Oral health in patients on inhaled corticosteroid treatment
Identifieur interne : 005C08 ( Istex/Corpus ); précédent : 005C07; suivant : 005C09Oral health in patients on inhaled corticosteroid treatment
Auteurs : N. Komerik ; A. Akkaya ; M. Y Ld Z ; Us Buyukkaplan ; L. KuruSource :
- Oral Diseases [ 1354-523X ] ; 2005-09.
English descriptors
- KwdEn :
- Alkaline phosphatase, Bone density, Bone formation, Bone metabolism, Bone mineral density, Clin periodontol, Control group, Control subjects, Copd, Copd patient group, Copd patients, Corticosteroid, Corticosteroid treatment, Cortisol, Cortisol levels, Cumulative dose, Dentate, Dentate patients, Female patients, Hanania, Inhaled, Inhaled corticosteroid therapy, Inhaled corticosteroid treatment, Inhaled corticosteroids, Less teeth, Lumbar, Lumbar spine, Mandible, Mandibular, Mandibular bone, Mandibular bone mass, Mineral status, Oral diseases, Oral hygiene, Osteocalcin, Osteoporosis, Patient group, Periodontal, Periodontal condition, Periodontal disease, Periodontal parameters, Periodontal status, Phosphatase, Present study, Pulmonary disease, Risk factor, Serum calcium, Serum calcium levels, Smoking status, Suleyman demirel university, Tooth loss, Wowern.
- Teeft :
- Alkaline phosphatase, Bone density, Bone formation, Bone metabolism, Bone mineral density, Clin periodontol, Control group, Control subjects, Copd, Copd patient group, Copd patients, Corticosteroid, Corticosteroid treatment, Cortisol, Cortisol levels, Cumulative dose, Dentate, Dentate patients, Female patients, Hanania, Inhaled, Inhaled corticosteroid therapy, Inhaled corticosteroid treatment, Inhaled corticosteroids, Less teeth, Lumbar, Lumbar spine, Mandible, Mandibular, Mandibular bone, Mandibular bone mass, Mineral status, Oral diseases, Oral hygiene, Osteocalcin, Osteoporosis, Patient group, Periodontal, Periodontal condition, Periodontal disease, Periodontal parameters, Periodontal status, Phosphatase, Present study, Pulmonary disease, Risk factor, Serum calcium, Serum calcium levels, Smoking status, Suleyman demirel university, Tooth loss, Wowern.
Abstract
Objective: The aim of this study was to investigate the effects of long‐term inhaled corticosteroids on bone mineral density (BMD) of the mandible in relation with the tooth loss.
Url:
DOI: 10.1111/j.1601-0825.2005.01122.x
Links to Exploration step
ISTEX:B8CA297CE7F856516BC8D450FC358A5413DE344ELe document en format XML
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Y Ld Z</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Faculty of Medicine, Suleyman Demirel University</mods:affiliation></affiliation></author><author><name sortKey="Buyukkaplan, Us" sort="Buyukkaplan, Us" uniqKey="Buyukkaplan U" first="Us" last="Buyukkaplan">Us Buyukkaplan</name><affiliation><mods:affiliation>Department of Prosthodontics, Faculty of Dentistry, Suleyman Demirel University, Isparta</mods:affiliation></affiliation></author><author><name sortKey="Kuru, L" sort="Kuru, L" uniqKey="Kuru L" first="L" last="Kuru">L. 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Komerik</name><affiliation><mods:affiliation>Department of Oral Surgery, Faculty of Dentistry, Suleyman Demirel University</mods:affiliation></affiliation></author><author><name sortKey="Akkaya, A" sort="Akkaya, A" uniqKey="Akkaya A" first="A" last="Akkaya">A. Akkaya</name><affiliation><mods:affiliation>Department of Pulmonary Diseases, Faculty of Medicine, Suleyman Demirel University</mods:affiliation></affiliation></author><author><name sortKey="Y Ld Z, M" sort="Y Ld Z, M" uniqKey="Y Ld Z M" first="M" last="Y Ld Z">M. Y Ld Z</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Faculty of Medicine, Suleyman Demirel University</mods:affiliation></affiliation></author><author><name sortKey="Buyukkaplan, Us" sort="Buyukkaplan, Us" uniqKey="Buyukkaplan U" first="Us" last="Buyukkaplan">Us Buyukkaplan</name><affiliation><mods:affiliation>Department of Prosthodontics, Faculty of Dentistry, Suleyman Demirel University, Isparta</mods:affiliation></affiliation></author><author><name sortKey="Kuru, L" sort="Kuru, L" uniqKey="Kuru L" first="L" last="Kuru">L. 