EdenteV2, Istex, Corpus, bibRecord, 007259

Heat and radiofrequency plasma glow discharge pretreatment of a titanium alloy promote bone formation and osseointegration

Identifieur interne : 007259 ( Istex/Corpus ); précédent : 007258; suivant : 007260

Heat and radiofrequency plasma glow discharge pretreatment of a titanium alloy promote bone formation and osseointegration

Auteurs : Daniel E. Macdonald ; Bruce E. Rapuano ; Parth Vyas ; Joseph M. Lane ; Kathleen Meyers ; Timothy Wright

Source :

Journal of Cellular Biochemistry [ 0730-2312 ] ; 2013-10.

RBID : ISTEX:E6B7C3B83A7C61CACE4942948230DF8FDC6DE741

English descriptors

Abstract

Orthopedic and dental implants manifest increased failure rates when inserted into low density bone. We determined whether chemical pretreatments of a titanium alloy implant material stimulated new bone formation to increase osseointegration in vivo in trabecular bone using a rat model. Titanium alloy rods were untreated or pretreated with heat (600°C) or radiofrequency plasma glow discharge (RFGD). The rods were then coated with the extracellular matrix protein fibronectin (1 nM) or left uncoated and surgically implanted into the rat femoral medullary cavity. Animals were euthanized 3 or 6 weeks later, and femurs were removed for analysis. The number of trabeculae in contact with the implant surface, surface contact between trabeculae and the implant, and the length and area of bone attached to the implant were measured by histomorphometry. Implant shear strength was measured by a pull‐out test. Both pretreatments and fibronectin enhanced the number of trabeculae bonding with the implant and trabeculae‐to‐implant surface contact, with greater effects of fibronectin observed with pretreated compared to untreated implants. RFGD pretreatment modestly increased implant shear strength, which was highly correlated (r2 = 0.87–0.99) with measures of trabecular bonding for untreated and RFGD‐pretreated implants. In contrast, heat pretreatment increased shear strength 3–5‐fold for both uncoated and fibronectin‐coated implants at 3 and 6 weeks, suggesting a more rapid increase in implant‐femur bonding compared to the other groups. In summary, our findings suggest that the heat and RFGD pretreatments can promote the osseointegration of a titanium alloy implant material. J. Cell. Biochem. 114: 2363–2374, 2013. © 2013 Wiley Periodicals, Inc.

Url:

https://api.istex.fr/document/E6B7C3B83A7C61CACE4942948230DF8FDC6DE741/fulltext/pdf

