Clinical and functional prediction of moderate to severe obstructive sleep apnoea
Identifieur interne : 007026 ( Istex/Corpus ); précédent : 007025; suivant : 007027Clinical and functional prediction of moderate to severe obstructive sleep apnoea
Auteurs : Caterina Bucca ; Luisa Brussino ; Milena Maria Maule ; Ileana Baldi ; Giuseppe Guida ; Beatrice Culla ; Franco Merletti ; Antonio Foresi ; Giovanni Rolla ; Roberto Mutani ; Alessandro CicolinSource :
- The Clinical Respiratory Journal [ 1752-6981 ] ; 2011-10.
English descriptors
- KwdEn :
- Ahisq, Airway, American academy, American thoracic society, Apnea, Apnea syndrome, Apnoea, Arterial blood, Arterial desaturation, Blackwell publishing, Body mass index, Breath condensate, Breathing disorders, Bucca, Calibration graph, Carbon dioxide, Carboxyhaemoglobin percent saturation, Chapman hall, Clinical examination, Clinical information, Cohb, Concordance index, Cubic spline, Daytime sleepiness, Diastolic heart failure, Elective treatment, Expiratory volume, Feno, Functional prediction, Hydrogen peroxide, Hypopnoea index, Information theory, Inspiratory, Interaction term, Interpretative strategies, Issn, Linear regression model, Lung function tests, Maximum inspiratory pressure, Moderate amount, Nadir oxyhaemoglobin saturation, Neck circumference, Nitric, Nitric oxide, Nomogram, Nonlinear effect, Obese patients, Obstructive, Overnight polysomnography, Oxide, Peak expiratory, Relative weight, Respir, Respir crit care, Respiratory journal, Respiratory muscle testing, Screening test, Statistical analysis, Torino, Total points, Upper airway, Upper airway obstruction, Validation indices, Vital capacity.
- Teeft :
- Ahisq, Airway, American academy, American thoracic society, Apnea, Apnea syndrome, Apnoea, Arterial blood, Arterial desaturation, Blackwell publishing, Body mass index, Breath condensate, Breathing disorders, Bucca, Calibration graph, Carbon dioxide, Carboxyhaemoglobin percent saturation, Chapman hall, Clinical examination, Clinical information, Cohb, Concordance index, Cubic spline, Daytime sleepiness, Diastolic heart failure, Elective treatment, Expiratory volume, Feno, Functional prediction, Hydrogen peroxide, Hypopnoea index, Information theory, Inspiratory, Interaction term, Interpretative strategies, Issn, Linear regression model, Lung function tests, Maximum inspiratory pressure, Moderate amount, Nadir oxyhaemoglobin saturation, Neck circumference, Nitric, Nitric oxide, Nomogram, Nonlinear effect, Obese patients, Obstructive, Overnight polysomnography, Oxide, Peak expiratory, Relative weight, Respir, Respir crit care, Respiratory journal, Respiratory muscle testing, Screening test, Statistical analysis, Torino, Total points, Upper airway, Upper airway obstruction, Validation indices, Vital capacity.
Abstract
Introduction: Upper airway inflammation and narrowing are characteristics of obstructive sleep apnoea (OSA). Inflammatory markers have been found to be increased in exhaled breath and induced sputum of patients with OSA.