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density</term><term>Bone formation</term><term>Bone metabolism</term><term>Bone mineral density</term><term>Clin periodontol</term><term>Control group</term><term>Control subjects</term><term>Copd</term><term>Copd patient group</term><term>Copd patients</term><term>Corticosteroid</term><term>Corticosteroid treatment</term><term>Cortisol</term><term>Cortisol levels</term><term>Cumulative dose</term><term>Dentate</term><term>Dentate patients</term><term>Female patients</term><term>Hanania</term><term>Inhaled</term><term>Inhaled corticosteroid therapy</term><term>Inhaled corticosteroid treatment</term><term>Inhaled corticosteroids</term><term>Less teeth</term><term>Lumbar</term><term>Lumbar spine</term><term>Mandible</term><term>Mandibular</term><term>Mandibular bone</term><term>Mandibular bone mass</term><term>Mineral status</term><term>Oral diseases</term><term>Oral hygiene</term><term>Osteocalcin</term><term>Osteoporosis</term><term>Patient group</term><term>Periodontal</term><term>Periodontal condition</term><term>Periodontal disease</term><term>Periodontal parameters</term><term>Periodontal status</term><term>Phosphatase</term><term>Present study</term><term>Pulmonary disease</term><term>Risk factor</term><term>Serum calcium</term><term>Serum calcium levels</term><term>Smoking status</term><term>Suleyman demirel university</term><term>Tooth loss</term><term>Wowern</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Alkaline phosphatase</term><term>Bone density</term><term>Bone formation</term><term>Bone metabolism</term><term>Bone mineral density</term><term>Clin periodontol</term><term>Control group</term><term>Control subjects</term><term>Copd</term><term>Copd patient group</term><term>Copd patients</term><term>Corticosteroid</term><term>Corticosteroid treatment</term><term>Cortisol</term><term>Cortisol levels</term><term>Cumulative dose</term><term>Dentate</term><term>Dentate patients</term><term>Female patients</term><term>Hanania</term><term>Inhaled</term><term>Inhaled corticosteroid therapy</term><term>Inhaled corticosteroid treatment</term><term>Inhaled corticosteroids</term><term>Less teeth</term><term>Lumbar</term><term>Lumbar spine</term><term>Mandible</term><term>Mandibular</term><term>Mandibular bone</term><term>Mandibular bone mass</term><term>Mineral status</term><term>Oral diseases</term><term>Oral hygiene</term><term>Osteocalcin</term><term>Osteoporosis</term><term>Patient group</term><term>Periodontal</term><term>Periodontal condition</term><term>Periodontal disease</term><term>Periodontal parameters</term><term>Periodontal status</term><term>Phosphatase</term><term>Present study</term><term>Pulmonary disease</term><term>Risk factor</term><term>Serum calcium</term><term>Serum calcium levels</term><term>Smoking status</term><term>Suleyman demirel university</term><term>Tooth loss</term><term>Wowern</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Objective: The aim of this study was to investigate the effects of long‐term inhaled corticosteroids on bone mineral density (BMD) of the mandible in relation with the tooth loss.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>corticosteroid</json:string><json:string>inhaled</json:string><json:string>mandible</json:string><json:string>copd</json:string><json:string>periodontal</json:string><json:string>inhaled corticosteroids</json:string><json:string>mandibular</json:string><json:string>osteocalcin</json:string><json:string>copd patients</json:string><json:string>control group</json:string><json:string>corticosteroid treatment</json:string><json:string>tooth loss</json:string><json:string>periodontal disease</json:string><json:string>cortisol</json:string><json:string>phosphatase</json:string><json:string>bone metabolism</json:string><json:string>osteoporosis</json:string><json:string>lumbar spine</json:string><json:string>inhaled 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levels</json:string><json:string>periodontal status</json:string><json:string>less teeth</json:string><json:string>cortisol levels</json:string><json:string>cumulative dose</json:string><json:string>risk factor</json:string><json:string>mineral status</json:string><json:string>mandibular bone mass</json:string><json:string>inhaled corticosteroid therapy</json:string><json:string>pulmonary disease</json:string><json:string>oral