Active peptides in the skins of two hundred and thirty American amphibian species
Identifieur interne : 006970 ( Istex/Curation ); précédent : 006969; suivant : 006971Active peptides in the skins of two hundred and thirty American amphibian species
Auteurs : V. Erspamer ; G. Falconieri Erspamer ; J. M. Cei [Argentine]Source :
- Comparative Biochemistry and Physiology, Part C: Comparative Pharmacology [ 0306-4492 ] ; 1988.
Descripteurs français
English descriptors
- KwdEn :
- Active peptides, American amphibians, Amphibian, Amphibian skin, Amphibian skin peptides, Amphibian species, Anastasi, April, Argentina, August, Average weight, Bioassay, Biogenic amines, Blood pressure, Bombesins, Brad, Bradykinin, Bradykinins, Bufo, Caer, Caerulein, Chile, Costa, Dermorphin, Dermorphins, Ecuador, Erspamer, Falconieri, Falconieri erspamer, Fresh skin, Frog, Hyla, Hylid frogs, Janeiro, July, June, Leptodactylus, Melchiorri, Methanol, Methanol extracts, Montecucchi, Napo, Parallel bioassay, Peptide, Peptide families, Peptide molecules, Peptide protein, Peptides skin, Personal communication, Peru, Pharmac, Pharmacological actions, Phyllokinin, Phyllomedusa, Phyllomedusa bicolor, Phyllomedusa sauvagei, Phyllomedusa sauvagei skin, Phyllomedusid, Phyllomedusid frogs, Phyllomedusin, Phys, Physalaemin, Physalaemus, Pleurodema, Rana, Rica, Rohdei, Rohdeilitorin, Sauvagei, Sauvagine, Sept, Skin, Skin extracts, Smilisca, Spinulosus, Subfamily, Tachykinins, Telmatobius, Trypt, Tucuman, Whole bodies, Whole body.
- Teeft :
- Active peptides, American amphibians, Amphibian, Amphibian skin, Amphibian skin peptides, Amphibian species, Anastasi, April, Argentina, August, Average weight, Bioassay, Biogenic amines, Blood pressure, Bombesins, Brad, Bradykinin, Bradykinins, Bufo, Caer, Caerulein, Chile, Costa, Dermorphin, Dermorphins, Ecuador, Erspamer, Falconieri, Falconieri erspamer, Fresh skin, Frog, Hyla, Hylid frogs, Janeiro, July, June, Leptodactylus, Melchiorri, Methanol, Methanol extracts, Montecucchi, Napo, Parallel bioassay, Peptide, Peptide families, Peptide molecules, Peptide protein, Peptides skin, Personal communication, Peru, Pharmac, Pharmacological actions, Phyllokinin, Phyllomedusa, Phyllomedusa bicolor, Phyllomedusa sauvagei, Phyllomedusa sauvagei skin, Phyllomedusid, Phyllomedusid frogs, Phyllomedusin, Phys, Physalaemin, Physalaemus, Pleurodema, Rana, Rica, Rohdei, Rohdeilitorin, Sauvagei, Sauvagine, Sept, Skin, Skin extracts, Smilisca, Spinulosus, Subfamily, Tachykinins, Telmatobius, Trypt, Tucuman, Whole bodies, Whole body.
Abstract
Abstract: 1. 1. Extracts prepared from dried or fresh skins of more than 200 American amphibian species were subjected to biological screening in order to determine occurrence and contents of peptides active on smooth muscle preparations, systemic blood pressure and, subordinately, external secretions, anterior pituitary and the central nervous system. 2. 2. The peptide families identified in skin extracts were as follows: caruleins (caerulein, phyllocaerulein), tachykinins (physalaemin, phyllomedusin), bombesins (phyllolitorin, [Leu8]phyllolitorin, rohdeilitorin), bradykinins (phyllokinin and others), sauvagine, dermorphins (dermorphin, [Hyp6]dermorphin), tryptophyllins (numerous peptides) and, finally, miscellaneous peptides. None of the above peptide families showed a widespread distribution, but all were restricted to particular amphibian genera or stocks. 3. 3. The hylid frogs of the Phyllomedusinae family occupy a unique position, as their skin displayed the greatest variety and abundance of active peptides ever found in any amphibian stock in the world. 4. 4. The array of peptide molecules occurring in the skin of the American amphibians is destined to increase because numerous other peptide molecules await isolation, elucidation of structure and definition of possible biological activities.
