Alveolar Bone Regeneration around Immediate Implants Using an Injectable nHAC/CSH Loaded with Autogenic Blood‐Acquired Mesenchymal Progenitor Cells: An Experimental Study in the Dog Mandible
Identifieur interne : 006729 ( Istex/Corpus ); précédent : 006728; suivant : 006730Alveolar Bone Regeneration around Immediate Implants Using an Injectable nHAC/CSH Loaded with Autogenic Blood‐Acquired Mesenchymal Progenitor Cells: An Experimental Study in the Dog Mandible
Auteurs : Xue Han ; Hongchen Liu ; Dongsheng Wang ; Fang Su ; Yong Zhang ; Wei Zhou ; Shujun Li ; Rui YangSource :
- Clinical Implant Dentistry and Related Research [ 1523-0899 ] ; 2013-06.
English descriptors
- KwdEn :
- Adherent cells, Adipogenic differentiation, Adipogenic inductive medium, Alveolar bone, Alveolar bone regeneration, Appl biomater, Assistant professor, Beijing, Biomed mater, Biomedical applications, Bmpc, Bone defects, Bone density, Bone formation, Bone marrow, Bone regeneration, Bone substitute, Calcium sulfate, Calcium sulfate hemihydrate, Calcium sulphate, Canine mandible, Cell adhesion, Chinese academy, Clinical implant dentistry, Clinical report, Composite cement, Control group, Control slide, Cultured dbmpc, Cylindrical implants, Dbmpc, Dbmpc group, Dbmpc nhac, Defect, Defect area, Defect sites, Dental implants, Dental institute, Distal bone defects, Experimental study, Extraction sockets, General hospital, Higher percentage, Immediate implantation, Immediate implants, Implant, Implant placement, Implant surface, Implantation, Initial plating, Injectable, Injectable bone, Injectable bone cement, Injectable bone regeneration, Injectable bone substitute, Injectable cement, Injectable tissue, Material science, Maxillary sinus, Mesenchymal, Mesenchymal progenitor cells, Mesenchymal properties, Mesial sockets, Metal research, Mineralized collagen, Mononuclear cells, Negative staining, Nhac, Oral maxillofac implants, Osseous defects, Osteoblast, Osteogenic, Peripheral blood, Positive staining, Previous study, Progenitor, Regeneration, Seeding cells, Standardized defects, Stromal cells, Sulfate, Tissue engineering, Tissue response, Titanium, Titanium alloy, Titanium implants, Trabecular bone.
- Teeft :
- Adherent cells, Adipogenic differentiation, Adipogenic inductive medium, Alveolar bone, Alveolar bone regeneration, Appl biomater, Assistant professor, Beijing, Biomed mater, Biomedical applications, Bmpc, Bone defects, Bone density, Bone formation, Bone marrow, Bone regeneration, Bone substitute, Calcium sulfate, Calcium sulfate hemihydrate, Calcium sulphate, Canine mandible, Cell adhesion, Chinese academy, Clinical implant dentistry, Clinical report, Composite cement, Control group, Control slide, Cultured dbmpc, Cylindrical implants, Dbmpc, Dbmpc group, Dbmpc nhac, Defect, Defect area, Defect sites, Dental implants, Dental institute, Distal bone defects, Experimental study, Extraction sockets, General hospital, Higher percentage, Immediate implantation, Immediate implants, Implant, Implant placement, Implant surface, Implantation, Initial plating, Injectable, Injectable bone, Injectable bone cement, Injectable bone regeneration, Injectable bone substitute, Injectable cement, Injectable tissue, Material science, Maxillary sinus, Mesenchymal, Mesenchymal progenitor cells, Mesenchymal properties, Mesial sockets, Metal research, Mineralized collagen, Mononuclear cells, Negative staining, Nhac, Oral maxillofac implants, Osseous defects, Osteoblast, Osteogenic, Peripheral blood, Positive staining, Previous study, Progenitor, Regeneration, Seeding cells, Standardized defects, Stromal cells, Sulfate, Tissue engineering, Tissue response, Titanium, Titanium alloy, Titanium implants, Trabecular bone.
