The roles of surface chemistry and topography in the strength and rate of osseointegration of titanium implants in bone
Identifieur interne : 005F37 ( Istex/Corpus ); précédent : 005F36; suivant : 005F38The roles of surface chemistry and topography in the strength and rate of osseointegration of titanium implants in bone
Auteurs : Young-Taeg Sul ; Byung-Soo Kang ; Carina Johansson ; Heung-Sik Um ; Chan-Jin Park ; Tomas AlbrektssonSource :
- Journal of Biomedical Materials Research Part A [ 1549-3296 ] ; 2009-06-15.
English descriptors
- KwdEn :
- Albrektsson, Bioactive, Biomed mater, Biomedical, Biomedical materials research part, Bone growth, Bone integration, Bone response, Bone tissue, Clin, Clin implant dent relat, Healing intervals, Healing period, Healing time, Height deviation, Implant, Implant groups, Implant insertion, Implant surface, Johansson, Oral maxillofac implants, Osseointegration, Osseointegration rate, Osseointegration strength, Oxidized, Oxidized implants, Oxidized titanium implants, Present study, Rabbit bone, Removal torque, Roughness, Strong integration, Surface chemistry, Surface properties, Surface ratio, Surface roughness, Surface topography, Tibia, Titanium, Titanium implants.
- Teeft :
- Albrektsson, Bioactive, Biomed mater, Biomedical, Biomedical materials research part, Bone growth, Bone integration, Bone response, Bone tissue, Clin, Clin implant dent relat, Healing intervals, Healing period, Healing time, Height deviation, Implant, Implant groups, Implant insertion, Implant surface, Johansson, Oral maxillofac implants, Osseointegration, Osseointegration rate, Osseointegration strength, Oxidized, Oxidized implants, Oxidized titanium implants, Present study, Rabbit bone, Removal torque, Roughness, Strong integration, Surface chemistry, Surface properties, Surface ratio, Surface roughness, Surface topography, Tibia, Titanium, Titanium implants.
Abstract
The present study investigated the effects of surface chemistry and topography on the strength and rate of osseointegration of titanium implants in bone. Three groups of implants were compared: (1) machine‐turned implants (turned implants), (2) machine‐turned and aluminum oxide‐blasted implants (blasted implants), and (3) implants that were machine‐turned, aluminum oxide‐blasted, and processed with the micro‐arc oxidation method (Mg implants). Three and six weeks after implant insertion in rabbit tibiae, the implant osseointegration strength and rate were evaluated. Surface chemistry revealed characteristic differences of nine at.% Mg for Mg implants and 11 at.% Al for blasted implants. In terms of surface roughness, there was no difference between Mg implants and blasted implants in developed surface ratio (Sdr; p = 0.69) or summit density (Sds; p = 0.96), but Mg implants had a significantly lower arithmetic average height deviation (Sa) value than blasted implants (p = 0.007). At both 3 and 6 weeks, Mg implants demonstrated significantly higher osseointegration strength compared with turned (p = 0.0001, p = 0.0001) and blasted (p = 0.0001, p = 0.035) implants, whereas blasted implants showed significantly higher osseointegration than turned implants at 6 weeks (p = 0.02) but not at 3 weeks (p = 0.199). The present results not only support the hypothesis that biochemical bonding facilitates rapid and strong integration of implants in bone, but also provide evidence for biochemical bonding theory previously proposed by Sul. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
Url:
DOI: 10.1002/jbm.a.32041
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ISTEX:BF925C26CDD10F66200A1F7E946941BBE5D13382Le document en format XML
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first="Byung-Soo" last="Kang">Byung-Soo Kang</name><affiliation><mods:affiliation>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Johansson, Carina" sort="Johansson, Carina" uniqKey="Johansson C" first="Carina" last="Johansson">Carina Johansson</name><affiliation><mods:affiliation>Department of Clinical Medicine/Medical Technology, Örebro University, Örebro, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Um, Heung Ik" sort="Um, Heung Ik" uniqKey="Um H" first="Heung-Sik" last="Um">Heung-Sik Um</name><affiliation><mods:affiliation>Department of Periodontology, College of Dentistry, Kangnung National University, Kangnung, Korea</mods:affiliation></affiliation></author><author><name sortKey="Park, Chan In" sort="Park, Chan In" uniqKey="Park C" first="Chan-Jin" last="Park">Chan-Jin 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Oo" uniqKey="Kang B" first="Byung-Soo" last="Kang">Byung-Soo