Url:
DOI: 10.1016/0742-8413(86)90063-0
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V. Erspamer<affiliation><mods:affiliation>Institutes of Medical Pharmacology and of Pharmacology and Pharmacognosy, 1st University of Rome, I 00 100 Rome, Italy. Telephone: (06)4940094</mods:affiliation><wicri:noCountry code="subField">(06)4940094</wicri:noCountry></affiliation><affiliation><mods:affiliation>Institutes of Medical Pharmacology and of Pharmacology and Pharmacognosy, 1st University of Rome, I 00 100 Rome, Italy. Telephone: (06)4940094</mods:affiliation><wicri:noCountry code="subField">(06)4940094</wicri:noCountry></affiliation>Le document en format XML
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Telephone: (06)4940094</mods:affiliation><wicri:noCountry code="subField">(06)4940094</wicri:noCountry></affiliation></author><author><name sortKey="Cei, J M" sort="Cei, J M" uniqKey="Cei J" first="J. M." last="Cei">J. M. Cei</name><affiliation wicri:level="1"><mods:affiliation>Department of Natural Sciences, National University of Rio Cuarto, 5800 Rio Cuarto, Cordoba, Argentina</mods:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Department of Natural Sciences, National University of Rio Cuarto, 5800 Rio Cuarto, Cordoba</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D48B434AA053010E26649DF8B1775116AAF2A822</idno><date when="1988" year="1988">1988</date><idno type="doi">10.1016/0742-8413(86)90063-0</idno><idno type="url">https://api.istex.fr/document/D48B434AA053010E26649DF8B1775116AAF2A822/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">006970</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">006970</idno><idno type="wicri:Area/Istex/Curation">006970</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Active peptides in the skins of two hundred and thirty American amphibian species</title><author><name sortKey="Erspamer, V" sort="Erspamer, V" uniqKey="Erspamer V" first="V." last="Erspamer">V. Erspamer</name><affiliation><mods:affiliation>Institutes of Medical Pharmacology and of Pharmacology and Pharmacognosy, 1st University of Rome, I 00 100 Rome, Italy. Telephone: (06)4940094</mods:affiliation><wicri:noCountry code="subField">(06)4940094</wicri:noCountry></affiliation></author><author><name sortKey="Erspamer, G Falconieri" sort="Erspamer, G Falconieri" uniqKey="Erspamer G" first="G. Falconieri" last="Erspamer">G. Falconieri Erspamer</name><affiliation><mods:affiliation>Institutes of Medical Pharmacology and of Pharmacology and Pharmacognosy, 1st University of Rome, I 00 100 Rome, Italy. Telephone: (06)4940094</mods:affiliation><wicri:noCountry code="subField">(06)4940094</wicri:noCountry></affiliation></author><author><name sortKey="Cei, J M" sort="Cei, J M" uniqKey="Cei J" first="J. M." last="Cei">J. M. Cei</name><affiliation wicri:level="1"><mods:affiliation>Department of Natural Sciences, National University of Rio Cuarto, 5800 Rio Cuarto, Cordoba, Argentina</mods:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Department of Natural Sciences, National University of Rio Cuarto, 5800 Rio Cuarto, Cordoba</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Comparative Biochemistry and Physiology, Part C: Comparative Pharmacology</title><title level="j" type="abbrev">CBPC</title><idno type="ISSN">0306-4492</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988">1988</date><biblScope unit="volume">85</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="125">125</biblScope><biblScope unit="page" to="137">137</biblScope></imprint><idno type="ISSN">0306-4492</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-4492</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active peptides</term><term>American amphibians</term><term>Amphibian</term><term>Amphibian skin</term><term>Amphibian skin peptides</term><term>Amphibian species</term><term>Anastasi</term><term>April</term><term>Argentina</term><term>August</term><term>Average weight</term><term>Bioassay</term><term>Biogenic amines</term><term>Blood pressure</term><term>Bombesins</term><term>Brad</term><term>Bradykinin</term><term>Bradykinins</term><term>Bufo</term><term>Caer</term><term>Caerulein</term><term>Chile</term><term>Costa</term><term>Dermorphin</term><term>Dermorphins</term><term>Ecuador</term><term>Erspamer</term><term>Falconieri</term><term>Falconieri erspamer</term><term>Fresh skin</term><term>Frog</term><term>Hyla</term><term>Hylid frogs</term><term>Janeiro</term><term>July</term><term>June</term><term>Leptodactylus</term><term>Melchiorri</term><term>Methanol</term><term>Methanol extracts</term><term>Montecucchi</term><term>Napo</term><term>Parallel