The osseointegration behavior of titanium–zirconium implants in ovariectomized rabbits
Identifieur interne : 007892 ( Istex/Corpus ); précédent : 007891; suivant : 007893The osseointegration behavior of titanium–zirconium implants in ovariectomized rabbits
Auteurs : Bo Wen ; Feng Zhu ; Zhen Li ; Peng Zhang ; Xingnan Lin ; Michel DardSource :
- Clinical Oral Implants Research [ 0905-7161 ] ; 2014-07.
Abstract
The aim of this study is to compare the osseointegration behavior of titanium (Ti) and titanium–zirconium (TiZr) implants in ovariectomized (OVX) rabbits.
Url:
DOI: 10.1111/clr.12141
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Nanjing, 210008, Jiangsu, ChinaTel.:+86 159 5058 5821Fax: +86 25 8362 0202e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: wenboxmy@gmail.com</mods:affiliation></affiliation></author><author><name sortKey="Zhu, Feng" sort="Zhu, Feng" uniqKey="Zhu F" first="Feng" last="Zhu">Feng Zhu</name><affiliation><mods:affiliation>Division of Implant Dentistry, Department of Oral & Maxillofacial Surgery, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</mods:affiliation></affiliation></author><author><name sortKey="Li, Zhen" sort="Li, Zhen" uniqKey="Li Z" first="Zhen" last="Li">Zhen Li</name><affiliation><mods:affiliation>Division of Implant Dentistry, Department of Oral & Maxillofacial Surgery, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name><affiliation><mods:affiliation>Department of Periodontics, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</mods:affiliation></affiliation></author><author><name sortKey="Lin, Xingnan" sort="Lin, Xingnan" uniqKey="Lin X" first="Xingnan" last="Lin">Xingnan Lin</name><affiliation><mods:affiliation>Department of Orthodontics, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</mods:affiliation></affiliation></author><author><name sortKey="Dard, Michel" sort="Dard, Michel" uniqKey="Dard M" first="Michel" last="Dard">Michel Dard</name><affiliation><mods:affiliation>Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Oral Implants Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="ISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="819">819</biblScope><biblScope unit="page" to="825">825</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2014-07">2014-07</date></imprint><idno type="ISSN">0905-7161</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0905-7161</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The aim of this study is to compare the osseointegration behavior of titanium (Ti) and titanium–zirconium (TiZr) implants in ovariectomized (OVX) rabbits.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Bo Wen</name><affiliations><json:string>Division of Implant Dentistry, Department of Oral & Maxillofacial Surgery, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</json:string><json:string>Division of Implant DentistryDepartment of Oral & Maxillofacial SurgeryAffiliated Stomatological Hospital of Medical School, Nanjing University30 Central Rd. Nanjing, 210008, Jiangsu, ChinaTel.:+86 159 5058 5821Fax: +86 25 8362 0202e‐mail:</json:string><json:string>E-mail: wenboxmy@gmail.com</json:string></affiliations></json:item><json:item><name>Feng Zhu</name><affiliations><json:string>Division of Implant Dentistry, Department of Oral & Maxillofacial Surgery, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</json:string></affiliations></json:item><json:item><name>Zhen Li</name><affiliations><json:string>Division of Implant Dentistry, Department of Oral & Maxillofacial Surgery, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</json:string></affiliations></json:item><json:item><name>Peng Zhang</name><affiliations><json:string>Department of Periodontics, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</json:string></affiliations></json:item><json:item><name>Xingnan Lin</name><affiliations><json:string>Department of Orthodontics, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</json:string></affiliations></json:item><json:item><name>Michel Dard</name><affiliations><json:string>Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>osseointegration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>osteoporosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ovariectomized rabbits</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SLActive implants</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>titanium–zirconium implants</value></json:item></subject><articleId><json:string>CLR12141</json:string></articleId><arkIstex>ark:/67375/WNG-F100GC5W-V</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The aim of this study is to compare the osseointegration behavior of titanium (Ti) and titanium–zirconium (TiZr) implants in ovariectomized (OVX) rabbits.