Subgingival Aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease
Identifieur interne : 006A82 ( Istex/Corpus ); précédent : 006A81; suivant : 006A83Subgingival Aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease
Auteurs : P Ivi M Ntyl ; K Re Buhlin ; Susanna Paju ; G. Rutger Persson ; Markku S. Nieminen ; Juha Sinisalo ; Pirkko J. PussinenSource :
- Journal of Clinical Periodontology [ 0303-6979 ] ; 2013-06.
English descriptors
- KwdEn :
- Actinobacillus, Actinobacillus actinomycetemcomitans, Actinomycetemcomitans, Alveolar bone loss, Angiography, Angiography diagnosis groups, Artery disease, Atherosclerosis, Bacterial cells, Bacterial levels, Carotid thickness, Clinical microbiology, Clinical periodontology, Corogene study, Coronary angiography, Coronary artery disease, Coronary heart disease, Denticola, Detection level, Detection limit, Finnish, Forsythia, Gingivalis, Helsinki, Helsinki university, Host response, Hyvarinen, Individual bacteria, John wiley sons, Median, Microbiology, Ndings, Oral examination, Oral health, Oral microbiology, Paju, Pathogen, Pathogen levels, Pathogen positivity, Pearson test, Periodontal, Periodontal disease, Periodontal pathogens, Periodontitis, Periodontology, Persson, Porphyromonas gingivalis, Prevalence, Pussinen, Risk factors, Socransky, Stenosis, Study groups, Study participants, Study population, Subgingival, Subgingival samples, Threshold level, Threshold limit, Twofold risk, Vascular biology.
- Teeft :
- Actinobacillus, Actinobacillus actinomycetemcomitans, Actinomycetemcomitans, Alveolar bone loss, Angiography, Angiography diagnosis groups, Artery disease, Atherosclerosis, Bacterial cells, Bacterial levels, Carotid thickness, Clinical microbiology, Clinical periodontology, Corogene study, Coronary angiography, Coronary artery disease, Coronary heart disease, Denticola, Detection level, Detection limit, Finnish, Forsythia, Gingivalis, Helsinki, Helsinki university, Host response, Hyvarinen, Individual bacteria, John wiley sons, Median, Microbiology, Ndings, Oral examination, Oral health, Oral microbiology, Paju, Pathogen, Pathogen levels, Pathogen positivity, Pearson test, Periodontal, Periodontal disease, Periodontal pathogens, Periodontitis, Periodontology, Persson, Porphyromonas gingivalis, Prevalence, Pussinen, Risk factors, Socransky, Stenosis, Study groups, Study participants, Study population, Subgingival, Subgingival samples, Threshold level, Threshold limit, Twofold risk, Vascular biology.
Abstract
We investigated the association between angiographically verified coronary artery disease (CAD) and subgingival Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola.
Url:
DOI: 10.1111/jcpe.12098
Links to Exploration step
ISTEX:D75BF9F5A594FC1F750BE2D0979DD47C8B0C7AE0Le document en format XML
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disease</term><term>Atherosclerosis</term><term>Bacterial cells</term><term>Bacterial levels</term><term>Carotid thickness</term><term>Clinical microbiology</term><term>Clinical periodontology</term><term>Corogene study</term><term>Coronary angiography</term><term>Coronary artery disease</term><term>Coronary heart disease</term><term>Denticola</term><term>Detection level</term><term>Detection limit</term><term>Finnish</term><term>Forsythia</term><term>Gingivalis</term><term>Helsinki</term><term>Helsinki university</term><term>Host response</term><term>Hyvarinen</term><term>Individual bacteria</term><term>John wiley sons</term><term>Median</term><term>Microbiology</term><term>Ndings</term><term>Oral examination</term><term>Oral health</term><term>Oral microbiology</term><term>Paju</term><term>Pathogen</term><term>Pathogen levels</term><term>Pathogen positivity</term><term>Pearson test</term><term>Periodontal</term><term>Periodontal disease</term><term>Periodontal 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paivi.mantyla@helsinki.fi</json:string></affiliations></json:item><json:item><name>Kåre Buhlin</name><affiliations><json:string>Institute of Dentistry, University of Helsinki, Helsinki, Finland</json:string><json:string>Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden</json:string></affiliations></json:item><json:item><name>Susanna Paju</name><affiliations><json:string>Institute of Dentistry, University of Helsinki, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>G. Rutger Persson</name><affiliations><json:string>Departments of Periodontics