Composite reconstruction in advanced cancer of the mouth floor: Autogenous frozen‐thawed mandibular bone and free flaps
Identifieur interne : 005807 ( Istex/Corpus ); précédent : 005806; suivant : 005808Composite reconstruction in advanced cancer of the mouth floor: Autogenous frozen‐thawed mandibular bone and free flaps
Auteurs : Luca Calabrese ; Cristina Garusi ; Gioacchino Giugliano ; Mohssen Ansarin ; Roberto Bruschini ; Fausto ChiesaSource :
- Microsurgery [ 0738-1085 ] ; 2007.
English descriptors
- KwdEn :
- Arch otolaryngol head neck surg, Autogenous, Autogenous mandibular bone, Autogenous mandibular graft, Block resection, Bone graft, Bone insertion, Bone invasion, Bone reconstruction, Bone resection, Bone scan, Bone sequestrum, Bone spet, Bony involvement, Carcinoma, Cell carcinoma, Chronic infection, Dental rehabilitation, Donor site morbidity, European institute, Experimental study, Forearm, Free forearm, Functional results, Further surgery, Graft, Grafted bone, Head neck, Head neck surg, Human experience, Iliac crest, Immediate reconstruction, Inadequate vascularization, Insertion, Late complications, Liquid nitrogen, Mandible, Mandible reconstruction, Mandibular, Mandibular bone, Mandibular graft, Mandibular grafts, Mandibular insertions, Mandibular plate, Mandibular reconstruction, Mandibular segment, Marginal resection, Microsurgery, Mucosal diastasis, Muscle invasion, Neck recurrence, Neck surgery, None none, Oral cavity, Oral maxillofac surg, Oral surg, Oromandibular reconstruction, Osteoblast activity, Otolaryngol head neck surg, Partial glossectomy, Partial sequestrum, Patient characteristics, Periostal invasion, Periosteum, Pilot study, Plast, Plast reconstr surg, Postoperative, Postoperative radiotherapy, Postoperative view, Radiotherapy, Reconstr, Recurrence, Recurrent cancer, Resection, Room temperature, Sequestrum, Soft tissue, Squamous cell carcinoma, Subacute infection, Subsequent scans, Such cases, Surg, Surg oncol, Symphyseal, Symphyseal region, Total pelvectomy, Vascularized, Vascularized periosteum.
- Teeft :
- Arch otolaryngol head neck surg, Autogenous, Autogenous mandibular bone, Autogenous mandibular graft, Block resection, Bone graft, Bone insertion, Bone invasion, Bone reconstruction, Bone resection, Bone scan, Bone sequestrum, Bone spet, Bony involvement, Carcinoma, Cell carcinoma, Chronic infection, Dental rehabilitation, Donor site morbidity, European institute, Experimental study, Forearm, Free forearm, Functional results, Further surgery, Graft, Grafted bone, Head neck, Head neck surg, Human experience, Iliac crest, Immediate reconstruction, Inadequate vascularization, Insertion, Late complications, Liquid nitrogen, Mandible, Mandible reconstruction, Mandibular, Mandibular bone, Mandibular graft, Mandibular grafts, Mandibular insertions, Mandibular plate, Mandibular reconstruction, Mandibular segment, Marginal resection, Microsurgery, Mucosal diastasis, Muscle invasion, Neck recurrence, Neck surgery, None none, Oral cavity, Oral maxillofac surg, Oral surg, Oromandibular reconstruction, Osteoblast activity, Otolaryngol head neck surg, Partial glossectomy, Partial sequestrum, Patient characteristics, Periostal invasion, Periosteum, Pilot study, Plast, Plast reconstr surg, Postoperative, Postoperative radiotherapy, Postoperative view, Radiotherapy, Reconstr, Recurrence, Recurrent cancer, Resection, Room temperature, Sequestrum, Soft tissue, Squamous cell carcinoma, Subacute infection, Subsequent scans, Such cases, Surg, Surg oncol, Symphyseal, Symphyseal region, Total pelvectomy, Vascularized, Vascularized periosteum.