</abstract><qualityIndicators><score>7.087</score><pdfWordCount>4823</pdfWordCount><pdfCharCount>30718</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>22</abstractWordCount><abstractCharCount>154</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>The osseointegration behavior of titanium–zirconium implants in ovariectomized rabbits</title><genre><json:string>article</json:string></genre><host><title>Clinical Oral Implants Research</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0501</json:string></doi><issn><json:string>0905-7161</json:string></issn><eissn><json:string>1600-0501</json:string></eissn><publisherId><json:string>CLR</json:string></publisherId><volume>25</volume><issue>7</issue><pages><first>819</first><last>825</last><total>7</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item></subject></host><ark><json:string>ark:/67375/WNG-F100GC5W-V</json:string></ark><publicationDate>2014</publicationDate><copyrightDate>2014</copyrightDate><doi><json:string>10.1111/clr.12141</json:string></doi><id>F3DCE71551940969C7B99668518F72E35BF305C2</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/F3DCE71551940969C7B99668518F72E35BF305C2/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/F3DCE71551940969C7B99668518F72E35BF305C2/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/F3DCE71551940969C7B99668518F72E35BF305C2/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">The osseointegration behavior of titanium–zirconium implants in ovariectomized rabbits</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Publishing Ltd</publisher><availability><licence>© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd</licence></availability><date type="published" when="2014-07"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">The osseointegration behavior of titanium–zirconium implants in ovariectomized rabbits</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Bo</forename><surname>Wen</surname></persName><affiliation><orgName>Division of Implant Dentistry</orgName><orgName>Department of Oral & Maxillofacial Surgery</orgName><orgName>Affiliated Stomatological Hospital of Medical School</orgName><orgName>Nanjing University</orgName><address><settlement type="city">Nanjing</settlement><country key="CN">China</country></address></affiliation><affiliation>Corresponding author: Bo Wen Division of Implant Dentistry Department of Oral & Maxillofacial Surgery Affiliated Stomatological Hospital of Medical School, Nanjing University 30 Central Rd. Nanjing, 210008, Jiangsu, China Tel.:+86 159 5058 5821 Fax: +86 25 8362 0202 e‐mail: wenboxmy@gmail.com</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Feng</forename><surname>Zhu</surname></persName><affiliation><orgName>Division of Implant Dentistry</orgName><orgName>Department of Oral & Maxillofacial Surgery</orgName><orgName>Affiliated Stomatological Hospital of Medical School</orgName><orgName>Nanjing University</orgName><address><settlement type="city">Nanjing</settlement><country key="CN">China</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Zhen</forename><surname>Li</surname></persName><affiliation><orgName>Division of Implant Dentistry</orgName><orgName>Department of Oral & Maxillofacial Surgery</orgName><orgName>Affiliated Stomatological Hospital of Medical School</orgName><orgName>Nanjing University</orgName><address><settlement type="city">Nanjing</settlement><country key="CN">China</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Peng</forename><surname>Zhang</surname></persName><affiliation><orgName>Department of Periodontics</orgName><orgName>Affiliated Stomatological Hospital of Medical School</orgName><orgName>Nanjing University</orgName><address><settlement type="city">Nanjing</settlement><country key="CN">China</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Xingnan</forename><surname>Lin</surname></persName><affiliation><orgName>Department of Orthodontics</orgName><orgName>Affiliated Stomatological Hospital of Medical School</orgName><orgName>Nanjing University</orgName><address><settlement type="city">Nanjing</settlement><country key="CN">China</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Michel</forename><surname>Dard</surname></persName><affiliation><orgName>Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York</orgName><address><settlement type="city">NY</settlement><country key="US">USA</country></address></affiliation></author><idno type="istex">F3DCE71551940969C7B99668518F72E35BF305C2</idno><idno type="ark">ark:/67375/WNG-F100GC5W-V</idno><idno type="DOI">10.1111/clr.12141</idno><idno type="unit">CLR12141</idno><idno type="toTypesetVersion">file:CLR.CLR12141.