Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor
Identifieur interne : 001C33 ( Istex/Curation ); précédent : 001C32; suivant : 001C34Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor
Auteurs : Maria Hovorakova [République tchèque] ; Jan Prochazka [République tchèque] ; Herve Lesot [France] ; Lucie Smrckova [République tchèque] ; Svatava Churava [République tchèque] ; Tomas Boran [République tchèque] ; Zbynek Kozmik [République tchèque] ; Ophir Klein [États-Unis] ; Renata Peterkova [République tchèque] ; Miroslav Peterka [République tchèque]Source :
- Journal of Experimental Zoology Part B: Molecular and Developmental Evolution [ 1552-5007 ] ; 2011-07-15.
English descriptors
- KwdEn :
- Anat, Anlage, Anterior, Anterior base, Anterior part, Apoptosis, Arrowhead, Biol, Biol peterkova, Black arrowhead, Body weight, Charles university, Cheek region, Craniofac genet, Czech, Czech republic, Dental epithelium, Dentition, Developmentally, Dimensional reconstruction, Earliest stages, Early development, Early stages, Embryo, Enamel, Enamel knot, Epithelial, Epithelial anlage, Epithelial bridge, Epithelial bridges, Epithelial swellings, Epithelium, Evol, Expression domain, Expression domains, Expression regions, Frontal histological sections, Frontal sections, Functional incisor, Grant sponsor, Histological, Hovorakova, Incisor, Incisor development, Incisor enamel organ, Incisor germ, Incisor region, Lamina, Large incisor placode, Leica, Leica microsystems gmbh, Lesot, Lower incisor, Lower incisor area, Lower incisor region, Mandible, Mesenchyme, Molar, Morphogenesis, Mouse, Mouse embryos, Mouse incisor, Mouse incisors, Mouse mandible, Munne, Mutant mice, Oral vestibule, Peterka, Peterkova, Placode, Prelacteal, Previous stage, Previous stages, Primordium, Proc natl acad, Prochazka, Quadrant, Reporter mice, Rudimentary, Rudimentary incisor, Rudimentary tooth, Sonic hedgehog, Thesleff, Tooth development, Tooth formation, Tooth morphogenesis, Vestibular, Vestibular epithelia, Vestibular epithelium, Vestibular lamina, Vestibule, Vonesch, White arrowhead, Zool.
- Teeft :
- Anat, Anlage, Anterior, Anterior base, Anterior part, Apoptosis, Arrowhead, Biol, Biol peterkova, Black arrowhead, Body weight, Charles university, Cheek region, Craniofac genet, Czech, Czech republic, Dental epithelium, Dentition, Developmentally, Dimensional reconstruction, Earliest stages, Early development, Early stages, Embryo, Enamel, Enamel knot, Epithelial, Epithelial anlage, Epithelial bridge, Epithelial bridges, Epithelial swellings, Epithelium, Evol, Expression domain, Expression domains, Expression regions, Frontal histological sections, Frontal sections, Functional incisor, Grant sponsor, Histological, Hovorakova, Incisor, Incisor development, Incisor enamel organ, Incisor germ, Incisor region, Lamina, Large incisor placode, Leica, Leica microsystems gmbh, Lesot, Lower incisor, Lower incisor area, Lower incisor region, Mandible, Mesenchyme, Molar, Morphogenesis, Mouse, Mouse embryos, Mouse incisor, Mouse incisors, Mouse mandible, Munne, Mutant mice, Oral vestibule, Peterka, Peterkova, Placode, Prelacteal, Previous stage, Previous stages, Primordium, Proc natl acad, Prochazka, Quadrant, Reporter mice, Rudimentary, Rudimentary incisor, Rudimentary tooth, Sonic hedgehog, Thesleff, Tooth development, Tooth formation, Tooth morphogenesis, Vestibular, Vestibular epithelia, Vestibular epithelium, Vestibular lamina, Vestibule, Vonesch, White arrowhead, Zool.
