Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant?
Identifieur interne : 007223 ( Istex/Corpus ); précédent : 007222; suivant : 007224Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant?
Auteurs : Leo Meijndert ; Wil A. Van Der Reijden ; Gerry M. Raghoebar ; Henny J. A. Meijer ; Arjan VissinkSource :
- European Journal of Oral Sciences [ 0909-8836 ] ; 2010-08.
English descriptors
- KwdEn :
- Actinobacillus actinomycetemcomitans, Actinomycetemcomitans, Aggregatibacter actinomycetemcomitans, Bacteroides, Bacteroides forsythus, Baseline, Campylobacter rectus, Center groningen, Clin, Clin periodontol, Colonization, Dental implants, Detectable levels, Edentulous, Edentulous patients, Forsythia, Functional loading, Fusobacterium nucleatum, Gingivalis, Groningen, Implant, Implant placement, Intermedia, Maxillofacial, Maxillofacial surgery, Microbiol, Microbiological, Microbiological criteria, Microbiological testing, Microbiota, Microorganism, Micros, Nucleatum, Pathogen, Pathogen levels, Peptostreptococcus micros, Periodontal, Periodontal disease, Periodontal intervention, Periodontal marker pathogens, Periodontal pathogens, Periodontal pathogens threshold, Periodontal treatment, Periodontally, Periodontitis, Periodontol, Porphyromonas, Porphyromonas gingivalis, Prevotella intermedia, Putative, Rectus, Subgingival, Tannerella forsythia, Teeth implant, Threshold levels.
- Teeft :
- Actinobacillus actinomycetemcomitans, Actinomycetemcomitans, Aggregatibacter actinomycetemcomitans, Bacteroides, Bacteroides forsythus, Baseline, Campylobacter rectus, Center groningen, Clin, Clin periodontol, Colonization, Dental implants, Detectable levels, Edentulous, Edentulous patients, Forsythia, Functional loading, Fusobacterium nucleatum, Gingivalis, Groningen, Implant, Implant placement, Intermedia, Maxillofacial, Maxillofacial surgery, Microbiol, Microbiological, Microbiological criteria, Microbiological testing, Microbiota, Microorganism, Micros, Nucleatum, Pathogen, Pathogen levels, Peptostreptococcus micros, Periodontal, Periodontal disease, Periodontal intervention, Periodontal marker pathogens, Periodontal pathogens, Periodontal pathogens threshold, Periodontal treatment, Periodontally, Periodontitis, Periodontol, Porphyromonas, Porphyromonas gingivalis, Prevotella intermedia, Putative, Rectus, Subgingival, Tannerella forsythia, Teeth implant, Threshold levels.
Abstract
Meijndert L, van der Reijden WA, Raghoebar GM, Meijer HJA, Vissink A. Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant? Eur J Oral Sci 2010; 118: 357–363. © 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci This study aimed to assess the prevalence of seven periodontal marker pathogens, before implant placement and 1 yr after loading, in periodontally healthy individuals and to assess the long‐term effectiveness of pre‐implant reduction of pathogens to below threshold levels. In 93 individuals needing single tooth replacement, pooled subgingival microbiological samples from standard sites were cultured and analyzed before implant treatment and 1 yr after loading. Threshold levels commonly used in periodontology to predict periodontal breakdown were applied. Subjects with levels of pathogens above these thresholds received initial periodontal treatment including systemic antibiotics when indicated. At baseline, 49.5% of periodontally healthy subjects harboured one or more marker pathogens above threshold levels. Periodontal treatment reduced the pathogen levels below threshold values in 78.3% of these initially colonized subjects. In all cases Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis were reduced to below threshold. At 1 yr after loading, periodontal pathogens were present above threshold levels in 74.1% of all subjects. It is concluded that in almost half of periodontal healthy individuals the subgingival biofilm harbours periodontal pathogens above threshold values. Long‐term effectiveness of pre‐implant reduction of the selected marker pathogens appeared limited in our patient population, making pre‐implant reduction unpredictive for post‐implant levels of these pathogens. Thus, considering the applied microbiological criteria, generalized pre‐implant microbiological testing is not contributory in periodontally healthy subjects.