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Oral Implants Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="pISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><idno type="book-DOI">10.1111/(ISSN)1600-0501</idno><idno type="book-part-DOI">10.1111/clr.2014.25.issue-7</idno><idno type="product">CLR</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="819">819</biblScope><biblScope unit="page" to="825">825</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2014-07"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="clr12141-abs-0001"><head>Abstract</head>
Objective
<p>The aim of this study is to compare the osseointegration behavior of titanium (<hi rend="fc">T</hi>i) and titanium–zirconium (<hi rend="fc">T</hi>i<hi rend="fc">Z</hi>r) implants in ovariectomized (<hi rend="fc">OVX</hi>) rabbits.</p>
Materials and methods
<p>Twelve ovariectomized <hi rend="fc">N</hi>ew <hi rend="fc">Z</hi>ealand rabbits submitted to a hypocalcic diet and 12 sham‐aged rabbits were used. After the bone mass loss induction period, <hi rend="fc">T</hi>i<hi rend="fc">Z</hi>r or <hi rend="fc">T</hi>i implants both benefiting from a <hi rend="fc">SLA</hi>ctive surface treatment were randomly inserted in the tibia and femur of each animal. The total of 24 rabbits were divided in four groups (<hi rend="italic">n</hi> = 6): <hi rend="fc">SHAM</hi> + <hi rend="fc">T</hi>i, <hi rend="fc">OVX</hi> + <hi rend="fc">T</hi>i, <hi rend="fc">SHAM</hi> + <hi rend="fc">T</hi>i<hi rend="fc">Z</hi>r,<hi rend="fc">OVX</hi> + <hi rend="fc">T</hi>i<hi rend="fc">Z</hi>r. The animals were respectively sacrificed 3 and 6 weeks after dental implant placement. Six implants in each group at each time point were subjected to removal torque testing, and the remaining implants were prepared for histomorphometric analysis.</p>
Results
<p>At the end of the healing period, all implants were osseointegrated. The removal torque value of the <hi rend="fc">SHAM</hi>‐<hi rend="fc">T</hi>i<hi rend="fc">Z</hi>r group was significantly higher than those of the <hi rend="fc">SHAM</hi>‐<hi rend="fc">T</hi>i group (<hi rend="italic">P</hi> < 0.001). The removal torque of the <hi rend="fc">OVX</hi>‐<hi rend="fc">T</hi>i group was significantly lower than those of the <hi rend="fc">OVX</hi>‐<hi rend="fc">T</hi>i<hi rend="fc">Z</hi>r group. All groups demonstrated an increase in the peak torque value after 6 weeks: 46.0 and 50.8 Ncm for the <hi rend="fc">OVX</hi> and the <hi rend="fc">SHAM</hi> animals, respectively, in the case where Ti implants were used. When <hi rend="fc">T</hi>i<hi rend="fc">Z</hi>r implants were inserted, the values reached 60.7 and 76.2 Ncm with a similar group configuration. The <hi rend="fc">BIC</hi> and the <hi rend="fc">BA</hi>/<hi rend="fc">TA</hi> analysis showed an increase between week 3 and 6 in the case of nonovariectomized animals. From week 3 to 6, the <hi rend="fc">BIC</hi> went from 37.1 ± 14.3 to 47.7 ± 8.7 for the <hi rend="fc">SHAM</hi> + <hi rend="fc">T</hi>i group and from 37.6 ± 10.9 to 50.4 ± 11 for the <hi rend="fc">SHAM</hi> + <hi rend="fc">T</hi>i<hi rend="fc">Z</hi>r group. The <hi rend="fc">BIC</hi> values were not significantly different between groups.</p>
Conclusion
<p>The parameters intended to be representative of the bone morphology (<hi rend="fc">BIC</hi> & <hi rend="fc">BATA</hi>) did not help to discriminate between <hi rend="fc">T</hi>i and <hi rend="fc">T</hi>i<hi rend="fc">Z</hi>r which appeared to behave similarly in this experimental model. However, the removal torque values for the <hi rend="fc">T</hi>i<hi rend="fc">Z</hi>r group were statistically higher than those of the <hi rend="fc">T</hi>i group in both the <hi rend="fc">SHAM</hi> and the ovariectomized animals. That likely reflected an increased quality of bone around the TiZr implants.</p></abstract><textClass><keywords><term xml:id="clr12141-kwd-0001">osseointegration</term><term xml:id="clr12141-kwd-0002">osteoporosis</term><term xml:id="clr12141-kwd-0003">ovariectomized rabbits</term><term xml:id="clr12141-kwd-0004"><hi rend="fc">SLA</hi>ctive implants</term><term xml:id="clr12141-kwd-0005">titanium–zirconium implants</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="clr12141" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0501</doi><issn type="print">0905-7161</issn><issn type="electronic">1600-0501</issn><idGroup><id type="product" value="CLR"></id></idGroup><titleGroup><title sort="CLINICAL ORAL IMPLANTS RESEARCH" type="main">Clinical Oral Implants Research</title><title type="short">Clin. 