bioassay</term><term>Peptide</term><term>Peptide families</term><term>Peptide molecules</term><term>Peptide protein</term><term>Peptides skin</term><term>Personal communication</term><term>Peru</term><term>Pharmac</term><term>Pharmacological actions</term><term>Phyllokinin</term><term>Phyllomedusa</term><term>Phyllomedusa bicolor</term><term>Phyllomedusa sauvagei</term><term>Phyllomedusa sauvagei skin</term><term>Phyllomedusid</term><term>Phyllomedusid frogs</term><term>Phyllomedusin</term><term>Phys</term><term>Physalaemin</term><term>Physalaemus</term><term>Pleurodema</term><term>Rana</term><term>Rica</term><term>Rohdei</term><term>Rohdeilitorin</term><term>Sauvagei</term><term>Sauvagine</term><term>Sept</term><term>Skin</term><term>Skin extracts</term><term>Smilisca</term><term>Spinulosus</term><term>Subfamily</term><term>Tachykinins</term><term>Telmatobius</term><term>Trypt</term><term>Tucuman</term><term>Whole bodies</term><term>Whole body</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Active peptides</term><term>American amphibians</term><term>Amphibian</term><term>Amphibian skin</term><term>Amphibian skin peptides</term><term>Amphibian species</term><term>Anastasi</term><term>April</term><term>Argentina</term><term>August</term><term>Average weight</term><term>Bioassay</term><term>Biogenic amines</term><term>Blood pressure</term><term>Bombesins</term><term>Brad</term><term>Bradykinin</term><term>Bradykinins</term><term>Bufo</term><term>Caer</term><term>Caerulein</term><term>Chile</term><term>Costa</term><term>Dermorphin</term><term>Dermorphins</term><term>Ecuador</term><term>Erspamer</term><term>Falconieri</term><term>Falconieri erspamer</term><term>Fresh skin</term><term>Frog</term><term>Hyla</term><term>Hylid frogs</term><term>Janeiro</term><term>July</term><term>June</term><term>Leptodactylus</term><term>Melchiorri</term><term>Methanol</term><term>Methanol extracts</term><term>Montecucchi</term><term>Napo</term><term>Parallel bioassay</term><term>Peptide</term><term>Peptide families</term><term>Peptide molecules</term><term>Peptide protein</term><term>Peptides skin</term><term>Personal communication</term><term>Peru</term><term>Pharmac</term><term>Pharmacological actions</term><term>Phyllokinin</term><term>Phyllomedusa</term><term>Phyllomedusa bicolor</term><term>Phyllomedusa sauvagei</term><term>Phyllomedusa sauvagei skin</term><term>Phyllomedusid</term><term>Phyllomedusid frogs</term><term>Phyllomedusin</term><term>Phys</term><term>Physalaemin</term><term>Physalaemus</term><term>Pleurodema</term><term>Rana</term><term>Rica</term><term>Rohdei</term><term>Rohdeilitorin</term><term>Sauvagei</term><term>Sauvagine</term><term>Sept</term><term>Skin</term><term>Skin extracts</term><term>Smilisca</term><term>Spinulosus</term><term>Subfamily</term><term>Tachykinins</term><term>Telmatobius</term><term>Trypt</term><term>Tucuman</term><term>Whole bodies</term><term>Whole body</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Argentine</term><term>Chili</term><term>Équateur</term><term>Pérou</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Méthanol</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: 1. 1. Extracts prepared from dried or fresh skins of more than 200 American amphibian species were subjected to biological screening in order to determine occurrence and contents of peptides active on smooth muscle preparations, systemic blood pressure and, subordinately, external secretions, anterior pituitary and the central nervous system. 2. 2. The peptide families identified in skin extracts were as follows: caruleins (caerulein, phyllocaerulein), tachykinins (physalaemin, phyllomedusin), bombesins (phyllolitorin, [Leu8]phyllolitorin, rohdeilitorin), bradykinins (phyllokinin and others), sauvagine, dermorphins (dermorphin, [Hyp6]dermorphin), tryptophyllins (numerous peptides) and, finally, miscellaneous peptides. None of the above peptide families showed a widespread distribution, but all were restricted to particular amphibian genera or stocks. 3. 3. The hylid frogs of the Phyllomedusinae family occupy a unique position, as their skin displayed the greatest variety and abundance of active peptides ever found in any amphibian stock in the world. 4. 4. The array of peptide molecules occurring in the skin of the American amphibians is destined to increase because numerous other peptide molecules await isolation, elucidation of structure and definition of possible biological activities.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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