Relationships among bone turnover, renal function and periodontal disease in elderly Japanese
Identifieur interne : 007B74 ( Istex/Corpus ); précédent : 007B73; suivant : 007B75Relationships among bone turnover, renal function and periodontal disease in elderly Japanese
Auteurs : A. Yoshihara ; Y. Hayashi ; H. MiyazakiSource :
- Journal of Periodontal Research [ 0022-3484 ] ; 2011-08.
English descriptors
- KwdEn :
- Biochemical markers, Bone formation, Bone formation markers, Bone metabolism, Bone miner, Bone mineral density, Bone resorption markers, Bone turnover, Bone turnover markers, Chronic kidney disease, Clinical attachment level, Creatinine, Creatinine clearance, Deoxypyridinoline, Elderly japanese, Elderly japanese subjects, Fracture, Gender, Longitudinal study, Marker, Metabolism, Negative relationship, Niigata, Osteocalcin, Osteoporosis, Periodontal, Periodontal disease, Periodontal diseases, Periodontal examination, Periodontol, Phosphatase, Present study, Regression analysis, Renal, Renal function, Renal function markers, Resorption, Serum osteocalcin, Smoking habits, Tertile, Turnover, Urinary, Urinary deoxypyridinoline, Yoshihara.
- Teeft :
- Biochemical markers, Bone formation, Bone formation markers, Bone metabolism, Bone miner, Bone mineral density, Bone resorption markers, Bone turnover, Bone turnover markers, Chronic kidney disease, Clinical attachment level, Creatinine, Creatinine clearance, Deoxypyridinoline, Elderly japanese, Elderly japanese subjects, Fracture, Gender, Longitudinal study, Marker, Metabolism, Negative relationship, Niigata, Osteocalcin, Osteoporosis, Periodontal, Periodontal disease, Periodontal diseases, Periodontal examination, Periodontol, Phosphatase, Present study, Regression analysis, Renal, Renal function, Renal function markers, Resorption, Serum osteocalcin, Smoking habits, Tertile, Turnover, Urinary, Urinary deoxypyridinoline, Yoshihara.
Abstract
Yoshihara A, Hayashi Y, Miyazaki H. Relationships among bone turnover, renal function and periodontal disease in elderly Japanese. J Periodont Res 2011; 46: 491–496. © 2011 John Wiley & Sons A/S
Url:
DOI: 10.1111/j.1600-0765.2011.01365.x
Links to Exploration step
ISTEX:F9F40E20CBB48C612775A91285059EEBDABB0D6FLe document en format XML
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Relationships among bone turnover, renal function and periodontal disease in elderly Japanese. 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<hi rend="italic">Yoshihara A, Hayashi Y, Miyazaki H. Relationships among bone turnover, renal function and periodontal disease in elderly Japanese. J Periodont Res 2011; 46: 491–496. © 2011 John Wiley & Sons A/S</hi>
</p><p><hi rend="bold">Background and Objective: </hi> We hypothesized that renal function is associated with the relationship between periodontal disease and bone metabolism. The present study evaluated the relationship of bone formation and resorption markers to periodontal disease, taking renal function into consideration, in elderly Japanese subjects.</p><p><hi rend="bold">Material and Methods: </hi> We selected 148 subjects aged 77 years. The periodontal examination included the assessment of clinical attachment level (CAL). We measured two bone formation markers (serum bone‐specific alkaline phosphatase and serum osteocalcin) and two bone resorption markers (urinary deoxypyridinoline and urinary cross‐linked N‐telopeptide of type I collagen). Creatinine clearance per 24 h, as a measure of renal function, was also determined. The correlations between mean CAL or percentage of sites with ≥6 mm CAL (6+mm CAL) and bone turnover markers, and between bone turnover markers and creatinine clearance levels, were performed by multiple linear regression analysis.</p><p><hi rend="bold">Results: </hi> There were significant negative relationships between mean CAL or 6+mm CAL and serum osteocalcin levels adjusted for gender, smoking habits and oral care habits (β = −0.25, <hi rend="italic">p </hi>=<hi rend="italic"> </hi>0.014 and β = −0.35, <hi rend="italic">p </hi>=<hi rend="italic"> </hi>0.001, respectively). In addition, there was a negative relationship between serum osteocalcin and creatinine clearance levels adjusted for gender and smoking habits (β = −0.45, <hi rend="italic">p </hi><<hi rend="italic"> </hi>0.0001).</p><p><hi rend="bold">Conclusion: </hi> Results from the present study suggest that serum osteocalcin was significantly associated with renal function and periodontal disease. The low systemic bone metabolism, which might be caused by low renal function, is associated with periodontal disease.