DOI: 10.1002/jcb.24585

Links to Exploration step

ISTEX:E6B7C3B83A7C61CACE4942948230DF8FDC6DE741

Le document en format XML

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<front><div type="abstract" xml:lang="en">Orthopedic and dental implants manifest increased failure rates when inserted into low density bone. We determined whether chemical pretreatments of a titanium alloy implant material stimulated new bone formation to increase osseointegration in vivo in trabecular bone using a rat model. Titanium alloy rods were untreated or pretreated with heat (600°C) or radiofrequency plasma glow discharge (RFGD). The rods were then coated with the extracellular matrix protein fibronectin (1 nM) or left uncoated and surgically implanted into the rat femoral medullary cavity. Animals were euthanized 3 or 6 weeks later, and femurs were removed for analysis. The number of trabeculae in contact with the implant surface, surface contact between trabeculae and the implant, and the length and area of bone attached to the implant were measured by histomorphometry. Implant shear strength was measured by a pull‐out test. Both pretreatments and fibronectin enhanced the number of trabeculae bonding with the implant and trabeculae‐to‐implant surface contact, with greater effects of fibronectin observed with pretreated compared to untreated implants. RFGD pretreatment modestly increased implant shear strength, which was highly correlated (r2 = 0.87–0.99) with measures of trabecular bonding for untreated and RFGD‐pretreated implants. In contrast, heat pretreatment increased shear strength 3–5‐fold for both uncoated and fibronectin‐coated implants at 3 and 6 weeks, suggesting a more rapid increase in implant‐femur bonding compared to the other groups. In summary, our findings suggest that the heat and RFGD pretreatments can promote the osseointegration of a titanium alloy implant material. J. Cell. Biochem. 114: 2363–2374, 2013. © 2013 Wiley Periodicals, Inc.</div>
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<abstract>Orthopedic and dental implants manifest increased failure rates when inserted into low density bone. We determined whether chemical pretreatments of a titanium alloy implant material stimulated new bone formation to increase osseointegration in vivo in trabecular bone using a rat model. Titanium alloy rods were untreated or pretreated with heat (600°C) or radiofrequency plasma glow discharge (RFGD). The rods were then coated with the extracellular matrix protein fibronectin (1 nM) or left uncoated and surgically implanted into the rat femoral medullary cavity. Animals were euthanized 3 or 6 weeks later, and femurs were removed for analysis. The number of trabeculae in contact with the implant surface, surface contact between trabeculae and the implant, and the length and area of bone attached to the implant were measured by histomorphometry. Implant shear strength was measured by a pull‐out test. Both pretreatments and fibronectin enhanced the number of trabeculae bonding with the implant and trabeculae‐to‐implant surface contact, with greater effects of fibronectin observed with pretreated compared to untreated implants. RFGD pretreatment modestly increased implant shear strength, which was highly correlated (r2 = 0.87–0.99) with measures of trabecular bonding for untreated and RFGD‐pretreated implants. In contrast, heat pretreatment increased shear strength 3–5‐fold for both uncoated and fibronectin‐coated implants at 3 and 6 weeks, suggesting a more rapid increase in implant‐femur bonding compared to the other groups. In summary, our findings suggest that the heat and RFGD pretreatments can promote the osseointegration of a titanium alloy implant material. J. Cell. Biochem. 114: 2363–2374, 2013. © 2013 Wiley Periodicals, Inc.</abstract>
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<p>Orthopedic and dental implants manifest increased failure rates when inserted into low density bone. We determined whether chemical pretreatments of a titanium alloy implant material stimulated new bone formation to increase osseointegration in vivo in trabecular bone using a rat model. Titanium alloy rods were untreated or pretreated with heat (600°C) or radiofrequency plasma glow discharge (RFGD). The rods were then coated with the extracellular matrix protein fibronectin (1 nM) or left uncoated and surgically implanted into the rat femoral medullary cavity. Animals were euthanized 3 or 6 weeks later, and femurs were removed for analysis. The number of trabeculae in contact with the implant surface, surface contact between trabeculae and the implant, and the length and area of bone attached to the implant were measured by histomorphometry. Implant shear strength was measured by a pull‐out test. Both pretreatments and fibronectin enhanced the number of trabeculae bonding with the implant and trabeculae‐to‐implant surface contact, with greater effects of fibronectin observed with pretreated compared to untreated implants. RFGD pretreatment modestly increased implant shear strength, which was highly correlated (r<hi rend="superscript">2</hi>
 = 0.87–0.99) with measures of trabecular bonding for untreated and RFGD‐pretreated implants. In contrast, heat pretreatment increased shear strength 3–5‐fold for both uncoated and fibronectin‐coated implants at 3 and 6 weeks, suggesting a more rapid increase in implant‐femur bonding compared to the other groups. In summary, our findings suggest that the heat and RFGD pretreatments can promote the osseointegration of a titanium alloy implant material. J. Cell. Biochem. 114: 2363–2374, 2013. © 2013 Wiley Periodicals, Inc.</p>
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<section xml:id="jcb24585-sec-0001"><p>Orthopedic and dental implants manifest increased failure rates when inserted into low density bone. We determined whether chemical pretreatments of a titanium alloy implant material stimulated new bone formation to increase osseointegration in vivo in trabecular bone using a rat model. Titanium alloy rods were untreated or pretreated with heat (600°C) or radiofrequency plasma glow discharge (RFGD). The rods were then coated with the extracellular matrix protein fibronectin (1 nM) or left uncoated and surgically implanted into the rat femoral medullary cavity. Animals were euthanized 3 or 6 weeks later, and femurs were removed for analysis. The number of trabeculae in contact with the implant surface, surface contact between trabeculae and the implant, and the length and area of bone attached to the implant were measured by histomorphometry. Implant shear strength was measured by a pull‐out test. Both pretreatments and fibronectin enhanced the number of trabeculae bonding with the implant and trabeculae‐to‐implant surface contact, with greater effects of fibronectin observed with pretreated compared to untreated implants. RFGD pretreatment modestly increased implant shear strength, which was highly correlated (r<sup>2</sup>
