Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats
Identifieur interne : 006614 ( Istex/Corpus ); précédent : 006613; suivant : 006615Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats
Auteurs : Yunfeng Li ; Xudong Li ; Guodong Song ; Kan Chen ; Guozhu Yin ; Jing HuSource :
- Clinical Oral Implants Research [ 0905-7161 ] ; 2012-09.
English descriptors
- KwdEn :
- Bilateral ovariectomy, Biomechanical, Biomechanical test, Bone area density, Bone formation, Bone loss, Bone mass, Bone microarchitecture, Bone regeneration, Bone resorption, Bone tissue, Clin, Direct contact, Distal femora, Dual effects, Epiphyseal plate, Female rats, Femur, Growth plate, Histological, Histomorphometry, Impl, Implant, Implant dentistry, Implant osseointegration, Implant surface, International journal, John wiley sons, Maxillofacial surgery, Maximal force, Microarchitecture, Mineral research, Oral impl, Osseointegration, Osteoporosis, Osteoporotic, Osteoporotic rats, Ovariectomized, Ovariectomized rats, Parathyroid hormone, Percent osseointegration, Present study, Previous study, Quantitative results, Ranelate, Rat, Resorption, Serum analysis, Serum levels, Sichuan university, Strontium, Strontium ranelate, Strontium ranelate treatment, Titanium, Titanium implant, Titanium implant osseointegration, Titanium implants, Total voxels, Trabecular, Trabecular microarchitecture, Trabecular number, Trabecular separation, Trabecular thickness, Ultimate shear strength, Undisturbed bone tissue, Xation.
- Teeft :
- Bilateral ovariectomy, Biomechanical, Biomechanical test, Bone area density, Bone formation, Bone loss, Bone mass, Bone microarchitecture, Bone regeneration, Bone resorption, Bone tissue, Clin, Direct contact, Distal femora, Dual effects, Epiphyseal plate, Female rats, Femur, Growth plate, Histological, Histomorphometry, Impl, Implant, Implant dentistry, Implant osseointegration, Implant surface, International journal, John wiley sons, Maxillofacial surgery, Maximal force, Microarchitecture, Mineral research, Oral impl, Osseointegration, Osteoporosis, Osteoporotic, Osteoporotic rats, Ovariectomized, Ovariectomized rats, Parathyroid hormone, Percent osseointegration, Present study, Previous study, Quantitative results, Ranelate, Rat, Resorption, Serum analysis, Serum levels, Sichuan university, Strontium, Strontium ranelate, Strontium ranelate treatment, Titanium, Titanium implant, Titanium implant osseointegration, Titanium implants, Total voxels, Trabecular, Trabecular microarchitecture, Trabecular number, Trabecular separation, Trabecular thickness, Ultimate shear strength, Undisturbed bone tissue, Xation.
Abstract
Previous studies have demonstrated the dual effects of strontium ranelate (SR) on osteoporotic and undisturbed bone. However, reports of its effect on titanium implant osseointegration in osteoporotic bodies were limited. This study was designed to investigate the effects of SR on osseointegration of titanium implant in ovariectomized rats.
Url:
DOI: 10.1111/j.1600-0501.2011.02252.x
Links to Exploration step
ISTEX:CD651287253105A166BE9D2118C043A42FC9F387Le document en format XML
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Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="ISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><imprint><biblScope unit="vol">23</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1038">1038</biblScope><biblScope unit="page" to="1044">1044</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2012-09">2012-09</date></imprint><idno type="ISSN">0905-7161</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0905-7161</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bilateral ovariectomy</term><term>Biomechanical</term><term>Biomechanical test</term><term>Bone area density</term><term>Bone formation</term><term>Bone loss</term><term>Bone mass</term><term>Bone microarchitecture</term><term>Bone regeneration</term><term>Bone resorption</term><term>Bone tissue</term><term>Clin</term><term>Direct contact</term><term>Distal femora</term><term>Dual effects</term><term>Epiphyseal plate</term><term>Female rats</term><term>Femur</term><term>Growth plate</term><term>Histological</term><term>Histomorphometry</term><term>Impl</term><term>Implant</term><term>Implant dentistry</term><term>Implant osseointegration</term><term>Implant surface</term><term>International journal</term><term>John wiley sons</term><term>Maxillofacial surgery</term><term>Maximal force</term><term>Microarchitecture</term><term>Mineral research</term><term>Oral impl</term><term>Osseointegration</term><term>Osteoporosis</term><term>Osteoporotic</term><term>Osteoporotic rats</term><term>Ovariectomized</term><term>Ovariectomized rats</term><term>Parathyroid hormone</term><term>Percent osseointegration</term><term>Present study</term><term>Previous study</term><term>Quantitative results</term><term>Ranelate</term><term>Rat</term><term>Resorption</term><term>Serum