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">epidemiology</term><term xml:id="k2">periodontal disease</term><term xml:id="k3">bone turnover</term><term xml:id="k4">renal function</term></keywords><keywords rend="tocHeading1"><term>ORIGINAL ARTICLES</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/F9F40E20CBB48C612775A91285059EEBDABB0D6F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0765</doi><issn type="print">0022-3484</issn><issn type="electronic">1600-0765</issn><idGroup><id type="product" value="JRE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF PERIODONTAL RESEARCH">Journal of Periodontal Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="08104"><doi origin="wiley">10.1111/jre.2011.46.issue-4</doi><numberingGroup><numbering type="journalVolume" number="46">46</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2011-08">August 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="11" status="forIssue"><doi origin="wiley">10.1111/j.1600-0765.2011.01365.x</doi><idGroup><id type="unit" value="JRE1365"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">ORIGINAL ARTICLES</title></titleGroup><copyright>© 2011 John Wiley & Sons A/S</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.5.2 mode:FullText" date="2011-06-23"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-04-18"></event><event type="firstOnline" date="2011-04-18"></event><event type="publishedOnlineFinalForm" date="2011-06-23"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="491">491</numbering><numbering type="pageLast" number="496">496</numbering></numberingGroup><correspondenceTo>Akihiro Yoshihara, DDS, PhD, Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, 2‐5274 Gakkocho‐Dori, Chuo‐ku, Niigata 951‐8514, Japan
Tel: +81 25 227 2858
Fax: +81 25 227 0807
e‐mail: <email normalForm="akihiro@dent.niigata-u.ac.jp">akihiro@dent.niigata‐u.ac.jp</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JRE.JRE1365.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication February 19, 2011</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count></countGroup><titleGroup><title type="main">Relationships among bone turnover, renal function and periodontal disease in elderly Japanese</title><title type="shortAuthors"><i>Yoshihara</i> et al.</title><title type="short"><i>Bone turnover, renal function and periodontal diseases</i></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>A.</givenNames><familyName>Yoshihara</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>Y.</givenNames><familyName>Hayashi</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#aff-1-1"><personName><givenNames>H.</givenNames><familyName>Miyazaki</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="JP"><unparsedAffiliation>Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">epidemiology</keyword><keyword xml:id="k2">periodontal disease</keyword><keyword xml:id="k3">bone turnover</keyword><keyword xml:id="k4">renal function</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p> <i>Yoshihara A, Hayashi Y, Miyazaki H. Relationships among bone turnover, renal function and periodontal disease in elderly Japanese. J Periodont Res 2011; 46: 491–496. © 2011 John Wiley & Sons A/S</i> </p><p><b>Background and Objective: </b> We hypothesized that renal function is associated with the relationship between periodontal disease and bone metabolism. The present study evaluated the relationship of bone formation and resorption markers to periodontal disease, taking renal function into consideration, in elderly Japanese subjects.</p><p><b>Material and Methods: </b> We selected 148 subjects aged 77 years. The periodontal examination included the assessment of clinical attachment level (CAL). We measured two bone formation markers (serum bone‐specific alkaline phosphatase and serum osteocalcin) and two bone resorption markers (urinary deoxypyridinoline and urinary cross‐linked N‐telopeptide of type I collagen). Creatinine clearance per 24 h, as a measure of renal function, was also determined. The correlations between mean CAL or percentage of sites with ≥6 mm CAL (6+mm CAL) and bone turnover markers, and between bone turnover markers and creatinine clearance levels, were performed by multiple linear regression analysis.