Role of colony‐stimulating factor‐1 in bone metabolism
Identifieur interne : 006389 ( Istex/Corpus ); précédent : 006388; suivant : 006390Role of colony‐stimulating factor‐1 in bone metabolism
Auteurs : Rolf Felix ; Willy Hofstetter ; Antoinette Wetterwald ; Marco G. Cecchini ; Herbert FleischSource :
- Journal of Cellular Biochemistry [ 0730-2312 ] ; 1994-07.
English descriptors
- KwdEn :
- Amino acids, Binding sites, Bone metabolism, Bone resorption, Cecchini, Cell membrane, Cell populations, Cytokine, Exon, Extracellular matrix, Fleisch, Growth factor, Growth factors, Hemopoietic, Hofstetter, Long bones, Macrophage, Macrophage factor, Macrophage populations, Matrix, Mature osteoclasts, Metatarsal, Molecular forms, Mononuclear, Mrna, Murine, Opiop, Oplop, Oplop animals, Oplop mice, Oplop mouse, Osteoblast, Osteoclast, Osteoclast development, Osteoclast formation, Osteoclastic, Osteoclastic precursors, Osteoclastogenesis, Osteopetrosis, Osteopetrotic, Osteopetrotic phenotype, Precursor, Receptor, Resorbing cells, Resorption, Single injection, Strain oplop, Takahashi, Target cells, Tissue macrophages, Tlltl rats, Transcript, Translation product.
- Teeft :
- Amino acids, Binding sites, Bone metabolism, Bone resorption, Cecchini, Cell membrane, Cell populations, Cytokine, Exon, Extracellular matrix, Fleisch, Growth factor, Growth factors, Hemopoietic, Hofstetter, Long bones, Macrophage, Macrophage factor, Macrophage populations, Matrix, Mature osteoclasts, Metatarsal, Molecular forms, Mononuclear, Mrna, Murine, Opiop, Oplop, Oplop animals, Oplop mice, Oplop mouse, Osteoblast, Osteoclast, Osteoclast development, Osteoclast formation, Osteoclastic, Osteoclastic precursors, Osteoclastogenesis, Osteopetrosis, Osteopetrotic, Osteopetrotic phenotype, Precursor, Receptor, Resorbing cells, Resorption, Single injection, Strain oplop, Takahashi, Target cells, Tissue macrophages, Tlltl rats, Transcript, Translation product.
Abstract
Colony‐stimulating factor‐1 (CSF‐1) is a cytokine required for proliferation, differentiation, activity, and survival of cells of the mononuclear phagocytic system. The growth factor is synthesized as a soluble, matrix, or membrane associated molecule. The specific functions of these forms are not clear. However, some data suggest a dependence of the development of various populations of tissue macrophages on the locally expressed and presented cytokine. Deficiency in CSF‐1, as is the case in the murine mutant strain op/op, results in low numbers of macrophages and monocytes and, most striking, leads to osteopetrosis due to a virtual absence of osteoclasts. Using the op/op mutation as a model, CSF‐1 was established as one of the growth factors for osteoclasts. The expression of CSF‐1 receptors, encoded by the proto‐oncogene c‐fms, by osteoclast precursors and osteoclasts, suggested an effect of this cytokine not only during osteoclast formation but also on the mature cells. In fact, CSF‐1 was shown to inhibit the resorbing activity, to stimulate migration, and to support survival of isolated osteoclasts in vitro. By these actions on cells of the osteoclast lineage, CSF‐1 induces recruitment of new osteoclasts, leading to a net increase of bone resorption, and might govern the spatial distribution of resorption sites within the bone. During these processes, locally expressed and presented forms of the growth factor may play a crucial role, as will be discussed in this article. © 1994 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jcb.240550311
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Colony‐stimulating factor‐1 (CSF‐1) is a cytokine required for proliferation, differentiation, activity, and survival of cells of the mononuclear phagocytic system. The growth factor is synthesized as a soluble, matrix, or membrane associated molecule. The specific functions of these forms are not clear. However, some data suggest a dependence of the development of various populations of tissue macrophages on the locally expressed and presented cytokine. Deficiency in CSF‐1, as is the case in the murine mutant strain op/op, results in low numbers of macrophages and monocytes and, most striking, leads to osteopetrosis due to a virtual absence of osteoclasts. Using the op/op mutation as a model, CSF‐1 was established as one of the growth factors for osteoclasts. The expression of CSF‐1 receptors, encoded by the proto‐oncogene c‐fms, by osteoclast precursors and osteoclasts, suggested an effect of this cytokine not only during osteoclast formation but also on the mature cells. In fact, CSF‐1 was shown to inhibit the resorbing activity, to stimulate migration, and to support survival of isolated osteoclasts in vitro. By these actions on cells of the osteoclast lineage, CSF‐1 induces recruitment of new osteoclasts, leading to a net increase of bone resorption, and might govern the spatial distribution of resorption sites within the bone. During these processes, locally expressed and presented forms of the growth factor may play a crucial role, as will be discussed in this article. © 1994 Wiley‐Liss, Inc.</div>