analysis</term><term>Serum levels</term><term>Sichuan 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ranelate</term><term>Strontium ranelate treatment</term><term>Titanium</term><term>Titanium implant</term><term>Titanium implant osseointegration</term><term>Titanium implants</term><term>Total voxels</term><term>Trabecular</term><term>Trabecular microarchitecture</term><term>Trabecular number</term><term>Trabecular separation</term><term>Trabecular thickness</term><term>Ultimate shear strength</term><term>Undisturbed bone tissue</term><term>Xation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Previous studies have demonstrated the dual effects of strontium ranelate (SR) on osteoporotic and undisturbed bone. However, reports of its effect on titanium implant osseointegration in osteoporotic bodies were limited. This study was designed to investigate the effects of SR on osseointegration of titanium implant in ovariectomized rats.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>implant</json:string><json:string>osseointegration</json:string><json:string>strontium</json:string><json:string>ranelate</json:string><json:string>strontium ranelate</json:string><json:string>trabecular</json:string><json:string>xation</json:string><json:string>osteoporotic</json:string><json:string>biomechanical</json:string><json:string>implant osseointegration</json:string><json:string>histomorphometry</json:string><json:string>bone mass</json:string><json:string>microarchitecture</json:string><json:string>femur</json:string><json:string>bone formation</json:string><json:string>ovariectomized</json:string><json:string>resorption</json:string><json:string>biomechanical test</json:string><json:string>maximal 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Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China</json:string></affiliations></json:item><json:item><name>Guozhu Yin</name><affiliations><json:string>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China</json:string></affiliations></json:item><json:item><name>Jing Hu</name><affiliations><json:string>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China</json:string><json:string>Corresponding author:The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial SurgeryWest China College of Stomatology, Sichuan UniversityChengdu 610041ChinaTel.: +86 28 61153299Fax: +86 28 85582167e‐mail:</json:string><json:string>E-mail: drhu@vip.sohu.com</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>implant</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>osseointegration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>osteoporosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>strontium ranelate</value></json:item></subject><articleId><json:string>CLR2252</json:string></articleId><arkIstex>ark:/67375/WNG-ZJVM260G-T</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Previous studies have demonstrated the dual effects of strontium ranelate (SR) on osteoporotic and undisturbed bone. However, reports of its effect on titanium implant osseointegration in osteoporotic bodies were limited. This study was designed to investigate the effects of SR on osseointegration of titanium implant in ovariectomized rats.</abstract><qualityIndicators><score>6.92</score><pdfWordCount>4344</pdfWordCount><pdfCharCount>28529</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>48</abstractWordCount><abstractCharCount>342</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats</title><pmid><json:string>22117625</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Clinical Oral Implants Research</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0501</json:string></doi><issn><json:string>0905-7161</json:string></issn><eissn><json:string>1600-0501</json:string></eissn><publisherId><json:string>CLR</json:string></publisherId><volume>23</volume><issue>9</issue><pages><first>1038</first><last>1044</last><total>7</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item></subject></host><namedEntities><unitex><date><json:string>2011-06-27</json:string><json:string>1039</json:string><json:string>1042</json:string></date><geogName></geogName><orgName><json:string>Animal Research Committee of the University</json:string><json:string>National Engineering Research Center for Biomaterials, Sichuan University</json:string><json:string>Consensus Development Conference</json:string><json:string>West China, Sichuan University</json:string><json:string>National Nature Science Foundation of China</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>College</json:string><json:string>John Wiley</json:string><json:string>J. 