Url:
DOI: 10.1111/j.1600-0722.2010.00750.x
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ISTEX:E60ACA679388C452C524B889BCB44AF044B3D507Le document en format XML
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SCIENCES</title><idno type="ISSN">0909-8836</idno><idno type="eISSN">1600-0722</idno><imprint><biblScope unit="vol">118</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="357">357</biblScope><biblScope unit="page" to="363">363</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-08">2010-08</date></imprint><idno type="ISSN">0909-8836</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0909-8836</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actinobacillus actinomycetemcomitans</term><term>Actinomycetemcomitans</term><term>Aggregatibacter actinomycetemcomitans</term><term>Bacteroides</term><term>Bacteroides forsythus</term><term>Baseline</term><term>Campylobacter rectus</term><term>Center groningen</term><term>Clin</term><term>Clin periodontol</term><term>Colonization</term><term>Dental implants</term><term>Detectable levels</term><term>Edentulous</term><term>Edentulous patients</term><term>Forsythia</term><term>Functional loading</term><term>Fusobacterium nucleatum</term><term>Gingivalis</term><term>Groningen</term><term>Implant</term><term>Implant placement</term><term>Intermedia</term><term>Maxillofacial</term><term>Maxillofacial surgery</term><term>Microbiol</term><term>Microbiological</term><term>Microbiological criteria</term><term>Microbiological testing</term><term>Microbiota</term><term>Microorganism</term><term>Micros</term><term>Nucleatum</term><term>Pathogen</term><term>Pathogen levels</term><term>Peptostreptococcus micros</term><term>Periodontal</term><term>Periodontal disease</term><term>Periodontal intervention</term><term>Periodontal marker pathogens</term><term>Periodontal pathogens</term><term>Periodontal pathogens threshold</term><term>Periodontal treatment</term><term>Periodontally</term><term>Periodontitis</term><term>Periodontol</term><term>Porphyromonas</term><term>Porphyromonas gingivalis</term><term>Prevotella intermedia</term><term>Putative</term><term>Rectus</term><term>Subgingival</term><term>Tannerella forsythia</term><term>Teeth implant</term><term>Threshold levels</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Actinobacillus actinomycetemcomitans</term><term>Actinomycetemcomitans</term><term>Aggregatibacter actinomycetemcomitans</term><term>Bacteroides</term><term>Bacteroides forsythus</term><term>Baseline</term><term>Campylobacter rectus</term><term>Center groningen</term><term>Clin</term><term>Clin periodontol</term><term>Colonization</term><term>Dental implants</term><term>Detectable levels</term><term>Edentulous</term><term>Edentulous patients</term><term>Forsythia</term><term>Functional loading</term><term>Fusobacterium nucleatum</term><term>Gingivalis</term><term>Groningen</term><term>Implant</term><term>Implant placement</term><term>Intermedia</term><term>Maxillofacial</term><term>Maxillofacial surgery</term><term>Microbiol</term><term>Microbiological</term><term>Microbiological criteria</term><term>Microbiological testing</term><term>Microbiota</term><term>Microorganism</term><term>Micros</term><term>Nucleatum</term><term>Pathogen</term><term>Pathogen levels</term><term>Peptostreptococcus micros</term><term>Periodontal</term><term>Periodontal disease</term><term>Periodontal intervention</term><term>Periodontal marker pathogens</term><term>Periodontal pathogens</term><term>Periodontal pathogens threshold</term><term>Periodontal treatment</term><term>Periodontally</term><term>Periodontitis</term><term>Periodontol</term><term>Porphyromonas</term><term>Porphyromonas gingivalis</term><term>Prevotella intermedia</term><term>Putative</term><term>Rectus</term><term>Subgingival</term><term>Tannerella forsythia</term><term>Teeth implant</term><term>Threshold levels</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Meijndert L, van der Reijden WA, Raghoebar GM, Meijer HJA, Vissink A. Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant? Eur J Oral Sci 2010; 118: 357–363. © 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci This study aimed to assess the prevalence of seven periodontal marker pathogens, before implant placement and 1 yr after loading, in periodontally healthy individuals and to assess the long‐term effectiveness of pre‐implant reduction of pathogens to below threshold levels. In 93 individuals needing single tooth replacement, pooled subgingival microbiological samples from standard sites were cultured and analyzed before implant treatment and 1 yr after loading. Threshold levels commonly used in periodontology to predict periodontal breakdown were applied. Subjects with levels of pathogens above these thresholds received initial periodontal treatment including systemic antibiotics when indicated. At baseline, 49.5% of periodontally healthy subjects harboured one or more marker pathogens above threshold levels. Periodontal treatment reduced the pathogen levels below threshold values in 78.3% of these initially colonized subjects. In all cases Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis were reduced to below threshold. At 1 yr after loading, periodontal pathogens were present above threshold levels in 74.1% of all subjects. It is concluded that in almost half of periodontal healthy individuals the subgingival biofilm harbours periodontal pathogens above threshold values. Long‐term effectiveness of pre‐implant reduction of the selected marker pathogens appeared limited in our patient population, making pre‐implant reduction unpredictive for post‐implant levels of these pathogens. Thus, considering the applied microbiological criteria, generalized pre‐implant microbiological testing is not contributory in periodontally healthy subjects.