Url:
DOI: 10.1111/j.1752-699X.2010.00223.x
Links to Exploration step
ISTEX:E1D9BAF2361A029ACA6C87C0623964A9D13DECF9Le document en format XML
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effect</json:string><json:string>concordance index</json:string><json:string>american thoracic society</json:string><json:string>hypopnoea index</json:string><json:string>arterial desaturation</json:string><json:string>clinical information</json:string><json:string>linear regression model</json:string><json:string>validation indices</json:string><json:string>diastolic heart failure</json:string><json:string>moderate amount</json:string><json:string>calibration graph</json:string><json:string>breathing disorders</json:string><json:string>relative weight</json:string><json:string>elective treatment</json:string><json:string>screening test</json:string><json:string>obese patients</json:string><json:string>daytime sleepiness</json:string><json:string>apnea syndrome</json:string><json:string>chapman hall</json:string><json:string>nadir oxyhaemoglobin saturation</json:string><json:string>torino</json:string></teeft></keywords><author><json:item><name>Caterina Bucca</name><affiliations><json:string>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</json:string><json:string>E-mail: caterina.bucca@unito.it</json:string></affiliations></json:item><json:item><name>Luisa Brussino</name><affiliations><json:string>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</json:string></affiliations></json:item><json:item><name>Milena Maria Maule</name><affiliations><json:string>Unità di Epidemiologia dei Tumori, CPO Piemonte, CeRMS, Università di Torino, Torino, Italia</json:string></affiliations></json:item><json:item><name>Ileana Baldi</name><affiliations><json:string>Unità di Epidemiologia dei Tumori, CPO Piemonte, CeRMS, Università di Torino, Torino, Italia</json:string></affiliations></json:item><json:item><name>Giuseppe Guida</name><affiliations><json:string>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</json:string></affiliations></json:item><json:item><name>Beatrice Culla</name><affiliations><json:string>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</json:string></affiliations></json:item><json:item><name>Franco Merletti</name><affiliations><json:string>Unità di Epidemiologia dei Tumori, CPO Piemonte, CeRMS, Università di Torino, Torino, Italia</json:string></affiliations></json:item><json:item><name>Antonio Foresi</name><affiliations><json:string>Unità Respiratoria, Sesto San Giovanni Hospital, Sesto San Giovanni, Italia</json:string></affiliations></json:item><json:item><name>Giovanni Rolla</name><affiliations><json:string>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</json:string></affiliations></json:item><json:item><name>Roberto Mutani</name><affiliations><json:string>Centro di Medicina del Sonno, Dipartimento di Neuroscienze, Università di Torino, Torino, Italia</json:string></affiliations></json:item><json:item><name>Alessandro Cicolin</name><affiliations><json:string>Centro di Medicina del Sonno, Dipartimento di Neuroscienze, Università di Torino, Torino, Italia</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>BMI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>exhaled nitric oxide</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>inspiratory flow–volume curve</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>nomogram</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>obstructive sleep apnoea</value></json:item></subject><articleId><json:string>CRJ223</json:string></articleId><arkIstex>ark:/67375/WNG-MDVJTX77-9</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Introduction: Upper airway inflammation and narrowing are characteristics of obstructive sleep apnoea (OSA). Inflammatory markers have been found to be increased in exhaled breath and induced sputum of patients with OSA.</abstract><qualityIndicators><score>6.578</score><pdfWordCount>4206</pdfWordCount><pdfCharCount>27520</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>31</abstractWordCount><abstractCharCount>221</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Clinical and functional prediction of moderate to severe obstructive sleep apnoea</title><pmid><json:string>21801324</json:string></pmid><genre><json:string>article</json:string></genre><host><title>The Clinical Respiratory Journal</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1752-699X</json:string></doi><issn><json:string>1752-6981</json:string></issn><eissn><json:string>1752-699X</json:string></eissn><publisherId><json:string>CRJ</json:string></publisherId><volume>5</volume><issue>4</issue><pages><first>219</first><last>226</last><total>8</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2011</json:string><json:string>between January 2004 and December 2005</json:string></date><geogName></geogName><orgName><json:string>R Development Core Team</json:string><json:string>American Thoracic Society/European Respiratory Society Statement</json:string><json:string>American Academy of Sleep medicine Task Force</json:string><json:string>Boulder, CO</json:string><json:string>Medical Inc.