Kang</name><affiliation><mods:affiliation>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Johansson, Carina" sort="Johansson, Carina" uniqKey="Johansson C" first="Carina" last="Johansson">Carina Johansson</name><affiliation><mods:affiliation>Department of Clinical Medicine/Medical Technology, Örebro University, Örebro, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Um, Heung Ik" sort="Um, Heung Ik" uniqKey="Um H" first="Heung-Sik" last="Um">Heung-Sik Um</name><affiliation><mods:affiliation>Department of Periodontology, College of Dentistry, Kangnung National University, Kangnung, Korea</mods:affiliation></affiliation></author><author><name sortKey="Park, Chan In" sort="Park, Chan In" uniqKey="Park C" first="Chan-Jin" last="Park">Chan-Jin Park</name><affiliation><mods:affiliation>Department of Prosthodontics, College of Dentistry, Kangnung National University, Kangnung, Korea</mods:affiliation></affiliation></author><author><name sortKey="Albrektsson, Tomas" sort="Albrektsson, Tomas" uniqKey="Albrektsson T" first="Tomas" last="Albrektsson">Tomas Albrektsson</name><affiliation><mods:affiliation>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Biomedical Materials Research Part A</title><title level="j" type="alt">JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A</title><idno type="ISSN">1549-3296</idno><idno type="eISSN">1552-4965</idno><imprint><biblScope unit="vol">89A</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="942">942</biblScope><biblScope unit="page" to="950">950</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date></imprint><idno type="ISSN">1549-3296</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1549-3296</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Albrektsson</term><term>Bioactive</term><term>Biomed mater</term><term>Biomedical</term><term>Biomedical materials research part</term><term>Bone growth</term><term>Bone integration</term><term>Bone response</term><term>Bone tissue</term><term>Clin</term><term>Clin implant dent relat</term><term>Healing intervals</term><term>Healing period</term><term>Healing time</term><term>Height deviation</term><term>Implant</term><term>Implant groups</term><term>Implant insertion</term><term>Implant surface</term><term>Johansson</term><term>Oral maxillofac implants</term><term>Osseointegration</term><term>Osseointegration rate</term><term>Osseointegration strength</term><term>Oxidized</term><term>Oxidized implants</term><term>Oxidized titanium implants</term><term>Present study</term><term>Rabbit bone</term><term>Removal torque</term><term>Roughness</term><term>Strong integration</term><term>Surface chemistry</term><term>Surface properties</term><term>Surface ratio</term><term>Surface roughness</term><term>Surface topography</term><term>Tibia</term><term>Titanium</term><term>Titanium implants</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Albrektsson</term><term>Bioactive</term><term>Biomed mater</term><term>Biomedical</term><term>Biomedical materials research part</term><term>Bone growth</term><term>Bone integration</term><term>Bone response</term><term>Bone tissue</term><term>Clin</term><term>Clin implant dent relat</term><term>Healing intervals</term><term>Healing period</term><term>Healing time</term><term>Height deviation</term><term>Implant</term><term>Implant groups</term><term>Implant insertion</term><term>Implant surface</term><term>Johansson</term><term>Oral maxillofac implants</term><term>Osseointegration</term><term>Osseointegration rate</term><term>Osseointegration strength</term><term>Oxidized</term><term>Oxidized implants</term><term>Oxidized titanium implants</term><term>Present study</term><term>Rabbit bone</term><term>Removal torque</term><term>Roughness</term><term>Strong integration</term><term>Surface chemistry</term><term>Surface properties</term><term>Surface ratio</term><term>Surface roughness</term><term>Surface topography</term><term>Tibia</term><term>Titanium</term><term>Titanium implants</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study investigated the effects of surface chemistry and topography on the strength and rate of osseointegration of titanium implants in bone. Three groups of implants were compared: (1) machine‐turned implants (turned implants), (2) machine‐turned and aluminum oxide‐blasted implants (blasted implants), and (3) implants that were machine‐turned, aluminum oxide‐blasted, and processed with the micro‐arc oxidation method (Mg implants). Three and six weeks after implant insertion in rabbit tibiae, the implant osseointegration strength and rate were evaluated. Surface chemistry revealed characteristic differences of nine at.% Mg for Mg implants and 11 at.