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Reversibility of experimental peri‐implant mucositis compared with experimental gingivitis in humans

Identifieur interne : 006C07 ( Istex/Corpus ); précédent : 006C06; suivant : 006C08

Reversibility of experimental peri‐implant mucositis compared with experimental gingivitis in humans

Auteurs : Giovanni E. Salvi ; Marco Aglietta ; Sigrun Eick ; Anton Sculean ; Niklaus P. Lang ; Christoph A. Ramseier

Source :

RBID : ISTEX:D9EBE4D727B6D8B57D6A551FB16DDF4D544F415E

English descriptors

Abstract

Objective: To monitor clinical, microbiological and host‐derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis/mucositis and their respective healing sequence in humans.

Url:
DOI: 10.1111/j.1600-0501.2011.02220.x

Links to Exploration step

ISTEX:D9EBE4D727B6D8B57D6A551FB16DDF4D544F415E

Le document en format XML

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<p>
<hi rend="bold">Material and methods: </hi>
Fifteen subjects with healthy or treated periodontal conditions and restored with dental implants underwent an experimental 3‐week period of undisturbed plaque accumulation in the mandible. Subsequently, a 3‐week period with optimal plaque control was instituted. At Days 0, 7, 14, 21, 28, 35 and 42, the presence/absence of plaque deposits around teeth and implants was assessed, (plaque index [PlI]) and the gingival/mucosal conditions were evaluated (gingival index[GI]). Subgingival/submucosal plaque samples and gingival/mucosal crevicular fluid (CF) samples were collected from two pre‐determined sites around each experimental unit. CF samples were analyzed for matrix‐metalloproteinase‐8 (MMP‐8) and interleukin‐1beta (IL‐1β). Microbial samples were analyzed using DNA–DNA hybridization for 40 species.</p>
<p>
<hi rend="bold">Results: </hi>
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Peri‐implant soft tissues developed a stronger inflammatory response to experimental plaque accumulation when compared with that of their gingival counterparts. Experimental gingivitis and peri‐implant mucositis were reversible at the biomarker level. Clinically, however, 3 weeks of resumed plaque control did not yield pre‐experimental levels of gingival and peri‐implant mucosal health indicating that longer healing periods are needed.</p>
<p>
<hi rend="bold">To cite this article:</hi>

Salvi GE, Aglietta M, Eick S, Sculean A, Lang NP & Ramseier CA. Reversibility of experimental peri‐implant mucositis compared with experimental gingivitis in humans.

<hi rend="italic">Clin. Oral Impl. Res</hi>
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<hi rend="bold">23</hi>
, 2012; 182–190. 
doi: 10.1111/j.1600‐0501.2011.02220.x</p>
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Prof. Dr
<i>Giovanni E. Salvi</i>

Department of Periodontology
School of Dental Medicine
University of Bern
Freiburgstrasse 7
CH‐3010 Bern
Switzerland
Tel.: +41 31 632 35 51
Fax: ++41 31 632 49 15
e‐mail:
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<p>
<b>Objective: </b>
To monitor clinical, microbiological and host‐derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis/mucositis and their respective healing sequence in humans.</p>
<p>
<b>Material and methods: </b>
Fifteen subjects with healthy or treated periodontal conditions and restored with dental implants underwent an experimental 3‐week period of undisturbed plaque accumulation in the mandible. Subsequently, a 3‐week period with optimal plaque control was instituted. At Days 0, 7, 14, 21, 28, 35 and 42, the presence/absence of plaque deposits around teeth and implants was assessed, (plaque index [PlI]) and the gingival/mucosal conditions were evaluated (gingival index[GI]). Subgingival/submucosal plaque samples and gingival/mucosal crevicular fluid (CF) samples were collected from two pre‐determined sites around each experimental unit. CF samples were analyzed for matrix‐metalloproteinase‐8 (MMP‐8) and interleukin‐1beta (IL‐1β). Microbial samples were analyzed using DNA–DNA hybridization for 40 species.</p>
<p>
<b>Results: </b>
During 3 weeks of plaque accumulation, the median PlI and GI increased significantly at implants and teeth. Implant sites yielded a greater increase in the median GI compared with tooth sites. Over the 6‐week experimental period, the CF levels of MMP‐8 were statistically significantly higher at implants compared with teeth (
<i>P</i>
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<p>
<b>Conclusion: </b>
Peri‐implant soft tissues developed a stronger inflammatory response to experimental plaque accumulation when compared with that of their gingival counterparts. Experimental gingivitis and peri‐implant mucositis were reversible at the biomarker level. Clinically, however, 3 weeks of resumed plaque control did not yield pre‐experimental levels of gingival and peri‐implant mucosal health indicating that longer healing periods are needed.</p>
<p>
<b>To cite this article:</b>

Salvi GE, Aglietta M, Eick S, Sculean A, Lang NP & Ramseier CA. Reversibility of experimental peri‐implant mucositis compared with experimental gingivitis in humans.

<i>Clin. Oral Impl. Res</i>
.
<b>23</b>
, 2012; 182–190. 
doi: 10.1111/j.1600‐0501.2011.02220.x</p>
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<abstract>Material and methods: Fifteen subjects with healthy or treated periodontal conditions and restored with dental implants underwent an experimental 3‐week period of undisturbed plaque accumulation in the mandible. Subsequently, a 3‐week period with optimal plaque control was instituted. At Days 0, 7, 14, 21, 28, 35 and 42, the presence/absence of plaque deposits around teeth and implants was assessed, (plaque index [PlI]) and the gingival/mucosal conditions were evaluated (gingival index[GI]). Subgingival/submucosal plaque samples and gingival/mucosal crevicular fluid (CF) samples were collected from two pre‐determined sites around each experimental unit. CF samples were analyzed for matrix‐metalloproteinase‐8 (MMP‐8) and interleukin‐1beta (IL‐1β). Microbial samples were analyzed using DNA–DNA hybridization for 40 species.</abstract>
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<abstract>Conclusion: Peri‐implant soft tissues developed a stronger inflammatory response to experimental plaque accumulation when compared with that of their gingival counterparts. Experimental gingivitis and peri‐implant mucositis were reversible at the biomarker level. Clinically, however, 3 weeks of resumed plaque control did not yield pre‐experimental levels of gingival and peri‐implant mucosal health indicating that longer healing periods are needed.</abstract>
<abstract>To cite this article:
Salvi GE, Aglietta M, Eick S, Sculean A, Lang NP & Ramseier CA. Reversibility of experimental peri‐implant mucositis compared with experimental gingivitis in humans.
Clin. Oral Impl. Res. 23, 2012; 182–190. 
doi: 10.1111/j.1600‐0501.2011.02220.x</abstract>
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