Abstract
Background: Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO4.½H2O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.
Url:
DOI: 10.1111/j.1708-8208.2011.00373.x
Links to Exploration step
ISTEX:CF9759B8D1138549C82208FED3B3D51FF838FE64Le document en format XML
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liuhch301@sina.com</mods:affiliation></affiliation></author><author><name sortKey="Wang, Dongsheng" sort="Wang, Dongsheng" uniqKey="Wang D" first="Dongsheng" last="Wang">Dongsheng Wang</name><affiliation><mods:affiliation>assistant professor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</mods:affiliation></affiliation></author><author><name sortKey="Su, Fang" sort="Su, Fang" uniqKey="Su F" first="Fang" last="Su">Fang Su</name><affiliation><mods:affiliation>postdoctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Yong" sort="Zhang, Yong" uniqKey="Zhang Y" first="Yong" last="Zhang">Yong Zhang</name><affiliation><mods:affiliation>attending doctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</mods:affiliation></affiliation></author><author><name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei 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sort="Liu, Hongchen" uniqKey="Liu H" first="Hongchen" last="Liu">Hongchen Liu</name><affiliation><mods:affiliation>professor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: liuhch301@sina.com</mods:affiliation></affiliation></author><author><name sortKey="Wang, Dongsheng" sort="Wang, Dongsheng" uniqKey="Wang D" first="Dongsheng" last="Wang">Dongsheng Wang</name><affiliation><mods:affiliation>assistant professor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</mods:affiliation></affiliation></author><author><name sortKey="Su, Fang" sort="Su, Fang" uniqKey="Su F" first="Fang" last="Su">Fang Su</name><affiliation><mods:affiliation>postdoctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Yong" sort="Zhang, Yong" uniqKey="Zhang Y" first="Yong" last="Zhang">Yong Zhang</name><affiliation><mods:affiliation>attending doctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</mods:affiliation></affiliation></author><author><name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name><affiliation><mods:affiliation>professor, Department of Stomatology, The 309th Hospital of Chinese People's Liberation Army, Beijing, China;</mods:affiliation></affiliation></author><author><name sortKey="Li, Shujun" sort="Li, Shujun" uniqKey="Li S" first="Shujun" last="Li">Shujun Li</name><affiliation><mods:affiliation>assistant professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China;</mods:affiliation></affiliation></author><author><name sortKey="Yang, Rui" sort="Yang, Rui" uniqKey="Yang R" first="Rui" last="Yang">Rui Yang</name><affiliation><mods:affiliation>professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY RELATED RESEARCH</title><idno type="ISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><imprint><biblScope unit="vol">15</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="390">390</biblScope><biblScope unit="page" to="401">401</biblScope><biblScope unit="page-count">12</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-06">2013-06</date></imprint><idno type="ISSN">1523-0899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1523-0899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adherent cells</term><term>Adipogenic differentiation</term><term>Adipogenic inductive medium</term><term>Alveolar bone</term><term>Alveolar bone regeneration</term><term>Appl biomater</term><term>Assistant professor</term><term>Beijing</term><term>Biomed mater</term><term>Biomedical applications</term><term>Bmpc</term><term>Bone defects</term><term>Bone density</term><term>Bone formation</term><term>Bone marrow</term><term>Bone regeneration</term><term>Bone substitute</term><term>Calcium sulfate</term><term>Calcium sulfate hemihydrate</term><term>Calcium sulphate</term><term>Canine mandible</term><term>Cell adhesion</term><term>Chinese academy</term><term>Clinical implant dentistry</term><term>Clinical report</term><term>Composite cement</term><term>Control group</term><term>Control slide</term><term>Cultured dbmpc</term><term>Cylindrical implants</term><term>Dbmpc</term><term>Dbmpc group</term><term>Dbmpc nhac</term><term>Defect</term><term>Defect area</term><term>Defect sites</term><term>Dental implants</term><term>Dental institute</term><term>Distal bone defects</term><term>Experimental study</term><term>Extraction sockets</term><term>General hospital</term><term>Higher percentage</term><term>Immediate implantation</term><term>Immediate implants</term><term>Implant</term><term>Implant placement</term><term>Implant surface</term><term>Implantation</term><term>Initial plating</term><term>Injectable</term><term>Injectable bone</term><term>Injectable bone