% Al for blasted implants. In terms of surface roughness, there was no difference between Mg implants and blasted implants in developed surface ratio (Sdr; p = 0.69) or summit density (Sds; p = 0.96), but Mg implants had a significantly lower arithmetic average height deviation (Sa) value than blasted implants (p = 0.007). At both 3 and 6 weeks, Mg implants demonstrated significantly higher osseointegration strength compared with turned (p = 0.0001, p = 0.0001) and blasted (p = 0.0001, p = 0.035) implants, whereas blasted implants showed significantly higher osseointegration than turned implants at 6 weeks (p = 0.02) but not at 3 weeks (p = 0.199). The present results not only support the hypothesis that biochemical bonding facilitates rapid and strong integration of implants in bone, but also provide evidence for biochemical bonding theory previously proposed by Sul. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>implant</json:string><json:string>osseointegration</json:string><json:string>surface chemistry</json:string><json:string>johansson</json:string><json:string>oxidized</json:string><json:string>albrektsson</json:string><json:string>osseointegration strength</json:string><json:string>healing time</json:string><json:string>tibia</json:string><json:string>biomedical</json:string><json:string>biomedical materials research part</json:string><json:string>osseointegration rate</json:string><json:string>clin</json:string><json:string>bioactive</json:string><json:string>bone tissue</json:string><json:string>present study</json:string><json:string>bone response</json:string><json:string>surface roughness</json:string><json:string>titanium implants</json:string><json:string>oxidized implants</json:string><json:string>bone integration</json:string><json:string>bone growth</json:string><json:string>implant groups</json:string><json:string>surface topography</json:string><json:string>surface properties</json:string><json:string>titanium</json:string><json:string>rabbit bone</json:string><json:string>clin implant dent relat</json:string><json:string>implant insertion</json:string><json:string>oral maxillofac implants</json:string><json:string>healing intervals</json:string><json:string>biomed mater</json:string><json:string>height deviation</json:string><json:string>removal torque</json:string><json:string>implant surface</json:string><json:string>oxidized titanium implants</json:string><json:string>healing period</json:string><json:string>strong integration</json:string><json:string>surface ratio</json:string><json:string>roughness</json:string><json:string>biomechanical measurements</json:string><json:string>unit sampling area</json:string><json:string>moist chicken tibiae</json:string><json:string>rabbit tibia</json:string><json:string>sampling area</json:string><json:string>biological integration</json:string><json:string>survey spectra</json:string><json:string>characteristic elements</json:string><json:string>common elements</json:string><json:string>titanium oxides</json:string><json:string>main peak</json:string><json:string>machine margins</json:string><json:string>roughness values</json:string><json:string>interfacial area</json:string><json:string>outer diameter</json:string><json:string>static torque</json:string><json:string>bioactive implants</json:string><json:string>test group</json:string><json:string>healing periods</json:string><json:string>osseointegration behavior</json:string><json:string>implant integration</json:string><json:string>wiley periodicals</json:string><json:string>present results</json:string><json:string>higher osseointegration strength</json:string><json:string>operator errors</json:string><json:string>rabbit tibiae</json:string><json:string>special emphasis</json:string><json:string>oxide thickness</json:string><json:string>crystal structure</json:string><json:string>chemical composition</json:string><json:string>scanning electron</json:string></teeft></keywords><author><json:item><name>Young‐Taeg Sul</name><affiliations><json:string>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</json:string><json:string>E-mail: young‐taeg.sul@biomaterials.gu.se</json:string><json:string>Correspondence address: Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</json:string></affiliations></json:item><json:item><name>Byung‐Soo Kang</name><affiliations><json:string>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</json:string></affiliations></json:item><json:item><name>Carina Johansson</name><affiliations><json:string>Department of Clinical Medicine/Medical Technology, Örebro University, Örebro, Sweden</json:string></affiliations></json:item><json:item><name>Heung‐Sik