Alveolar Bone Regeneration around Immediate Implants Using an Injectable nHAC/CSH Loaded with Autogenic Blood‐Acquired Mesenchymal Progenitor Cells: An Experimental Study in the Dog Mandible
Identifieur interne : 006729 ( Istex/Corpus ); précédent : 006728; suivant : 006730Alveolar Bone Regeneration around Immediate Implants Using an Injectable nHAC/CSH Loaded with Autogenic Blood‐Acquired Mesenchymal Progenitor Cells: An Experimental Study in the Dog Mandible
Auteurs : Xue Han ; Hongchen Liu ; Dongsheng Wang ; Fang Su ; Yong Zhang ; Wei Zhou ; Shujun Li ; Rui YangSource :
- Clinical Implant Dentistry and Related Research [ 1523-0899 ] ; 2013-06.
English descriptors
- KwdEn :
- Adherent cells, Adipogenic differentiation, Adipogenic inductive medium, Alveolar bone, Alveolar bone regeneration, Appl biomater, Assistant professor, Beijing, Biomed mater, Biomedical applications, Bmpc, Bone defects, Bone density, Bone formation, Bone marrow, Bone regeneration, Bone substitute, Calcium sulfate, Calcium sulfate hemihydrate, Calcium sulphate, Canine mandible, Cell adhesion, Chinese academy, Clinical implant dentistry, Clinical report, Composite cement, Control group, Control slide, Cultured dbmpc, Cylindrical implants, Dbmpc, Dbmpc group, Dbmpc nhac, Defect, Defect area, Defect sites, Dental implants, Dental institute, Distal bone defects, Experimental study, Extraction sockets, General hospital, Higher percentage, Immediate implantation, Immediate implants, Implant, Implant placement, Implant surface, Implantation, Initial plating, Injectable, Injectable bone, Injectable bone cement, Injectable bone regeneration, Injectable bone substitute, Injectable cement, Injectable tissue, Material science, Maxillary sinus, Mesenchymal, Mesenchymal progenitor cells, Mesenchymal properties, Mesial sockets, Metal research, Mineralized collagen, Mononuclear cells, Negative staining, Nhac, Oral maxillofac implants, Osseous defects, Osteoblast, Osteogenic, Peripheral blood, Positive staining, Previous study, Progenitor, Regeneration, Seeding cells, Standardized defects, Stromal cells, Sulfate, Tissue engineering, Tissue response, Titanium, Titanium alloy, Titanium implants, Trabecular bone.
- Teeft :
- Adherent cells, Adipogenic differentiation, Adipogenic inductive medium, Alveolar bone, Alveolar bone regeneration, Appl biomater, Assistant professor, Beijing, Biomed mater, Biomedical applications, Bmpc, Bone defects, Bone density, Bone formation, Bone marrow, Bone regeneration, Bone substitute, Calcium sulfate, Calcium sulfate hemihydrate, Calcium sulphate, Canine mandible, Cell adhesion, Chinese academy, Clinical implant dentistry, Clinical report, Composite cement, Control group, Control slide, Cultured dbmpc, Cylindrical implants, Dbmpc, Dbmpc group, Dbmpc nhac, Defect, Defect area, Defect sites, Dental implants, Dental institute, Distal bone defects, Experimental study, Extraction sockets, General hospital, Higher percentage, Immediate implantation, Immediate implants, Implant, Implant placement, Implant surface, Implantation, Initial plating, Injectable, Injectable bone, Injectable bone cement, Injectable bone regeneration, Injectable bone substitute, Injectable cement, Injectable tissue, Material science, Maxillary sinus, Mesenchymal, Mesenchymal progenitor cells, Mesenchymal properties, Mesial sockets, Metal research, Mineralized collagen, Mononuclear cells, Negative staining, Nhac, Oral maxillofac implants, Osseous defects, Osteoblast, Osteogenic, Peripheral blood, Positive staining, Previous study, Progenitor, Regeneration, Seeding cells, Standardized defects, Stromal cells, Sulfate, Tissue engineering, Tissue response, Titanium, Titanium alloy, Titanium implants, Trabecular bone.
Abstract
Background: Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO4.½H2O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.
