The ultrastructure of osteoclasts in microphthalmic mice
Identifieur interne : 007D17 ( Istex/Curation ); précédent : 007D16; suivant : 007D18The ultrastructure of osteoclasts in microphthalmic mice
Auteurs : M. E. Holtrop [États-Unis] ; K. A. Cox [États-Unis] ; G. Eilon [États-Unis] ; H. A. Simmons [États-Unis] ; L. G. Raisz [États-Unis]Source :
- Metabolic Bone Disease and Related Research [ 0221-8747 ] ; 1981.
English descriptors
- KwdEn :
- Bone resorption, Bone surface, Calvaria, Clear zones, Holtrop, Light microscopy, Littermates, Lysosomal, Lysosomal enzymes, Milmi, Milmi mice, Mouse, Normal littermates, Organ culture, Osteoclast, Osteoclast function, Osteoclast profile, Osteoclast profiles, Osteopetrosis, Osteopetrotic, Osteopetrotic mice, Parathyroid hormone, Raisz, Resorption, Spleen cells, Tibia, Ultrastructure.
- Teeft :
- Bone resorption, Bone surface, Calvaria, Clear zones, Holtrop, Light microscopy, Littermates, Lysosomal, Lysosomal enzymes, Milmi, Milmi mice, Mouse, Normal littermates, Organ culture, Osteoclast, Osteoclast function, Osteoclast profile, Osteoclast profiles, Osteopetrosis, Osteopetrotic, Osteopetrotic mice, Parathyroid hormone, Raisz, Resorption, Spleen cells, Tibia, Ultrastructure.
Abstract
Abstract: Osteoclasts in microphthalmic (mi/mi) mice were significantly smaller than in their heterozygous (mi/+) or normal (+/+) littermates as measured by electronmicroscopic morphometry. Clear zones were also significantly smaller and normal ruffled borders were absent. The cytoplasm was not fully differentiated. No differences were seen between osteoclasts from mi/+ and +/+ mice. The number of osteoclasts was not different in mi/mi, mi/+ or +/+ mice. Lysosomal enzymes and collagenase content of bones in the three genotypes did not show marked differences.
Url:
DOI: 10.1016/0221-8747(81)90030-8
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E." last="Holtrop">M. E. Holtrop</name><affiliation wicri:level="1"><mods:affiliation>Department of Orthopaedic Surgery, Harvard Medical School, Children's Hospital Medical Center, Boston, Massachusetts, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, Harvard Medical School, Children's Hospital Medical Center, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Cox, K A" sort="Cox, K A" uniqKey="Cox K" first="K. A." last="Cox">K. A. Cox</name><affiliation wicri:level="1"><mods:affiliation>Department of Orthopaedic Surgery, Harvard Medical School, Children's Hospital Medical Center, Boston, Massachusetts, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, Harvard Medical School, Children's Hospital Medical Center, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Eilon, G" sort="Eilon, G" uniqKey="Eilon G" first="G." last="Eilon">G. 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Simmons</name><affiliation wicri:level="1"><mods:affiliation>Department of Orthopaedic Surgery, Harvard Medical School, Children's Hospital Medical Center, Boston, Massachusetts, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, Harvard Medical School, Children's Hospital Medical Center, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Raisz, L G" sort="Raisz, L G" uniqKey="Raisz L" first="L. G." last="Raisz">L. G. Raisz</name><affiliation wicri:level="1"><mods:affiliation>Department of Orthopaedic Surgery, Harvard Medical School, Children's Hospital Medical Center, Boston, Massachusetts, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, Harvard Medical School, Children's Hospital Medical Center, Boston, Massachusetts</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Metabolic Bone Disease and Related Research</title><title level="j" type="abbrev">MBDRR</title><idno type="ISSN">0221-8747</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1981">1981</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="123">123</biblScope><biblScope unit="page" to="129">129</biblScope></imprint><idno type="ISSN">0221-8747</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0221-8747</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bone resorption</term><term>Bone surface</term><term>Calvaria</term><term>Clear zones</term><term>Holtrop</term><term>Light microscopy</term><term>Littermates</term><term>Lysosomal</term><term>Lysosomal enzymes</term><term>Milmi</term><term>Milmi mice</term><term>Mouse</term><term>Normal littermates</term><term>Organ culture</term><term>Osteoclast</term><term>Osteoclast function</term><term>Osteoclast profile</term><term>Osteoclast profiles</term><term>Osteopetrosis</term><term>Osteopetrotic</term><term>Osteopetrotic mice</term><term>Parathyroid hormone</term><term>Raisz</term><term>Resorption</term><term>Spleen cells</term><term>Tibia</term><term>Ultrastructure</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Bone resorption</term><term>Bone surface</term><term>Calvaria</term><term>Clear zones</term><term>Holtrop</term><term>Light microscopy</term><term>Littermates</term><term>Lysosomal</term><term>Lysosomal enzymes</term><term>Milmi</term><term>Milmi mice</term><term>Mouse</term><term>Normal littermates</term><term>Organ culture</term><term>Osteoclast</term><term>Osteoclast function</term><term>Osteoclast profile</term><term>Osteoclast profiles</term><term>Osteopetrosis</term><term>Osteopetrotic</term><term>Osteopetrotic mice</term><term>Parathyroid hormone</term><term>Raisz</term><term>Resorption</term><term>Spleen cells</term><term>Tibia</term><term>Ultrastructure</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Osteoclasts in microphthalmic (mi/mi) mice were significantly smaller than in their heterozygous (mi/+) or normal (+/+) littermates as measured by electronmicroscopic morphometry. Clear zones were also significantly smaller and normal ruffled borders were absent. The cytoplasm was not fully differentiated. No differences were seen between osteoclasts from mi/+ and +/+ mice. The number of osteoclasts was not different in mi/mi, mi/+ or +/+ mice. Lysosomal enzymes and collagenase content of bones in the three genotypes did not show marked differences.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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