Tissue macrophage identity and self‐renewal
Identifieur interne : 002846 ( Istex/Curation ); précédent : 002845; suivant : 002847Tissue macrophage identity and self‐renewal
Auteurs : Rebecca Gentek [France] ; Kaaweh Molawi [France, Allemagne] ; Michael H. Sieweke [France, Allemagne]Source :
- Immunological Reviews [ 0105-2896 ] ; 2014-11.
Abstract
Macrophages are cellular components of the innate immune system that reside in virtually all tissues and contribute to immunity, repair, and homeostasis. The traditional view that all tissue‐resident macrophages derive from the bone marrow through circulating monocyte intermediates has dramatically shifted recently with the observation that macrophages from embryonic progenitors can persist into adulthood and self‐maintain by local proliferation. In several tissues, however, monocytes also contribute to the resident macrophage population, on which the local environment can impose tissue‐specific macrophage functions. These observations have raised important questions: What determines resident macrophage identity and function, ontogeny or environment? How is macrophage proliferation regulated? In this review, we summarize the current knowledge about the identity, proliferation, and turnover of tissue‐resident macrophages and how they differ from freshly recruited short‐lived monocyte‐derived cells. We examine whether macrophage proliferation can be qualified as self‐renewal of mature differentiated cells and whether the concepts and molecular pathways are comparable to self‐renewal mechanisms in stem cells. Finally, we discuss how improved understanding of macrophage identity and self‐renewal could be exploited for therapeutic intervention of macrophage‐mediated pathologies by selectively targeting freshly recruited or resident macrophages.
Url:
DOI: 10.1111/imr.12224
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002846
Links to Exploration step
ISTEX:5220BE20FDF5F717974C613E4F021C8BBEB060A6Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tissue macrophage identity and self‐renewal</title>
<author><name sortKey="Gentek, Rebecca" sort="Gentek, Rebecca" uniqKey="Gentek R" first="Rebecca" last="Gentek">Rebecca Gentek</name>
<affiliation wicri:level="1"><mods:affiliation>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Molawi, Kaaweh" sort="Molawi, Kaaweh" uniqKey="Molawi K" first="Kaaweh" last="Molawi">Kaaweh Molawi</name>
<affiliation wicri:level="1"><mods:affiliation>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Max‐Delbrück‐Centrum für Molekulare Medizin (MDC), Robert‐Rössle‐Strasse 10, Berlin, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max‐Delbrück‐Centrum für Molekulare Medizin (MDC), Robert‐Rössle‐Strasse 10, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sieweke, Michael H" sort="Sieweke, Michael H" uniqKey="Sieweke M" first="Michael H." last="Sieweke">Michael H. Sieweke</name>
<affiliation wicri:level="1"><mods:affiliation>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Max‐Delbrück‐Centrum für Molekulare Medizin (MDC), Robert‐Rössle‐Strasse 10, Berlin, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max‐Delbrück‐Centrum für Molekulare Medizin (MDC), Robert‐Rössle‐Strasse 10, Berlin</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Correspondence to:Centre d'Immunologie de Marseille‐LuminyCampus de Luminy, Case 90613288 Marseille Cedex 9, FranceTel.: +33 4 9126 9184Fax: + 33 4 9126 9430e‐mail:</mods:affiliation>
<wicri:noCountry code="subField">9430e‐mail:</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: sieweke@ciml.univ-mrs.fr</mods:affiliation>
<country wicri:rule="url">France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:5220BE20FDF5F717974C613E4F021C8BBEB060A6</idno>
<date when="2014" year="2014">2014</date>
<idno type="doi">10.1111/imr.12224</idno>
<idno type="url">https://api.istex.fr/document/5220BE20FDF5F717974C613E4F021C8BBEB060A6/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002846</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002846</idno>
<idno type="wicri:Area/Istex/Curation">002846</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Tissue macrophage identity and self‐renewal</title>
<author><name sortKey="Gentek, Rebecca" sort="Gentek, Rebecca" uniqKey="Gentek R" first="Rebecca" last="Gentek">Rebecca Gentek</name>
<affiliation wicri:level="1"><mods:affiliation>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Molawi, Kaaweh" sort="Molawi, Kaaweh" uniqKey="Molawi K" first="Kaaweh" last="Molawi">Kaaweh Molawi</name>
<affiliation wicri:level="1"><mods:affiliation>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Max‐Delbrück‐Centrum für Molekulare Medizin (MDC), Robert‐Rössle‐Strasse 10, Berlin, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max‐Delbrück‐Centrum für Molekulare Medizin (MDC), Robert‐Rössle‐Strasse 10, Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sieweke, Michael H" sort="Sieweke, Michael H" uniqKey="Sieweke M" first="Michael H." last="Sieweke">Michael H. Sieweke</name>
<affiliation wicri:level="1"><mods:affiliation>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Immunologie de Marseille‐Luminy, Aix‐Marseille Université, UM2, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institute National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Max‐Delbrück‐Centrum für Molekulare Medizin (MDC), Robert‐Rössle‐Strasse 10, Berlin, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max‐Delbrück‐Centrum für Molekulare Medizin (MDC), Robert‐Rössle‐Strasse 10, Berlin</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Correspondence to:Centre d'Immunologie de Marseille‐LuminyCampus de Luminy, Case 90613288 Marseille Cedex 9, FranceTel.: +33 4 9126 9184Fax: + 33 4 9126 9430e‐mail:</mods:affiliation>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: sieweke@ciml.univ-mrs.fr</mods:affiliation>
<country wicri:rule="url">France</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Immunological Reviews</title>
<title level="j" type="sub">Monocytes and Macrophages</title>
<title level="j" type="alt">IMMUNOLOGICAL REVIEWS</title>
<idno type="ISSN">0105-2896</idno>
<idno type="eISSN">1600-065X</idno>
<imprint><biblScope unit="vol">262</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="56">56</biblScope>
<biblScope unit="page" to="73">73</biblScope>
<biblScope unit="page-count">18</biblScope>
<date type="published" when="2014-11">2014-11</date>
</imprint>
<idno type="ISSN">0105-2896</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0105-2896</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Macrophages are cellular components of the innate immune system that reside in virtually all tissues and contribute to immunity, repair, and homeostasis. The traditional view that all tissue‐resident macrophages derive from the bone marrow through circulating monocyte intermediates has dramatically shifted recently with the observation that macrophages from embryonic progenitors can persist into adulthood and self‐maintain by local proliferation. In several tissues, however, monocytes also contribute to the resident macrophage population, on which the local environment can impose tissue‐specific macrophage functions. These observations have raised important questions: What determines resident macrophage identity and function, ontogeny or environment? How is macrophage proliferation regulated? In this review, we summarize the current knowledge about the identity, proliferation, and turnover of tissue‐resident macrophages and how they differ from freshly recruited short‐lived monocyte‐derived cells. We examine whether macrophage proliferation can be qualified as self‐renewal of mature differentiated cells and whether the concepts and molecular pathways are comparable to self‐renewal mechanisms in stem cells. Finally, we discuss how improved understanding of macrophage identity and self‐renewal could be exploited for therapeutic intervention of macrophage‐mediated pathologies by selectively targeting freshly recruited or resident macrophages.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002846 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 002846 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:5220BE20FDF5F717974C613E4F021C8BBEB060A6 |texte= Tissue macrophage identity and self‐renewal }}
This area was generated with Dilib version V0.6.32. |