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Transcriptional regulation of bone and joint remodeling by NFAT

Identifieur interne : 007509 ( Istex/Corpus ); précédent : 007508; suivant : 007510

Transcriptional regulation of bone and joint remodeling by NFAT

Auteurs : Despina Sitara ; Antonios O. Aliprantis

Source :

RBID : ISTEX:EC49CD2549DD9BB3A2BFFF0ED9D42705BA48F99D

English descriptors

Abstract

Summary:  Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture‐prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that links NFAT‐regulated gene transcription to bone and joint pathology. A particular emphasis is placed on the role of NFATs in bone resorption and formation by osteoclasts and osteoblasts, respectively. In addition, emerging data that connect NFATs with cartilage biology, angiogenesis, nociception, and neurogenic inflammation are explored. The goal of this article is to highlight the importance of tissue remodeling in musculoskeletal disease and situate NFAT‐driven cellular responses within this context to inspire future research endeavors.

Url:
DOI: 10.1111/j.0105-2896.2009.00849.x

Links to Exploration step

ISTEX:EC49CD2549DD9BB3A2BFFF0ED9D42705BA48F99D

Le document en format XML

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<div type="abstract">Summary:  Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture‐prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that links NFAT‐regulated gene transcription to bone and joint pathology. A particular emphasis is placed on the role of NFATs in bone resorption and formation by osteoclasts and osteoblasts, respectively. In addition, emerging data that connect NFATs with cartilage biology, angiogenesis, nociception, and neurogenic inflammation are explored. The goal of this article is to highlight the importance of tissue remodeling in musculoskeletal disease and situate NFAT‐driven cellular responses within this context to inspire future research endeavors.</div>
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