and Oral Medicine, University of Washington, Seattle, WA, USA</json:string><json:string>Department of Periodontology, University of Bern, Bern, Switzerland</json:string><json:string>Oral Health Sciences, University of Kristianstad, Kristianstad, Sweden</json:string></affiliations></json:item><json:item><name>Markku S. Nieminen</name><affiliations><json:string>Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Juha Sinisalo</name><affiliations><json:string>Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Pirkko J. Pussinen</name><affiliations><json:string>Institute of Dentistry, University of Helsinki, Helsinki, Finland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Aggregatibacter actinomycetemcomitans</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>angiography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>coronary artery disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DNA–DNA hybridization</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subgingival bacteria</value></json:item></subject><articleId><json:string>JCPE12098</json:string></articleId><arkIstex>ark:/67375/WNG-54JLF84Z-8</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>We investigated the association between angiographically verified coronary artery disease (CAD) and subgingival Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola.</abstract><qualityIndicators><score>7.264</score><pdfWordCount>5418</pdfWordCount><pdfCharCount>37778</pdfCharCount><pdfVersion>1.7</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>22</abstractWordCount><abstractCharCount>222</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Subgingival Aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease</title><pmid><json:string>23521427</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Clinical Periodontology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-051X</json:string></doi><issn><json:string>0303-6979</json:string></issn><eissn><json:string>1600-051X</json:string></eissn><publisherId><json:string>JCPE</json:string></publisherId><volume>40</volume><issue>6</issue><pages><first>583</first><last>590</last><total>8</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item></subject></host><namedEntities><unitex><date><json:string>between June 2006 and March 2008</json:string><json:string>between October 2007 and May 2008</json:string><json:string>2013-02-18</json:string></date><geogName></geogName><orgName><json:string>University of Kristianstad, Kristianstad, Sweden</json:string><json:string>Sigrid Juselius Foundation, the Finnish Dental Society Apollonia, Finnish Medical Society</json:string><json:string>Aarne Koskelo Foundation, and the Paulo Foundation</json:string><json:string>Sons Ltd</json:string><json:string>Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden</json:string><json:string>Institute of Dentistry, University of Helsinki</json:string><json:string>Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland Key</json:string><json:string>Karin Stroems Foundation</json:string><json:string>Oral Microbiology Laboratory, University of Bern, Switzerland</json:string><json:string>The Helsinki University</json:string><json:string>Institute of Dentistry, University of Helsinki, Helsinki, Finland</json:string><json:string>Division of Cardiology</json:string><json:string>Helsinki University Central Hospital Ethics Committee</json:string><json:string>Division of Periodontology</json:string><json:string>Department of Periodontology, University of Bern, Bern, Switzerland</json:string><json:string>University of Washington</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>John Wiley</json:string><json:string>S. Nieminen</json:string><json:string>Pearson Chi-Square</json:string><json:string>J. Pussinen</json:string><json:string>Wallis Test</json:string><json:string>Pearson Chi</json:string><json:string>Susanna Paju</json:string><json:string>Investigations</json:string><json:string>Regula Hirchi-Imfeld</json:string><json:string>Marianne Weibel</json:string><json:string>Never Former</json:string><json:string>S. Published</json:string><json:string>G. Rutger</json:string></persName><placeName><json:string>Eppendorf</json:string><json:string>Helsinki</json:string><json:string>USA</json:string><json:string>WA</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Haraszthy et al. 2000</json:string><json:string>Beck et al. 2005a, b</json:string><json:string>Lockhart et al. 2008</json:string><json:string>Renvert et al. (2006)</json:string><json:string>Renvert et al. 2006</json:string><json:string>Yakob et al. 2011</json:string><json:string>Persson et al. 