Url:
DOI: 10.1111/j.1708-8208.2011.00373.x
Links to Exploration step
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<front><div type="abstract">Background: Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO4.½H2O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.</div>
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<abstract>Background: Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO4.½H2O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.</abstract>
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<profileDesc><abstract xml:lang="en" style="main"><head>ABSTRACT</head>
<p><hi rend="bold">Background:</hi>
Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO<hi rend="subscript">4</hi>
.½H<hi rend="subscript">2</hi>
O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.</p>
<p><hi rend="bold">Purpose:</hi>
The aim of the study was to assess the new bone formation around immediate dental implants using nHAC/CSH loaded with dog blood‐acquired mesenchymal progenitor cells (dBMPC) in a canine model.</p>
<p><hi rend="bold">Materials and Methods:</hi>
dBMPC were first isolated from peripheral blood of healthy adult dogs. Alizarin red and oil red O staining were then used to evaluate the potential of dBMPC to differentiate into bi‐lineage mesenchymal tissues in vitro. Four healthy mongrel dogs were used in this study. The alveolar bone defects around immediate implants of dogs were created. Each defect was randomly assigned to one of the following three groups: (1) the ITB group (dBMPC + nHAC/CSH); (2) injectable bone cement nHAC/CSH; or (3) no materials (controls). Methylene blue staining was used to examine the bone formation after 3 months.</p>
<p><hi rend="bold">Results:</hi>
Studies in vitro revealed that dBMPC could be induced to osteoblasts and adipocytes. The ITB group (dBMPC + nHAC/CSH) showed significantly more bone‐implant contact and bone density than either nHAC/CSH or control groups in the areas with peri‐implant defects 3 months after implantation.</p>
<p><hi rend="bold">Conclusion:</hi>
The results indicate that the ITB composed of nHAC/CSH and dBMPC may represent a useful strategy for the clinical reconstruction of bone defects around immediate implantation. However, further investigation is needed involving the use of human BMPC as well as possible use of stem cells.</p>
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<p><b>Background:</b>
Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO<sub>4</sub>
.½H<sub>2</sub>
O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.</p>
<p><b>Purpose:</b>
The aim of the study was to assess the new bone formation around immediate dental implants using nHAC/CSH loaded with dog blood‐acquired mesenchymal progenitor cells (dBMPC) in a canine model.</p>
<p><b>Materials and Methods:</b>
dBMPC were first isolated from peripheral blood of healthy adult dogs. Alizarin red and oil red O staining were then used to evaluate the potential of dBMPC to differentiate into bi‐lineage mesenchymal tissues in vitro. Four healthy mongrel dogs were used in this study. The alveolar bone defects around immediate implants of dogs were created. Each defect was randomly assigned to one of the following three groups: (1) the ITB group (dBMPC + nHAC/CSH); (2) injectable bone cement nHAC/CSH; or (3) no materials (controls). Methylene blue staining was used to examine the bone formation after 3 months.</p>
<p><b>Results:</b>
Studies in vitro revealed that dBMPC could be induced to osteoblasts and adipocytes. The ITB group (dBMPC + nHAC/CSH) showed significantly more bone‐implant contact and bone density than either nHAC/CSH or control groups in the areas with peri‐implant defects 3 months after implantation.</p>
<p><b>Conclusion:</b>
The results indicate that the ITB composed of nHAC/CSH and dBMPC may represent a useful strategy for the clinical reconstruction of bone defects around immediate implantation. However, further investigation is needed involving the use of human BMPC as well as possible use of stem cells.</p>
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<namePart type="family">Li</namePart>
<namePart type="termsOfAddress">PhD</namePart>
<affiliation>assistant professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China;</affiliation>
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<name type="personal"><namePart type="given">Rui</namePart>
<namePart type="family">Yang</namePart>
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<affiliation>professor, Shenyang National Laboratory for Material Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China</affiliation>
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<place><placeTerm type="text">Oxford, UK</placeTerm>
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<dateIssued encoding="w3cdtf">2013-06</dateIssued>
<copyrightDate encoding="w3cdtf">2013</copyrightDate>
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<abstract>Background: Lack of osseointegration between a dental implant and the walls of the alveolar bone is a common problem in immediate implantation. Injectable tissue‐engineered bone (ITB) may be an effective and minimally invasive solution to the problem. In this study, an injectable bone cement, nHAC/CSH, which consists of nano‐hydroxyapatite/collagen (nHAC) and calcium sulfate hemihydrate (CaSO4.½H2O; CSH) was investigated as a tissue‐engineered scaffold material with blood‐acquired mesenchymal progenitor cells (BMPC) as seeding cells.</abstract>
<abstract>Purpose: The aim of the study was to assess the new bone formation around immediate dental implants using nHAC/CSH loaded with dog blood‐acquired mesenchymal progenitor cells (dBMPC) in a canine model.</abstract>
<abstract>Materials and Methods: dBMPC were first isolated from peripheral blood of healthy adult dogs. Alizarin red and oil red O staining were then used to evaluate the potential of dBMPC to differentiate into bi‐lineage mesenchymal tissues in vitro. Four healthy mongrel dogs were used in this study. The alveolar bone defects around immediate implants of dogs were created. Each defect was randomly assigned to one of the following three groups: (1) the ITB group (dBMPC + nHAC/CSH); (2) injectable bone cement nHAC/CSH; or (3) no materials (controls). Methylene blue staining was used to examine the bone formation after 3 months.</abstract>
<abstract>Results: Studies in vitro revealed that dBMPC could be induced to osteoblasts and adipocytes. The ITB group (dBMPC + nHAC/CSH) showed significantly more bone‐implant contact and bone density than either nHAC/CSH or control groups in the areas with peri‐implant defects 3 months after implantation.</abstract>
<abstract>Conclusion: The results indicate that the ITB composed of nHAC/CSH and dBMPC may represent a useful strategy for the clinical reconstruction of bone defects around immediate implantation. However, further investigation is needed involving the use of human BMPC as well as possible use of stem cells.</abstract>
<subject lang="en"><genre>keywords</genre>
<topic>dental implants</topic>
<topic>injectable bone</topic>
<topic>peripheral blood</topic>
<topic>regeneration</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Clinical Implant Dentistry and Related Research</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<subject><genre>article-category</genre>
<topic>ARTICLE</topic>
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<identifier type="ISSN">1523-0899</identifier>
<identifier type="eISSN">1708-8208</identifier>
<identifier type="DOI">10.1111/(ISSN)1708-8208</identifier>
<identifier type="PublisherID">CID</identifier>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>15</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>390</start>
<end>401</end>
<total>12</total>
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<identifier type="ark">ark:/67375/WNG-M2ST7FC2-C</identifier>
<identifier type="DOI">10.1111/j.1708-8208.2011.00373.x</identifier>
<identifier type="ArticleID">CID373</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 Wiley Periodicals, Inc.© 2011 Wiley Periodicals, Inc.</accessCondition>
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