and women (age 68.7 ± 8.6 years). 4561 biofilm samples were collected in the two most posterior teeth of each quadrant (average 7/participant) for quantitative assessment of 11 bacterial species using DNA–DNA checkerboard hybridization. Mean concentration of s-PLA2 and activities of s-PLA2 and Lp-PLA2 were regressed on tertiles of etiologic dominance (ED). ED is defined as the level of presumed periodontopathic species/combined level of all eleven species measured, and represents the relative abundance of periodontopathic organisms. Analyses were adjusted for age, sex, race/ethnicity, education, smoking, BMI, diabetes, LDL cholesterol and HDL cholesterol, and systolic blood pressure.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Higher levels of s-PLA2 activity were observed across increasing tertiles of etiologic dominance (0.66 ± 0.04 nmol ml<sup>−1</sup>
min<sup>−1</sup>
, 0.73 ± 0.04 nmol ml<sup>−1</sup>
min<sup>−1</sup>
, 0.89 ± 0.04 nmol ml<sup>−1</sup>
min<sup>−1</sup>
; p < 0.001), with also a trend of association between Lp-PLA2 activity and ED (p = 0.07), while s-PLA2 concentration was unrelated to ED.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Increasingly greater s-PLA2 activity at higher tertiles of etiologic dominance may provide a mechanistic explanatory link of the relationship between periodontal microbiota and vascular diseases. Additional studies investigating the role of s-PLA2 are needed.</p>
</sec>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E39 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000E39 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Main |étape= Curation |type= RBID |clé= PMC:4862208 |texte= Periodontal microbiota and phospholipases: The Oral Infections and Vascular Disease Epidemiology Study (INVEST) }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:26282947" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
This area was generated with Dilib version V0.6.32. |