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<abstract>Colony‐stimulating factor‐1 (CSF‐1) is a cytokine required for proliferation, differentiation, activity, and survival of cells of the mononuclear phagocytic system. The growth factor is synthesized as a soluble, matrix, or membrane associated molecule. The specific functions of these forms are not clear. However, some data suggest a dependence of the development of various populations of tissue macrophages on the locally expressed and presented cytokine. Deficiency in CSF‐1, as is the case in the murine mutant strain op/op, results in low numbers of macrophages and monocytes and, most striking, leads to osteopetrosis due to a virtual absence of osteoclasts. Using the op/op mutation as a model, CSF‐1 was established as one of the growth factors for osteoclasts. The expression of CSF‐1 receptors, encoded by the proto‐oncogene c‐fms, by osteoclast precursors and osteoclasts, suggested an effect of this cytokine not only during osteoclast formation but also on the mature cells. In fact, CSF‐1 was shown to inhibit the resorbing activity, to stimulate migration, and to support survival of isolated osteoclasts in vitro. By these actions on cells of the osteoclast lineage, CSF‐1 induces recruitment of new osteoclasts, leading to a net increase of bone resorption, and might govern the spatial distribution of resorption sites within the bone. During these processes, locally expressed and presented forms of the growth factor may play a crucial role, as will be discussed in this article. © 1994 Wiley‐Liss, Inc.</abstract>
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<p>Colony‐stimulating factor‐1 (CSF‐1) is a cytokine required for proliferation, differentiation, activity, and survival of cells of the mononuclear phagocytic system. The growth factor is synthesized as a soluble, matrix, or membrane associated molecule. The specific functions of these forms are not clear. However, some data suggest a dependence of the development of various populations of tissue macrophages on the locally expressed and presented cytokine. Deficiency in CSF‐1, as is the case in the murine mutant strain <hi rend="italic">op</hi>
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/<hi rend="italic">op</hi>
mutation as a model, CSF‐1 was established as one of the growth factors for osteoclasts. The expression of CSF‐1 receptors, encoded by the proto‐oncogene <hi rend="italic">c</hi>
‐<hi rend="italic">fms</hi>
, by osteoclast precursors and osteoclasts, suggested an effect of this cytokine not only during osteoclast formation but also on the mature cells. In fact, CSF‐1 was shown to inhibit the resorbing activity, to stimulate migration, and to support survival of isolated osteoclasts in vitro. By these actions on cells of the osteoclast lineage, CSF‐1 induces recruitment of new osteoclasts, leading to a net increase of bone resorption, and might govern the spatial distribution of resorption sites within the bone. During these processes, locally expressed and presented forms of the growth factor may play a crucial role, as will be discussed in this article. © 1994 Wiley‐Liss, Inc.</p>
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<p>Colony‐stimulating factor‐1 (CSF‐1) is a cytokine required for proliferation, differentiation, activity, and survival of cells of the mononuclear phagocytic system. The growth factor is synthesized as a soluble, matrix, or membrane associated molecule. The specific functions of these forms are not clear. However, some data suggest a dependence of the development of various populations of tissue macrophages on the locally expressed and presented cytokine. Deficiency in CSF‐1, as is the case in the murine mutant strain <i>op</i>
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<abstract lang="en">Colony‐stimulating factor‐1 (CSF‐1) is a cytokine required for proliferation, differentiation, activity, and survival of cells of the mononuclear phagocytic system. The growth factor is synthesized as a soluble, matrix, or membrane associated molecule. The specific functions of these forms are not clear. However, some data suggest a dependence of the development of various populations of tissue macrophages on the locally expressed and presented cytokine. Deficiency in CSF‐1, as is the case in the murine mutant strain op/op, results in low numbers of macrophages and monocytes and, most striking, leads to osteopetrosis due to a virtual absence of osteoclasts. Using the op/op mutation as a model, CSF‐1 was established as one of the growth factors for osteoclasts. The expression of CSF‐1 receptors, encoded by the proto‐oncogene c‐fms, by osteoclast precursors and osteoclasts, suggested an effect of this cytokine not only during osteoclast formation but also on the mature cells. In fact, CSF‐1 was shown to inhibit the resorbing activity, to stimulate migration, and to support survival of isolated osteoclasts in vitro. By these actions on cells of the osteoclast lineage, CSF‐1 induces recruitment of new osteoclasts, leading to a net increase of bone resorption, and might govern the spatial distribution of resorption sites within the bone. During these processes, locally expressed and presented forms of the growth factor may play a crucial role, as will be discussed in this article. © 1994 Wiley‐Liss, Inc.</abstract>
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