cement</term><term>Injectable bone regeneration</term><term>Injectable bone substitute</term><term>Injectable cement</term><term>Injectable tissue</term><term>Material science</term><term>Maxillary sinus</term><term>Mesenchymal</term><term>Mesenchymal progenitor cells</term><term>Mesenchymal properties</term><term>Mesial sockets</term><term>Metal research</term><term>Mineralized collagen</term><term>Mononuclear cells</term><term>Negative staining</term><term>Nhac</term><term>Oral maxillofac implants</term><term>Osseous defects</term><term>Osteoblast</term><term>Osteogenic</term><term>Peripheral blood</term><term>Positive staining</term><term>Previous study</term><term>Progenitor</term><term>Regeneration</term><term>Seeding cells</term><term>Standardized defects</term><term>Stromal cells</term><term>Sulfate</term><term>Tissue engineering</term><term>Tissue response</term><term>Titanium</term><term>Titanium alloy</term><term>Titanium implants</term><term>Trabecular bone</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adherent cells</term><term>Adipogenic differentiation</term><term>Adipogenic inductive medium</term><term>Alveolar bone</term><term>Alveolar bone regeneration</term><term>Appl biomater</term><term>Assistant professor</term><term>Beijing</term><term>Biomed mater</term><term>Biomedical applications</term><term>Bmpc</term><term>Bone defects</term><term>Bone density</term><term>Bone formation</term><term>Bone marrow</term><term>Bone regeneration</term><term>Bone substitute</term><term>Calcium sulfate</term><term>Calcium sulfate hemihydrate</term><term>Calcium sulphate</term><term>Canine mandible</term><term>Cell adhesion</term><term>Chinese academy</term><term>Clinical implant dentistry</term><term>Clinical report</term><term>Composite cement</term><term>Control group</term><term>Control slide</term><term>Cultured dbmpc</term><term>Cylindrical implants</term><term>Dbmpc</term><term>Dbmpc group</term><term>Dbmpc nhac</term><term>Defect</term><term>Defect area</term><term>Defect sites</term><term>Dental implants</term><term>Dental institute</term><term>Distal bone defects</term><term>Experimental study</term><term>Extraction sockets</term><term>General hospital</term><term>Higher percentage</term><term>Immediate implantation</term><term>Immediate implants</term><term>Implant</term><term>Implant placement</term><term>Implant surface</term><term>Implantation</term><term>Initial plating</term><term>Injectable</term><term>Injectable bone</term><term>Injectable bone cement</term><term>Injectable bone regeneration</term><term>Injectable bone substitute</term><term>Injectable cement</term><term>Injectable tissue</term><term>Material science</term><term>Maxillary sinus</term><term>Mesenchymal</term><term>Mesenchymal progenitor cells</term><term>Mesenchymal properties</term><term>Mesial sockets</term><term>Metal research</term><term>Mineralized collagen</term><term>Mononuclear cells</term><term>Negative staining</term><term>Nhac</term><term>Oral maxillofac implants</term><term>Osseous defects</term><term>Osteoblast</term><term>Osteogenic</term><term>Peripheral blood</term><term>Positive staining</term><term>Previous study</term><term>Progenitor</term><term>Regeneration</term><term>Seeding cells</term><term>Standardized defects</term><term>Stromal cells</term><term>Sulfate</term><term>Tissue engineering</term><term>Tissue response</term><term>Titanium</term><term>Titanium alloy</term><term>Titanium implants</term><term>Trabecular bone</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO4.½H2O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>implant</json:string><json:string>dbmpc</json:string><json:string>mesenchymal</json:string><json:string>injectable</json:string><json:string>bone regeneration</json:string><json:string>progenitor</json:string><json:string>bmpc</json:string><json:string>regeneration</json:string><json:string>sulfate</json:string><json:string>beijing</json:string><json:string>mesenchymal progenitor cells</json:string><json:string>nhac</json:string><json:string>general hospital</json:string><json:string>osteogenic</json:string><json:string>immediate implants</json:string><json:string>osteoblast</json:string><json:string>bone 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area</json:string><json:string>tissue engineering</json:string><json:string>bone marrow</json:string><json:string>stromal cells</json:string><json:string>higher percentage</json:string><json:string>previous study</json:string><json:string>canine mandible</json:string><json:string>implant placement</json:string><json:string>calcium sulphate</json:string><json:string>titanium alloy</json:string><json:string>injectable bone substitute</json:string><json:string>assistant professor</json:string><json:string>injectable cement</json:string><json:string>mononuclear