Um</name><affiliations><json:string>Department of Periodontology, College of Dentistry, Kangnung National University, Kangnung, Korea</json:string></affiliations></json:item><json:item><name>Chan‐Jin Park</name><affiliations><json:string>Department of Prosthodontics, College of Dentistry, Kangnung National University, Kangnung, Korea</json:string></affiliations></json:item><json:item><name>Tomas Albrektsson</name><affiliations><json:string>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>strength and rate of osseointegration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>titanium implant</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>surface topography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>surface chemistry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bone</value></json:item></subject><articleId><json:string>JBM32041</json:string></articleId><arkIstex>ark:/67375/WNG-X3MKKKFX-F</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The present study investigated the effects of surface chemistry and topography on the strength and rate of osseointegration of titanium implants in bone. Three groups of implants were compared: (1) machine‐turned implants (turned implants), (2) machine‐turned and aluminum oxide‐blasted implants (blasted implants), and (3) implants that were machine‐turned, aluminum oxide‐blasted, and processed with the micro‐arc oxidation method (Mg implants). Three and six weeks after implant insertion in rabbit tibiae, the implant osseointegration strength and rate were evaluated. Surface chemistry revealed characteristic differences of nine at.% Mg for Mg implants and 11 at.% Al for blasted implants. In terms of surface roughness, there was no difference between Mg implants and blasted implants in developed surface ratio (Sdr; p = 0.69) or summit density (Sds; p = 0.96), but Mg implants had a significantly lower arithmetic average height deviation (Sa) value than blasted implants (p = 0.007). At both 3 and 6 weeks, Mg implants demonstrated significantly higher osseointegration strength compared with turned (p = 0.0001, p = 0.0001) and blasted (p = 0.0001, p = 0.035) implants, whereas blasted implants showed significantly higher osseointegration than turned implants at 6 weeks (p = 0.02) but not at 3 weeks (p = 0.199). The present results not only support the hypothesis that biochemical bonding facilitates rapid and strong integration of implants in bone, but also provide evidence for biochemical bonding theory previously proposed by Sul. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</abstract><qualityIndicators><score>9.556</score><pdfWordCount>4652</pdfWordCount><pdfCharCount>29711</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>242</abstractWordCount><abstractCharCount>1605</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>The roles of surface chemistry and topography in the strength and rate of osseointegration of titanium implants in bone</title><pmid><json:string>18470920</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Biomedical Materials Research Part A</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1552-4965</json:string></doi><issn><json:string>1549-3296</json:string></issn><eissn><json:string>1552-4965</json:string></eissn><publisherId><json:string>JBM</json:string></publisherId><volume>89A</volume><issue>4</issue><pages><first>942</first><last>950</last><total>9</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2009</json:string></date><geogName></geogName><orgName><json:string>Swedish Medical Research Council, the Sylvan Foundation, Hjalmar Svensson Research Foundation Ó</json:string><json:string>Biomedical Materials Research Part A Figure</json:string><json:string>MediSciTec, Inc.</json:string><json:string>Biomedical Materials Research Part A</json:string><json:string>Department of Prosthodontics, College of Dentistry, Kangnung National University, Kangnung, Korea Received</json:string><json:string>Ministry of Science and Technology, Republic of Korea</json:string><json:string>Department of Periodontology, College of Dentistry, Kangnung National University, Kangnung, Korea</json:string><json:string>Biomedical Materials Research Part A SUL ET AL</json:string><json:string>Karolinska Institute, Sweden</json:string><json:string>Department of Clinical Medicine/Medical Technology, Orebro University, Orebro, Sweden</json:string><json:string>Biomedical Materials Research Part A SURFACE CHEMISTRY IN THE STRENGTH AND RATE OF OSSEOINTEGRATION</json:string><json:string>Gothenburg University</json:string><json:string>Wiley Periodicals, Inc</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>A. 