Abstract
Mandibular symphyseal resection requires composite reconstructions, often with unsatisfactory morphofunctional results. Seven patients with advanced squamous cell carcinoma of the floor of the mouth underwent block resection with immediate reconstruction, using the removed mandible treated with liquid nitrogen and covered with a free forearm flap. In all cases, the resection was radical and no major postoperative complications occurred. Two patients died in 6 months for distant metastases and regional recurrence. In the other 5 patients, no local recurrence occurred at a mean follow‐up of 52 months (36–70). Immediate cosmetic and functional results were good. Of the 5 patients, 4 had late complications requiring further surgery. This technique of bone reimplantation produces no donor site morbidity, perfect immediate morphological result, and is of low cost. The free forearm flap is effective in sealing the oral cavity, though further clinical and experimental studies are necessary to reduce late local complications. © 2007 Wiley‐Liss, Inc. Microsurgery, 2007.
Url:
DOI: 10.1002/micr.20301
Links to Exploration step
ISTEX:B0644853804A92368C6F15AF8A4A61EC24FB73DFLe document en format XML
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European Institute of Oncology, Milan, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Microsurgery</title><title level="j" type="alt">MICROSURGERY</title><idno type="ISSN">0738-1085</idno><idno type="eISSN">1098-2752</idno><imprint><biblScope unit="vol">27</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="21">21</biblScope><biblScope unit="page" to="26">26</biblScope><biblScope unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007">2007</date></imprint><idno type="ISSN">0738-1085</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0738-1085</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arch otolaryngol head neck surg</term><term>Autogenous</term><term>Autogenous mandibular bone</term><term>Autogenous mandibular graft</term><term>Block resection</term><term>Bone graft</term><term>Bone insertion</term><term>Bone invasion</term><term>Bone reconstruction</term><term>Bone resection</term><term>Bone scan</term><term>Bone sequestrum</term><term>Bone spet</term><term>Bony involvement</term><term>Carcinoma</term><term>Cell carcinoma</term><term>Chronic infection</term><term>Dental rehabilitation</term><term>Donor site morbidity</term><term>European institute</term><term>Experimental study</term><term>Forearm</term><term>Free forearm</term><term>Functional results</term><term>Further surgery</term><term>Graft</term><term>Grafted bone</term><term>Head neck</term><term>Head neck surg</term><term>Human experience</term><term>Iliac crest</term><term>Immediate reconstruction</term><term>Inadequate vascularization</term><term>Insertion</term><term>Late complications</term><term>Liquid nitrogen</term><term>Mandible</term><term>Mandible reconstruction</term><term>Mandibular</term><term>Mandibular bone</term><term>Mandibular graft</term><term>Mandibular grafts</term><term>Mandibular insertions</term><term>Mandibular plate</term><term>Mandibular reconstruction</term><term>Mandibular segment</term><term>Marginal resection</term><term>Microsurgery</term><term>Mucosal diastasis</term><term>Muscle invasion</term><term>Neck recurrence</term><term>Neck surgery</term><term>None none</term><term>Oral cavity</term><term>Oral maxillofac surg</term><term>Oral surg</term><term>Oromandibular reconstruction</term><term>Osteoblast activity</term><term>Otolaryngol head neck surg</term><term>Partial glossectomy</term><term>Partial sequestrum</term><term>Patient characteristics</term><term>Periostal invasion</term><term>Periosteum</term><term>Pilot study</term><term>Plast</term><term>Plast reconstr surg</term><term>Postoperative</term><term>Postoperative radiotherapy</term><term>Postoperative view</term><term>Radiotherapy</term><term>Reconstr</term><term>Recurrence</term><term>Recurrent 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cavity</term><term>Oral maxillofac surg</term><term>Oral surg</term><term>Oromandibular reconstruction</term><term>Osteoblast activity</term><term>Otolaryngol head neck surg</term><term>Partial glossectomy</term><term>Partial sequestrum</term><term>Patient characteristics</term><term>Periostal invasion</term><term>Periosteum</term><term>Pilot study</term><term>Plast</term><term>Plast reconstr surg</term><term>Postoperative</term><term>Postoperative radiotherapy</term><term>Postoperative view</term><term>Radiotherapy</term><term>Reconstr</term><term>Recurrence</term><term>Recurrent cancer</term><term>Resection</term><term>Room temperature</term><term>Sequestrum</term><term>Soft tissue</term><term>Squamous cell carcinoma</term><term>Subacute infection</term><term>Subsequent scans</term><term>Such cases</term><term>Surg</term><term>Surg oncol</term><term>Symphyseal</term><term>Symphyseal region</term><term>Total pelvectomy</term><term>Vascularized</term><term>Vascularized 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M.D.</name><affiliations><json:string>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy</json:string><json:string>E-mail: luca.calabrese@ieo.it</json:string><json:string>Correspondence address: Head and Neck Surgery Division, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy</json:string></affiliations></json:item><json:item><name>Cristina Garusi M.D.