cells</json:string><json:string>adherent cells</json:string><json:string>cultured dbmpc</json:string><json:string>material science</json:string><json:string>cell adhesion</json:string><json:string>initial plating</json:string><json:string>adipogenic inductive medium</json:string><json:string>adipogenic differentiation</json:string><json:string>mesial sockets</json:string><json:string>distal bone 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bone</json:string><json:string>biomedical applications</json:string><json:string>standardized defects</json:string><json:string>titanium</json:string></teeft></keywords><author><json:item><name>Xue Han DDS, PhD</name><affiliations><json:string>Postdoctor, Dental Institute, Chinese PLA General Hospital, Beijing, China, and Department of Stomatology, General Hospital of Shenyang Military Region, Shenyang, China;</json:string></affiliations></json:item><json:item><name>Hongchen Liu DDS, PhD</name><affiliations><json:string>professor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</json:string><json:string>E-mail: liuhch301@sina.com</json:string></affiliations></json:item><json:item><name>Dongsheng Wang DDS</name><affiliations><json:string>assistant professor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</json:string></affiliations></json:item><json:item><name>Fang Su DDS, PhD</name><affiliations><json:string>postdoctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</json:string></affiliations></json:item><json:item><name>Yong Zhang DDS, PhD</name><affiliations><json:string>attending doctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</json:string></affiliations></json:item><json:item><name>Wei Zhou DDS, PhD</name><affiliations><json:string>professor, Department of Stomatology, The 309th Hospital of Chinese People's Liberation Army, Beijing, China;</json:string></affiliations></json:item><json:item><name>Shujun Li PhD</name><affiliations><json:string>assistant professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China;</json:string></affiliations></json:item><json:item><name>Rui Yang PhD</name><affiliations><json:string>professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>dental implants</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>injectable bone</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>peripheral blood</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>regeneration</value></json:item></subject><articleId><json:string>CID373</json:string></articleId><arkIstex>ark:/67375/WNG-M2ST7FC2-C</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Background: Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO4.½H2O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.</abstract><qualityIndicators><score>7.864</score><pdfWordCount>5022</pdfWordCount><pdfCharCount>32558</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>12</pdfPageCount><pdfPageSize>585 x 783 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>72</abstractWordCount><abstractCharCount>539</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Alveolar Bone Regeneration around Immediate Implants Using an Injectable nHAC/CSH Loaded with Autogenic Blood‐Acquired Mesenchymal Progenitor Cells: An Experimental Study in the Dog Mandible</title><pmid><json:string>21745333</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Clinical Implant Dentistry and Related Research</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1708-8208</json:string></doi><issn><json:string>1523-0899</json:string></issn><eissn><json:string>1708-8208</json:string></eissn><publisherId><json:string>CID</json:string></publisherId><volume>15</volume><issue>3</issue><pages><first>390</first><last>401</last><total>12</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>ARTICLE</value></json:item></subject></host><namedEntities><unitex><date><json:string>2013</json:string></date><geogName></geogName><orgName><json:string>Wiley Periodicals, Inc.</json:string><json:string>Liberation Army, Beijing, China</json:string><json:string>Hospital of Chinese People</json:string><json:string>Dental Institute, Chinese PLA General Hospital, Beijing, China, and Department of Stomatology, General Hospital of Shenyang Military Region, Shenyang, China</json:string><json:string>Dental Institute, Chinese PLA General Hospital</json:string><json:string>Related Research, Volume</json:string><json:string>Institute of Metal Research, Chinese Academy of Sciences</json:string><json:string>Beijing Allgens Medical Science and Technology Co.