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role="corresp"><persName><forename type="first">Young‐Taeg</forename><surname>Sul</surname></persName><email>young‐taeg.sul@biomaterials.gu.se</email><affiliation>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden<address><country key="SE"></country></address></affiliation><affiliation>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Byung‐Soo</forename><surname>Kang</surname></persName><affiliation>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden<address><country key="SE"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Carina</forename><surname>Johansson</surname></persName><affiliation>Department of Clinical Medicine/Medical Technology, Örebro University, Örebro, Sweden<address><country key="SE"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Heung‐Sik</forename><surname>Um</surname></persName><affiliation>Department of Periodontology, College of Dentistry, Kangnung National University, Kangnung, Korea<address><country key="KR"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Chan‐Jin</forename><surname>Park</surname></persName><affiliation>Department of Prosthodontics, College of Dentistry, Kangnung National University, Kangnung, Korea<address><country key="KR"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Tomas</forename><surname>Albrektsson</surname></persName><affiliation>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden<address><country key="SE"></country></address></affiliation></author><idno type="istex">BF925C26CDD10F66200A1F7E946941BBE5D13382</idno><idno type="ark">ark:/67375/WNG-X3MKKKFX-F</idno><idno type="DOI">10.1002/jbm.a.32041</idno><idno type="unit">JBM32041</idno><idno type="toTypesetVersion">file:JBM.JBM32041.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Biomedical Materials Research Part A</title><title level="j" type="alt">JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A</title><idno type="pISSN">1549-3296</idno><idno type="eISSN">1552-4965</idno><idno type="book-DOI">10.1002/(ISSN)1552-4965</idno><idno type="book-part-DOI">10.1002/jbm.a.v89a:4</idno><idno type="product">JBM</idno><imprint><biblScope unit="vol">89A</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="942">942</biblScope><biblScope unit="page" to="950">950</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>The present study investigated the effects of surface chemistry and topography on the strength and rate of osseointegration of titanium implants in bone. Three groups of implants were compared: (1) machine‐turned implants (turned implants), (2) machine‐turned and aluminum oxide‐blasted implants (blasted implants), and (3) implants that were machine‐turned, aluminum oxide‐blasted, and processed with the micro‐arc oxidation method (Mg implants). Three and six weeks after implant insertion in rabbit tibiae, the implant osseointegration strength and rate were evaluated. Surface chemistry revealed characteristic differences of nine at.% Mg for Mg implants and 11 at.% Al for blasted implants. In terms of surface roughness, there was no difference between Mg implants and blasted implants in developed surface ratio (Sdr; <hi rend="italic">p</hi> = 0.69) or summit density (Sds; <hi rend="italic">p</hi> = 0.96), but Mg implants had a significantly lower arithmetic average height deviation (Sa) value than blasted implants (<hi rend="italic">p</hi> = 0.007). At both 3 and 6 weeks, Mg implants demonstrated significantly higher osseointegration strength compared with turned (<hi rend="italic">p</hi> = 0.0001, <hi rend="italic">p</hi> = 0.0001) and blasted (<hi rend="italic">p</hi> = 0.0001, <hi rend="italic">p</hi> = 0.035) implants, whereas blasted implants showed significantly higher osseointegration than turned implants at 6 weeks (<hi rend="italic">p</hi> = 0.02) but not at 3 weeks (<hi rend="italic">p</hi> = 0.199). The present results not only support the hypothesis that biochemical bonding facilitates rapid and strong integration of implants in bone, but also provide evidence for biochemical bonding theory previously proposed by Sul. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">strength and rate of osseointegration</term><term xml:id="kwd2">titanium implant</term><term xml:id="kwd3">surface topography</term><term xml:id="kwd4">surface chemistry</term><term xml:id="kwd5">bone</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/BF925C26CDD10F66200A1F7E946941BBE5D13382/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1552-4965</doi><issn type="print">1549-3296</issn><issn type="electronic">1552-4965</issn><idGroup><id type="product" value="JBM"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A">Journal of Biomedical Materials Research Part A</title><title type="subtitle">An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials</title><title type="short">J. Biomed. Mater. 