</p><p><b>Results: </b> There were significant negative relationships between mean CAL or 6+mm CAL and serum osteocalcin levels adjusted for gender, smoking habits and oral care habits (β = −0.25, <i>p </i>=<i> </i>0.014 and β = −0.35, <i>p </i>=<i> </i>0.001, respectively). In addition, there was a negative relationship between serum osteocalcin and creatinine clearance levels adjusted for gender and smoking habits (β = −0.45, <i>p </i><<i> </i>0.0001).</p><p><b>Conclusion: </b> Results from the present study suggest that serum osteocalcin was significantly associated with renal function and periodontal disease. The low systemic bone metabolism, which might be caused by low renal function, is associated with periodontal disease.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Relationships among bone turnover, renal function and periodontal disease in elderly Japanese</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Bone turnover, renal function and periodontal diseases</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Relationships among bone turnover, renal function and periodontal disease in elderly Japanese</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Yoshihara</namePart><affiliation>Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Hayashi</namePart><affiliation>Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Miyazaki</namePart><affiliation>Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-08</dateIssued><edition>Accepted for publication February 19, 2011</edition><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">3</extent></physicalDescription><abstract>Yoshihara A, Hayashi Y, Miyazaki H. Relationships among bone turnover, renal function and periodontal disease in elderly Japanese. J Periodont Res 2011; 46: 491–496. © 2011 John Wiley & Sons A/S</abstract><abstract>Background and Objective: We hypothesized that renal function is associated with the relationship between periodontal disease and bone metabolism. The present study evaluated the relationship of bone formation and resorption markers to periodontal disease, taking renal function into consideration, in elderly Japanese subjects.</abstract><abstract>Material and Methods: We selected 148 subjects aged 77 years. The periodontal examination included the assessment of clinical attachment level (CAL). We measured two bone formation markers (serum bone‐specific alkaline phosphatase and serum osteocalcin) and two bone resorption markers (urinary deoxypyridinoline and urinary cross‐linked N‐telopeptide of type I collagen). Creatinine clearance per 24 h, as a measure of renal function, was also determined. The correlations between mean CAL or percentage of sites with ≥6 mm CAL (6+mm CAL) and bone turnover markers, and between bone turnover markers and creatinine clearance levels, were performed by multiple linear regression analysis.</abstract><abstract>Results: There were significant negative relationships between mean CAL or 6+mm CAL and serum osteocalcin levels adjusted for gender, smoking habits and oral care habits (β = −0.25, p = 0.014 and β = −0.35, p = 0.001, respectively). In addition, there was a negative relationship between serum osteocalcin and creatinine clearance levels adjusted for gender and smoking habits (β = −0.45, p < 0.0001).</abstract><abstract>Conclusion: Results from the present study suggest that serum osteocalcin was significantly associated with renal function and periodontal disease. The low systemic bone metabolism, which might be caused by low renal function, is associated with periodontal disease.</abstract><subject lang="en"><genre>keywords</genre><topic>epidemiology</topic><topic>periodontal disease</topic><topic>bone turnover</topic><topic>renal function</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Periodontal Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0022-3484</identifier><identifier type="eISSN">1600-0765</identifier><identifier type="DOI">10.1111/(ISSN)1600-0765</identifier><identifier type="PublisherID">JRE</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>491</start><end>496</end><total>6</total></extent></part></relatedItem><identifier type="istex">F9F40E20CBB48C612775A91285059EEBDABB0D6F</identifier><identifier type="ark">ark:/67375/WNG-76NNX68F-T</identifier><identifier type="DOI">10.1111/j.1600-0765.2011.01365.x</identifier><identifier type="ArticleID">JRE1365</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2011 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/F9F40E20CBB48C612775A91285059EEBDABB0D6F/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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