</json:string><json:string>and National Natural Science Foundation of China</json:string><json:string>Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Reprint</json:string><json:string>Dental Institute, Chinese PLA General Hospital, Beijing, China</json:string><json:string>Santa Cruz Biotechnology</json:string><json:string>Department of Stomatology</json:string><json:string>Ethical Committee on Animal Research of the Chinese PLA General Hospital</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Lazarus</json:string><json:string>O. Construction</json:string><json:string>Boix</json:string><json:string>Hongchen Liu</json:string><json:string>Rui Yang</json:string><json:string>Bajada</json:string><json:string>I. Adipogenesis</json:string><json:string>Li</json:string><json:string>Wexler</json:string><json:string>Shujun Li</json:string><json:string>Silver Spring</json:string><json:string>Vimentin</json:string></persName><placeName><json:string>Switzerland</json:string><json:string>Germany</json:string><json:string>Beijing</json:string><json:string>China</json:string><json:string>USA</json:string><json:string>Santa Cruz</json:string><json:string>Herford</json:string><json:string>CA</json:string></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-M2ST7FC2-C</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - General Dentistry</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Oral Surgery</json:string></scopus></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1111/j.1708-8208.2011.00373.x</json:string></doi><id>CF9759B8D1138549C82208FED3B3D51FF838FE64</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/CF9759B8D1138549C82208FED3B3D51FF838FE64/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/CF9759B8D1138549C82208FED3B3D51FF838FE64/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/CF9759B8D1138549C82208FED3B3D51FF838FE64/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Alveolar Bone Regeneration around Immediate Implants Using an Injectable nHAC/CSH Loaded with Autogenic Blood‐Acquired Mesenchymal Progenitor Cells: An Experimental Study in the Dog Mandible</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2011 Wiley Periodicals, Inc.</licence></availability><date type="published" when="2013-06"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Alveolar Bone Regeneration around Immediate Implants Using an Injectable nHAC/CSH Loaded with Autogenic Blood‐Acquired Mesenchymal Progenitor Cells: An Experimental Study in the Dog Mandible</title><title level="a" type="short">Bone Regeneration around Immediate Implants</title><author xml:id="author-0000"><persName><forename type="first">Xue</forename><surname>Han</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation>Postdoctor, Dental Institute, Chinese PLA General Hospital, Beijing, China, and Department of Stomatology, General Hospital of Shenyang Military Region, Shenyang, China;<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0001" role="corresp"><persName><forename type="first">Hongchen</forename><surname>Liu</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation>professor, Dental Institute, Chinese PLA General Hospital, Beijing, China;<address><country key="CN"></country></address></affiliation><affiliation>Dr. Hongchen Liu, Dental Institute, Chinese PLA General Hospital, 28 Fuxing Rd., Beijing 100853, China; e‐mail: liuhch301@sina.com</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Dongsheng</forename><surname>Wang</surname><roleName type="degree">DDS</roleName></persName><affiliation>assistant professor, Dental Institute, Chinese PLA General Hospital, Beijing, China;<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Fang</forename><surname>Su</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation>postdoctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Yong</forename><surname>Zhang</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation>attending doctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Wei</forename><surname>Zhou</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation>professor, Department of Stomatology, The 309th Hospital of Chinese People's Liberation Army, Beijing, China;<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Shujun</forename><surname>Li</surname><roleName type="degree">PhD</roleName></persName><affiliation>assistant professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China;<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Rui</forename><surname>Yang</surname><roleName type="degree">PhD</roleName></persName><affiliation>professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China<address><country key="CN"></country></address></affiliation></author><idno type="istex">CF9759B8D1138549C82208FED3B3D51FF838FE64</idno><idno type="ark">ark:/67375/WNG-M2ST7FC2-C</idno><idno type="DOI">10.1111/j.1708-8208.2011.00373.x</idno><idno type="unit">CID373</idno><idno type="toTypesetVersion">file:CID.CID373.