</json:string><json:string>American Academy of Sleep Medicine</json:string><json:string>Sesto San Giovanni Hospital, Sesto San Giovanni, Italia</json:string><json:string>Blackwell Publishing Ltd</json:string><json:string>American Thoracic Society</json:string><json:string>Department of Clinical Pathophysiology, Università</json:string><json:string>Università</json:string><json:string>Micro Medical Ltd, Rochester</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>A. Clinical</json:string><json:string>Ileana Baldi</json:string><json:string>Antonio Foresi</json:string><json:string>E. Fattori</json:string><json:string>Giuseppe Guida</json:string><json:string>Luisa Brussino</json:string><json:string>Via Genova</json:string><json:string>E. Saracco</json:string><json:string>Milena Maria</json:string><json:string>Caterina Bucca</json:string><json:string>E. Chiarot</json:string><json:string>A. Ferraiolo</json:string><json:string>A. Robert</json:string><json:string>Giordano E. Peila</json:string><json:string>A. Terreni</json:string><json:string>A. Tribolo</json:string><json:string>Roberto Mutani</json:string><json:string>C. Collino</json:string><json:string>Giovanni Rolla</json:string><json:string>Beatrice Culla</json:string><json:string>Alessandro Cicolin</json:string><json:string>Via Lamarmora</json:string><json:string>M. Rosso</json:string></persName><placeName><json:string>UK</json:string><json:string>Denmark</json:string><json:string>Copenhagen</json:string><json:string>Italy</json:string><json:string>Warwick</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Bucca et al.</json:string><json:string>Herer et al.</json:string><json:string>Foresi et al.</json:string><json:string>Kashyap et al.</json:string><json:string>Katz et al.</json:string><json:string>Pellegrino et al.</json:string><json:string>Depalo et al.</json:string><json:string>Stauffer et al.</json:string><json:string>Rowley et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-MDVJTX77-9</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - respiratory system</json:string></wos><scienceMetrix></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Genetics(clinical)</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Pulmonary and Respiratory Medicine</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1111/j.1752-699X.2010.00223.x</json:string></doi><id>E1D9BAF2361A029ACA6C87C0623964A9D13DECF9</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/E1D9BAF2361A029ACA6C87C0623964A9D13DECF9/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/E1D9BAF2361A029ACA6C87C0623964A9D13DECF9/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/E1D9BAF2361A029ACA6C87C0623964A9D13DECF9/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Clinical and functional prediction of moderate to severe obstructive sleep apnoea</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2010 Blackwell Publishing Ltd</licence></availability><date type="published" when="2011-10"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Clinical and functional prediction of moderate to severe obstructive sleep apnoea</title><title level="a" type="short">Clinical and functional prediction of OSA</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Caterina</forename><surname>Bucca</surname></persName><affiliation>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</affiliation><affiliation>Caterina Bucca, MD, Department of Clinical Pathophysiology, Università di Torino, Via Genova 3 – 10126 Torino, Abitazione: Via Lamarmora 41, 10128 Turin, Italy. Tel: +39 011 633 6748, Fax: +39 011 663 7238, email: caterina.bucca@unito.it</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Luisa</forename><surname>Brussino</surname></persName><affiliation>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Milena Maria</forename><surname>Maule</surname></persName><affiliation>Unità di Epidemiologia dei Tumori, CPO Piemonte, CeRMS, Università di Torino, Torino, Italia</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Ileana</forename><surname>Baldi</surname></persName><affiliation>Unità