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(2006)</json:string><json:string>Kolenbrander et al. 2002</json:string><json:string>Epstein et al. 1999</json:string><json:string>o Zeigler et al. 2012</json:string><json:string>Pussinen et al. 2003, 2005, 2007</json:string><json:string>Spahr et al. 2006</json:string><json:string>Zambon et al. 1983</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-54JLF84Z-8</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Periodontics</json:string></scopus></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1111/jcpe.12098</json:string></doi><id>D75BF9F5A594FC1F750BE2D0979DD47C8B0C7AE0</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/D75BF9F5A594FC1F750BE2D0979DD47C8B0C7AE0/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/D75BF9F5A594FC1F750BE2D0979DD47C8B0C7AE0/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/D75BF9F5A594FC1F750BE2D0979DD47C8B0C7AE0/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Subgingival <hi rend="italic">Aggregatibacter actinomycetemcomitans</hi> associates with the risk of coronary artery disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Publishing Ltd</publisher><availability><licence>© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</licence></availability><date type="published" when="2013-06"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Subgingival <hi rend="italic">Aggregatibacter actinomycetemcomitans</hi> associates with the risk of coronary artery disease</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Päivi</forename><surname>Mäntylä</surname></persName><affiliation><orgName>Institute of Dentistry</orgName><orgName>University of Helsinki</orgName><address><settlement type="city">Helsinki</settlement><country key="FI">Finland</country></address></affiliation><affiliation>Address: Päivi Mäntylä, Institute of Dentistry, P. O. Box 41, Institute of Dentistry, 00014 University of Helsinki, Helsinki, Finland E‐mail: paivi.mantyla@helsinki.fi</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Kåre</forename><surname>Buhlin</surname></persName><affiliation><orgName>Institute of Dentistry</orgName><orgName>University of Helsinki</orgName><address><settlement type="city">Helsinki</settlement><country key="FI">Finland</country></address></affiliation><affiliation><orgName>Division of Periodontology</orgName><orgName>Department of Dental Medicine</orgName><orgName>Karolinska Institutet</orgName><address><settlement type="city">Huddinge</settlement><country key="SE">Sweden</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Susanna</forename><surname>Paju</surname></persName><affiliation><orgName>Institute of Dentistry</orgName><orgName>University of Helsinki</orgName><address><settlement type="city">Helsinki</settlement><country key="FI">Finland</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">G. Rutger</forename><surname>Persson</surname></persName><affiliation><orgName>Departments of Periodontics and Oral Medicine</orgName><orgName>University of Washington</orgName><address><settlement type="city">Seattle</settlement><region>WA</region><country key="US">USA</country></address></affiliation><affiliation><orgName>Department of Periodontology</orgName><orgName>University of Bern</orgName><address><settlement type="city">Bern</settlement><country key="CH">Switzerland</country></address></affiliation><affiliation><orgName>Oral Health Sciences</orgName><orgName>University of Kristianstad</orgName><address><settlement type="city">Kristianstad</settlement><country key="SE">Sweden</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Markku S.</forename><surname>Nieminen</surname></persName><affiliation><orgName>Division of Cardiology</orgName><orgName>Department of Medicine</orgName><orgName>Helsinki University Central Hospital</orgName><address><settlement type="city">Helsinki</settlement><country key="FI">Finland</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Juha</forename><surname>Sinisalo</surname></persName><affiliation><orgName>Division of Cardiology</orgName><orgName>Department of Medicine</orgName><orgName>Helsinki University Central Hospital</orgName><address><settlement type="city">Helsinki</settlement><country key="FI">Finland</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Pirkko J.