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xml:id="author-0000"><persName><forename type="first">Yunfeng</forename><surname>Li</surname></persName><affiliation><orgName>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery</orgName><orgName>West China College of Stomatology</orgName><orgName>Sichuan University</orgName><address><settlement type="city">Chengdu</settlement><country key="CN">China</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Xudong</forename><surname>Li</surname></persName><affiliation><orgName>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery</orgName><orgName>West China College of Stomatology</orgName><orgName>Sichuan University</orgName><address><settlement type="city">Chengdu</settlement><country key="CN">China</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Guodong</forename><surname>Song</surname></persName><affiliation><orgName>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery</orgName><orgName>West China College of Stomatology</orgName><orgName>Sichuan University</orgName><address><settlement type="city">Chengdu</settlement><country key="CN">China</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Kan</forename><surname>Chen</surname></persName><affiliation><orgName>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery</orgName><orgName>West China College of Stomatology</orgName><orgName>Sichuan University</orgName><address><settlement type="city">Chengdu</settlement><country key="CN">China</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Guozhu</forename><surname>Yin</surname></persName><affiliation><orgName>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery</orgName><orgName>West China College of Stomatology</orgName><orgName>Sichuan University</orgName><address><settlement type="city">Chengdu</settlement><country key="CN">China</country></address></affiliation></author><author xml:id="author-0005" role="corresp"><persName><forename type="first">Jing</forename><surname>Hu</surname></persName><affiliation><orgName>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery</orgName><orgName>West China College of Stomatology</orgName><orgName>Sichuan University</orgName><address><settlement type="city">Chengdu</settlement><country key="CN">China</country></address></affiliation><affiliation>Corresponding author: Jing HuThe State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial SurgeryWest China College of Stomatology, Sichuan UniversityChengdu 610041ChinaTel.: +86 28 61153299Fax: +86 28 85582167e‐mail: drhu@vip.sohu.com</affiliation></author><idno type="istex">CD651287253105A166BE9D2118C043A42FC9F387</idno><idno type="ark">ark:/67375/WNG-ZJVM260G-T</idno><idno type="DOI">10.1111/j.1600-0501.2011.02252.x</idno><idno type="unit">CLR2252</idno><idno type="toTypesetVersion">file:CLR.CLR2252.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Oral Implants Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="pISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><idno type="book-DOI">10.1111/(ISSN)1600-0501</idno><idno type="book-part-DOI">10.1111/clr.2012.23.issue-9</idno><idno type="product">CLR</idno><imprint><biblScope unit="vol">23</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1038">1038</biblScope><biblScope unit="page" to="1044">1044</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2012-09"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="clr2252-abs-0001"><head>Abstract</head>
Objectives
<p>Previous studies have demonstrated the dual effects of strontium ranelate (<hi rend="fc">SR</hi>) on osteoporotic and undisturbed bone. However, reports of its effect on titanium implant osseointegration in osteoporotic bodies were limited. This study was designed to investigate the effects of <hi rend="fc">SR</hi> on osseointegration of titanium implant in ovariectomized rats.</p>
Material and methods
<p>Twelve weeks after bilateral ovariectomy in female Sprague‐Dawley rats, each animal received two titanium implants in the distal metaphysis of femur. All rats were then randomly divided into two groups: Control and <hi rend="fc">SR</hi> (625 mg/kg/day). Twelve weeks after implantation, serum levels of osteocalcin (OCN) and tartrate‐resistant acid phosphatase (<hi rend="fc">TRAP</hi>) 5b, implant osseointegration and peri‐implant trabecular microarchitecture were analyzed by histomorphometry, micro‐computerized tomography (micro‐<hi rend="fc">CT</hi>), and biomechanical test.</p>
Results
<p>Compared with control, <hi rend="fc">SR</hi> treatment increased serum levels of OCN by 29.2%, and decreased the levels of <hi rend="fc">TRAP</hi> 5b by 25.5% in serum analysis; <hi rend="fc">SR</hi> treatment increased percent bone volume by 63.1% and percent osseointegration by 48.3% in micro‐<hi rend="fc">CT</hi> assessment, and increased bone area density by 55.6% and bone‐to‐implant contact by 49.0% in histomorphometry; <hi rend="fc">SR</hi> treatment also increased the maximal push‐out force by 117.7% and the ultimate shear strength by 103.5% in push‐out test.</p>
Conclusions