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>pathogen</json:string><json:string>periodontal</json:string><json:string>implant</json:string><json:string>gingivalis</json:string><json:string>actinomycetemcomitans</json:string><json:string>clin</json:string><json:string>periodontal pathogens</json:string><json:string>subgingival</json:string><json:string>threshold levels</json:string><json:string>colonization</json:string><json:string>periodontally</json:string><json:string>periodontol</json:string><json:string>microbiota</json:string><json:string>microbiological</json:string><json:string>baseline</json:string><json:string>nucleatum</json:string><json:string>micros</json:string><json:string>periodontitis</json:string><json:string>putative</json:string><json:string>porphyromonas</json:string><json:string>clin periodontol</json:string><json:string>forsythia</json:string><json:string>porphyromonas gingivalis</json:string><json:string>intermedia</json:string><json:string>dental implants</json:string><json:string>groningen</json:string><json:string>rectus</json:string><json:string>periodontal disease</json:string><json:string>periodontal pathogens threshold</json:string><json:string>microbiol</json:string><json:string>maxillofacial</json:string><json:string>bacteroides</json:string><json:string>periodontal marker pathogens</json:string><json:string>edentulous patients</json:string><json:string>functional loading</json:string><json:string>detectable levels</json:string><json:string>prevotella intermedia</json:string><json:string>fusobacterium nucleatum</json:string><json:string>tannerella forsythia</json:string><json:string>campylobacter rectus</json:string><json:string>maxillofacial surgery</json:string><json:string>teeth implant</json:string><json:string>peptostreptococcus micros</json:string><json:string>periodontal intervention</json:string><json:string>microorganism</json:string><json:string>edentulous</json:string><json:string>center groningen</json:string><json:string>microbiological criteria</json:string><json:string>pathogen levels</json:string><json:string>aggregatibacter actinomycetemcomitans</json:string><json:string>implant placement</json:string><json:string>microbiological testing</json:string><json:string>actinobacillus actinomycetemcomitans</json:string><json:string>bacteroides forsythus</json:string><json:string>periodontal treatment</json:string></teeft></keywords><author><json:item><name>Leo Meijndert</name><affiliations><json:string>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string><json:string>Department of Oral and Maxillofacial Surgery, Nij Smellinghe Christian Hospital, Drachten, the Netherlands</json:string></affiliations></json:item><json:item><name>Wil A. Van Der Reijden</name><affiliations><json:string>Department of Oral Microbiology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit, Amsterdam, the Netherlands</json:string></affiliations></json:item><json:item><name>Gerry M. Raghoebar</name><affiliations><json:string>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string></affiliations></json:item><json:item><name>Henny J. A. Meijer</name><affiliations><json:string>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string><json:string>Department of Oral Function, Dental School, Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string></affiliations></json:item><json:item><name>Arjan Vissink</name><affiliations><json:string>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>bacterial colonization</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dental implants</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>microbiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>periodontal health</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>periodontal pathogens</value></json:item></subject><articleId><json:string>EOS750</json:string></articleId><arkIstex>ark:/67375/WNG-9XMX0G83-V</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Meijndert L, van der Reijden WA, Raghoebar GM, Meijer HJA, Vissink A. Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant? Eur J Oral Sci 2010; 118: 357–363. © 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci This study aimed to assess the prevalence of seven periodontal marker pathogens, before implant placement and 1 yr after loading, in periodontally healthy individuals and to assess the long‐term effectiveness of pre‐implant reduction of pathogens to below threshold levels. In 93 individuals needing single tooth replacement, pooled subgingival microbiological samples from standard sites were cultured and analyzed before implant treatment and 1 yr after loading. Threshold levels commonly used in periodontology to predict periodontal breakdown were applied. Subjects with levels of pathogens above these thresholds received initial periodontal treatment including systemic antibiotics when indicated. At baseline, 49.5% of periodontally healthy subjects harboured one or more marker pathogens above threshold levels. Periodontal treatment reduced the pathogen levels below threshold values in 78.3% of these initially colonized subjects. In all cases Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis were reduced to below threshold. At 1 yr after loading, periodontal pathogens were present above threshold levels in 74.1% of all subjects. It is concluded that in almost half of periodontal healthy individuals the subgingival biofilm harbours periodontal pathogens above threshold values. Long‐term effectiveness of pre‐implant reduction of the selected marker pathogens appeared limited in our patient population, making pre‐implant reduction unpredictive for post‐implant levels of these pathogens. Thus, considering the applied microbiological criteria, generalized pre‐implant microbiological testing is not contributory in periodontally healthy subjects.