</forename><surname>Pussinen</surname></persName><affiliation><orgName>Institute of Dentistry</orgName><orgName>University of Helsinki</orgName><address><settlement type="city">Helsinki</settlement><country key="FI">Finland</country></address></affiliation></author><idno type="istex">D75BF9F5A594FC1F750BE2D0979DD47C8B0C7AE0</idno><idno type="ark">ark:/67375/WNG-54JLF84Z-8</idno><idno type="DOI">10.1111/jcpe.12098</idno><idno type="unit">JCPE12098</idno><idno type="toTypesetVersion">file:JCPE.JCPE12098.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Clinical Periodontology</title><title level="j" type="alt">JOURNAL OF CLINICAL PERIODONTOLOGY</title><idno type="pISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><idno type="book-DOI">10.1111/(ISSN)1600-051X</idno><idno type="book-part-DOI">10.1111/jcpe.2013.40.issue-6</idno><idno type="product">JCPE</idno><imprint><biblScope unit="vol">40</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="583">583</biblScope><biblScope unit="page" to="590">590</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2013-06"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main" xml:id="jcpe12098-abs-0001"><head>Abstract</head>
Aim
<p>We investigated the association between angiographically verified coronary artery disease (<hi rend="fc">CAD</hi>) and subgingival <hi rend="italic">Aggregatibacter actinomycetemcomitans</hi>,<hi rend="italic"> Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola</hi>.</p>
Materials and Methods
<p>The cross‐sectional study population (<hi rend="italic">n</hi> = 445) comprised 171 (38.4%) patients with Stable <hi rend="fc">CAD</hi>, 158 (35.5%) with acute coronary syndrome (<hi rend="fc">ACS</hi>) and 116 (26.1%) with no significant <hi rend="fc">CAD</hi> (No <hi rend="fc">CAD</hi>). All patients participated in clinical and radiological oral health examinations. Pooled subgingival bacterial samples were analysed by checkerboard <hi rend="fc">DNA</hi>–<hi rend="fc">DNA</hi> hybridization assays.</p>
Results
<p>In all study groups, the presence of <hi rend="italic">P. gingivalis, T. forsythia</hi> and <hi rend="italic">T. denticola</hi> indicated a significant (<hi rend="italic">p</hi> ≤ 0.001) linear association with the extent of alveolar bone loss (<hi rend="fc">ABL</hi>), but <hi rend="italic">A. actinomycetemcomitans</hi> did not (<hi rend="italic">p</hi> = 0.074). With a threshold level of bacterial cells 1 × 10<hi rend="superscript">5</hi>
<hi rend="italic">A. actinomycetemcomitans</hi> was significantly more prevalent in the Stable <hi rend="fc">CAD</hi> group (42.1%) compared to the No <hi rend="fc">CAD</hi> group (30.2%) (<hi rend="italic">p</hi> = 0.040). In a multi‐adjusted logistic regression analysis using this threshold, <hi rend="italic">A. actinomycetemcomitans</hi> positivity associated with Stable <hi rend="fc">CAD</hi> (<hi rend="fc">OR</hi> 1.83, 95% <hi rend="fc">CI</hi> 1.00–3.35, <hi rend="italic">p</hi> = 0.049), but its level or levels of other bacteria did not.</p>
Conclusions
<p>The presence of subgingival <hi rend="italic">A. actinomycetemcomitans</hi> associates with an almost twofold risk of Stable <hi rend="fc">CAD</hi> independently of alveolar bone loss.</p></abstract><textClass><keywords><term xml:id="jcpe12098-kwd-0001"><hi rend="italic">Aggregatibacter actinomycetemcomitans</hi></term><term xml:id="jcpe12098-kwd-0002">angiography</term><term xml:id="jcpe12098-kwd-0003">coronary artery disease</term><term xml:id="jcpe12098-kwd-0004"><hi rend="fc">DNA</hi>–<hi rend="fc">DNA</hi> hybridization</term><term xml:id="jcpe12098-kwd-0005">subgingival bacteria</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Periodontal Diseases</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/D75BF9F5A594FC1F750BE2D0979DD47C8B0C7AE0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="jcpe12098" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-051X</doi><issn type="print">0303-6979</issn><issn type="electronic">1600-051X</issn><idGroup><id type="product" value="JCPE"></id></idGroup><titleGroup><title sort="JOURNAL OF CLINICAL PERIODONTOLOGY" type="main">Journal of Clinical Periodontology</title><title type="short">J Clin Periodontol</title></titleGroup></publicationMeta><publicationMeta level="part" position="60"><doi origin="wiley">10.1111/jcpe.2013.40.issue-6</doi><copyright