diseases</json:string></teeft></keywords><author><json:item><name>N Komerik</name><affiliations><json:string>Department of Oral Surgery, Faculty of Dentistry, Suleyman Demirel University</json:string></affiliations></json:item><json:item><name>A Akkaya</name><affiliations><json:string>Department of Pulmonary Diseases, Faculty of Medicine, Suleyman Demirel University</json:string></affiliations></json:item><json:item><name>M Yıldız</name><affiliations><json:string>Department of Nuclear Medicine, Faculty of Medicine, Suleyman Demirel University</json:string></affiliations></json:item><json:item><name>US Buyukkaplan</name><affiliations><json:string>Department of Prosthodontics, Faculty of Dentistry, Suleyman Demirel University, Isparta</json:string></affiliations></json:item><json:item><name>L Kuru</name><affiliations><json:string>Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul, Turkey</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>corticosteroids</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bone mineral density</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mandible</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>periodontitis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tooth loss</value></json:item></subject><articleId><json:string>ODI1122</json:string></articleId><arkIstex>ark:/67375/WNG-HCN9JFXX-K</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Objective: The aim of this study was to investigate the effects of long‐term inhaled corticosteroids on bone mineral density (BMD) of the mandible in relation with the tooth loss.</abstract><qualityIndicators><score>6.452</score><pdfWordCount>4104</pdfWordCount><pdfCharCount>26196</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>595 x 782 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>29</abstractWordCount><abstractCharCount>180</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Oral health in patients on inhaled corticosteroid 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Atkinson</json:string><json:string>France</json:string><json:string>WI</json:string><json:string>Sweden</json:string></placeName><ref_url><json:string>http://www.blackwellmunksgaard.com</json:string></ref_url><ref_bibl><json:string>Wisniewski et al (1997)</json:string><json:string>Wisniewski et al, 1997</json:string><json:string>von Wowern et al, 1992</json:string><json:string>Southard et al, 2000</json:string><json:string>Wilson and Lipworth, 1999</json:string><json:string>Dubois et al, 2002</json:string><json:string>Gennari, 1993</json:string><json:string>Komerik et al</json:string><json:string>Krall et al, 1996</json:string><json:string>Lipworth, 1999</json:string><json:string>Horner et al (1996)</json:string><json:string>Ronderos et al (2000)</json:string><json:string>Olgaard et al, 1992</json:string><json:string>Taguchi et al (1999)</json:string><json:string>Loe and Silness, 1963</json:string><json:string>GOLD Workshop Report, 2003</json:string><json:string>Krall et al (2001)</json:string><json:string>Taguchi et al, 1999</json:string><json:string>Sivri and Coplu, 2001</json:string><json:string>Meeran et al, 1995</json:string><json:string>Kerstjens et al (1994)</json:string><json:string>Hanania et al, 1995</json:string><json:string>Ainamo et al, 1982</json:string><json:string>Silness and Loe, 1964</json:string><json:string>Klemetti et al (1994)</json:string><json:string>von Wowern et al, 1994</json:string><json:string>Kerstjens et al, 1994</json:string><json:string>Wong et al, 2000</json:string><json:string>Hanania et al (1995)</json:string><json:string>Sivri and Coplu (2001)</json:string><json:string>Scannapieco and Ho (2001)</json:string><json:string>Southard et al (2000)</json:string><json:string>Lundstrom et al, 2001</json:string><json:string>Kribbs, 1990</json:string><json:string>Meeran et al (1995)</json:string><json:string>Kribbs (1992)</json:string><json:string>Safkan and Knuuttila, 1984</json:string><json:string>Olgaard et al (1992)</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-HCN9JFXX-K</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - General Dentistry</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - 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type="first">A</forename><surname>Akkaya</surname></persName><affiliation>Department