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Published by Blackwell Publishing Ltd</copyright><eventGroup><event date="2013-01-17" type="manuscriptAccepted"></event><event agent="SPS" date="2013-01-29" type="xmlCreated"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.2 mode:FullText" date="2014-06-13"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-02-21"></event><event type="firstOnline" date="2013-02-21"></event><event type="publishedOnlineFinalForm" date="2014-06-13"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-08"></event></eventGroup><numberingGroup><numbering type="pageFirst">819</numbering><numbering type="pageLast">825</numbering></numberingGroup><correspondenceTo><lineatedText><line><b>Corresponding author:</b></line><line><i>Bo Wen</i></line><line>Division of Implant Dentistry</line><line>Department of Oral & Maxillofacial Surgery</line><line>Affiliated Stomatological Hospital of Medical School, Nanjing University</line><line>30 Central Rd. Nanjing, 210008, Jiangsu, China</line><line>Tel.:+86 159 5058 5821</line><line>Fax: +86 25 8362 0202</line><line>e‐mail: <email>wenboxmy@gmail.com</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="clr12141-cit-1001"><author><familyName>Wen</familyName> <givenNames>B</givenNames></author>, <author><familyName>Zhu</familyName> <givenNames>F</givenNames></author>, <author><familyName>Li</familyName> <givenNames>Z</givenNames></author>, <author><familyName>Zhang</familyName> <givenNames>P</givenNames></author>, <author><familyName>Lin</familyName> <givenNames>X</givenNames></author>, <author><familyName>Dard</familyName> <givenNames>M</givenNames></author>. <articleTitle>The osseointegration behavior of titanium–zirconium implants in ovariectomized rabbits</articleTitle>. <journalTitle>Clin. Oral Impl. Res.</journalTitle> <vol>25</vol>, <pubYear year="2014">2014</pubYear>, <pageFirst>819</pageFirst>–<pageLast>825</pageLast> doi: <accessionId ref="info:doi/10.1111/clr.12141">10.1111/clr.12141</accessionId></citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:CLR.CLR12141.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">The osseointegration behavior of titanium–zirconium implants in ovariectomized rabbits</title><title type="shortAuthors">Wen et al</title></titleGroup><creators><creator affiliationRef="#clr12141-aff-0001" corresponding="yes" creatorRole="author" xml:id="clr12141-cr-0001"><personName><givenNames>Bo</givenNames> <familyName>Wen</familyName></personName></creator><creator affiliationRef="#clr12141-aff-0001" creatorRole="author" xml:id="clr12141-cr-0002"><personName><givenNames>Feng</givenNames> <familyName>Zhu</familyName></personName></creator><creator affiliationRef="#clr12141-aff-0001" creatorRole="author" xml:id="clr12141-cr-0003"><personName><givenNames>Zhen</givenNames> <familyName>Li</familyName></personName></creator><creator affiliationRef="#clr12141-aff-0002" creatorRole="author" xml:id="clr12141-cr-0004"><personName><givenNames>Peng</givenNames> <familyName>Zhang</familyName></personName></creator><creator affiliationRef="#clr12141-aff-0003" creatorRole="author" xml:id="clr12141-cr-0005"><personName><givenNames>Xingnan</givenNames> <familyName>Lin</familyName></personName></creator><creator affiliationRef="#clr12141-aff-0004" creatorRole="author" xml:id="clr12141-cr-0006"><personName><givenNames>Michel</givenNames> <familyName>Dard</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="CN" type="organization" xml:id="clr12141-aff-0001"><orgDiv>Division of Implant Dentistry</orgDiv> <orgDiv>Department of Oral & Maxillofacial Surgery</orgDiv> <orgDiv>Affiliated Stomatological Hospital of Medical School</orgDiv> <orgName>Nanjing University</orgName> <address><city>Nanjing</city> <country>China</country></address></affiliation><affiliation countryCode="CN" type="organization" xml:id="clr12141-aff-0002"><orgDiv>Department of Periodontics</orgDiv> <orgDiv>Affiliated Stomatological Hospital of Medical School</orgDiv> <orgName>Nanjing University</orgName> <address><city>Nanjing</city> <country>China</country></address></affiliation><affiliation countryCode="CN" type="organization" xml:id="clr12141-aff-0003"><orgDiv>Department of Orthodontics</orgDiv> <orgDiv>Affiliated Stomatological Hospital of Medical School</orgDiv> <orgName>Nanjing University</orgName> <address><city>Nanjing</city> <country>China</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="clr12141-aff-0004"><orgName>Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York</orgName> <address><city>NY</city> <country>USA</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="clr12141-kwd-0001">osseointegration</keyword><keyword