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY RELATED RESEARCH</title><idno type="pISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><idno type="book-DOI">10.1111/(ISSN)1708-8208</idno><idno type="book-part-DOI">10.1111/cid.2013.15.issue-3</idno><idno type="product">CID</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">15</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="390">390</biblScope><biblScope unit="page" to="401">401</biblScope><biblScope unit="page-count">12</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-06"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>ABSTRACT</head><p><hi rend="bold">Background:</hi> Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO<hi rend="subscript">4</hi>.½H<hi rend="subscript">2</hi>O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.</p><p><hi rend="bold">Purpose:</hi> The aim of the study was to assess the new bone formation around immediate dental implants using nHAC/CSH loaded with dog blood‐acquired mesenchymal progenitor cells (dBMPC) in a canine model.</p><p><hi rend="bold">Materials and Methods:</hi> dBMPC were first isolated from peripheral blood of healthy adult dogs. Alizarin red and oil red O staining were then used to evaluate the potential of dBMPC to differentiate into bi‐lineage mesenchymal tissues in vitro. Four healthy mongrel dogs were used in this study. The alveolar bone defects around immediate implants of dogs were created. Each defect was randomly assigned to one of the following three groups: (1) the ITB group (dBMPC + nHAC/CSH); (2) injectable bone cement nHAC/CSH; or (3) no materials (controls). Methylene blue staining was used to examine the bone formation after 3 months.</p><p><hi rend="bold">Results:</hi> Studies in vitro revealed that dBMPC could be induced to osteoblasts and adipocytes. The ITB group (dBMPC + nHAC/CSH) showed significantly more bone‐implant contact and bone density than either nHAC/CSH or control groups in the areas with peri‐implant defects 3 months after implantation.</p><p><hi rend="bold">Conclusion:</hi> The results indicate that the ITB composed of nHAC/CSH and dBMPC may represent a useful strategy for the clinical reconstruction of bone defects around immediate implantation. However, further investigation is needed involving the use of human BMPC as well as possible use of stem cells.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">dental implants</term><term xml:id="k2">injectable bone</term><term xml:id="k3">peripheral blood</term><term xml:id="k4">regeneration</term></keywords><keywords rend="tocHeading1"><term>ARTICLES</term></keywords><keywords rend="articleCategory"><term>ARTICLE</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/CF9759B8D1138549C82208FED3B3D51FF838FE64/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1708-8208</doi><issn type="print">1523-0899</issn><issn type="electronic">1708-8208</issn><idGroup><id type="product" value="CID"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="CLINICAL IMPLANT DENTISTRY RELATED RESEARCH">Clinical Implant Dentistry and Related Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="06103"><doi>10.1111/cid.2013.15.issue-3</doi><copyright ownership="publisher">Copyright © 2013 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering number="15" type="journalVolume">15</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2013-06">June 2013</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="90" status="forIssue"><doi origin="wiley">10.1111/j.1708-8208.2011.00373.x</doi><idGroup><id type="unit" value="CID373"></id></idGroup><countGroup><count type="pageTotal" number="12"></count></countGroup><titleGroup><title type="tocHeading1">ARTICLES</title><title type="articleCategory">ARTICLE</title></titleGroup><copyright>© 2011 Wiley Periodicals, Inc.</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.2.2 mode:FullText" date="2013-05-22"></event><event date="2013-05-22" type="xmlCorrected"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-07-11"></event><event type="firstOnline" date="2011-07-11"></event><event type="publishedOnlineFinalForm" date="2013-06-04"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-03"></event></eventGroup><numberingGroup><numbering type="pageFirst">390</numbering><numbering type="pageLast">401</numbering></numberingGroup><correspondenceTo>Dr. Hongchen Liu, Dental Institute, Chinese PLA General Hospital, 28 Fuxing Rd., Beijing 100853, China; e‐mail: <email>liuhch301@sina.com</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CID.CID373.