</name><affiliations><json:string>Division of Plastic Surgery, European Institute of Oncology, Milan, Italy</json:string></affiliations></json:item><json:item><name>Gioacchino Giugliano M.D.</name><affiliations><json:string>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy</json:string></affiliations></json:item><json:item><name>Mohssen Ansarin M.D.</name><affiliations><json:string>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy</json:string></affiliations></json:item><json:item><name>Roberto Bruschini M.D.</name><affiliations><json:string>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy</json:string></affiliations></json:item><json:item><name>Fausto Chiesa M.D.</name><affiliations><json:string>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy</json:string></affiliations></json:item></author><articleId><json:string>MICR20301</json:string></articleId><arkIstex>ark:/67375/WNG-65SN682W-J</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Mandibular symphyseal resection requires composite reconstructions, often with unsatisfactory morphofunctional results. Seven patients with advanced squamous cell carcinoma of the floor of the mouth underwent block resection with immediate reconstruction, using the removed mandible treated with liquid nitrogen and covered with a free forearm flap. In all cases, the resection was radical and no major postoperative complications occurred. Two patients died in 6 months for distant metastases and regional recurrence. In the other 5 patients, no local recurrence occurred at a mean follow‐up of 52 months (36–70). Immediate cosmetic and functional results were good. Of the 5 patients, 4 had late complications requiring further surgery. This technique of bone reimplantation produces no donor site morbidity, perfect immediate morphological result, and is of low cost. The free forearm flap is effective in sealing the oral cavity, though further clinical and experimental studies are necessary to reduce late local complications. © 2007 Wiley‐Liss, Inc. Microsurgery, 2007.</abstract><qualityIndicators><refBibsNative>true</refBibsNative><abstractWordCount>154</abstractWordCount><abstractCharCount>1076</abstractCharCount><keywordCount>0</keywordCount><score>7.376</score><pdfWordCount>3528</pdfWordCount><pdfCharCount>22763</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>612 x 810 pts</pdfPageSize></qualityIndicators><title>Composite reconstruction in advanced cancer of the mouth floor: Autogenous frozen‐thawed mandibular bone and free flaps</title><pmid><json:string>17205573</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Microsurgery</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1098-2752</json:string></doi><issn><json:string>0738-1085</json:string></issn><eissn><json:string>1098-2752</json:string></eissn><publisherId><json:string>MICR</json:string></publisherId><volume>27</volume><issue>1</issue><pages><first>21</first><last>26</last><total>6</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Clinical Article and Case Report</value></json:item></subject></host><namedEntities><unitex><date><json:string>1997</json:string><json:string>2007</json:string><json:string>1970s</json:string></date><geogName></geogName><orgName><json:string>European Institute of Oncology, Milan, Italy</json:string><json:string>Division of Head</json:string><json:string>European Institute of Oncology, Via Ripamonti</json:string><json:string>Wiley-Liss, Inc.</json:string><json:string>Division of Plastic Surgery</json:string><json:string>European Institute of Oncology</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Characteristics</json:string><json:string>D. 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flaps</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><licence>Copyright © 2007 Wiley‐Liss, Inc.</licence></availability><date type="published" when="2007"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">Composite reconstruction in advanced cancer of the mouth floor: Autogenous frozen‐thawed mandibular bone and free flaps</title><title level="a" type="short" xml:lang="en">Frozen Autogenous Mandibular Graft</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Luca</forename><surname>Calabrese</surname><roleName type="degree">M.D.</roleName></persName><email>luca.calabrese@ieo.it</email><affiliation>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy<address><country key="IT"></country></address></affiliation><affiliation>Head and Neck Surgery Division, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Cristina</forename><surname>Garusi</surname><roleName type="degree">M.D.</roleName></persName><affiliation>Division of Plastic Surgery, European Institute of Oncology, Milan, Italy<address><country key="IT"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Gioacchino</forename><surname>Giugliano</surname><roleName type="degree">M.D.</roleName></persName><affiliation>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy<address><country key="IT"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Mohssen</forename><surname>Ansarin</surname><roleName type="degree">M.D.