Nanocrystalline Hydroxyapatite Bone Substitute Leads to Sufficient Bone Tissue Formation Already after 3 Months: Histological and Histomorphometrical Analysis 3 and 6 Months following Human Sinus Cavity Augmentation
Identifieur interne : 005813 ( Istex/Corpus ); précédent : 005812; suivant : 005814Nanocrystalline Hydroxyapatite Bone Substitute Leads to Sufficient Bone Tissue Formation Already after 3 Months: Histological and Histomorphometrical Analysis 3 and 6 Months following Human Sinus Cavity Augmentation
Auteurs : Shahram Ghanaati ; Mike Barbeck ; Ines Willershausen ; Benjamin Thimm ; Stefan Stuebinger ; Tadas Korzinskas ; Karina Obreja ; Constantin Landes ; Charles J. Kirkpatrick ; Robert A. SaderSource :
- Clinical Implant Dentistry and Related Research [ 1523-0899 ] ; 2013-12.
English descriptors
- KwdEn :
- Arrow heads, Augmentation, Augmentation area, Autogenous bone, Autologous, Autologous bone, Autologous bone grafts, Biomaterial, Biomaterial degradation, Biomaterial granules, Biomed mater, Biopsy, Bone, Bone biopsies, Bone formation, Bone regeneration, Bone substitute, Bone substitute material, Bone substitutes, Bone tissue, Bone tissue formation, Bone trabeculae, Canullo, Cells trap, Cellular degradation, Clinical application, Clinical implant dentistry, Connective, Connective tissue, Connective tissue formation, Continuous degradation, Cranial parts, Degradation, Dental implants, Facial plastic surgery, Graft, Healing period, Histological, Histomorphometric evaluation, Histomorphometrical, Histomorphometrical analysis, Human sinus cavity, Hydroxyapatite, Implant, Implant insertion, Implant placement, Implantation, Insertion, Johannes gutenberg university mainz, Masson goldner stain, Matrix, Maxillary, Maxillary sinus, Maxillofac, Multinucleated, Multinucleated giant cells, Nanobone, Nanocrystalline, Nanocrystalline bone substitute material, Nanocrystalline hydroxyapatite bone substitute, Nanocrystalline hydroxyapatite silica, Oral maxillofac implants, Oral maxillofac surg, Osteoblast proliferation, Osteoconductive properties, Other bone substitute materials, Percentage distribution, Present study, Regeneration, Residual, Residual bone, Residual bone fractions, Residual fraction, Retrospective analysis, Screw line, Second stage surgery, Shahram ghanaati, Silica, Silica matrix, Sinus, Sinus augmentation, Sinus augmentation procedure, Sinus cavity, Sinus elevation procedure, Statistical analysis, Subsequent study, Surgical site, Synthetic bone substitute material, Time point, Tissue distribution, Tissue reaction, Total scan, Trap staining, Vessel density, Vessel number trap, Xenograft.
- Teeft :
- Arrow heads, Augmentation, Augmentation area, Autogenous bone, Autologous, Autologous bone, Autologous bone grafts, Biomaterial, Biomaterial degradation, Biomaterial granules, Biomed mater, Biopsy, Bone, Bone biopsies, Bone formation, Bone regeneration, Bone substitute, Bone substitute material, Bone substitutes, Bone tissue, Bone tissue formation, Bone trabeculae, Canullo, Cells trap, Cellular degradation, Clinical application, Clinical implant dentistry, Connective, Connective tissue, Connective tissue formation, Continuous degradation, Cranial parts, Degradation, Dental implants, Facial plastic surgery, Graft, Healing period, Histological, Histomorphometric evaluation, Histomorphometrical, Histomorphometrical analysis, Human sinus cavity, Hydroxyapatite, Implant, Implant insertion, Implant placement, Implantation, Insertion, Johannes gutenberg university mainz, Masson goldner stain, Matrix, Maxillary, Maxillary sinus, Maxillofac, Multinucleated, Multinucleated giant cells, Nanobone, Nanocrystalline, Nanocrystalline bone substitute material, Nanocrystalline hydroxyapatite bone substitute, Nanocrystalline hydroxyapatite silica, Oral maxillofac implants, Oral maxillofac surg, Osteoblast proliferation, Osteoconductive properties, Other bone substitute materials, Percentage distribution, Present study, Regeneration, Residual, Residual bone, Residual bone fractions, Residual fraction, Retrospective analysis, Screw line, Second stage surgery, Shahram ghanaati, Silica, Silica matrix, Sinus, Sinus augmentation, Sinus augmentation procedure, Sinus cavity, Sinus elevation procedure, Statistical analysis, Subsequent study, Surgical site, Synthetic bone substitute material, Time point, Tissue distribution, Tissue reaction, Total scan, Trap staining, Vessel density, Vessel number trap, Xenograft.