di Epidemiologia dei Tumori, CPO Piemonte, CeRMS, Università di Torino, Torino, Italia</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Giuseppe</forename><surname>Guida</surname></persName><affiliation>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Beatrice</forename><surname>Culla</surname></persName><affiliation>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</affiliation></author><author xml:id="author-0006"><persName><forename type="first">Franco</forename><surname>Merletti</surname></persName><affiliation>Unità di Epidemiologia dei Tumori, CPO Piemonte, CeRMS, Università di Torino, Torino, Italia</affiliation></author><author xml:id="author-0007"><persName><forename type="first">Antonio</forename><surname>Foresi</surname></persName><affiliation>Unità Respiratoria, Sesto San Giovanni Hospital, Sesto San Giovanni, Italia</affiliation></author><author xml:id="author-0008"><persName><forename type="first">Giovanni</forename><surname>Rolla</surname></persName><affiliation>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</affiliation></author><author xml:id="author-0009"><persName><forename type="first">Roberto</forename><surname>Mutani</surname></persName><affiliation>Centro di Medicina del Sonno, Dipartimento di Neuroscienze, Università di Torino, Torino, Italia</affiliation></author><author xml:id="author-0010"><persName><forename type="first">Alessandro</forename><surname>Cicolin</surname></persName><affiliation>Centro di Medicina del Sonno, Dipartimento di Neuroscienze, Università di Torino, Torino, Italia</affiliation></author><idno type="istex">E1D9BAF2361A029ACA6C87C0623964A9D13DECF9</idno><idno type="ark">ark:/67375/WNG-MDVJTX77-9</idno><idno type="DOI">10.1111/j.1752-699X.2010.00223.x</idno><idno type="unit">CRJ223</idno><idno type="toTypesetVersion">file:CRJ.CRJ223.pdf</idno></analytic><monogr><title level="j" type="main">The Clinical Respiratory Journal</title><title level="j" type="alt">CLINICAL RESPIRATORY JOURNAL</title><idno type="pISSN">1752-6981</idno><idno type="eISSN">1752-699X</idno><idno type="book-DOI">10.1111/(ISSN)1752-699X</idno><idno type="book-part-DOI">10.1111/crj.2011.5.issue-4</idno><idno type="product">CRJ</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">5</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="219">219</biblScope><biblScope unit="page" to="226">226</biblScope><biblScope unit="page-count">8</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-10"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p><hi rend="bold">Introduction: </hi> Upper airway inflammation and narrowing are characteristics of obstructive sleep apnoea (OSA). Inflammatory markers have been found to be increased in exhaled breath and induced sputum of patients with OSA.</p><p><hi rend="bold">Objectives: </hi> The aim of this study was to investigate if the measurement of exhaled nitric oxide (F<hi rend="subscript">ENO</hi>), as marker of airway inflammation, together with the forced mid‐expiratory/mid‐inspiratory airflow ratio (FEF<hi rend="subscript">50</hi>/FIF<hi rend="subscript">50</hi>), as marker of upper airway narrowing, may help to predict OSA.</p><p><hi rend="bold">Methods: </hi> Two hundred one consecutive outpatients with suspected OSA were prospectively studied between January 2004 and December 2005. All patients underwent clinical examination, spirometry with measurement of FEF<hi rend="subscript">50</hi>/FIF<hi rend="subscript">50</hi>, maximum inspiratory pressure, arterial blood gas analysis, exhaled nitric oxide (F<hi rend="subscript">ENO</hi>) and overnight polysomnography. Linear regression models were used to evaluate the effect of measured variables on the apnoea–hypopnoea index (AHI). Models were cross‐validated by bootstrapping.</p><p><hi rend="bold">Results: </hi> Most of the patients were obese and had severe OSA. FEF<hi rend="subscript">50</hi>/FIF<hi rend="subscript">50</hi>, F<hi rend="subscript">ENO</hi> and an interaction term between smoking and F<hi rend="subscript">ENO</hi> contributed significantly to the predictive model for AHI, in addition to age, neck circumference, body mass index and carboxyhaemoglobin saturation. A nomogram to predict AHI was obtained, which converted the effect of each covariate in the model to a 0–100 scale. The nomogram showed a good predictive ability for AHI values between 25 and 64.</p><p><hi rend="bold">Conclusions: </hi> The measurement of F<hi rend="subscript">ENO</hi> and of FEF<hi rend="subscript">50</hi>/FIF<hi rend="subscript">50</hi> improves the ability to predict OSA and may be used to identify patients who require a sleep study.