Abstract
For teeth as for any organ, knowledge of normal development is essential for the proper interpretation of developmental anomalies in mutant mice. It is generally accepted that tooth formation is initiated with a single signaling center that, in the incisor region, is exclusively related to the development of the functional adult incisor. Here, using a unique combination of computer‐aided three‐dimensional reconstructions and whole mount in situ hybridization of mandibles from finely staged wild‐type mouse embryos, we demonstrate that several Sonic hedgehog (Shh) expression domains sequentially appear in the lower incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5–13.5, we identified two spatially distinct regions of Shh expression that appear in an anterior–posterior sequence during this period. The initial anterior, more superficially located Shh expression region represented the rudimentary (so‐called deciduous) incisor, whereas only the later posterior deeper situated region corresponded to the prospective functional incisor. In the more advanced embryos, only this posterior Shh expression in the incisor bud was detectable as a precursor of the enamel knot. This study offers a new interpretation of published molecular data on the mouse incisor from initiation through ED13.5. We suggest that, as with Shh expression, other molecular data that have been ascribed to the progressive development of the mouse functional incisor at early stages, in fact, correspond to a rudimentary incisor whose development is aborted. J. Exp. Zool. (Mol. Dev. Evol.) 316:347–358, 2011. © 2011 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jez.b.21408
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Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: marhor@biomed.cas.cz</mods:affiliation><country wicri:rule="url">République tchèque</country></affiliation><affiliation wicri:level="1"><mods:affiliation>Correspondence address: Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 14220 Prague 4, Czech Republic===</mods:affiliation><country xml:lang="fr" wicri:curation="lc">République tchèque</country><wicri:regionArea>Correspondence address: Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 14220 Prague 4</wicri:regionArea></affiliation></author><author><name sortKey="Prochazka, Jan" sort="Prochazka, Jan" uniqKey="Prochazka J" first="Jan" last="Prochazka">Jan Prochazka</name><affiliation wicri:level="1"><mods:affiliation>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Cell Biology, Faculty of Science, Charles University, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Lesot, Herve" sort="Lesot, Herve" uniqKey="Lesot H" first="Herve" last="Lesot">Herve Lesot</name><affiliation wicri:level="1"><mods:affiliation>INSERM UMR 977, Faculte de Chirurgie Dentaire, Universite de Strasbourg, Strasbourg, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 977, Faculte de Chirurgie Dentaire, Universite de Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Smrckova, Lucie" sort="Smrckova, Lucie" uniqKey="Smrckova L" first="Lucie" last="Smrckova">Lucie Smrckova</name><affiliation wicri:level="1"><mods:affiliation>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Cell Biology, Faculty of Science, Charles University, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Churava, Svatava" sort="Churava, Svatava" uniqKey="Churava S" first="Svatava" last="Churava">Svatava Churava</name><affiliation wicri:level="1"><mods:affiliation>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Boran, Tomas" sort="Boran, Tomas" uniqKey="Boran T" first="Tomas" last="Boran">Tomas Boran</name><affiliation wicri:level="1"><mods:affiliation>Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Prague</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Histology and Embryology, Third Medical Faculty, Charles University, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Histology and Embryology, Third Medical Faculty, Charles University, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Kozmik, Zbynek" sort="Kozmik, Zbynek" uniqKey="Kozmik Z" first="Zbynek" last="Kozmik">Zbynek Kozmik</name><affiliation wicri:level="1"><mods:affiliation>Department of Transcriptional Regulation, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Transcriptional Regulation, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Ophir" sort="Klein, Ophir" uniqKey="Klein O" first="Ophir" last="Klein">Ophir Klein</name><affiliation wicri:level="2"><mods:affiliation>Departments of Orofacial Sciences and Pediatrics and Program in Craniofacial and Mesenchymal Biology, University of California at San Francisco, San Francisco, California</mods:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Orofacial Sciences and Pediatrics and Program in Craniofacial and Mesenchymal Biology, University of California at San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Peterkova, Renata" sort="Peterkova, Renata" uniqKey="Peterkova R" first="Renata" last="Peterkova">Renata Peterkova</name><affiliation wicri:level="1"><mods:affiliation>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea></affiliation></author><author><name sortKey="Peterka, Miroslav" sort="Peterka, Miroslav" uniqKey="Peterka M" first="Miroslav" last="Peterka">Miroslav Peterka</name><affiliation wicri:level="1"><mods:affiliation>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Prague, Czech Republic</mods:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Prague</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</title><title level="j" type="alt">JOURNAL OF EXPERIMENTAL ZOOLOGY PART B: MOLECULAR AND DEVELOPMENTAL EVOLUTION</title><idno type="ISSN">1552-5007</idno><idno type="eISSN">1552-5015</idno><imprint><biblScope unit="vol">316B</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="347">347</biblScope><biblScope unit="page" to="358">358</biblScope><biblScope unit="page-count">12</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-07-15">2011-07-15</date></imprint><idno type="ISSN">1552-5007</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-5007</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anat</term><term>Anlage</term><term>Anterior</term><term>Anterior base</term><term>Anterior part</term><term>Apoptosis</term><term>Arrowhead</term><term>Biol</term><term>Biol peterkova</term><term>Black arrowhead</term><term>Body weight</term><term>Charles