Abstract
Purpose: In this study the de novo bone formation capacity of a nanocrystalline hydroxyapatite bone substitute was assessed 3 and 6 months after its insertion into the human sinus cavity.
Url:
DOI: 10.1111/j.1708-8208.2011.00433.x
Links to Exploration step
ISTEX:B07A9B9DEC8F9B25B6525ECEBC1FFA2EC0595BBDLe document en format XML
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Kirkpatrick</name><affiliation><mods:affiliation>Institute of Pathology, REPAIR‐Lab, University Medical Center, Johannes Gutenberg University Mainz, Germany;</mods:affiliation></affiliation></author><author><name sortKey="Sader, Robert A" sort="Sader, Robert A" uniqKey="Sader R" first="Robert A." last="Sader">Robert A. Sader</name><affiliation><mods:affiliation>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY RELATED RESEARCH</title><idno type="ISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><imprint><biblScope unit="vol">15</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="883">883</biblScope><biblScope unit="page" to="892">892</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-12">2013-12</date></imprint><idno type="ISSN">1523-0899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1523-0899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arrow heads</term><term>Augmentation</term><term>Augmentation area</term><term>Autogenous bone</term><term>Autologous</term><term>Autologous bone</term><term>Autologous bone grafts</term><term>Biomaterial</term><term>Biomaterial degradation</term><term>Biomaterial granules</term><term>Biomed mater</term><term>Biopsy</term><term>Bone</term><term>Bone biopsies</term><term>Bone formation</term><term>Bone regeneration</term><term>Bone substitute</term><term>Bone substitute material</term><term>Bone substitutes</term><term>Bone tissue</term><term>Bone tissue formation</term><term>Bone trabeculae</term><term>Canullo</term><term>Cells trap</term><term>Cellular degradation</term><term>Clinical application</term><term>Clinical implant dentistry</term><term>Connective</term><term>Connective tissue</term><term>Connective tissue formation</term><term>Continuous degradation</term><term>Cranial parts</term><term>Degradation</term><term>Dental implants</term><term>Facial plastic surgery</term><term>Graft</term><term>Healing period</term><term>Histological</term><term>Histomorphometric evaluation</term><term>Histomorphometrical</term><term>Histomorphometrical analysis</term><term>Human sinus cavity</term><term>Hydroxyapatite</term><term>Implant</term><term>Implant insertion</term><term>Implant placement</term><term>Implantation</term><term>Insertion</term><term>Johannes gutenberg university mainz</term><term>Masson goldner stain</term><term>Matrix</term><term>Maxillary</term><term>Maxillary sinus</term><term>Maxillofac</term><term>Multinucleated</term><term>Multinucleated giant cells</term><term>Nanobone</term><term>Nanocrystalline</term><term>Nanocrystalline bone substitute material</term><term>Nanocrystalline hydroxyapatite bone substitute</term><term>Nanocrystalline hydroxyapatite silica</term><term>Oral maxillofac implants</term><term>Oral maxillofac surg</term><term>Osteoblast proliferation</term><term>Osteoconductive properties</term><term>Other bone substitute materials</term><term>Percentage distribution</term><term>Present study</term><term>Regeneration</term><term>Residual</term><term>Residual bone</term><term>Residual bone fractions</term><term>Residual fraction</term><term>Retrospective analysis</term><term>Screw line</term><term>Second stage surgery</term><term>Shahram ghanaati</term><term>Silica</term><term>Silica matrix</term><term>Sinus</term><term>Sinus augmentation</term><term>Sinus augmentation procedure</term><term>Sinus cavity</term><term>Sinus elevation procedure</term><term>Statistical analysis</term><term>Subsequent study</term><term>Surgical site</term><term>Synthetic bone substitute material</term><term>Time point</term><term>Tissue distribution</term><term>Tissue reaction</term><term>Total scan</term><term>Trap staining</term><term>Vessel density</term><term>Vessel number trap</term><term>Xenograft</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Arrow heads</term><term>Augmentation</term><term>Augmentation area</term><term>Autogenous bone</term><term>Autologous</term><term>Autologous bone</term><term>Autologous bone grafts</term><term>Biomaterial</term><term>Biomaterial