Nitrite studies in oesophageal cancer.
Identifieur interne : 002C96 ( Istex/Curation ); précédent : 002C95; suivant : 002C97Nitrite studies in oesophageal cancer.
Auteurs : A B Lowenfels ; A J Tuyns ; E A Walker ; A. RousselSource :
- Gut [ 0017-5749 ] ; 1978-03.
Descripteurs français
- Wicri :
- topic : Toxicologie.
English descriptors
- KwdEn :
- Amine, Average number, Basal, Beet, Beet juice, Cancer groups, Cancer patients, Control subjects, Cosmetics toxicology, Dental status, Gastric, Gastric cancer, Gastric juice studies, Human saliva, International agency, Nitrate, Nitrite, Nitrite content, Nitrite levels, Nitrite studies, Nitrosamines, Oesophageal, Oesophageal cancer, Oesophageal cancer patients, Risk factor, Ruddell, Salivary, Salivary nitrite, Salivary nitrite levels, Significant difference, Tannenbaum, Toxicology, Tuyns, Vivo formation.
- Teeft :
- Amine, Average number, Basal, Beet, Beet juice, Cancer groups, Cancer patients, Control subjects, Cosmetics toxicology, Dental status, Gastric, Gastric cancer, Gastric juice studies, Human saliva, International agency, Nitrate, Nitrite, Nitrite content, Nitrite levels, Nitrite studies, Nitrosamines, Oesophageal, Oesophageal cancer, Oesophageal cancer patients, Risk factor, Ruddell, Salivary, Salivary nitrite, Salivary nitrite levels, Significant difference, Tannenbaum, Toxicology, Tuyns, Vivo formation.
Abstract
As nitrate consumption may have considerable importance for the in vivo formation of nitrites and potentially carcinogenic N-Nitroso compounds, we have studied salivary nitrite levels in patients with oesophageal cancer and adult volunteers before and after administering 100 ml beet juice containing 160 mg nitrate. Initial salivary nitrite levels were slightly lower in the cancer patients, perhaps because of previous malnutrition. In both groups there was a marked increase in salivary nitrite levels 90 minutes after ingesting beet juice and the attained levels in the two groups were similar. The results imply that formation of salivary nitrite is highly dependent on exogenous dietary nitrate and that there is no difference in the capacity to form nitrites between oesophageal cancer patients and healthy adult subjects.
Url:
DOI: 10.1136/gut.19.3.199
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ISTEX:5B4EB5DB4CC0AA1BEB7FA4D9F25E5BA83FEB6A9DLe document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amine</term>
<term>Average number</term>
<term>Basal</term>
<term>Beet</term>
<term>Beet juice</term>
<term>Cancer groups</term>
<term>Cancer patients</term>
<term>Control subjects</term>
<term>Cosmetics toxicology</term>
<term>Dental status</term>
<term>Gastric</term>
<term>Gastric cancer</term>
<term>Gastric juice studies</term>
<term>Human saliva</term>
<term>International agency</term>
<term>Nitrate</term>
<term>Nitrite</term>
<term>Nitrite content</term>
<term>Nitrite levels</term>
<term>Nitrite studies</term>
<term>Nitrosamines</term>
<term>Oesophageal</term>
<term>Oesophageal cancer</term>
<term>Oesophageal cancer patients</term>
<term>Risk factor</term>
<term>Ruddell</term>
<term>Salivary</term>
<term>Salivary nitrite</term>
<term>Salivary nitrite levels</term>
<term>Significant difference</term>
<term>Tannenbaum</term>
<term>Toxicology</term>
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<term>Average number</term>
<term>Basal</term>
<term>Beet</term>
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<term>Cancer patients</term>
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<term>Dental status</term>
<term>Gastric</term>
<term>Gastric cancer</term>
<term>Gastric juice studies</term>
<term>Human saliva</term>
<term>International agency</term>
<term>Nitrate</term>
<term>Nitrite</term>
<term>Nitrite content</term>
<term>Nitrite levels</term>
<term>Nitrite studies</term>
<term>Nitrosamines</term>
<term>Oesophageal</term>
<term>Oesophageal cancer</term>
<term>Oesophageal cancer patients</term>
<term>Risk factor</term>
<term>Ruddell</term>
<term>Salivary</term>
<term>Salivary nitrite</term>
<term>Salivary nitrite levels</term>
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<term>Toxicology</term>
<term>Tuyns</term>
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<front><div type="abstract" xml:lang="en">As nitrate consumption may have considerable importance for the in vivo formation of nitrites and potentially carcinogenic N-Nitroso compounds, we have studied salivary nitrite levels in patients with oesophageal cancer and adult volunteers before and after administering 100 ml beet juice containing 160 mg nitrate. Initial salivary nitrite levels were slightly lower in the cancer patients, perhaps because of previous malnutrition. In both groups there was a marked increase in salivary nitrite levels 90 minutes after ingesting beet juice and the attained levels in the two groups were similar. The results imply that formation of salivary nitrite is highly dependent on exogenous dietary nitrate and that there is no difference in the capacity to form nitrites between oesophageal cancer patients and healthy adult subjects.</div>
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