</abstract><qualityIndicators><score>9.953</score><pdfWordCount>4953</pdfWordCount><pdfCharCount>33606</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>595.276 x 799.37 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>264</abstractWordCount><abstractCharCount>1998</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant?</title><pmid><json:string>20662908</json:string></pmid><genre><json:string>article</json:string></genre><host><title>European Journal of Oral Sciences</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0722</json:string></doi><issn><json:string>0909-8836</json:string></issn><eissn><json:string>1600-0722</json:string></eissn><publisherId><json:string>EOS</json:string></publisherId><volume>118</volume><issue>4</issue><pages><first>357</first><last>363</last><total>7</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1999</json:string><json:string>2010</json:string></date><geogName></geogName><orgName><json:string>Department of Oral Function, Dental School, Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string><json:string>University of Groningen</json:string><json:string>University Medical Center Groningen</json:string><json:string>Netherlands Telefax</json:string><json:string>Department of Oral and Maxillofacial Surgery</json:string><json:string>Department of Oral Microbiology, Academic Centre for Dentistry Amsterdam, University of Amsterdam</json:string><json:string>Central Committee on Research</json:string><json:string>Nij Smellinghe Christian Hospital, Drachten, the Netherlands</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Prosthetics</json:string><json:string>La Balme</json:string><json:string>A. van der Reijden</json:string><json:string>J. 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Journal compilation © 2010 Eur J Oral Sci</licence></availability><date type="published" when="2010-08"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant?</title><title level="a" type="short">Microbiota of teeth and dental implants</title><author xml:id="author-0000"><persName><forename type="first">Leo</forename><surname>Meijndert</surname></persName><affiliation>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands<address><country key="NL"></country></address></affiliation><affiliation>Department of Oral and Maxillofacial Surgery, Nij Smellinghe Christian Hospital, Drachten, the Netherlands<address><country key="NL"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Wil A.</forename><surname>Van Der Reijden</surname></persName><affiliation>Department of Oral Microbiology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit, Amsterdam, the Netherlands<address><country key="NL"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Gerry M.</forename><surname>Raghoebar</surname></persName><affiliation>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands<address><country key="NL"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Henny J. A.</forename><surname>Meijer</surname></persName><affiliation>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands<address><country key="NL"></country></address></affiliation><affiliation>Department of Oral Function, Dental School, Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands<address><country key="NL"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Arjan</forename><surname>Vissink</surname></persName><affiliation>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands<address><country key="NL"></country></address></affiliation></author><idno type="istex">E60ACA679388C452C524B889BCB44AF044B3D507</idno><idno type="ark">ark:/67375/WNG-9XMX0G83-V</idno><idno type="DOI">10.1111/j.1600-0722.2010.00750.x</idno><idno type="unit">EOS750</idno><idno type="toTypesetVersion">file:EOS.EOS750.pdf</idno></analytic><monogr><title level="j" type="main">European Journal of Oral Sciences</title><title level="j" type="alt">EUROPEAN JOURNAL OF ORAL SCIENCES</title><idno type="pISSN">0909-8836</idno><idno type="eISSN">1600-0722</idno><idno type="book-DOI">10.1111/(ISSN)1600-0722</idno><idno type="book-part-DOI">10.1111/eos.2010.118.issue-4</idno><idno type="product">EOS</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">118</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="357">357</biblScope><biblScope unit="page" to="363">363</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-08"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>
<hi rend="italic">Meijndert L, van der Reijden WA, Raghoebar GM, Meijer HJA, Vissink A. Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant? Eur J Oral Sci 2010; 118: 357–363. © 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci</hi>