university</term><term>Cheek region</term><term>Craniofac genet</term><term>Czech</term><term>Czech republic</term><term>Dental epithelium</term><term>Dentition</term><term>Developmentally</term><term>Dimensional reconstruction</term><term>Earliest stages</term><term>Early development</term><term>Early stages</term><term>Embryo</term><term>Enamel</term><term>Enamel knot</term><term>Epithelial</term><term>Epithelial anlage</term><term>Epithelial bridge</term><term>Epithelial bridges</term><term>Epithelial swellings</term><term>Epithelium</term><term>Evol</term><term>Expression domain</term><term>Expression domains</term><term>Expression regions</term><term>Frontal histological sections</term><term>Frontal sections</term><term>Functional incisor</term><term>Grant sponsor</term><term>Histological</term><term>Hovorakova</term><term>Incisor</term><term>Incisor development</term><term>Incisor enamel organ</term><term>Incisor germ</term><term>Incisor region</term><term>Lamina</term><term>Large incisor placode</term><term>Leica</term><term>Leica microsystems gmbh</term><term>Lesot</term><term>Lower incisor</term><term>Lower incisor area</term><term>Lower incisor region</term><term>Mandible</term><term>Mesenchyme</term><term>Molar</term><term>Morphogenesis</term><term>Mouse</term><term>Mouse embryos</term><term>Mouse incisor</term><term>Mouse incisors</term><term>Mouse mandible</term><term>Munne</term><term>Mutant mice</term><term>Oral vestibule</term><term>Peterka</term><term>Peterkova</term><term>Placode</term><term>Prelacteal</term><term>Previous stage</term><term>Previous stages</term><term>Primordium</term><term>Proc natl acad</term><term>Prochazka</term><term>Quadrant</term><term>Reporter mice</term><term>Rudimentary</term><term>Rudimentary incisor</term><term>Rudimentary tooth</term><term>Sonic hedgehog</term><term>Thesleff</term><term>Tooth development</term><term>Tooth formation</term><term>Tooth morphogenesis</term><term>Vestibular</term><term>Vestibular epithelia</term><term>Vestibular epithelium</term><term>Vestibular lamina</term><term>Vestibule</term><term>Vonesch</term><term>White arrowhead</term><term>Zool</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Anat</term><term>Anlage</term><term>Anterior</term><term>Anterior base</term><term>Anterior part</term><term>Apoptosis</term><term>Arrowhead</term><term>Biol</term><term>Biol peterkova</term><term>Black arrowhead</term><term>Body weight</term><term>Charles university</term><term>Cheek region</term><term>Craniofac genet</term><term>Czech</term><term>Czech republic</term><term>Dental epithelium</term><term>Dentition</term><term>Developmentally</term><term>Dimensional reconstruction</term><term>Earliest stages</term><term>Early development</term><term>Early stages</term><term>Embryo</term><term>Enamel</term><term>Enamel knot</term><term>Epithelial</term><term>Epithelial anlage</term><term>Epithelial bridge</term><term>Epithelial bridges</term><term>Epithelial swellings</term><term>Epithelium</term><term>Evol</term><term>Expression domain</term><term>Expression domains</term><term>Expression regions</term><term>Frontal histological sections</term><term>Frontal sections</term><term>Functional incisor</term><term>Grant sponsor</term><term>Histological</term><term>Hovorakova</term><term>Incisor</term><term>Incisor development</term><term>Incisor enamel organ</term><term>Incisor germ</term><term>Incisor region</term><term>Lamina</term><term>Large incisor placode</term><term>Leica</term><term>Leica microsystems gmbh</term><term>Lesot</term><term>Lower incisor</term><term>Lower incisor area</term><term>Lower incisor region</term><term>Mandible</term><term>Mesenchyme</term><term>Molar</term><term>Morphogenesis</term><term>Mouse</term><term>Mouse embryos</term><term>Mouse incisor</term><term>Mouse incisors</term><term>Mouse mandible</term><term>Munne</term><term>Mutant mice</term><term>Oral vestibule</term><term>Peterka</term><term>Peterkova</term><term>Placode</term><term>Prelacteal</term><term>Previous stage</term><term>Previous stages</term><term>Primordium</term><term>Proc natl acad</term><term>Prochazka</term><term>Quadrant</term><term>Reporter mice</term><term>Rudimentary</term><term>Rudimentary incisor</term><term>Rudimentary tooth</term><term>Sonic hedgehog</term><term>Thesleff</term><term>Tooth development</term><term>Tooth formation</term><term>Tooth morphogenesis</term><term>Vestibular</term><term>Vestibular epithelia</term><term>Vestibular epithelium</term><term>Vestibular lamina</term><term>Vestibule</term><term>Vonesch</term><term>White arrowhead</term><term>Zool</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For teeth as for any organ, knowledge of normal development is essential for the proper interpretation of developmental anomalies in mutant mice. It is generally accepted that tooth formation is initiated with a single signaling center that, in the incisor region, is exclusively related to the development of the functional adult incisor. Here, using a unique combination of computer‐aided three‐dimensional reconstructions and whole mount in situ hybridization of mandibles from finely staged wild‐type mouse embryos, we demonstrate that several Sonic hedgehog (Shh) expression domains sequentially appear in the lower incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5–13.5, we identified two spatially distinct regions of Shh expression that appear in an anterior–posterior sequence during this period. The initial anterior, more superficially located Shh expression region represented the rudimentary (so‐called deciduous) incisor, whereas only the later posterior deeper situated region corresponded to the prospective functional incisor. In the more advanced embryos, only this posterior Shh expression in the incisor bud was detectable as a precursor of the enamel knot. This study offers a new interpretation of published molecular data on the mouse incisor from initiation through ED13.5. We suggest that, as with Shh expression, other molecular data that have been ascribed to the progressive development of the mouse functional incisor at early stages, in fact, correspond to a rudimentary incisor whose development is aborted. J. Exp. Zool. (Mol. Dev. Evol.) 316:347–358, 2011. © 2011 Wiley‐Liss, Inc.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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