</p><p>Please cite this paper as: Bucca C, Brussino L, Maule MM, Baldi I, Guida G, Culla B, Merletti F, Foresi A, Rolla G, Mutani R and Cicolin A. Clinical and functional prediction of moderate to severe obstructive sleep apnoea. <hi rend="italic">Clin Respir J</hi> 2011; 5: 219–226.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">BMI</term><term xml:id="k2">exhaled nitric oxide</term><term xml:id="k3">inspiratory flow–volume curve</term><term xml:id="k4">nomogram</term><term xml:id="k5">obstructive sleep apnoea</term></keywords><keywords rend="tocHeading1"><term>ORIGINAL ARTICLES</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/E1D9BAF2361A029ACA6C87C0623964A9D13DECF9/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1752-699X</doi><issn type="print">1752-6981</issn><issn type="electronic">1752-699X</issn><idGroup><id type="product" value="CRJ"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="CLINICAL RESPIRATORY JOURNAL">The Clinical Respiratory Journal</title></titleGroup></publicationMeta><publicationMeta level="part" position="10104"><doi origin="wiley">10.1111/crj.2011.5.issue-4</doi><numberingGroup><numbering type="journalVolume" number="5">5</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2011-10">October 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="6" status="forIssue"><doi origin="wiley">10.1111/j.1752-699X.2010.00223.x</doi><idGroup><id type="unit" value="CRJ223"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">ORIGINAL ARTICLES</title></titleGroup><copyright>© 2010 Blackwell Publishing Ltd</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.10 mode:FullText" date="2011-09-19"></event><event type="publishedOnlineEarlyUnpaginated" date="2010-09-22"></event><event type="firstOnline" date="2010-09-22"></event><event type="publishedOnlineFinalForm" date="2011-09-19"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-16"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="219">219</numbering><numbering type="pageLast" number="226">226</numbering></numberingGroup><correspondenceTo>Caterina Bucca, MD, Department of Clinical Pathophysiology, Università di Torino, Via Genova 3 – 10126 Torino, Abitazione: Via Lamarmora 41, 10128 Turin, Italy. Tel: +39 011 633 6748, Fax: +39 011 663 7238, email: <email>caterina.bucca@unito.it</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CRJ.CRJ223.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received: 25 January 2010; Revision requested: 05 July 2010; Accepted: 22 August 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="38"></count><count type="wordTotal" number="4687"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Clinical and functional prediction of moderate to severe obstructive sleep apnoea</title><title type="shortAuthors">Bucca <i>et al</i>.</title><title type="short">Clinical and functional prediction of OSA</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Caterina</givenNames><familyName>Bucca</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Luisa</givenNames><familyName>Brussino</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>Milena Maria</givenNames><familyName>Maule</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>Ileana</givenNames><familyName>Baldi</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Giuseppe</givenNames><familyName>Guida</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>Beatrice</givenNames><familyName>Culla</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a2"><personName><givenNames>Franco</givenNames><familyName>Merletti</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a3"><personName><givenNames>Antonio</givenNames><familyName>Foresi</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a1"><personName><givenNames>Giovanni</givenNames><familyName>Rolla</familyName></personName></creator><creator creatorRole="author" xml:id="cr10" affiliationRef="#a4"><personName><givenNames>Roberto</givenNames><familyName>Mutani</familyName></personName></creator><creator creatorRole="author" xml:id="cr11" affiliationRef="#a4"><personName><givenNames>Alessandro</givenNames><familyName>Cicolin</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Unità di Epidemiologia dei Tumori, CPO Piemonte, CeRMS, Università di Torino, Torino, Italia</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>Unità Respiratoria, Sesto San Giovanni Hospital, Sesto San Giovanni, Italia</unparsedAffiliation></affiliation><affiliation xml:id="a4"><unparsedAffiliation>Centro di Medicina del Sonno, Dipartimento di Neuroscienze, Università di Torino, Torino, Italia</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">BMI</keyword><keyword xml:id="k2">exhaled nitric oxide</keyword><keyword xml:id="k3">inspiratory flow–volume curve</keyword><keyword xml:id="k4">nomogram</keyword><keyword xml:id="k5">obstructive sleep apnoea</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><b>Introduction: </b> Upper airway inflammation and narrowing are characteristics of obstructive sleep apnoea (OSA). Inflammatory markers have been found to be increased in exhaled breath and induced sputum of patients with OSA.