degradation</term><term>Biomaterial granules</term><term>Biomed mater</term><term>Biopsy</term><term>Bone</term><term>Bone biopsies</term><term>Bone formation</term><term>Bone regeneration</term><term>Bone substitute</term><term>Bone substitute material</term><term>Bone substitutes</term><term>Bone tissue</term><term>Bone tissue formation</term><term>Bone trabeculae</term><term>Canullo</term><term>Cells trap</term><term>Cellular degradation</term><term>Clinical application</term><term>Clinical implant dentistry</term><term>Connective</term><term>Connective tissue</term><term>Connective tissue formation</term><term>Continuous degradation</term><term>Cranial parts</term><term>Degradation</term><term>Dental implants</term><term>Facial plastic surgery</term><term>Graft</term><term>Healing period</term><term>Histological</term><term>Histomorphometric evaluation</term><term>Histomorphometrical</term><term>Histomorphometrical analysis</term><term>Human sinus cavity</term><term>Hydroxyapatite</term><term>Implant</term><term>Implant insertion</term><term>Implant placement</term><term>Implantation</term><term>Insertion</term><term>Johannes gutenberg university mainz</term><term>Masson goldner stain</term><term>Matrix</term><term>Maxillary</term><term>Maxillary sinus</term><term>Maxillofac</term><term>Multinucleated</term><term>Multinucleated giant cells</term><term>Nanobone</term><term>Nanocrystalline</term><term>Nanocrystalline bone substitute material</term><term>Nanocrystalline hydroxyapatite bone substitute</term><term>Nanocrystalline hydroxyapatite silica</term><term>Oral maxillofac implants</term><term>Oral maxillofac surg</term><term>Osteoblast proliferation</term><term>Osteoconductive properties</term><term>Other bone substitute materials</term><term>Percentage distribution</term><term>Present study</term><term>Regeneration</term><term>Residual</term><term>Residual bone</term><term>Residual bone fractions</term><term>Residual fraction</term><term>Retrospective analysis</term><term>Screw line</term><term>Second stage surgery</term><term>Shahram ghanaati</term><term>Silica</term><term>Silica matrix</term><term>Sinus</term><term>Sinus augmentation</term><term>Sinus augmentation procedure</term><term>Sinus cavity</term><term>Sinus elevation procedure</term><term>Statistical analysis</term><term>Subsequent study</term><term>Surgical site</term><term>Synthetic bone substitute material</term><term>Time point</term><term>Tissue distribution</term><term>Tissue reaction</term><term>Total scan</term><term>Trap staining</term><term>Vessel density</term><term>Vessel number trap</term><term>Xenograft</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Purpose: In this study the de novo bone formation capacity of a nanocrystalline hydroxyapatite bone substitute was assessed 3 and 6 months after its insertion into the human sinus cavity.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>augmentation</json:string><json:string>multinucleated</json:string><json:string>implant</json:string><json:string>bone formation</json:string><json:string>sinus</json:string><json:string>nanocrystalline</json:string><json:string>multinucleated giant cells</json:string><json:string>implantation</json:string><json:string>histological</json:string><json:string>connective tissue</json:string><json:string>maxillary</json:string><json:string>histomorphometrical</json:string><json:string>biomaterial</json:string><json:string>nanobone</json:string><json:string>histomorphometrical analysis</json:string><json:string>hydroxyapatite</json:string><json:string>autologous</json:string><json:string>maxillary sinus</json:string><json:string>bone substitute</json:string><json:string>maxillofac</json:string><json:string>xenograft</json:string><json:string>residual bone</json:string><json:string>time point</json:string><json:string>canullo</json:string><json:string>residual</json:string><json:string>bone substitute material</json:string><json:string>oral maxillofac implants</json:string><json:string>present study</json:string><json:string>bone tissue</json:string><json:string>biopsy</json:string><json:string>clinical application</json:string><json:string>tissue reaction</json:string><json:string>healing period</json:string><json:string>autologous bone grafts</json:string><json:string>clinical implant