of Pulmonary Diseases, Faculty of Medicine, Suleyman Demirel University</affiliation></author><author xml:id="author-0002"><persName><forename type="first">M</forename><surname>Yıldız</surname></persName><affiliation>Department of Nuclear Medicine, Faculty of Medicine, Suleyman Demirel University</affiliation></author><author xml:id="author-0003"><persName><forename type="first">US</forename><surname>Buyukkaplan</surname></persName><affiliation>Department of Prosthodontics, Faculty of Dentistry, Suleyman Demirel University, Isparta</affiliation></author><author xml:id="author-0004"><persName><forename type="first">L</forename><surname>Kuru</surname></persName><affiliation>Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul, Turkey<address><country key="TR"></country></address></affiliation></author><idno type="istex">B8CA297CE7F856516BC8D450FC358A5413DE344E</idno><idno type="ark">ark:/67375/WNG-HCN9JFXX-K</idno><idno type="DOI">10.1111/j.1601-0825.2005.01122.x</idno><idno type="unit">ODI1122</idno><idno type="toTypesetVersion">file:ODI.ODI1122.pdf</idno></analytic><monogr><title level="j" type="main">Oral Diseases</title><title level="j" type="alt">ORAL DISEASES</title><idno type="pISSN">1354-523X</idno><idno type="eISSN">1601-0825</idno><idno type="book-DOI">10.1111/(ISSN)1601-0825</idno><idno type="book-part-DOI">10.1111/odi.2005.11.issue-5</idno><idno type="product">ODI</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">11</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="303">303</biblScope><biblScope unit="page" to="308">308</biblScope><biblScope unit="page-count">6</biblScope><publisher>Munksgaard International Publishers</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2005-09"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Objective: </hi> The aim of this study was to investigate the effects of long‐term inhaled corticosteroids on bone mineral density (BMD) of the mandible in relation with the tooth loss.</p><p><hi rend="bold">Design: </hi> Cross sectional analytic study.</p><p><hi rend="bold">Subjects and methods: </hi> Patients (<hi rend="italic">n</hi> = 30) with chronic obstructive pulmonary disease under inhaled corticosteroid therapy for at least 1 year were compared with sex‐ and age‐matched healthy controls (<hi rend="italic">n</hi> = 30). BMD of the mandible was measured by dual‐energy X‐ray absorptiometry. The clinical examination included recording the number of teeth present together with periodontal condition. Levels of serum osteocalcin, alkaline phosphatase, calcium, phosphorus and cortisol were also assessed.</p><p><hi rend="bold">Results: </hi> BMD of the mandible in patients on corticosteroid treatment was significantly lower than that in the control group (<hi rend="italic">P</hi> = 0.001). Patients under treatment had more missing teeth than the control group but the difference did not reach statistical significance. The two groups exhibited similar clinical parameters of periodontal condition. Significantly lower levels of osteocalcin (<hi rend="italic">P</hi> < 0.0001), calcium (<hi rend="italic">P</hi> = 0.004) and cortisol (<hi rend="italic">P</hi> = 0.03) were observed in the patients on corticosteroid treatment.</p><p><hi rend="bold">Conclusion: </hi> Long‐term use of inhaled corticosteroids may impair bone metabolism and lead to a marked decrease in the mandibular BMD.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">corticosteroids</term><term xml:id="k2">bone mineral density</term><term xml:id="k3">mandible</term><term xml:id="k4">periodontitis</term><term xml:id="k5">tooth loss</term></keywords><keywords rend="tocHeading1"><term>ORIGINAL ARTICLES</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/B8CA297CE7F856516BC8D450FC358A5413DE344E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Munksgaard International Publishers</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1601-0825</doi><issn type="print">1354-523X</issn><issn type="electronic">1601-0825</issn><idGroup><id type="product" value="ODI"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ORAL DISEASES">Oral Diseases</title></titleGroup></publicationMeta><publicationMeta level="part" position="09005"><doi