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ownership="publisher">Copyright © 2008 Wiley Periodicals, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2007-04-23"></event><event type="manuscriptRevised" date="2007-08-21"></event><event type="manuscriptAccepted" date="2007-11-14"></event><event type="publishedOnlineEarlyUnpaginated" date="2008-05-09"></event><event type="firstOnline" date="2008-05-09"></event><event type="publishedOnlineFinalForm" date="2009-05-04"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText" date="2010-05-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-28"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-24"></event></eventGroup><numberingGroup><numbering type="pageFirst">942</numbering><numbering type="pageLast">950</numbering></numberingGroup><correspondenceTo>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JBM.JBM32041.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="9"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="31"></count><count type="wordTotal" number="5718"></count></countGroup><titleGroup><title type="main" xml:lang="en">The roles of surface chemistry and topography in the strength and rate of osseointegration of titanium implants in bone</title><title type="short" xml:lang="en">Surface Chemistry in the Strength and Rate of Osseointegration</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Young‐Taeg</givenNames><familyName>Sul</familyName></personName><contactDetails><email 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countryCode="SE" type="organization"><unparsedAffiliation>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="SE" type="organization"><unparsedAffiliation>Department of Clinical Medicine/Medical Technology, Örebro University, Örebro, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="KR" type="organization"><unparsedAffiliation>Department of Periodontology, College of Dentistry, Kangnung National University, Kangnung, Korea</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="KR" type="organization"><unparsedAffiliation>Department of Prosthodontics, College of Dentistry, Kangnung National University, Kangnung, Korea</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">strength and rate of osseointegration</keyword><keyword xml:id="kwd2">titanium implant</keyword><keyword xml:id="kwd3">surface topography</keyword><keyword xml:id="kwd4">surface chemistry</keyword><keyword xml:id="kwd5">bone</keyword></keywordGroup><fundingInfo><fundingAgency>Ministry of Science and Technology</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Republic of Korea</fundingAgency></fundingInfo><fundingInfo><fundingAgency>MediSciTec, Inc.</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Swedish Medical Research Council</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Sylvan Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Hjalmar Svensson Research Foundation</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The present study investigated the effects of surface chemistry and topography on the strength and rate of osseointegration of titanium implants in bone. Three groups of implants were compared: (1) machine‐turned implants (turned implants), (2) machine‐turned and aluminum oxide‐blasted implants (blasted implants), and (3) implants that were machine‐turned, aluminum oxide‐blasted, and processed with the micro‐arc oxidation method (Mg implants). Three and six weeks after implant insertion in rabbit tibiae, the implant osseointegration strength and rate were evaluated. Surface chemistry revealed characteristic differences of nine at.% Mg for Mg implants and 11 at.% Al for blasted implants. In terms of surface roughness, there was no difference between Mg implants and blasted implants in developed surface ratio (Sdr; <i>p</i> = 0.69) or summit density (Sds; <i>p</i> = 0.96), but Mg implants had a significantly lower arithmetic average height deviation (Sa) value than blasted implants (<i>p</i> = 0.007). At both 3 and 6 weeks, Mg implants demonstrated significantly higher osseointegration strength compared with turned (<i>p</i> = 0.0001, <i>p</i> = 0.0001) and blasted (<i>p</i> = 0.0001, <i>p</i> = 0.035) implants, whereas blasted implants showed significantly higher osseointegration than turned implants at 6 weeks (<i>p</i> = 0.02) but not at 3 weeks (<i>p</i> = 0.199). The present results not only support the hypothesis that biochemical bonding facilitates rapid and strong integration of implants in bone, but also provide evidence for biochemical bonding theory previously proposed by Sul. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The roles of surface chemistry and topography in the strength and rate of osseointegration of titanium implants in bone</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Surface Chemistry in the Strength and Rate of Osseointegration</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The roles of surface chemistry and topography in the strength and rate of osseointegration of titanium implants in bone</title></titleInfo><name type="personal"><namePart type="given">Young‐Taeg</namePart><namePart type="family">Sul</namePart><affiliation>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</affiliation><affiliation>E-mail: young‐taeg.sul@biomaterials.gu.se</affiliation><affiliation>Correspondence address: Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Byung‐Soo</namePart><namePart type="family">Kang</namePart><affiliation>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carina</namePart><namePart type="family">Johansson</namePart><affiliation>Department of Clinical Medicine/Medical Technology, Örebro University, Örebro, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Heung‐Sik</namePart><namePart type="family">Um</namePart><affiliation>Department of Periodontology, College of Dentistry, Kangnung National University, Kangnung, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chan‐Jin</namePart><namePart type="family">Park</namePart><affiliation>Department of Prosthodontics, College of Dentistry, Kangnung National University, Kangnung, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tomas</namePart><namePart type="family">Albrektsson</namePart><affiliation>Department of Biomaterials/Handicap Research, Institute for Clinical Sciences, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-06-15</dateIssued><dateCaptured encoding="w3cdtf">2007-04-23</dateCaptured><dateValid encoding="w3cdtf">2007-11-14</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">9</extent><extent unit="tables">2</extent><extent unit="references">31</extent><extent unit="words">5718</extent></physicalDescription><abstract lang="en">The present study investigated the effects of surface chemistry and topography on the strength and rate of osseointegration of titanium implants in bone. Three groups of implants were compared: (1) machine‐turned implants (turned implants), (2) machine‐turned and aluminum oxide‐blasted implants (blasted implants), and (3) implants that were machine‐turned, aluminum oxide‐blasted, and processed with the micro‐arc oxidation method (Mg implants). Three and six weeks after implant insertion in rabbit tibiae, the implant osseointegration strength and rate were evaluated. Surface chemistry revealed characteristic differences of nine at.% Mg for Mg implants and 11 at.% Al for blasted implants. In terms of surface roughness, there was no difference between Mg implants and blasted implants in developed surface ratio (Sdr; p = 0.69) or summit density (Sds; p = 0.96), but Mg implants had a significantly lower arithmetic average height deviation (Sa) value than blasted implants (p = 0.007). At both 3 and 6 weeks, Mg implants demonstrated significantly higher osseointegration strength compared with turned (p = 0.0001, p = 0.0001) and blasted (p = 0.0001, p = 0.035) implants, whereas blasted implants showed significantly higher osseointegration than turned implants at 6 weeks (p = 0.02) but not at 3 weeks (p = 0.199). The present results not only support the hypothesis that biochemical bonding facilitates rapid and strong integration of implants in bone, but also provide evidence for biochemical bonding theory previously proposed by Sul. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</abstract><note type="funding">Ministry of Science and Technology</note><note type="funding">Republic of Korea</note><note type="funding">MediSciTec, Inc.</note><note type="funding">Swedish Medical Research Council</note><note type="funding">Sylvan Foundation</note><note type="funding">Hjalmar Svensson Research Foundation</note><subject lang="en"><genre>keywords</genre><topic>strength and rate of osseointegration</topic><topic>titanium implant</topic><topic>surface topography</topic><topic>surface chemistry</topic><topic>bone</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Biomedical Materials Research Part A</title><subTitle>An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials</subTitle></titleInfo><titleInfo type="abbreviated"><title>J. Biomed. Mater. 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