Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re‐treatment: a randomized controlled clinical trial
Identifieur interne : 007797 ( Istex/Corpus ); précédent : 007796; suivant : 007798Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re‐treatment: a randomized controlled clinical trial
Auteurs : Gareth S. Griffiths ; Rasidah Ayob ; Adrian Guerrero ; Luigi Nibali ; Jean Suvan ; David R. Moles ; Maurizio S. TonettiSource :
- Journal of Clinical Periodontology [ 0303-6979 ] ; 2011-01.
English descriptors
- KwdEn :
- Academic unit, Adjunctive, Adjunctive antimicrobials, Adjunctive treatment, Adverse events, Aggressive periodontitis, Aggressive periodontitis therapy, Allocation concealment, Amoxicillin, Antibiotic, Antibiotic therapy, Antibiotic treatment, Antimicrobial, Attachment loss, Baseline, Blue line, Clin periodontol, Clinical characteristics, Clinical examination, Clinical parameters, Clinical periodontology, Clinical trial, Deep pockets, Fmrsd, Further instrumentation, Further treatment, Guerrero, Initial phase, Initial ppdx7, Initial study, Initial therapy, Initial treatment, Interquartile range, Intervention group, John wiley sons, Last observation, Lcal, Lcal gain, Medication, Metronidazole, Microbiological effects, Moderate pockets, Months evaluation, Numerical data, Periodontal, Periodontal diseases, Periodontal therapy, Periodontal treatment, Periodontitis, Periodontitis patients, Periodontology, Phase study, Placebo, Placebo group, Placebo medication, Pocket depth, Pocket depth reduction, Pocket reduction, Pocket therapy, Posttreatment, Primary outcome, Protocol analysis, Random events, Randomized, Root planing, Root surface, Sample size calculation, Second phase, Second phase study, Similar outcomes, Similar pattern, Statistical analysis, Subset analysis, Systematic review, Systemic, Systemic antibiotics, Systemic antimicrobials, Systemic metronidazole, Test group, Treatment assignment, True difference, Value estimate, Value months.
- Teeft :
- Academic unit, Adjunctive, Adjunctive antimicrobials, Adjunctive treatment, Adverse events, Aggressive periodontitis, Aggressive periodontitis therapy, Allocation concealment, Amoxicillin, Antibiotic, Antibiotic therapy, Antibiotic treatment, Antimicrobial, Attachment loss, Baseline, Blue line, Clin periodontol, Clinical characteristics, Clinical examination, Clinical parameters, Clinical periodontology, Clinical trial, Deep pockets, Fmrsd, Further instrumentation, Further treatment, Guerrero, Initial phase, Initial ppdx7, Initial study, Initial therapy, Initial treatment, Interquartile range, Intervention group, John wiley sons, Last observation, Lcal, Lcal gain, Medication, Metronidazole, Microbiological effects, Moderate pockets, Months evaluation, Numerical data, Periodontal, Periodontal diseases, Periodontal therapy, Periodontal treatment, Periodontitis, Periodontitis patients, Periodontology, Phase study, Placebo, Placebo group, Placebo medication, Pocket depth, Pocket depth reduction, Pocket reduction, Pocket therapy, Posttreatment, Primary outcome, Protocol analysis, Random events, Randomized, Root planing, Root surface, Sample size calculation, Second phase, Second phase study, Similar outcomes, Similar pattern, Statistical analysis, Subset analysis, Systematic review, Systemic, Systemic antibiotics, Systemic antimicrobials, Systemic metronidazole, Test group, Treatment assignment, True difference, Value estimate, Value months.