dentistry</json:string><json:string>insertion</json:string><json:string>graft</json:string><json:string>degradation</json:string><json:string>arrow heads</json:string><json:string>bone substitutes</json:string><json:string>augmentation area</json:string><json:string>masson goldner stain</json:string><json:string>matrix</json:string><json:string>regeneration</json:string><json:string>dental implants</json:string><json:string>cellular degradation</json:string><json:string>total scan</json:string><json:string>bone trabeculae</json:string><json:string>tissue distribution</json:string><json:string>nanocrystalline hydroxyapatite bone substitute</json:string><json:string>bone regeneration</json:string><json:string>biomaterial degradation</json:string><json:string>biomed mater</json:string><json:string>connective</json:string><json:string>silica</json:string><json:string>bone</json:string><json:string>second stage surgery</json:string><json:string>screw line</json:string><json:string>bone biopsies</json:string><json:string>shahram ghanaati</json:string><json:string>implant placement</json:string><json:string>bone tissue formation</json:string><json:string>osteoconductive properties</json:string><json:string>silica matrix</json:string><json:string>facial plastic surgery</json:string><json:string>statistical analysis</json:string><json:string>biomaterial granules</json:string><json:string>johannes gutenberg university mainz</json:string><json:string>implant insertion</json:string><json:string>vessel density</json:string><json:string>human sinus cavity</json:string><json:string>cranial parts</json:string><json:string>trap staining</json:string><json:string>subsequent study</json:string><json:string>sinus cavity</json:string><json:string>residual bone fractions</json:string><json:string>percentage distribution</json:string><json:string>retrospective analysis</json:string><json:string>connective tissue formation</json:string><json:string>synthetic bone substitute material</json:string><json:string>residual fraction</json:string><json:string>vessel number trap</json:string><json:string>cells trap</json:string><json:string>osteoblast proliferation</json:string><json:string>continuous degradation</json:string><json:string>other bone substitute materials</json:string><json:string>autologous bone</json:string><json:string>autogenous bone</json:string><json:string>sinus elevation procedure</json:string><json:string>sinus augmentation procedure</json:string><json:string>oral maxillofac surg</json:string><json:string>sinus augmentation</json:string><json:string>nanocrystalline hydroxyapatite silica</json:string><json:string>surgical site</json:string><json:string>histomorphometric evaluation</json:string><json:string>nanocrystalline bone substitute material</json:string></teeft></keywords><author><json:item><name>Shahram Ghanaati MD, DDS</name><affiliations><json:string>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;</json:string><json:string>Institute of Pathology, REPAIR‐Lab, University Medical Center, Johannes Gutenberg University Mainz, Germany;</json:string><json:string>E-mail: Ghanaati@uni-mainz.de</json:string></affiliations></json:item><json:item><name>Mike Barbeck MSc</name><affiliations><json:string>Institute of Pathology, REPAIR‐Lab, University Medical Center, Johannes Gutenberg University Mainz, Germany;</json:string></affiliations></json:item><json:item><name>Ines Willershausen DDS</name><affiliations><json:string>Institute for Dental Material Sciences and Technology, University Medical Center of the Johannes Gutenberg University Mainz, Germany;</json:string></affiliations></json:item><json:item><name>Benjamin Thimm PhD</name><affiliations><json:string>Institute for Biomechanics, ETH Zurich, Switzerland;</json:string></affiliations></json:item><json:item><name>Stefan Stuebinger DDS</name><affiliations><json:string>Center for Applied Biotechnology and Molecular Medicine, Zurich, Switzerland</json:string></affiliations></json:item><json:item><name>Tadas Korzinskas DDS</name><affiliations><json:string>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;</json:string></affiliations></json:item><json:item><name>Karina Obreja</name><affiliations><json:string>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;</json:string></affiliations></json:item><json:item><name>Constantin Landes MD, DDS, PhD</name><affiliations><json:string>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;</json:string></affiliations></json:item><json:item><name>Charles J. Kirkpatrick MD, PhD</name><affiliations><json:string>Institute of Pathology, REPAIR‐Lab, University Medical Center, Johannes Gutenberg University Mainz, Germany;</json:string></affiliations></json:item><json:item><name>Robert A. 