 = 0.87–0.99) with measures of trabecular bonding for untreated and RFGD‐pretreated implants. In contrast, heat pretreatment increased shear strength 3–5‐fold for both uncoated and fibronectin‐coated implants at 3 and 6 weeks, suggesting a more rapid increase in implant‐femur bonding compared to the other groups. In summary, our findings suggest that the heat and RFGD pretreatments can promote the osseointegration of a titanium alloy implant material. J. Cell. Biochem. 114: 2363–2374, 2013. © 2013 Wiley Periodicals, Inc.</p>
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<noteGroup><note xml:id="jcb24585-note-0001" numbered="no">The authors declare that they have no conflict of interest.</note>
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<mods version="3.6"><titleInfo lang="en"><title>Heat and radiofrequency plasma glow discharge pretreatment of a titanium alloy promote bone formation and osseointegration</title>
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<titleInfo type="abbreviated" lang="en"><title>Ti6Al4V Treatments Enhance Osseointegration</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Heat and radiofrequency plasma glow discharge pretreatment of a titanium alloy promote bone formation and osseointegration</title>
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<name type="personal"><namePart type="given">Daniel E.</namePart>
<namePart type="family">MacDonald</namePart>
<affiliation>Hospital for Special Surgery Affiliated With the Weill Medical College of Cornell University, 535 East 70th Street, 10021, New York, New York</affiliation>
<affiliation>General Medical Research, James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, New York</affiliation>
<affiliation>Langmuir Center for Colloids and Interfaces, Columbia University, 911 S.W. Mudd Building, Mail Code 4711, 500 West 120th Street, New York, 10027, New York</affiliation>
<affiliation>Correspondence to: Dr. Daniel E. MacDonald, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021.E‐mail:</affiliation>
<affiliation>E-mail: dem14@columbia.edu</affiliation>
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<name type="personal"><namePart type="given">Bruce E.</namePart>
<namePart type="family">Rapuano</namePart>
<affiliation>Hospital for Special Surgery Affiliated With the Weill Medical College of Cornell University, 535 East 70th Street, New York, 10021, New York</affiliation>
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<name type="personal"><namePart type="given">Parth</namePart>
<namePart type="family">Vyas</namePart>
<affiliation>Hospital for Special Surgery Affiliated With the Weill Medical College of Cornell University, 535 East 70th Street, New York, 10021, New York</affiliation>
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<name type="personal"><namePart type="given">Joseph M.</namePart>
<namePart type="family">Lane</namePart>
<affiliation>Hospital for Special Surgery Affiliated With the Weill Medical College of Cornell University, 535 East 70th Street, New York, 10021, New York</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Kathleen</namePart>
<namePart type="family">Meyers</namePart>
<affiliation>Hospital for Special Surgery Affiliated With the Weill Medical College of Cornell University, 535 East 70th Street, New York, 10021, New York</affiliation>
<role><roleTerm type="text">author</roleTerm>
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<name type="personal"><namePart type="given">Timothy</namePart>
<namePart type="family">Wright</namePart>
<affiliation>Hospital for Special Surgery Affiliated With the Weill Medical College of Cornell University, 535 East 70th Street, New York, 10021, New York</affiliation>
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<dateIssued encoding="w3cdtf">2013-10</dateIssued>
<dateCreated encoding="w3cdtf">2013-06-03</dateCreated>
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<abstract lang="en">Orthopedic and dental implants manifest increased failure rates when inserted into low density bone. We determined whether chemical pretreatments of a titanium alloy implant material stimulated new bone formation to increase osseointegration in vivo in trabecular bone using a rat model. Titanium alloy rods were untreated or pretreated with heat (600°C) or radiofrequency plasma glow discharge (RFGD). The rods were then coated with the extracellular matrix protein fibronectin (1 nM) or left uncoated and surgically implanted into the rat femoral medullary cavity. Animals were euthanized 3 or 6 weeks later, and femurs were removed for analysis. The number of trabeculae in contact with the implant surface, surface contact between trabeculae and the implant, and the length and area of bone attached to the implant were measured by histomorphometry. Implant shear strength was measured by a pull‐out test. Both pretreatments and fibronectin enhanced the number of trabeculae bonding with the implant and trabeculae‐to‐implant surface contact, with greater effects of fibronectin observed with pretreated compared to untreated implants. RFGD pretreatment modestly increased implant shear strength, which was highly correlated (r2 = 0.87–0.99) with measures of trabecular bonding for untreated and RFGD‐pretreated implants. In contrast, heat pretreatment increased shear strength 3–5‐fold for both uncoated and fibronectin‐coated implants at 3 and 6 weeks, suggesting a more rapid increase in implant‐femur bonding compared to the other groups. In summary, our findings suggest that the heat and RFGD pretreatments can promote the osseointegration of a titanium alloy implant material. J. Cell. Biochem. 114: 2363–2374, 2013. © 2013 Wiley Periodicals, Inc.</abstract>
<note type="funding">NIH - No. RO1 DE017695; </note>
<note type="funding">National Center for Research Resources, NIH - No. C06‐RR12538‐01; </note>
<subject lang="en"><genre>keywords</genre>
<topic>DENTAL IMPLANT</topic>
<topic>FIBRONECTIN</topic>
<topic>OSTEOBLAST</topic>
<topic>CELL DIFFERENTIATION</topic>
<topic>BONE MINERALIZATION</topic>
<topic>OSSEOINTEGRATION</topic>
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<identifier type="ISSN">0730-2312</identifier>
<identifier type="eISSN">1097-4644</identifier>
<identifier type="DOI">10.1002/(ISSN)1097-4644</identifier>
<identifier type="PublisherID">JCB</identifier>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>114</number>
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<detail type="issue"><caption>no.</caption>
<number>10</number>
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<extent unit="pages"><start>2363</start>
<end>2374</end>
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<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 Wiley Periodicals, Inc. This article is a U.S. Government work and is in the public domain in the USA.Copyright © 2013 Wiley Periodicals, Inc. This article is a U.S. Government work and is in the public domain in the USA.</accessCondition>
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Heat and radiofrequency plasma glow discharge pretreatment of a titanium alloy promote bone formation and osseointegration

Heat and radiofrequency plasma glow discharge pretreatment of a titanium alloy promote bone formation and osseointegration

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