<p>Strontium ranelate treatment could improve titanium implant osseointegration in osteoporotic rats.</p></abstract><textClass><keywords><term xml:id="clr2252-kwd-0001">implant</term><term xml:id="clr2252-kwd-0002">osseointegration</term><term xml:id="clr2252-kwd-0003">osteoporosis</term><term xml:id="clr2252-kwd-0004">strontium ranelate</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/CD651287253105A166BE9D2118C043A42FC9F387/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="clr2252" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0501</doi><issn type="print">0905-7161</issn><issn type="electronic">1600-0501</issn><idGroup><id type="product" value="CLR"></id></idGroup><titleGroup><title sort="CLINICAL ORAL IMPLANTS RESEARCH" type="main">Clinical Oral Implants Research</title><title type="short">Clin. Oral Impl. Res.</title></titleGroup></publicationMeta><publicationMeta level="part" position="09109"><doi origin="wiley">10.1111/clr.2012.23.issue-9</doi><copyright ownership="publisher">Copyright © 2012 John Wiley & Sons A/S</copyright><numberingGroup><numbering type="journalVolume" number="23">23</numbering><numbering type="journalIssue">9</numbering></numberingGroup><coverDate startDate="2012-09">September 2012</coverDate></publicationMeta><publicationMeta level="unit" position="50" status="forIssue" type="article"><doi>10.1111/j.1600-0501.2011.02252.x</doi><idGroup><id type="unit" value="CLR2252"></id></idGroup><countGroup><count number="7" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">© 2011 John Wiley & Sons A/S</copyright><eventGroup><event date="2011-05-23" type="manuscriptAccepted"></event><event agent="SPS" date="2011-06-27" type="xmlCreated"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-11-25"></event><event type="firstOnline" date="2011-11-25"></event><event type="publishedOnlineFinalForm" date="2012-08-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-25"></event></eventGroup><numberingGroup><numbering type="pageFirst">1038</numbering><numbering type="pageLast">1044</numbering></numberingGroup><correspondenceTo><lineatedText><line>Corresponding author:</line> <line><i>Jing Hu</i></line><line>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery</line><line>West China College of Stomatology, Sichuan University</line><line>Chengdu 610041</line><line>China</line><line>Tel.: +86 28 61153299</line><line>Fax: +86 28 85582167</line><line>e‐mail: <email>drhu@vip.sohu.com</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="clr2252-cit-0030">Li Y, Li X, Song G, Chen K, Yin G, Hu J. Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats. <i>Clin. Oral Impl. Res.</i> <b>23</b>, 2012, 1038–1044</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:CLR.CLR2252.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats</title><title type="shortAuthors">Li et al</title></titleGroup><creators><creator affiliationRef="#clr2252-aff-0001" creatorRole="author" xml:id="clr2252-cr-0001"><personName><givenNames>Yunfeng</givenNames> <familyName>Li</familyName></personName></creator><creator affiliationRef="#clr2252-aff-0001" creatorRole="author" xml:id="clr2252-cr-0002"><personName><givenNames>Xudong</givenNames> <familyName>Li</familyName></personName></creator><creator affiliationRef="#clr2252-aff-0001" creatorRole="author" xml:id="clr2252-cr-0003"><personName><givenNames>Guodong</givenNames> <familyName>Song</familyName></personName></creator><creator affiliationRef="#clr2252-aff-0001" creatorRole="author" xml:id="clr2252-cr-0004"><personName><givenNames>Kan</givenNames> <familyName>Chen</familyName></personName></creator><creator affiliationRef="#clr2252-aff-0001" creatorRole="author" xml:id="clr2252-cr-0005"><personName><givenNames>Guozhu</givenNames> <familyName>Yin</familyName></personName></creator><creator affiliationRef="#clr2252-aff-0001" corresponding="yes" creatorRole="author" xml:id="clr2252-cr-0006"><personName><givenNames>Jing</givenNames> <familyName>Hu</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="CN" type="organization" xml:id="clr2252-aff-0001"><orgDiv>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery</orgDiv> <orgName>West China College of Stomatology</orgName> <orgName>Sichuan University</orgName> <address><city>Chengdu</city> <country>China</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="clr2252-kwd-0001">implant</keyword><keyword xml:id="clr2252-kwd-0002">osseointegration</keyword><keyword xml:id="clr2252-kwd-0003">osteoporosis</keyword><keyword xml:id="clr2252-kwd-0004">strontium ranelate</keyword></keywordGroup><fundingInfo><fundingAgency>National Nature Science Foundation of China</fundingAgency><fundingNumber>81070869</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:id="clr2252-abs-0001"><title type="main">Abstract</title><section xml:id="clr2252-sec-0001"><title type="main">Objectives</title><p>Previous studies have demonstrated the dual effects of strontium ranelate (<fc>SR</fc>) on osteoporotic and undisturbed bone. However, reports of its effect on titanium implant osseointegration in osteoporotic bodies were limited. This study was designed to investigate the effects of <fc>SR</fc> on osseointegration of titanium implant in ovariectomized rats.