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Kirkpatrick</json:string><json:string>Stefan Stuebinger</json:string><json:string>Traini</json:string><json:string>Robert A. Sader</json:string><json:string>Karina Obreja</json:string><json:string>Tarnow</json:string><json:string>Carl Roth</json:string><json:string>Constantin Landes</json:string><json:string>Ines Willershausen</json:string><json:string>Benjamin Thimm</json:string></persName><placeName><json:string>Karlsruhe</json:string><json:string>Switzerland</json:string><json:string>Germany</json:string><json:string>Frankfurt/Main</json:string><json:string>Japan</json:string><json:string>Basel</json:string><json:string>Frankfurt</json:string><json:string>Tokyo</json:string><json:string>Rostock</json:string><json:string>Wetzlar</json:string><json:string>Italy</json:string><json:string>Mainz</json:string><json:string>Zurich</json:string></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-C572FKL7-5</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - General Dentistry</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Oral Surgery</json:string></scopus></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1111/j.1708-8208.2011.00433.x</json:string></doi><id>B07A9B9DEC8F9B25B6525ECEBC1FFA2EC0595BBD</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/B07A9B9DEC8F9B25B6525ECEBC1FFA2EC0595BBD/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/B07A9B9DEC8F9B25B6525ECEBC1FFA2EC0595BBD/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/B07A9B9DEC8F9B25B6525ECEBC1FFA2EC0595BBD/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Nanocrystalline Hydroxyapatite Bone Substitute Leads to Sufficient Bone Tissue Formation Already after 3 Months: Histological and Histomorphometrical Analysis 3 and 6 Months following Human Sinus Cavity Augmentation</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2012 Wiley Periodicals, Inc.</licence></availability><date type="published" when="2013-12"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Nanocrystalline Hydroxyapatite Bone Substitute Leads to Sufficient Bone Tissue Formation Already after 3 Months: Histological and Histomorphometrical Analysis 3 and 6 Months following Human Sinus Cavity Augmentation</title><title level="a" type="short">Clinical Application of NanoBone in Humans</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Shahram</forename><surname>Ghanaati</surname><roleName type="degree">MD, DDS</roleName></persName><affiliation>
Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany; <address><country key="DE"></country></address></affiliation><affiliation>Institute of Pathology, REPAIR‐Lab, University Medical Center, Johannes Gutenberg University Mainz, Germany;<address><country key="DE"></country></address></affiliation><affiliation>Dr. Shahram Ghanaati, Clinic for Maxillofacial and Plastic Surgery, Johann Wolfgang Goethe University, Frankfurt/Main, Germany; e‐mail: Ghanaati@uni-mainz.de</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Mike</forename><surname>Barbeck</surname><roleName type="degree">MSc</roleName></persName><affiliation>Institute of Pathology, REPAIR‐Lab, University Medical Center, Johannes Gutenberg University Mainz, Germany;<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Ines</forename><surname>Willershausen</surname><roleName type="degree">DDS</roleName></persName><affiliation>Institute for Dental Material Sciences and Technology, University Medical Center of the Johannes Gutenberg University Mainz, Germany;<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Benjamin</forename><surname>Thimm</surname><roleName type="degree">PhD</roleName></persName><affiliation>Institute for Biomechanics, ETH Zurich, Switzerland;<address><country key="CH"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Stefan</forename><surname>Stuebinger</surname><roleName type="degree">DDS</roleName></persName><affiliation>Center for Applied Biotechnology and Molecular Medicine, Zurich, Switzerland<address><country key="CH"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Tadas</forename><surname>Korzinskas</surname><roleName type="degree">DDS</roleName></persName><affiliation>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Karina</forename><surname>Obreja</surname></persName><affiliation>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Constantin</forename><surname>Landes</surname><roleName type="degree">MD, DDS, PhD</roleName></persName><affiliation>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Charles J.