origin="wiley">10.1111/odi.2005.11.issue-5</doi><numberingGroup><numbering type="journalVolume" number="11">11</numbering><numbering type="journalIssue" number="5">5</numbering></numberingGroup><coverDate startDate="2005-09">September 2005</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="8" status="forIssue"><doi origin="wiley">10.1111/j.1601-0825.2005.01122.x</doi><idGroup><id type="unit" value="ODI1122"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">ORIGINAL ARTICLES</title></titleGroup><eventGroup><event type="firstOnline" date="2005-08-25"></event><event type="publishedOnlineFinalForm" date="2005-08-25"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-06"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-03"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="303">303</numbering><numbering type="pageLast" number="308">308</numbering></numberingGroup><correspondenceTo>Nurgül Kömerik, Süleyman Demirel Üniversitesi, Diş Hekimliǧi Fakültesi, Isparta – Turkey. Tel: 90 246 2113270, Fax: 90 246 2370607, E‐mail: <email>nkomerik@med.sdu.edu.tr</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ODI.ODI1122.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 1 October 2003; revised 22 September 2004; accepted 18 January 2005</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="3"></count></countGroup><titleGroup><title type="main">Oral health in patients on inhaled corticosteroid treatment</title><title type="shortAuthors">N Komerik <i>et al</i></title><title type="short"><b>Inhaled corticosteroid treatment</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>N</givenNames><familyName>Komerik</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>A</givenNames><familyName>Akkaya</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>M</givenNames><familyName>Yıldız</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a4"><personName><givenNames>US</givenNames><familyName>Buyukkaplan</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a5"><personName><givenNames>L</givenNames><familyName>Kuru</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Oral Surgery, Faculty of Dentistry, Suleyman Demirel University</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Department of Pulmonary Diseases, Faculty of Medicine, Suleyman Demirel University</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>Department of Nuclear Medicine, Faculty of Medicine, Suleyman Demirel University</unparsedAffiliation></affiliation><affiliation xml:id="a4"><unparsedAffiliation>Department of Prosthodontics, Faculty of Dentistry, Suleyman Demirel University, Isparta</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="TR"><unparsedAffiliation>Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul, Turkey</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">corticosteroids</keyword><keyword xml:id="k2">bone mineral density</keyword><keyword xml:id="k3">mandible</keyword><keyword xml:id="k4">periodontitis</keyword><keyword xml:id="k5">tooth loss</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Objective: </b> The aim of this study was to investigate the effects of long‐term inhaled corticosteroids on bone mineral density (BMD) of the mandible in relation with the tooth loss.</p><p><b>Design: </b> Cross sectional analytic study.</p><p><b>Subjects and methods: </b> Patients (<i>n</i> = 30) with chronic obstructive pulmonary disease under inhaled corticosteroid therapy for at least 1 year were compared with sex‐ and age‐matched healthy controls (<i>n</i> = 30). BMD of the mandible was measured by dual‐energy X‐ray absorptiometry. The clinical examination included recording the number of teeth present together with periodontal condition. Levels of serum osteocalcin, alkaline phosphatase, calcium, phosphorus and cortisol were also assessed.</p><p><b>Results: </b> BMD of the mandible in patients on corticosteroid treatment was significantly lower than that in the control group (<i>P</i> = 0.001). Patients under treatment had more missing teeth than the control group but the difference did not reach statistical significance. The two groups exhibited similar clinical parameters of periodontal condition. Significantly lower levels of osteocalcin (<i>P</i> < 0.0001), calcium (<i>P</i> = 0.004) and cortisol (<i>P</i> = 0.03) were observed in the patients on corticosteroid treatment.