ownership="publisher">Copyright © 2013 John Wiley & Sons A/S</copyright><numberingGroup><numbering type="journalVolume" number="40">40</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="2013-06">June 2013</coverDate></publicationMeta><publicationMeta level="unit" position="30" status="forIssue" type="article"><doi>10.1111/jcpe.12098</doi><idGroup><id type="unit" value="JCPE12098"></id></idGroup><countGroup><count number="8" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Periodontal Diseases</title></titleGroup><copyright ownership="publisher">© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</copyright><eventGroup><event date="2013-02-11" type="manuscriptAccepted"></event><event agent="SPS" date="2013-02-18" type="xmlCreated"></event><event type="publishedOnlineAccepted" date="2013-02-13"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-03-25"></event><event type="publishedOnlineFinalForm" date="2013-05-06"></event><event type="firstOnline" date="2013-03-25"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-02"></event></eventGroup><numberingGroup><numbering type="pageFirst">583</numbering><numbering type="pageLast">590</numbering></numberingGroup><correspondenceTo><lineatedText><line>Address: <i>Päivi Mäntylä, Institute of Dentistry, P. O. Box 41, Institute of Dentistry, 00014 University of Helsinki, Helsinki, Finland</i></line><line>E‐mail: <email>paivi.mantyla@helsinki.fi</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="jcpe12098-cit-1001"><author><familyName>Mäntylä</familyName> <givenNames>P</givenNames></author>, <author><familyName>Buhlin</familyName> <givenNames>K</givenNames></author>, <author><familyName>Paju</familyName> <givenNames>S</givenNames></author>, <author><familyName>Persson</familyName> <givenNames>GR</givenNames></author>, <author><familyName>Nieminen</familyName> <givenNames>MS</givenNames></author>, <author><familyName>Sinisalo</familyName> <givenNames>J</givenNames></author>, <author><familyName>Pussinen</familyName> <givenNames>PJ</givenNames></author>. <articleTitle>Subgingival <i>Aggregatibacter actinomycetemcomitans</i> associates with the risk of coronary artery disease</articleTitle>. <journalTitle>J Clin Periodontol</journalTitle> <pubYear year="2013">2013</pubYear>; <vol>40</vol>: <pageFirst>583</pageFirst>–<pageLast>590</pageLast>. doi: 10.1111/jcpe.12098.</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:JCPE.JCPE12098.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Subgingival <i>Aggregatibacter actinomycetemcomitans</i> associates with the risk of coronary artery disease</title><title type="shortAuthors"><i>Mäntylä et al</i>.</title></titleGroup><creators><creator affiliationRef="#jcpe12098-aff-0001" corresponding="yes" creatorRole="author" xml:id="jcpe12098-cr-0001"><personName><givenNames>Päivi</givenNames> <familyName>Mäntylä</familyName></personName></creator><creator affiliationRef="#jcpe12098-aff-0001 #jcpe12098-aff-0002" creatorRole="author" xml:id="jcpe12098-cr-0002"><personName><givenNames>Kåre</givenNames> <familyName>Buhlin</familyName></personName></creator><creator affiliationRef="#jcpe12098-aff-0001" creatorRole="author" xml:id="jcpe12098-cr-0003"><personName><givenNames>Susanna</givenNames> <familyName>Paju</familyName></personName></creator><creator affiliationRef="#jcpe12098-aff-0003 #jcpe12098-aff-0004 #jcpe12098-aff-0005" creatorRole="author" xml:id="jcpe12098-cr-0004"><personName><givenNames>G. Rutger</givenNames> <familyName>Persson</familyName></personName></creator><creator affiliationRef="#jcpe12098-aff-0006" creatorRole="author" xml:id="jcpe12098-cr-0005"><personName><givenNames>Markku S.</givenNames> <familyName>Nieminen</familyName></personName></creator><creator affiliationRef="#jcpe12098-aff-0006" creatorRole="author" xml:id="jcpe12098-cr-0006"><personName><givenNames>Juha</givenNames> <familyName>Sinisalo</familyName></personName></creator><creator affiliationRef="#jcpe12098-aff-0001" creatorRole="author" xml:id="jcpe12098-cr-0007"><personName><givenNames>Pirkko J.