Abstract
Griffiths GS, Ayob R, Guerrero A, Nibali L, Suvan J, Moles DR, Tonetti MS. Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re‐treatment: a randomized controlled clinical trial. J Clin Periodontol 2011; 38: 43–49. doi: 10.1111/j.1600‐051X.2010.01632.x
Url:
DOI: 10.1111/j.1600-051X.2010.01632.x
Links to Exploration step
ISTEX:F208DB0A02839B94739422DB786E878C8953693CLe document en format XML
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Griffiths</name><affiliations><json:string>University of Sheffield, Academic Unit of Restorative Dentistry, Sheffield, UK</json:string></affiliations></json:item><json:item><name>Rasidah Ayob</name><affiliations><json:string>Unit of Periodontology and Eastman Clinical Investigation Centre, UCL Eastman Dental, Institute, London, UK</json:string></affiliations></json:item><json:item><name>Adrian Guerrero</name><affiliations><json:string>Graduate Comprehensive Dentistry, University of Barcelona, and Private Periodontal Practice, Malaga, Spain</json:string></affiliations></json:item><json:item><name>Luigi Nibali</name><affiliations><json:string>Unit of Periodontology and Eastman Clinical Investigation Centre, UCL Eastman Dental, Institute, London, UK</json:string></affiliations></json:item><json:item><name>Jean Suvan</name><affiliations><json:string>Unit of Periodontology and Eastman Clinical Investigation Centre, UCL Eastman Dental, Institute, London, UK</json:string></affiliations></json:item><json:item><name>David R. Moles</name><affiliations><json:string>Health Services Research, Peninsula Dental School, University of Plymouth, Plymouth, UK</json:string></affiliations></json:item><json:item><name>Maurizio S. Tonetti</name><affiliations><json:string>European Research Group on Periodontology (ERGOPerio), Berne, Switzerland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>generalized aggressive periodontitis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>antibiotics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>treatment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>randomized controlled clinical trial</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>human</value></json:item></subject><articleId><json:string>JCPE1632</json:string></articleId><arkIstex>ark:/67375/WNG-3CBK37FT-Z</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Griffiths GS, Ayob R, Guerrero A, Nibali L, Suvan J, Moles DR, Tonetti MS. Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re‐treatment: a randomized controlled clinical trial. 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Tonetti</json:string><json:string>Luigi Nibali</json:string><json:string>David R. Moles</json:string><json:string>Jean Suvan</json:string><json:string>Amoxicillin</json:string></persName><placeName><json:string>Switzerland</json:string><json:string>Helsinki</json:string><json:string>Nyon</json:string><json:string>Spain</json:string><json:string>Malaga</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Xajigeorgiou et al. 2006</json:string><json:string>Demmer & Papapanou 2010</json:string><json:string>Loesche et al. 1991, 1992</json:string><json:string>Rooney et al. 2002</json:string><json:string>Dunn et al. 2005</json:string><json:string>Kaner et al. (2007)</json:string><json:string>Flemmig et al. 1998</json:string><json:string>Haffajee et al. 2003</json:string><json:string>Herrera et al. 2008</json:string><json:string>van Winkelhoff et al. 1989</json:string><json:string>Mestnik et al. 2010</json:string><json:string>Kaner et al. 2007</json:string><json:string>Herrera et al. 2002</json:string><json:string>Armitage 1999</json:string><json:string>Hollis & Campbell 1999</json:string><json:string>Guerrero et al. 2005</json:string><json:string>Guerrero et al. (2005)</json:string><json:string>Sigusch et al. (2001)</json:string><json:string>Winkel et al. 1998</json:string><json:string>Quirynen et al. 2001</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-3CBK37FT-Z</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - 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type="first">Gareth S.</forename><surname>Griffiths</surname></persName><affiliation>University of Sheffield, Academic Unit of Restorative Dentistry, Sheffield, UK<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Rasidah</forename><surname>Ayob</surname></persName><affiliation>Unit of Periodontology and Eastman Clinical Investigation Centre, UCL Eastman Dental, Institute, London, UK<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Adrian</forename><surname>Guerrero</surname></persName><affiliation>Graduate Comprehensive Dentistry, University of Barcelona, and Private Periodontal Practice, Malaga, Spain<address><country key="ES"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Luigi</forename><surname>Nibali</surname></persName><affiliation>Unit of Periodontology and Eastman Clinical Investigation Centre, UCL Eastman Dental, Institute, London, UK<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Jean</forename><surname>Suvan</surname></persName><affiliation>Unit of Periodontology and Eastman Clinical Investigation Centre, UCL Eastman Dental, Institute, London, UK<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">David R.