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="6"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="42"></count><count type="wordTotal" number="5636"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Alveolar Bone Regeneration around Immediate Implants Using an Injectable nHAC/CSH Loaded with Autogenic Blood‐Acquired Mesenchymal Progenitor Cells: An Experimental Study in the Dog Mandible</title><title type="shortAuthors">Clinical Implant Dentistry and Related Research, Volume *, Number *, 2011</title><title type="short">Bone Regeneration around Immediate Implants</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Xue</givenNames><familyName>Han</familyName><degrees>DDS, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2" corresponding="yes"><personName><givenNames>Hongchen</givenNames><familyName>Liu</familyName><degrees>DDS, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>Dongsheng</givenNames><familyName>Wang</familyName><degrees>DDS</degrees></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a4"><personName><givenNames>Fang</givenNames><familyName>Su</familyName><degrees>DDS, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a5"><personName><givenNames>Yong</givenNames><familyName>Zhang</familyName><degrees>DDS, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a6"><personName><givenNames>Wei</givenNames><familyName>Zhou</familyName><degrees>DDS, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a7"><personName><givenNames>Shujun</givenNames><familyName>Li</familyName><degrees>PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a8"><personName><givenNames>Rui</givenNames><familyName>Yang</familyName><degrees>PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="CN"><unparsedAffiliation>Postdoctor, Dental Institute, Chinese PLA General Hospital, Beijing, China, and Department of Stomatology, General Hospital of Shenyang Military Region, Shenyang, China;</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="CN"><unparsedAffiliation>professor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="CN"><unparsedAffiliation>assistant professor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="CN"><unparsedAffiliation>postdoctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="CN"><unparsedAffiliation>attending doctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="CN"><unparsedAffiliation>professor, Department of Stomatology, The 309th Hospital of Chinese People's Liberation Army, Beijing, China;</unparsedAffiliation></affiliation><affiliation xml:id="a7" countryCode="CN"><unparsedAffiliation>assistant professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China;</unparsedAffiliation></affiliation><affiliation xml:id="a8" countryCode="CN"><unparsedAffiliation>professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">dental implants</keyword><keyword xml:id="k2">injectable bone</keyword><keyword xml:id="k3">peripheral blood</keyword><keyword xml:id="k4">regeneration</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">ABSTRACT</title><p><b>Background:</b> Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO<sub>4</sub>.½H<sub>2</sub>O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.</p><p><b>Purpose:</b> The aim of the study was to assess the new bone formation around immediate dental implants using nHAC/CSH loaded with dog blood‐acquired mesenchymal progenitor cells (dBMPC) in a canine model.</p><p><b>Materials and Methods:</b> dBMPC were first isolated from peripheral blood of healthy adult dogs. Alizarin red and oil red O staining were then used to evaluate the potential of dBMPC to differentiate into bi‐lineage mesenchymal tissues in vitro. Four healthy mongrel dogs were used in this study. The alveolar bone defects around immediate implants of dogs were created. Each defect was randomly assigned to one of the following three groups: (1) the ITB group (dBMPC + nHAC/CSH); (2) injectable bone cement nHAC/CSH; or (3) no materials (controls). Methylene blue staining was used to examine the bone formation after 3 months.</p><p><b>Results:</b> Studies in vitro revealed that dBMPC could be induced to osteoblasts and adipocytes. The ITB group (dBMPC + nHAC/CSH) showed significantly more bone‐implant contact and bone density than either nHAC/CSH or control groups in the areas with peri‐implant defects 3 months after implantation.</p><p><b>Conclusion:</b> The results indicate that the ITB composed of nHAC/CSH and dBMPC may represent a useful strategy for the clinical reconstruction of bone defects around immediate implantation. However, further investigation is needed involving the use of human BMPC as well as possible use of stem cells.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Alveolar Bone Regeneration around Immediate Implants Using an Injectable nHAC/CSH Loaded with Autogenic Blood‐Acquired Mesenchymal Progenitor Cells: An Experimental Study in the Dog Mandible</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Bone Regeneration around Immediate Implants</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Alveolar Bone Regeneration around Immediate Implants Using an Injectable nHAC/CSH Loaded with Autogenic Blood‐Acquired Mesenchymal Progenitor Cells: An Experimental Study in the Dog Mandible</title></titleInfo><name type="personal"><namePart type="given">Xue</namePart><namePart type="family">Han</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Postdoctor, Dental Institute, Chinese PLA General Hospital, Beijing, China, and Department of Stomatology, General Hospital of Shenyang Military Region, Shenyang, China;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hongchen</namePart><namePart type="family">Liu</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>professor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</affiliation><affiliation>E-mail: liuhch301@sina.