</givenNames> <familyName>Pussinen</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="FI" type="organization" xml:id="jcpe12098-aff-0001"><orgDiv>Institute of Dentistry</orgDiv> <orgName>University of Helsinki</orgName> <address><city>Helsinki</city> <country>Finland</country></address></affiliation><affiliation countryCode="SE" type="organization" xml:id="jcpe12098-aff-0002"><orgDiv>Division of Periodontology</orgDiv> <orgDiv>Department of Dental Medicine</orgDiv> <orgName>Karolinska Institutet</orgName> <address><city>Huddinge</city> <country>Sweden</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="jcpe12098-aff-0003"><orgDiv>Departments of Periodontics and Oral Medicine</orgDiv> <orgName>University of Washington</orgName> <address><city>Seattle</city> <countryPart>WA</countryPart><country>USA</country></address></affiliation><affiliation countryCode="CH" type="organization" xml:id="jcpe12098-aff-0004"><orgDiv>Department of Periodontology</orgDiv> <orgName>University of Bern</orgName> <address><city>Bern</city> <country>Switzerland</country></address></affiliation><affiliation countryCode="SE" type="organization" xml:id="jcpe12098-aff-0005"><orgDiv>Oral Health Sciences</orgDiv> <orgName>University of Kristianstad</orgName> <address><city>Kristianstad</city> <country>Sweden</country></address></affiliation><affiliation countryCode="FI" type="organization" xml:id="jcpe12098-aff-0006"><orgDiv>Division of Cardiology</orgDiv> <orgDiv>Department of Medicine</orgDiv> <orgName>Helsinki University Central Hospital</orgName> <address><city>Helsinki</city> <country>Finland</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="jcpe12098-kwd-0001"><i>Aggregatibacter actinomycetemcomitans</i></keyword><keyword xml:id="jcpe12098-kwd-0002">angiography</keyword><keyword xml:id="jcpe12098-kwd-0003">coronary artery disease</keyword><keyword xml:id="jcpe12098-kwd-0004"><fc>DNA</fc>–<fc>DNA</fc> hybridization</keyword><keyword xml:id="jcpe12098-kwd-0005">subgingival bacteria</keyword></keywordGroup><abstractGroup><abstract type="main" xml:id="jcpe12098-abs-0001" xml:lang="en"><title type="main">Abstract</title><section xml:id="jcpe12098-sec-0001"><title type="main">Aim</title><p>We investigated the association between angiographically verified coronary artery disease (<fc>CAD</fc>) and subgingival <i>Aggregatibacter actinomycetemcomitans</i>,<i> Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola</i>.</p></section><section xml:id="jcpe12098-sec-0002"><title type="main">Materials and Methods</title><p>The cross‐sectional study population (<i>n</i> = 445) comprised 171 (38.4%) patients with Stable <fc>CAD</fc>, 158 (35.5%) with acute coronary syndrome (<fc>ACS</fc>) and 116 (26.1%) with no significant <fc>CAD</fc> (No <fc>CAD</fc>). All patients participated in clinical and radiological oral health examinations. Pooled subgingival bacterial samples were analysed by checkerboard <fc>DNA</fc>–<fc>DNA</fc> hybridization assays.</p></section><section xml:id="jcpe12098-sec-0003"><title type="main">Results</title><p>In all study groups, the presence of <i>P. gingivalis, T. forsythia</i> and <i>T. denticola</i> indicated a significant (<i>p</i> ≤ 0.001) linear association with the extent of alveolar bone loss (<fc>ABL</fc>), but <i>A. actinomycetemcomitans</i> did not (<i>p</i> = 0.074). With a threshold level of bacterial cells 1 × 10<sup>5</sup> <i>A. actinomycetemcomitans</i> was significantly more prevalent in the Stable <fc>CAD</fc> group (42.1%) compared to the No <fc>CAD</fc> group (30.2%) (<i>p</i> = 0.040). In a multi‐adjusted logistic regression analysis using this threshold, <i>A. actinomycetemcomitans</i> positivity associated with Stable <fc>CAD</fc> (<fc>OR</fc> 1.83, 95% <fc>CI</fc> 1.00–3.35, <i>p</i> = 0.049), but its level or levels of other bacteria did not.</p></section><section xml:id="jcpe12098-sec-0004"><title type="main">Conclusions</title><p>The presence of subgingival <i>A. actinomycetemcomitans</i> associates with an almost twofold risk of Stable <fc>CAD</fc> independently of alveolar bone loss.</p></section></abstract></abstractGroup></contentMeta><noteGroup xml:id="jcpe12098-ntgp-0001"><note numbered="no" xml:id="jcpe12098-note-0001"><p><b>Conflict of interest and source of funding statement</b></p><p>The authors declare that they have no conflict of interest.</p><p>The study was financially supported by the Academy of Finland (#118391), the Sigrid Juselius Foundation, the Finnish Dental Society Apollonia, Finnish Medical Society (Einar and Karin Stroems Foundation), Aarne Koskelo Foundation, and the Paulo Foundation.