</roleName></persName><affiliation>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy<address><country key="IT"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Roberto</forename><surname>Bruschini</surname><roleName type="degree">M.D.</roleName></persName><affiliation>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy<address><country key="IT"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Fausto</forename><surname>Chiesa</surname><roleName type="degree">M.D.</roleName></persName><affiliation>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy<address><country 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Seven patients with advanced squamous cell carcinoma of the floor of the mouth underwent block resection with immediate reconstruction, using the removed mandible treated with liquid nitrogen and covered with a free forearm flap. In all cases, the resection was radical and no major postoperative complications occurred. Two patients died in 6 months for distant metastases and regional recurrence. In the other 5 patients, no local recurrence occurred at a mean follow‐up of 52 months (36–70). Immediate cosmetic and functional results were good. Of the 5 patients, 4 had late complications requiring further surgery. This technique of bone reimplantation produces no donor site morbidity, perfect immediate morphological result, and is of low cost. The free forearm flap is effective in sealing the oral cavity, though further clinical and experimental studies are necessary to reduce late local complications. © 2007 Wiley‐Liss, Inc. 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Seven patients with advanced squamous cell carcinoma of the floor of the mouth underwent block resection with immediate reconstruction, using the removed mandible treated with liquid nitrogen and covered with a free forearm flap. In all cases, the resection was radical and no major postoperative complications occurred. Two patients died in 6 months for distant metastases and regional recurrence. In the other 5 patients, no local recurrence occurred at a mean follow‐up of 52 months (36–70). Immediate cosmetic and functional results were good. Of the 5 patients, 4 had late complications requiring further surgery. This technique of bone reimplantation produces no donor site morbidity, perfect immediate morphological result, and is of low cost. The free forearm flap is effective in sealing the oral cavity, though further clinical and experimental studies are necessary to reduce late local complications. © 2007 Wiley‐Liss, Inc. Microsurgery, 2007.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Composite reconstruction in advanced cancer of the mouth floor: Autogenous frozen‐thawed mandibular bone and free flaps</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Frozen Autogenous Mandibular Graft</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Composite reconstruction in advanced cancer of the mouth floor: Autogenous frozen‐thawed mandibular bone and free flaps</title></titleInfo><name type="personal"><namePart type="given">Luca</namePart><namePart type="family">Calabrese</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy</affiliation><affiliation>E-mail: luca.calabrese@ieo.it</affiliation><affiliation>Correspondence address: Head and Neck Surgery Division, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cristina</namePart><namePart type="family">Garusi</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Division of Plastic Surgery, European Institute of Oncology, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gioacchino</namePart><namePart type="family">Giugliano</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mohssen</namePart><namePart type="family">Ansarin</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Bruschini</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fausto</namePart><namePart type="family">Chiesa</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007</dateIssued><dateCaptured encoding="w3cdtf">2006-09-28</dateCaptured><dateValid encoding="w3cdtf">2006-09-28</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">6</extent><extent unit="tables">1</extent><extent unit="references">45</extent><extent unit="words">1005</extent></physicalDescription><abstract lang="en">Mandibular symphyseal resection requires composite reconstructions, often with unsatisfactory morphofunctional results. Seven patients with advanced squamous cell carcinoma of the floor of the mouth underwent block resection with immediate reconstruction, using the removed mandible treated with liquid nitrogen and covered with a free forearm flap. In all cases, the resection was radical and no major postoperative complications occurred. Two patients died in 6 months for distant metastases and regional recurrence. In the other 5 patients, no local recurrence occurred at a mean follow‐up of 52 months (36–70). Immediate cosmetic and functional results were good. Of the 5 patients, 4 had late complications requiring further surgery. This technique of bone reimplantation produces no donor site morbidity, perfect immediate morphological result, and is of low cost. The free forearm flap is effective in sealing the oral cavity, though further clinical and experimental studies are necessary to reduce late local complications. © 2007 Wiley‐Liss, Inc. 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