</p><p>This study aimed to assess the prevalence of seven periodontal marker pathogens, before implant placement and 1 yr after loading, in periodontally healthy individuals and to assess the long‐term effectiveness of pre‐implant reduction of pathogens to below threshold levels. In 93 individuals needing single tooth replacement, pooled subgingival microbiological samples from standard sites were cultured and analyzed before implant treatment and 1 yr after loading. Threshold levels commonly used in periodontology to predict periodontal breakdown were applied. Subjects with levels of pathogens above these thresholds received initial periodontal treatment including systemic antibiotics when indicated. At baseline, 49.5% of periodontally healthy subjects harboured one or more marker pathogens above threshold levels. Periodontal treatment reduced the pathogen levels below threshold values in 78.3% of these initially colonized subjects. In all cases <hi rend="italic">Aggregatibacter actinomycetemcomitans</hi> and <hi rend="italic">Porphyromonas gingivalis</hi> were reduced to below threshold. At 1 yr after loading, periodontal pathogens were present above threshold levels in 74.1% of all subjects. It is concluded that in almost half of periodontal healthy individuals the subgingival biofilm harbours periodontal pathogens above threshold values. Long‐term effectiveness of pre‐implant reduction of the selected marker pathogens appeared limited in our patient population, making pre‐implant reduction unpredictive for post‐implant levels of these pathogens. Thus, considering the applied microbiological criteria, generalized pre‐implant microbiological testing is not contributory in periodontally healthy subjects.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">bacterial colonization</term><term xml:id="k2">dental implants</term><term xml:id="k3">microbiology</term><term xml:id="k4">periodontal health</term><term xml:id="k5">periodontal pathogens</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/E60ACA679388C452C524B889BCB44AF044B3D507/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0722</doi><issn type="print">0909-8836</issn><issn type="electronic">1600-0722</issn><idGroup><id type="product" value="EOS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF ORAL SCIENCES">European Journal of Oral Sciences</title></titleGroup></publicationMeta><publicationMeta level="part" position="08004"><doi origin="wiley">10.1111/eos.2010.118.issue-4</doi><numberingGroup><numbering type="journalVolume" number="118">118</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2010-08">August 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="6" status="forIssue"><doi origin="wiley">10.1111/j.1600-0722.2010.00750.x</doi><idGroup><id type="unit" value="EOS750"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.12 mode:FullText" date="2010-07-12"></event><event type="firstOnline" date="2010-07-12"></event><event type="publishedOnlineFinalForm" date="2010-07-12"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="357">357</numbering><numbering type="pageLast" number="363">363</numbering></numberingGroup><correspondenceTo>Dr Leo Meijndert, DMD, PhD, Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands
Telefax: +31–50–3611136
E‐mail: <email>l.meijndert@planet.nl</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:EOS.EOS750.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication April 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant?</title><title type="shortAuthors"><i>Meijndert</i> et al.</title><title type="short"><i>Microbiota of teeth and dental implants</i></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>Leo</givenNames><familyName>Meijndert</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a3"><personName><givenNames>Wil A.</givenNames><familyName>Van Der Reijden</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Gerry M.</givenNames><familyName>Raghoebar</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1 #a4"><personName><givenNames>Henny J. A.</givenNames><familyName>Meijer</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Arjan</givenNames><familyName>Vissink</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="NL"><unparsedAffiliation>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="NL"><unparsedAffiliation>Department of Oral and Maxillofacial Surgery, Nij Smellinghe Christian Hospital, Drachten, the Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="NL"><unparsedAffiliation>Department of Oral Microbiology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit, Amsterdam, the Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="NL"><unparsedAffiliation>Department of Oral Function, Dental School, Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">bacterial colonization</keyword><keyword xml:id="k2">dental implants</keyword><keyword xml:id="k3">microbiology</keyword><keyword xml:id="k4">periodontal health</keyword><keyword xml:id="k5">periodontal pathogens</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p> <i>Meijndert L, van der Reijden WA, Raghoebar GM, Meijer HJA, Vissink A. Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant? Eur J Oral Sci 2010; 118: 357–363. © 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci</i> </p><p>This study aimed to assess the prevalence of seven periodontal marker pathogens, before implant placement and 1 yr after loading, in periodontally healthy individuals and to assess the long‐term effectiveness of pre‐implant reduction of pathogens to below threshold levels. In 93 individuals needing single tooth replacement, pooled subgingival microbiological samples from standard sites were cultured and analyzed before implant treatment and 1 yr after loading. Threshold levels commonly used in periodontology to predict periodontal breakdown were applied. Subjects with levels of pathogens above these thresholds received initial periodontal treatment including systemic antibiotics when indicated. At baseline, 49.5% of periodontally healthy subjects harboured one or more marker pathogens above threshold levels. Periodontal treatment reduced the pathogen levels below threshold values in 78.3% of these initially colonized subjects. In all cases <i>Aggregatibacter actinomycetemcomitans</i> and <i>Porphyromonas gingivalis</i> were reduced to below threshold. At 1 yr after loading, periodontal pathogens were present above threshold levels in 74.1% of all subjects. It is concluded that in almost half of periodontal healthy individuals the subgingival biofilm harbours periodontal pathogens above threshold values. Long‐term effectiveness of pre‐implant reduction of the selected marker pathogens appeared limited in our patient population, making pre‐implant reduction unpredictive for post‐implant levels of these pathogens. Thus, considering the applied microbiological criteria, generalized pre‐implant microbiological testing is not contributory in periodontally healthy subjects.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant?</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Microbiota of teeth and dental implants</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant?</title></titleInfo><name type="personal"><namePart type="given">Leo</namePart><namePart type="family">Meijndert</namePart><affiliation>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><affiliation>Department of Oral and Maxillofacial Surgery, Nij Smellinghe Christian Hospital, Drachten, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wil A.</namePart><namePart type="family">Van Der Reijden</namePart><affiliation>Department of Oral Microbiology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit, Amsterdam, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gerry M.</namePart><namePart type="family">Raghoebar</namePart><affiliation>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Henny J. A.</namePart><namePart type="family">Meijer</namePart><affiliation>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><affiliation>Department of Oral Function, Dental School, Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arjan</namePart><namePart type="family">Vissink</namePart><affiliation>Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-08</dateIssued><edition>Accepted for publication April 2010</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">4</extent></physicalDescription><abstract lang="en">Meijndert L, van der Reijden WA, Raghoebar GM, Meijer HJA, Vissink A. Microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre‐implant microbiological testing relevant? Eur J Oral Sci 2010; 118: 357–363. © 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci This study aimed to assess the prevalence of seven periodontal marker pathogens, before implant placement and 1 yr after loading, in periodontally healthy individuals and to assess the long‐term effectiveness of pre‐implant reduction of pathogens to below threshold levels. In 93 individuals needing single tooth replacement, pooled subgingival microbiological samples from standard sites were cultured and analyzed before implant treatment and 1 yr after loading. Threshold levels commonly used in periodontology to predict periodontal breakdown were applied. Subjects with levels of pathogens above these thresholds received initial periodontal treatment including systemic antibiotics when indicated. At baseline, 49.5% of periodontally healthy subjects harboured one or more marker pathogens above threshold levels. Periodontal treatment reduced the pathogen levels below threshold values in 78.3% of these initially colonized subjects. In all cases Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis were reduced to below threshold. At 1 yr after loading, periodontal pathogens were present above threshold levels in 74.1% of all subjects. It is concluded that in almost half of periodontal healthy individuals the subgingival biofilm harbours periodontal pathogens above threshold values. Long‐term effectiveness of pre‐implant reduction of the selected marker pathogens appeared limited in our patient population, making pre‐implant reduction unpredictive for post‐implant levels of these pathogens. Thus, considering the applied microbiological criteria, generalized pre‐implant microbiological testing is not contributory in periodontally healthy subjects.</abstract><subject lang="en"><genre>keywords</genre><topic>bacterial colonization</topic><topic>dental implants</topic><topic>microbiology</topic><topic>periodontal health</topic><topic>periodontal pathogens</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Oral Sciences</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0909-8836</identifier><identifier type="eISSN">1600-0722</identifier><identifier type="DOI">10.1111/(ISSN)1600-0722</identifier><identifier type="PublisherID">EOS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>118</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>357</start><end>363</end><total>7</total></extent></part></relatedItem><identifier type="istex">E60ACA679388C452C524B889BCB44AF044B3D507</identifier><identifier type="ark">ark:/67375/WNG-9XMX0G83-V</identifier><identifier type="DOI">10.1111/j.1600-0722.2010.00750.x</identifier><identifier type="ArticleID">EOS750</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 The Authors. 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