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Subgingival Aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Subgingival Aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease</title></titleInfo><name type="personal"><namePart type="given">Päivi</namePart><namePart type="family">Mäntylä</namePart><affiliation>Institute of Dentistry, University of Helsinki, Helsinki, Finland</affiliation><affiliation>Address: E‐mail:</affiliation><affiliation>E-mail: paivi.mantyla@helsinki.fi</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kåre</namePart><namePart type="family">Buhlin</namePart><affiliation>Institute of Dentistry, University of Helsinki, Helsinki, Finland</affiliation><affiliation>Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susanna</namePart><namePart type="family">Paju</namePart><affiliation>Institute of Dentistry, University of Helsinki, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. Rutger</namePart><namePart type="family">Persson</namePart><affiliation>Departments of Periodontics and Oral Medicine, University of Washington, Seattle, WA, USA</affiliation><affiliation>Department of Periodontology, University of Bern, Bern, Switzerland</affiliation><affiliation>Oral Health Sciences, University of Kristianstad, Kristianstad, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Markku S.</namePart><namePart type="family">Nieminen</namePart><affiliation>Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Juha</namePart><namePart type="family">Sinisalo</namePart><affiliation>Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pirkko J.</namePart><namePart type="family">Pussinen</namePart><affiliation>Institute of Dentistry, University of Helsinki, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-06</dateIssued><dateCreated encoding="w3cdtf">2013-02-18</dateCreated><dateValid encoding="w3cdtf">2013-02-11</dateValid><edition>Mäntylä P, Buhlin K, Paju S, Persson GR, Nieminen MS, Sinisalo J, Pussinen PJ. Subgingival Aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease. J Clin Periodontol 2013; 40: 583–590. doi: 10.1111/jcpe.12098.</edition><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>We investigated the association between angiographically verified coronary artery disease (CAD) and subgingival Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola.</abstract><abstract>The cross‐sectional study population (n = 445) comprised 171 (38.4%) patients with Stable CAD, 158 (35.5%) with acute coronary syndrome (ACS) and 116 (26.1%) with no significant CAD (No CAD). All patients participated in clinical and radiological oral health examinations. Pooled subgingival bacterial samples were analysed by checkerboard DNA–DNA hybridization assays.</abstract><abstract>In all study groups, the presence of P. gingivalis, T. forsythia and T. denticola indicated a significant (p ≤ 0.001) linear association with the extent of alveolar bone loss (ABL), but A. actinomycetemcomitans did not (p = 0.074). With a threshold level of bacterial cells 1 × 105 A. actinomycetemcomitans was significantly more prevalent in the Stable CAD group (42.1%) compared to the No CAD group (30.2%) (p = 0.040). In a multi‐adjusted logistic regression analysis using this threshold, A. actinomycetemcomitans positivity associated with Stable CAD (OR 1.83, 95% CI 1.00–3.35, p = 0.049), but its level or levels of other bacteria did not.</abstract><abstract>The presence of subgingival A. actinomycetemcomitans associates with an almost twofold risk of Stable CAD independently of alveolar bone loss.</abstract><subject><genre>keywords</genre><topic>Aggregatibacter actinomycetemcomitans</topic><topic>angiography</topic><topic>coronary artery disease</topic><topic>DNA–DNA hybridization</topic><topic>subgingival bacteria</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Clinical Periodontology</title></titleInfo><titleInfo type="abbreviated"><title>J Clin Periodontol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0303-6979</identifier><identifier type="eISSN">1600-051X</identifier><identifier type="DOI">10.1111/(ISSN)1600-051X</identifier><identifier type="PublisherID">JCPE</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>583</start><end>590</end><total>8</total></extent></part></relatedItem><identifier type="istex">D75BF9F5A594FC1F750BE2D0979DD47C8B0C7AE0</identifier><identifier type="ark">ark:/67375/WNG-54JLF84Z-8</identifier><identifier type="DOI">10.1111/jcpe.12098</identifier><identifier type="ArticleID">JCPE12098</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 John Wiley & Sons A/S© 2013 John Wiley & Sons A/S. 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