xml:id="clr12141-kwd-0002">osteoporosis</keyword><keyword xml:id="clr12141-kwd-0003">ovariectomized rabbits</keyword><keyword xml:id="clr12141-kwd-0004"><fc>SLA</fc>ctive implants</keyword><keyword xml:id="clr12141-kwd-0005">titanium–zirconium implants</keyword></keywordGroup><fundingInfo><fundingAgency>Institut Straumann AG, Basel, Switzerland</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Scientific Research Foundation of the Returned Overseas Scholars of CSCSE</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:id="clr12141-abs-0001"><title type="main">Abstract</title><section xml:id="clr12141-sec-0001"><title type="main">Objective</title><p>The aim of this study is to compare the osseointegration behavior of titanium (<fc>T</fc>i) and titanium–zirconium (<fc>T</fc>i<fc>Z</fc>r) implants in ovariectomized (<fc>OVX</fc>) rabbits.</p></section><section xml:id="clr12141-sec-0002"><title type="main">Materials and methods</title><p>Twelve ovariectomized <fc>N</fc>ew <fc>Z</fc>ealand rabbits submitted to a hypocalcic diet and 12 sham‐aged rabbits were used. After the bone mass loss induction period, <fc>T</fc>i<fc>Z</fc>r or <fc>T</fc>i implants both benefiting from a <fc>SLA</fc>ctive surface treatment were randomly inserted in the tibia and femur of each animal. The total of 24 rabbits were divided in four groups (<i>n</i> = 6): <fc>SHAM</fc> + <fc>T</fc>i, <fc>OVX</fc> + <fc>T</fc>i, <fc>SHAM</fc> + <fc>T</fc>i<fc>Z</fc>r,<fc>OVX</fc> + <fc>T</fc>i<fc>Z</fc>r. The animals were respectively sacrificed 3 and 6 weeks after dental implant placement. Six implants in each group at each time point were subjected to removal torque testing, and the remaining implants were prepared for histomorphometric analysis.</p></section><section xml:id="clr12141-sec-0003"><title type="main">Results</title><p>At the end of the healing period, all implants were osseointegrated. The removal torque value of the <fc>SHAM</fc>‐<fc>T</fc>i<fc>Z</fc>r group was significantly higher than those of the <fc>SHAM</fc>‐<fc>T</fc>i group (<i>P</i> < 0.001). The removal torque of the <fc>OVX</fc>‐<fc>T</fc>i group was significantly lower than those of the <fc>OVX</fc>‐<fc>T</fc>i<fc>Z</fc>r group. All groups demonstrated an increase in the peak torque value after 6 weeks: 46.0 and 50.8 Ncm for the <fc>OVX</fc> and the <fc>SHAM</fc> animals, respectively, in the case where Ti implants were used. When <fc>T</fc>i<fc>Z</fc>r implants were inserted, the values reached 60.7 and 76.2 Ncm with a similar group configuration. The <fc>BIC</fc> and the <fc>BA</fc>/<fc>TA</fc> analysis showed an increase between week 3 and 6 in the case of nonovariectomized animals. From week 3 to 6, the <fc>BIC</fc> went from 37.1 ± 14.3 to 47.7 ± 8.7 for the <fc>SHAM</fc> + <fc>T</fc>i group and from 37.6 ± 10.9 to 50.4 ± 11 for the <fc>SHAM</fc> + <fc>T</fc>i<fc>Z</fc>r group. The <fc>BIC</fc> values were not significantly different between groups.</p></section><section xml:id="clr12141-sec-0004"><title type="main">Conclusion</title><p>The parameters intended to be representative of the bone morphology (<fc>BIC</fc> & <fc>BATA</fc>) did not help to discriminate between <fc>T</fc>i and <fc>T</fc>i<fc>Z</fc>r which appeared to behave similarly in this experimental model. However, the removal torque values for the <fc>T</fc>i<fc>Z</fc>r group were statistically higher than those of the <fc>T</fc>i group in both the <fc>SHAM</fc> and the ovariectomized animals. That likely reflected an increased quality of bone around the TiZr implants.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The osseointegration behavior of titanium–zirconium implants in ovariectomized rabbits</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The osseointegration behavior of titanium–zirconium implants in ovariectomized rabbits</title></titleInfo><name type="personal"><namePart type="given">Bo</namePart><namePart type="family">Wen</namePart><affiliation>Division of Implant Dentistry, Department of Oral & Maxillofacial Surgery, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</affiliation><affiliation>Division of Implant DentistryDepartment of Oral & Maxillofacial SurgeryAffiliated Stomatological Hospital of Medical School, Nanjing University30 Central Rd. Nanjing, 210008, Jiangsu, ChinaTel.:+86 159 5058 5821Fax: +86 25 8362 0202e‐mail:</affiliation><affiliation>E-mail: wenboxmy@gmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Feng</namePart><namePart