</p></section><section xml:id="clr2252-sec-0002"><title type="main">Material and methods</title><p>Twelve weeks after bilateral ovariectomy in female Sprague‐Dawley rats, each animal received two titanium implants in the distal metaphysis of femur. All rats were then randomly divided into two groups: Control and <fc>SR</fc> (625 mg/kg/day). Twelve weeks after implantation, serum levels of osteocalcin (OCN) and tartrate‐resistant acid phosphatase (<fc>TRAP</fc>) 5b, implant osseointegration and peri‐implant trabecular microarchitecture were analyzed by histomorphometry, micro‐computerized tomography (micro‐<fc>CT</fc>), and biomechanical test.</p></section><section xml:id="clr2252-sec-0003"><title type="main">Results</title><p>Compared with control, <fc>SR</fc> treatment increased serum levels of OCN by 29.2%, and decreased the levels of <fc>TRAP</fc> 5b by 25.5% in serum analysis; <fc>SR</fc> treatment increased percent bone volume by 63.1% and percent osseointegration by 48.3% in micro‐<fc>CT</fc> assessment, and increased bone area density by 55.6% and bone‐to‐implant contact by 49.0% in histomorphometry; <fc>SR</fc> treatment also increased the maximal push‐out force by 117.7% and the ultimate shear strength by 103.5% in push‐out test.</p></section><section xml:id="clr2252-sec-0004"><title type="main">Conclusions</title><p>Strontium ranelate treatment could improve titanium implant osseointegration in osteoporotic rats.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats</title></titleInfo><name type="personal"><namePart type="given">Yunfeng</namePart><namePart type="family">Li</namePart><affiliation>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Xudong</namePart><namePart type="family">Li</namePart><affiliation>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guodong</namePart><namePart type="family">Song</namePart><affiliation>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kan</namePart><namePart type="family">Chen</namePart><affiliation>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guozhu</namePart><namePart type="family">Yin</namePart><affiliation>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jing</namePart><namePart type="family">Hu</namePart><affiliation>The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China</affiliation><affiliation>Corresponding author:The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial SurgeryWest China College of Stomatology, Sichuan UniversityChengdu 610041ChinaTel.: +86 28 61153299Fax: +86 28 85582167e‐mail:</affiliation><affiliation>E-mail: drhu@vip.sohu.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2012-09</dateIssued><dateCreated encoding="w3cdtf">2011-06-27</dateCreated><dateValid encoding="w3cdtf">2011-05-23</dateValid><edition>Li Y, Li X, Song G, Chen K, Yin G, Hu J. Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats. Clin. Oral Impl. Res. 23, 2012, 1038–1044</edition><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Previous studies have demonstrated the dual effects of strontium ranelate (SR) on osteoporotic and undisturbed bone. However, reports of its effect on titanium implant osseointegration in osteoporotic bodies were limited. This study was designed to investigate the effects of SR on osseointegration of titanium implant in ovariectomized rats.</abstract><abstract>Twelve weeks after bilateral ovariectomy in female Sprague‐Dawley rats, each animal received two titanium implants in the distal metaphysis of femur. All rats were then randomly divided into two groups: Control and SR (625 mg/kg/day). Twelve weeks after implantation, serum levels of osteocalcin (OCN) and tartrate‐resistant acid phosphatase (TRAP) 5b, implant osseointegration and peri‐implant trabecular microarchitecture were analyzed by histomorphometry, micro‐computerized tomography (micro‐CT), and biomechanical test.</abstract><abstract>Compared with control, SR treatment increased serum levels of OCN by 29.2%, and decreased the levels of TRAP 5b by 25.5% in serum analysis; SR treatment increased percent bone volume by 63.1% and percent osseointegration by 48.3% in micro‐CT assessment, and increased bone area density by 55.6% and bone‐to‐implant contact by 49.0% in histomorphometry; SR treatment also increased the maximal push‐out force by 117.7% and the ultimate shear strength by 103.5% in push‐out test.</abstract><abstract>Strontium ranelate treatment could improve titanium implant osseointegration in osteoporotic rats.</abstract><note type="funding">National Nature Science Foundation of China - No. 81070869; </note><subject><genre>keywords</genre><topic>implant</topic><topic>osseointegration</topic><topic>osteoporosis</topic><topic>strontium ranelate</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Oral Implants Research</title></titleInfo><titleInfo type="abbreviated"><title>Clin. 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