</forename><surname>Kirkpatrick</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Institute of Pathology, REPAIR‐Lab, University Medical Center, Johannes Gutenberg University Mainz, Germany;<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0009"><persName><forename type="first">Robert A.</forename><surname>Sader</surname><roleName type="degree">MD, DDS, PhD</roleName></persName><affiliation>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;<address><country key="DE"></country></address></affiliation></author><idno type="istex">B07A9B9DEC8F9B25B6525ECEBC1FFA2EC0595BBD</idno><idno type="ark">ark:/67375/WNG-C572FKL7-5</idno><idno 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xml:lang="en" style="main"><head>ABSTRACT</head><p><hi rend="bold">Purpose:</hi> In this study the de novo bone formation capacity of a nanocrystalline hydroxyapatite bone substitute was assessed 3 and 6 months after its insertion into the human sinus cavity.</p><p><hi rend="bold">Materials and Methods:</hi> Sinus cavity augmentation was performed in a total of 14 patients (<hi rend="italic">n</hi> = 7 implantation after 3 months; <hi rend="italic">n</hi> = 7 implantation after 6 months) with severely atrophic maxillary bone. The specimens obtained after 3 and 6 months were analyzed histologically and histomorphometrically with special focus on bone metabolism within the residual bone and the augmented region.</p><p><hi rend="bold">Results:</hi> This study revealed that bone tissue formation started from the bone‐biomaterial‐interface and was directed into the most cranial parts of the augmented region. There was no statistically significant difference in new bone formation after 3 and 6 months (24.89 ± 10.22% vs 31.29 ± 2.29%), respectively.</p><p><hi rend="bold">Conclusions:</hi> Within the limits of the present study and according to previously published data, implant insertion in regions augmented with this bone substitute material could be considered already after 3 months. Further clinical studies with bone substitute materials are necessary to validate these findings.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">NanoBone</term><term xml:id="k2">nanocrystalline hydroxyapatite</term><term xml:id="k3">sinus floor augmentation</term></keywords><keywords rend="tocHeading1"><term>ARTICLES</term></keywords><keywords rend="articleCategory"><term>ARTICLE</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/B07A9B9DEC8F9B25B6525ECEBC1FFA2EC0595BBD/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body" wicri:toSee="Element documentInfo"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Nanocrystalline Hydroxyapatite Bone Substitute Leads to Sufficient Bone Tissue Formation Already after 3 Months: Histological and Histomorphometrical Analysis 3 and 6 Months following Human Sinus Cavity Augmentation</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Clinical Application of NanoBone in Humans</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Nanocrystalline Hydroxyapatite Bone Substitute Leads to Sufficient Bone Tissue Formation Already after 3 Months: Histological and Histomorphometrical Analysis 3 and 6 Months following Human Sinus Cavity Augmentation</title></titleInfo><name type="personal"><namePart type="given">Shahram</namePart><namePart type="family">Ghanaati</namePart><namePart type="termsOfAddress">MD, DDS</namePart><affiliation>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;</affiliation><affiliation>Institute of Pathology, REPAIR‐Lab, University Medical Center, Johannes Gutenberg University Mainz, Germany;</affiliation><affiliation>E-mail: Ghanaati@uni-mainz.