</p><p><b>Objectives: </b> The aim of this study was to investigate if the measurement of exhaled nitric oxide (F<sub>ENO</sub>), as marker of airway inflammation, together with the forced mid‐expiratory/mid‐inspiratory airflow ratio (FEF<sub>50</sub>/FIF<sub>50</sub>), as marker of upper airway narrowing, may help to predict OSA.</p><p><b>Methods: </b> Two hundred one consecutive outpatients with suspected OSA were prospectively studied between January 2004 and December 2005. All patients underwent clinical examination, spirometry with measurement of FEF<sub>50</sub>/FIF<sub>50</sub>, maximum inspiratory pressure, arterial blood gas analysis, exhaled nitric oxide (F<sub>ENO</sub>) and overnight polysomnography. Linear regression models were used to evaluate the effect of measured variables on the apnoea–hypopnoea index (AHI). Models were cross‐validated by bootstrapping.</p><p><b>Results: </b> Most of the patients were obese and had severe OSA. FEF<sub>50</sub>/FIF<sub>50</sub>, F<sub>ENO</sub> and an interaction term between smoking and F<sub>ENO</sub> contributed significantly to the predictive model for AHI, in addition to age, neck circumference, body mass index and carboxyhaemoglobin saturation. A nomogram to predict AHI was obtained, which converted the effect of each covariate in the model to a 0–100 scale. The nomogram showed a good predictive ability for AHI values between 25 and 64.</p><p><b>Conclusions: </b> The measurement of F<sub>ENO</sub> and of FEF<sub>50</sub>/FIF<sub>50</sub> improves the ability to predict OSA and may be used to identify patients who require a sleep study.</p><p>Please cite this paper as: Bucca C, Brussino L, Maule MM, Baldi I, Guida G, Culla B, Merletti F, Foresi A, Rolla G, Mutani R and Cicolin A. Clinical and functional prediction of moderate to severe obstructive sleep apnoea. <i>Clin Respir J</i> 2011; 5: 219–226.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Authorship</b>: Bucca, Brussino and Cicolin are principal investigators and wrote the report. Bucca, Cicolin, Foresi, Mutani and Rolla were responsible for data review and interpretation. Maule, Baldi and Merletti planned and performed the statistical analysis. Culla and Guida did the clinical examination. The OSA group performed patients' selection, sleep questionnaire and polysomnography. All authors have participated in planning the study and in interpretation of the results and have seen and approved the final version.</p></note><note xml:id="fn2"><p><b>Ethics</b>: The study was approved by the local ethics committee, and patients gave their informed consent to the study.</p></note><note xml:id="fn3"><p><b>Conflicts of interest</b>: The authors have stated explicitly that there are no conflicts of interest in connection with this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Clinical and functional prediction of moderate to severe obstructive sleep apnoea</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Clinical and functional prediction of OSA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Clinical and functional prediction of moderate to severe obstructive sleep apnoea</title></titleInfo><name type="personal"><namePart type="given">Caterina</namePart><namePart type="family">Bucca</namePart><affiliation>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</affiliation><affiliation>E-mail: caterina.bucca@unito.it</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luisa</namePart><namePart type="family">Brussino</namePart><affiliation>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Milena Maria</namePart><namePart type="family">Maule</namePart><affiliation>Unità di Epidemiologia dei Tumori, CPO Piemonte, CeRMS, Università di Torino, Torino, Italia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ileana</namePart><namePart type="family">Baldi</namePart><affiliation>Unità di Epidemiologia dei Tumori, CPO Piemonte, CeRMS, Università di Torino, Torino, Italia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giuseppe</namePart><namePart