</forename><surname>Moles</surname></persName><affiliation>Health Services Research, Peninsula Dental School, University of Plymouth, Plymouth, UK<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Maurizio S.</forename><surname>Tonetti</surname></persName><affiliation>European Research Group on Periodontology (ERGOPerio), Berne, Switzerland<address><country key="CH"></country></address></affiliation></author><idno type="istex">F208DB0A02839B94739422DB786E878C8953693C</idno><idno type="ark">ark:/67375/WNG-3CBK37FT-Z</idno><idno type="DOI">10.1111/j.1600-051X.2010.01632.x</idno><idno type="unit">JCPE1632</idno><idno type="supplier">1632</idno><idno type="toTypesetVersion">file:JCPE.JCPE1632.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Clinical Periodontology</title><title level="j" type="alt">JOURNAL OF CLINICAL PERIODONTOLOGY</title><idno type="pISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><idno type="book-DOI">10.1111/(ISSN)1600-051X</idno><idno type="book-part-DOI">10.1111/cpe.2010.38.issue-1</idno><idno type="product">JCPE</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">38</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="43">43</biblScope><biblScope unit="page" to="49">49</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>Griffiths GS, Ayob R, Guerrero A, Nibali L, Suvan J, Moles DR, Tonetti MS. Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re‐treatment: a randomized controlled clinical trial. J Clin Periodontol 2011; 38: 43–49. doi: 10.1111/j.1600‐051X.2010.01632.x</p>
Abstract
<p><hi rend="bold">Background: </hi> Previously, we showed that systemic metronidazole and amoxicillin significantly improved the outcomes of non‐surgical debridement in generalized aggressive periodontitis patients. This study aimed to observe whether re‐treatment with adjunctive antimicrobials would give the placebo group benefits comparable with the test group.</p><p><hi rend="bold">Methods: </hi> Thirty‐eight of 41 subjects, from the initial 6‐month trial, completed the second phase, re‐treatment of sites with remaining pockets <graphic url="ges.gif" rend="geqslant R: gt-or-equal, slanted"></graphic>5 mm. Subjects on placebo in phase one, received adjunctive antibiotics for 7 days. Clinical parameters were collected at 2 months posttreatment (8 months from baseline).</p><p><hi rend="bold">Results: </hi> Patients who received antibiotics at initial therapy, showed statistically significant improvement in pocket depth reduction and in the % of sites improving above clinically relevant thresholds, compared with patients who received antibiotics at re‐treatment. In deep pockets (<graphic url="ges.gif" rend="geqslant R: gt-or-equal, slanted"></graphic>7 mm), the mean difference was 0.9 mm (<hi rend="italic">p</hi>=0.003) and in moderate pockets (4–6 mm) it was 0.4 mm (<hi rend="italic">p</hi>=0.036). For pockets converting from <graphic url="ges.gif" rend="geqslant R: gt-or-equal, slanted"></graphic>5 to <graphic url="les.gif" rend="leqslant R: less-than-or-eq, slant"></graphic>4 mm, this was 83% compared with 67% (<hi rend="italic">p</hi>=0.041) and pockets converting from <graphic url="ges.gif" rend="geqslant R: gt-or-equal, slanted"></graphic>4 to <graphic url="les.gif" rend="leqslant R: less-than-or-eq, slant"></graphic>3 mm was 63% compared with 49% (<hi rend="italic">p</hi>=0.297).</p><p><hi rend="bold">Conclusions: </hi> At 8 months, patients who had antibiotics at initial therapy showed statistically significant benefits compared with those who had antibiotics at re‐treatment.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">generalized aggressive periodontitis</term><term xml:id="k2">antibiotics</term><term xml:id="k3">treatment</term><term xml:id="k4">randomized controlled clinical trial</term><term xml:id="k5">human</term></keywords><keywords rend="tocHeading1"><term>Periodontal Therapy</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/F208DB0A02839B94739422DB786E878C8953693C/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-051X</doi><issn type="print">0303-6979</issn><issn type="electronic">1600-051X</issn><idGroup><id type="product" value="JCPE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF CLINICAL PERIODONTOLOGY">Journal of Clinical Periodontology</title></titleGroup></publicationMeta><publicationMeta level="part" position="01101"><doi origin="wiley">10.1111/cpe.2010.38.issue-1</doi><numberingGroup><numbering type="journalVolume" number="38">38</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="2011-01">January 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="6" status="forIssue"><doi origin="wiley">10.1111/j.1600-051X.2010.01632.x</doi><idGroup><id type="unit" value="JCPE1632"></id><id type="supplier" value="1632"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Periodontal Therapy</title></titleGroup><copyright>© 2010 John Wiley & Sons A/S</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.4 mode:FullText" date="2010-12-16"></event><event type="publishedOnlineEarlyUnpaginated" date="2010-11-10"></event><event type="firstOnline" date="2010-11-10"></event><event type="publishedOnlineFinalForm" date="2010-12-16"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-24"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="43">43</numbering><numbering type="pageLast" number="49">49</numbering></numberingGroup><correspondenceTo>Address:
<i>Gareth S. Griffiths</i>
<i>University of Sheffield</i>
<i>Academic Unit of Restorative Dentistry</i>
<i>Claremont Crescent</i>
<i>Sheffield S10 2TA</i>
<i>UK</i>
E‐mail: <email normalForm="g.s.griffiths@sheffield.ac.uk">g.s.griffiths@sheffield.ac.uk</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JCPE.JCPE1632.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 14 September 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="4"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="23"></count><count type="wordTotal" number="6391"></count><count type="linksCrossRef" number="55"></count></countGroup><titleGroup><title type="main">Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re‐treatment: a randomized controlled clinical trial</title><title type="shortAuthors">Griffiths et al.</title><title type="short">Gen aggressive periodontitis therapy</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Gareth S.</givenNames><familyName>Griffiths</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>Rasidah</givenNames><familyName>Ayob</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>Adrian</givenNames><familyName>Guerrero</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>Luigi</givenNames><familyName>Nibali</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>Jean</givenNames><familyName>Suvan</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a4"><personName><givenNames>David R.</givenNames><familyName>Moles</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a5"><personName><givenNames>Maurizio S.</givenNames><familyName>Tonetti</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="GB"><unparsedAffiliation>University of Sheffield, Academic Unit of Restorative Dentistry, Sheffield, UK</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="GB"><unparsedAffiliation>Unit of Periodontology and Eastman Clinical Investigation Centre, UCL Eastman Dental, Institute, London, UK</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="ES"><unparsedAffiliation>Graduate Comprehensive Dentistry, University of Barcelona, and Private Periodontal Practice, Malaga, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="GB"><unparsedAffiliation>Health Services Research, Peninsula Dental School, University of Plymouth, Plymouth, UK</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="CH"><unparsedAffiliation>European Research Group on Periodontology (ERGOPerio), Berne, Switzerland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">generalized aggressive periodontitis</keyword><keyword xml:id="k2">antibiotics</keyword><keyword xml:id="k3">treatment</keyword><keyword xml:id="k4">randomized controlled clinical trial</keyword><keyword xml:id="k5">human</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><section xml:id="sec-sum-1"><p>Griffiths GS, Ayob R, Guerrero A, Nibali L, Suvan J, Moles DR, Tonetti MS. Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re‐treatment: a randomized controlled clinical trial. J Clin Periodontol 2011; 38: 43–49. doi: 10.1111/j.1600‐051X.2010.01632.x</p></section><section xml:id="abs1-1"><title type="main">Abstract</title><p><b>Background: </b> Previously, we showed that systemic metronidazole and amoxicillin significantly improved the outcomes of non‐surgical debridement in generalized aggressive periodontitis patients. This study aimed to observe whether re‐treatment with adjunctive antimicrobials would give the placebo group benefits comparable with the test group.</p><p><b>Methods: </b> Thirty‐eight of 41 subjects, from the initial 6‐month trial, completed the second phase, re‐treatment of sites with remaining pockets <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" location="ges.gif" href=""></inlineGraphic>5 mm. Subjects on placebo in phase one, received adjunctive antibiotics for 7 days. Clinical parameters were collected at 2 months posttreatment (8 months from baseline).</p><p><b>Results: </b> Patients who received antibiotics at initial therapy, showed statistically significant improvement in pocket depth reduction and in the % of sites improving above clinically relevant thresholds, compared with patients who received antibiotics at re‐treatment. In deep pockets (<inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" location="ges.gif" href=""></inlineGraphic>7 mm), the mean difference was 0.9 mm (<i>p</i>=0.003) and in moderate pockets (4–6 mm) it was 0.4 mm (<i>p</i>=0.036). For pockets converting from <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" location="ges.gif" href=""></inlineGraphic>5 to <inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" location="les.gif" href=""></inlineGraphic>4 mm, this was 83% compared with 67% (<i>p</i>=0.041) and pockets converting from <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" location="ges.gif" href=""></inlineGraphic>4 to <inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" location="les.gif" href=""></inlineGraphic>3 mm was 63% compared with 49% (<i>p</i>=0.297).</p><p><b>Conclusions: </b> At 8 months, patients who had antibiotics at initial therapy showed statistically significant benefits compared with those who had antibiotics at re‐treatment.</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Conflict of interest and source of funding statement</b>