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mike</namePart><namePart type="family">Barbeck</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Institute of Pathology, REPAIR‐Lab, University Medical Center, Johannes Gutenberg University Mainz, Germany;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ines</namePart><namePart type="family">Willershausen</namePart><namePart type="termsOfAddress">DDS</namePart><affiliation>Institute for Dental Material Sciences and Technology, University Medical Center of the Johannes Gutenberg University Mainz, Germany;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Benjamin</namePart><namePart type="family">Thimm</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute for Biomechanics, ETH Zurich, Switzerland;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stefan</namePart><namePart type="family">Stuebinger</namePart><namePart type="termsOfAddress">DDS</namePart><affiliation>Center for Applied Biotechnology and Molecular Medicine, Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tadas</namePart><namePart type="family">Korzinskas</namePart><namePart type="termsOfAddress">DDS</namePart><affiliation>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karina</namePart><namePart type="family">Obreja</namePart><affiliation>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Constantin</namePart><namePart type="family">Landes</namePart><namePart type="termsOfAddress">MD, DDS, PhD</namePart><affiliation>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Charles J.</namePart><namePart type="family">Kirkpatrick</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institute of Pathology, REPAIR‐Lab, University Medical Center, Johannes Gutenberg University Mainz, Germany;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert A.</namePart><namePart type="family">Sader</namePart><namePart type="termsOfAddress">MD, DDS, PhD</namePart><affiliation>Department for Oral, Cranio‐Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2013-12</dateIssued><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">3</extent><extent unit="tables">0</extent><extent unit="formulas">0</extent><extent unit="references">39</extent><extent unit="linksCrossRef">0</extent><extent unit="words">4453</extent></physicalDescription><abstract>Purpose: In this study the de novo bone formation capacity of a nanocrystalline hydroxyapatite bone substitute was assessed 3 and 6 months after its insertion into the human sinus cavity.</abstract><abstract>Materials and Methods: Sinus cavity augmentation was performed in a total of 14 patients (n = 7 implantation after 3 months; n = 7 implantation after 6 months) with severely atrophic maxillary bone. The specimens obtained after 3 and 6 months were analyzed histologically and histomorphometrically with special focus on bone metabolism within the residual bone and the augmented region.</abstract><abstract>Results: This study revealed that bone tissue formation started from the bone‐biomaterial‐interface and was directed into the most cranial parts of the augmented region. There was no statistically significant difference in new bone formation after 3 and 6 months (24.89 ± 10.22% vs 31.29 ± 2.29%), respectively.</abstract><abstract>Conclusions: Within the limits of the present study and according to previously published data, implant insertion in regions augmented with this bone substitute material could be considered already after 3 months. Further clinical studies with bone substitute materials are necessary to validate these findings.</abstract><subject lang="en"><genre>keywords</genre><topic>NanoBone</topic><topic>nanocrystalline hydroxyapatite</topic><topic>sinus floor augmentation</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Implant Dentistry and Related Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>ARTICLE</topic></subject><identifier type="ISSN">1523-0899</identifier><identifier type="eISSN">1708-8208</identifier><identifier type="DOI">10.1111/(ISSN)1708-8208</identifier><identifier type="PublisherID">CID</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>883</start><end>892</end><total>10</total></extent></part></relatedItem><identifier type="istex">B07A9B9DEC8F9B25B6525ECEBC1FFA2EC0595BBD</identifier><identifier type="ark">ark:/67375/WNG-C572FKL7-5</identifier><identifier type="DOI">10.1111/j.1708-8208.2011.00433.x</identifier><identifier type="ArticleID">CID433</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 Wiley Periodicals, Inc.© 2012 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/B07A9B9DEC8F9B25B6525ECEBC1FFA2EC0595BBD/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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