type="family">Guida</namePart><affiliation>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Beatrice</namePart><namePart type="family">Culla</namePart><affiliation>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Franco</namePart><namePart type="family">Merletti</namePart><affiliation>Unità di Epidemiologia dei Tumori, CPO Piemonte, CeRMS, Università di Torino, Torino, Italia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">Foresi</namePart><affiliation>Unità Respiratoria, Sesto San Giovanni Hospital, Sesto San Giovanni, Italia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Rolla</namePart><affiliation>Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Torino, Italia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Mutani</namePart><affiliation>Centro di Medicina del Sonno, Dipartimento di Neuroscienze, Università di Torino, Torino, Italia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alessandro</namePart><namePart type="family">Cicolin</namePart><affiliation>Centro di Medicina del Sonno, Dipartimento di Neuroscienze, Università di Torino, Torino, Italia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-10</dateIssued><edition>Received: 25 January 2010; Revision requested: 05 July 2010; Accepted: 22 August 2010</edition><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="formulas">0</extent><extent unit="references">38</extent><extent unit="linksCrossRef">0</extent><extent unit="words">4687</extent></physicalDescription><abstract>Introduction: Upper airway inflammation and narrowing are characteristics of obstructive sleep apnoea (OSA). Inflammatory markers have been found to be increased in exhaled breath and induced sputum of patients with OSA.</abstract><abstract>Objectives: The aim of this study was to investigate if the measurement of exhaled nitric oxide (FENO), as marker of airway inflammation, together with the forced mid‐expiratory/mid‐inspiratory airflow ratio (FEF50/FIF50), as marker of upper airway narrowing, may help to predict OSA.</abstract><abstract>Methods: Two hundred one consecutive outpatients with suspected OSA were prospectively studied between January 2004 and December 2005. All patients underwent clinical examination, spirometry with measurement of FEF50/FIF50, maximum inspiratory pressure, arterial blood gas analysis, exhaled nitric oxide (FENO) and overnight polysomnography. Linear regression models were used to evaluate the effect of measured variables on the apnoea–hypopnoea index (AHI). Models were cross‐validated by bootstrapping.</abstract><abstract>Results: Most of the patients were obese and had severe OSA. FEF50/FIF50, FENO and an interaction term between smoking and FENO contributed significantly to the predictive model for AHI, in addition to age, neck circumference, body mass index and carboxyhaemoglobin saturation. A nomogram to predict AHI was obtained, which converted the effect of each covariate in the model to a 0–100 scale. The nomogram showed a good predictive ability for AHI values between 25 and 64.</abstract><abstract>Conclusions: The measurement of FENO and of FEF50/FIF50 improves the ability to predict OSA and may be used to identify patients who require a sleep study.</abstract><abstract>Please cite this paper as: Bucca C, Brussino L, Maule MM, Baldi I, Guida G, Culla B, Merletti F, Foresi A, Rolla G, Mutani R and Cicolin A. Clinical and functional prediction of moderate to severe obstructive sleep apnoea. Clin Respir J 2011; 5: 219–226.</abstract><subject lang="en"><genre>keywords</genre><topic>BMI</topic><topic>exhaled nitric oxide</topic><topic>inspiratory flow–volume curve</topic><topic>nomogram</topic><topic>obstructive sleep apnoea</topic></subject><relatedItem type="host"><titleInfo><title>The Clinical Respiratory Journal</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1752-6981</identifier><identifier type="eISSN">1752-699X</identifier><identifier type="DOI">10.1111/(ISSN)1752-699X</identifier><identifier type="PublisherID">CRJ</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>219</start><end>226</end><total>8</total></extent></part></relatedItem><identifier type="istex">E1D9BAF2361A029ACA6C87C0623964A9D13DECF9</identifier><identifier type="ark">ark:/67375/WNG-MDVJTX77-9</identifier><identifier type="DOI">10.1111/j.1752-699X.2010.00223.x</identifier><identifier type="ArticleID">CRJ223</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 Blackwell Publishing Ltd</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/E1D9BAF2361A029ACA6C87C0623964A9D13DECF9/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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