type="family">Zhu</namePart><affiliation>Division of Implant Dentistry, Department of Oral & Maxillofacial Surgery, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Zhen</namePart><namePart type="family">Li</namePart><affiliation>Division of Implant Dentistry, Department of Oral & Maxillofacial Surgery, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peng</namePart><namePart type="family">Zhang</namePart><affiliation>Department of Periodontics, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Xingnan</namePart><namePart type="family">Lin</namePart><affiliation>Department of Orthodontics, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michel</namePart><namePart type="family">Dard</namePart><affiliation>Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-07</dateIssued><dateCreated encoding="w3cdtf">2013-01-29</dateCreated><dateValid encoding="w3cdtf">2013-01-17</dateValid><edition>Wen B, Zhu F, Li Z, Zhang P, Lin X, Dard M. The osseointegration behavior of titanium–zirconium implants in ovariectomized rabbits. Clin. Oral Impl. Res. 25, 2014, 819–825 doi: 10.1111/clr.12141</edition><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>The aim of this study is to compare the osseointegration behavior of titanium (Ti) and titanium–zirconium (TiZr) implants in ovariectomized (OVX) rabbits.</abstract><abstract>Twelve ovariectomized New Zealand rabbits submitted to a hypocalcic diet and 12 sham‐aged rabbits were used. After the bone mass loss induction period, TiZr or Ti implants both benefiting from a SLActive surface treatment were randomly inserted in the tibia and femur of each animal. The total of 24 rabbits were divided in four groups (n = 6): SHAM + Ti, OVX + Ti, SHAM + TiZr,OVX + TiZr. The animals were respectively sacrificed 3 and 6 weeks after dental implant placement. Six implants in each group at each time point were subjected to removal torque testing, and the remaining implants were prepared for histomorphometric analysis.</abstract><abstract>At the end of the healing period, all implants were osseointegrated. The removal torque value of the SHAM‐TiZr group was significantly higher than those of the SHAM‐Ti group (P < 0.001). The removal torque of the OVX‐Ti group was significantly lower than those of the OVX‐TiZr group. All groups demonstrated an increase in the peak torque value after 6 weeks: 46.0 and 50.8 Ncm for the OVX and the SHAM animals, respectively, in the case where Ti implants were used. When TiZr implants were inserted, the values reached 60.7 and 76.2 Ncm with a similar group configuration. The BIC and the BA/TA analysis showed an increase between week 3 and 6 in the case of nonovariectomized animals. From week 3 to 6, the BIC went from 37.1 ± 14.3 to 47.7 ± 8.7 for the SHAM + Ti group and from 37.6 ± 10.9 to 50.4 ± 11 for the SHAM + TiZr group. The BIC values were not significantly different between groups.</abstract><abstract>The parameters intended to be representative of the bone morphology (BIC & BATA) did not help to discriminate between Ti and TiZr which appeared to behave similarly in this experimental model. However, the removal torque values for the TiZr group were statistically higher than those of the Ti group in both the SHAM and the ovariectomized animals. That likely reflected an increased quality of bone around the TiZr implants.</abstract><note type="funding">Institut Straumann AG, Basel, Switzerland</note><note type="funding">Scientific Research Foundation of the Returned Overseas Scholars of CSCSE</note><subject><genre>keywords</genre><topic>osseointegration</topic><topic>osteoporosis</topic><topic>ovariectomized rabbits</topic><topic>SLActive implants</topic><topic>titanium–zirconium implants</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Oral Implants Research</title></titleInfo><titleInfo type="abbreviated"><title>Clin. Oral Impl. Res.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0905-7161</identifier><identifier type="eISSN">1600-0501</identifier><identifier type="DOI">10.1111/(ISSN)1600-0501</identifier><identifier type="PublisherID">CLR</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>819</start><end>825</end><total>7</total></extent></part></relatedItem><identifier type="istex">F3DCE71551940969C7B99668518F72E35BF305C2</identifier><identifier type="ark">ark:/67375/WNG-F100GC5W-V</identifier><identifier type="DOI">10.1111/clr.12141</identifier><identifier type="ArticleID">CLR12141</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2014 John Wiley & Sons A/S© 2013 John Wiley & Sons A/S. 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