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dongsheng</namePart><namePart type="family">Wang</namePart><namePart type="termsOfAddress">DDS</namePart><affiliation>assistant professor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fang</namePart><namePart type="family">Su</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>postdoctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yong</namePart><namePart type="family">Zhang</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>attending doctor, Dental Institute, Chinese PLA General Hospital, Beijing, China;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wei</namePart><namePart type="family">Zhou</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>professor, Department of Stomatology, The 309th Hospital of Chinese People's Liberation Army, Beijing, China;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shujun</namePart><namePart type="family">Li</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>assistant professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rui</namePart><namePart type="family">Yang</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2013-06</dateIssued><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">6</extent><extent unit="tables">0</extent><extent unit="formulas">0</extent><extent unit="references">42</extent><extent unit="linksCrossRef">0</extent><extent unit="words">5636</extent></physicalDescription><abstract>Background: Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO4.½H2O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.</abstract><abstract>Purpose: The aim of the study was to assess the new bone formation around immediate dental implants using nHAC/CSH loaded with dog blood‐acquired mesenchymal progenitor cells (dBMPC) in a canine model.</abstract><abstract>Materials and Methods: dBMPC were first isolated from peripheral blood of healthy adult dogs. Alizarin red and oil red O staining were then used to evaluate the potential of dBMPC to differentiate into bi‐lineage mesenchymal tissues in vitro. Four healthy mongrel dogs were used in this study. The alveolar bone defects around immediate implants of dogs were created. Each defect was randomly assigned to one of the following three groups: (1) the ITB group (dBMPC + nHAC/CSH); (2) injectable bone cement nHAC/CSH; or (3) no materials (controls). Methylene blue staining was used to examine the bone formation after 3 months.</abstract><abstract>Results: Studies in vitro revealed that dBMPC could be induced to osteoblasts and adipocytes. The ITB group (dBMPC + nHAC/CSH) showed significantly more bone‐implant contact and bone density than either nHAC/CSH or control groups in the areas with peri‐implant defects 3 months after implantation.</abstract><abstract>Conclusion: The results indicate that the ITB composed of nHAC/CSH and dBMPC may represent a useful strategy for the clinical reconstruction of bone defects around immediate implantation. However, further investigation is needed involving the use of human BMPC as well as possible use of stem cells.</abstract><subject lang="en"><genre>keywords</genre><topic>dental implants</topic><topic>injectable bone</topic><topic>peripheral blood</topic><topic>regeneration</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Implant Dentistry and Related Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>ARTICLE</topic></subject><identifier type="ISSN">1523-0899</identifier><identifier type="eISSN">1708-8208</identifier><identifier type="DOI">10.1111/(ISSN)1708-8208</identifier><identifier type="PublisherID">CID</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>390</start><end>401</end><total>12</total></extent></part></relatedItem><identifier type="istex">CF9759B8D1138549C82208FED3B3D51FF838FE64</identifier><identifier type="ark">ark:/67375/WNG-M2ST7FC2-C</identifier><identifier type="DOI">10.1111/j.1708-8208.2011.00373.x</identifier><identifier type="ArticleID">CID373</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 Wiley Periodicals, Inc.© 2011 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/CF9759B8D1138549C82208FED3B3D51FF838FE64/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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