</p><p><b>Conclusion: </b> Long‐term use of inhaled corticosteroids may impair bone metabolism and lead to a marked decrease in the mandibular BMD.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Oral health in patients on inhaled corticosteroid treatment</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Inhaled corticosteroid treatment</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Oral health in patients on inhaled corticosteroid treatment</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Komerik</namePart><affiliation>Department of Oral Surgery, Faculty of Dentistry, Suleyman Demirel University</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Akkaya</namePart><affiliation>Department of Pulmonary Diseases, Faculty of Medicine, Suleyman Demirel University</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Yıldız</namePart><affiliation>Department of Nuclear Medicine, Faculty of Medicine, Suleyman Demirel University</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">US</namePart><namePart type="family">Buyukkaplan</namePart><affiliation>Department of Prosthodontics, Faculty of Dentistry, Suleyman Demirel University, Isparta</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Kuru</namePart><affiliation>Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Munksgaard International Publishers</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2005-09</dateIssued><edition>Received 1 October 2003; revised 22 September 2004; accepted 18 January 2005</edition><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">3</extent></physicalDescription><abstract>Objective: The aim of this study was to investigate the effects of long‐term inhaled corticosteroids on bone mineral density (BMD) of the mandible in relation with the tooth loss.</abstract><abstract>Design: Cross sectional analytic study.</abstract><abstract>Subjects and methods: Patients (n = 30) with chronic obstructive pulmonary disease under inhaled corticosteroid therapy for at least 1 year were compared with sex‐ and age‐matched healthy controls (n = 30). BMD of the mandible was measured by dual‐energy X‐ray absorptiometry. The clinical examination included recording the number of teeth present together with periodontal condition. Levels of serum osteocalcin, alkaline phosphatase, calcium, phosphorus and cortisol were also assessed.</abstract><abstract>Results: BMD of the mandible in patients on corticosteroid treatment was significantly lower than that in the control group (P = 0.001). Patients under treatment had more missing teeth than the control group but the difference did not reach statistical significance. The two groups exhibited similar clinical parameters of periodontal condition. Significantly lower levels of osteocalcin (P < 0.0001), calcium (P = 0.004) and cortisol (P = 0.03) were observed in the patients on corticosteroid treatment.</abstract><abstract>Conclusion: Long‐term use of inhaled corticosteroids may impair bone metabolism and lead to a marked decrease in the mandibular BMD.</abstract><subject lang="en"><genre>keywords</genre><topic>corticosteroids</topic><topic>bone mineral density</topic><topic>mandible</topic><topic>periodontitis</topic><topic>tooth loss</topic></subject><relatedItem type="host"><titleInfo><title>Oral Diseases</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1354-523X</identifier><identifier type="eISSN">1601-0825</identifier><identifier type="DOI">10.1111/(ISSN)1601-0825</identifier><identifier type="PublisherID">ODI</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>303</start><end>308</end><total>6</total></extent></part></relatedItem><identifier type="istex">B8CA297CE7F856516BC8D450FC358A5413DE344E</identifier><identifier type="ark">ark:/67375/WNG-HCN9JFXX-K</identifier><identifier type="DOI">10.1111/j.1601-0825.2005.01122.x</identifier><identifier type="ArticleID">ODI1122</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Munksgaard International Publishers</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/B8CA297CE7F856516BC8D450FC358A5413DE344E/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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