There is no conflict of interest associated with the present study. This study was supported by the Periodontal Research Fund of the Eastman Dental Institute. L. N. was supported by a fellowship from the Italian Society of Periodontology, SIdP.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re‐treatment: a randomized controlled clinical trial</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Gen aggressive periodontitis therapy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re‐treatment: a randomized controlled clinical trial</title></titleInfo><name type="personal"><namePart type="given">Gareth S.</namePart><namePart type="family">Griffiths</namePart><affiliation>University of Sheffield, Academic Unit of Restorative Dentistry, Sheffield, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rasidah</namePart><namePart type="family">Ayob</namePart><affiliation>Unit of Periodontology and Eastman Clinical Investigation Centre, UCL Eastman Dental, Institute, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Adrian</namePart><namePart type="family">Guerrero</namePart><affiliation>Graduate Comprehensive Dentistry, University of Barcelona, and Private Periodontal Practice, Malaga, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luigi</namePart><namePart type="family">Nibali</namePart><affiliation>Unit of Periodontology and Eastman Clinical Investigation Centre, UCL Eastman Dental, Institute, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean</namePart><namePart type="family">Suvan</namePart><affiliation>Unit of Periodontology and Eastman Clinical Investigation Centre, UCL Eastman Dental, Institute, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David R.</namePart><namePart type="family">Moles</namePart><affiliation>Health Services Research, Peninsula Dental School, University of Plymouth, Plymouth, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maurizio S.</namePart><namePart type="family">Tonetti</namePart><affiliation>European Research Group on Periodontology (ERGOPerio), Berne, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-01</dateIssued><edition>Accepted for publication 14 September 2010</edition><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">2</extent><extent unit="tables">4</extent><extent unit="formulas">0</extent><extent unit="references">23</extent><extent unit="linksCrossRef">55</extent><extent unit="words">6391</extent></physicalDescription><abstract>Griffiths GS, Ayob R, Guerrero A, Nibali L, Suvan J, Moles DR, Tonetti MS. Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re‐treatment: a randomized controlled clinical trial. J Clin Periodontol 2011; 38: 43–49. doi: 10.1111/j.1600‐051X.2010.01632.x</abstract><abstract>Background: Previously, we showed that systemic metronidazole and amoxicillin significantly improved the outcomes of non‐surgical debridement in generalized aggressive periodontitis patients. This study aimed to observe whether re‐treatment with adjunctive antimicrobials would give the placebo group benefits comparable with the test group. Methods: Thirty‐eight of 41 subjects, from the initial 6‐month trial, completed the second phase, re‐treatment of sites with remaining pockets 5 mm. Subjects on placebo in phase one, received adjunctive antibiotics for 7 days. Clinical parameters were collected at 2 months posttreatment (8 months from baseline). Results: Patients who received antibiotics at initial therapy, showed statistically significant improvement in pocket depth reduction and in the % of sites improving above clinically relevant thresholds, compared with patients who received antibiotics at re‐treatment. In deep pockets (7 mm), the mean difference was 0.9 mm (p=0.003) and in moderate pockets (4–6 mm) it was 0.4 mm (p=0.036). For pockets converting from 5 to 4 mm, this was 83% compared with 67% (p=0.041) and pockets converting from 4 to 3 mm was 63% compared with 49% (p=0.297). Conclusions: At 8 months, patients who had antibiotics at initial therapy showed statistically significant benefits compared with those who had antibiotics at re‐treatment.</abstract><subject lang="en"><genre>keywords</genre><topic>generalized aggressive periodontitis</topic><topic>antibiotics</topic><topic>treatment</topic><topic>randomized controlled clinical trial</topic><topic>human</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Clinical Periodontology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0303-6979</identifier><identifier type="eISSN">1600-051X</identifier><identifier type="DOI">10.1111/(ISSN)1600-051X</identifier><identifier type="PublisherID">JCPE</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>43</start><end>49</end><total>7</total></extent></part></relatedItem><identifier type="istex">F208DB0A02839B94739422DB786E878C8953693C</identifier><identifier type="ark">ark:/67375/WNG-3CBK37FT-Z</identifier><identifier type="DOI">10.1111/j.1600-051X.2010.01632.x</identifier><identifier type="ArticleID">JCPE1632</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/F208DB0A02839B94739422DB786E878C8953693C/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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