Changes in oral microflora after full‐mouth tooth extraction: a prospective cohort study
Identifieur interne : 005087 ( Istex/Corpus ); précédent : 005086; suivant : 005088Changes in oral microflora after full‐mouth tooth extraction: a prospective cohort study
Auteurs : Yvonne C. M. De Waal ; Edwin G. Winkel ; Gerwin C. Raangs ; Marleen L. Van Der Vusse ; John W. A. Rossen ; Arie Jan Van WinkelhoffSource :
- Journal of Clinical Periodontology [ 0303-6979 ] ; 2014-10.
Abstract
The aim of the study was to evaluate the effect of full‐mouth tooth extraction on the oral microflora, with emphasis on the presence and load of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis.
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DOI: 10.1111/jcpe.12297
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M." last="De Waal">Yvonne C. M. De Waal</name><affiliation><mods:affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>Address:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: y.c.m.de.waal@umcg.nl</mods:affiliation></affiliation></author><author><name sortKey="Winkel, Edwin G" sort="Winkel, Edwin G" uniqKey="Winkel E" first="Edwin G." last="Winkel">Edwin G. Winkel</name><affiliation><mods:affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Raangs, Gerwin C" sort="Raangs, Gerwin C" uniqKey="Raangs G" first="Gerwin C." last="Raangs">Gerwin C. Raangs</name><affiliation><mods:affiliation>Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Der Vusse, Marleen L" sort="Van Der Vusse, Marleen L" uniqKey="Van Der Vusse M" first="Marleen L." last="Van Der Vusse">Marleen L. Van Der Vusse</name><affiliation><mods:affiliation>Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Rossen, John W A" sort="Rossen, John W A" uniqKey="Rossen J" first="John W. A." last="Rossen">John W. A. Rossen</name><affiliation><mods:affiliation>Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Winkelhoff, Arie Jan" sort="Van Winkelhoff, Arie Jan" uniqKey="Van Winkelhoff A" first="Arie Jan" last="Van Winkelhoff">Arie Jan Van Winkelhoff</name><affiliation><mods:affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Clinical Periodontology</title><title level="j" type="alt">JOURNAL OF CLINICAL PERIODONTOLOGY</title><idno type="ISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><imprint><biblScope unit="vol">41</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="981">981</biblScope><biblScope unit="page" to="989">989</biblScope><biblScope unit="page-count">9</biblScope><date type="published" when="2014-10">2014-10</date></imprint><idno type="ISSN">0303-6979</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6979</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The aim of the study was to evaluate the effect of full‐mouth tooth extraction on the oral microflora, with emphasis on the presence and load of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Yvonne C.M. de Waal</name><affiliations><json:string>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string><json:string>Address:</json:string><json:string>E-mail: y.c.m.de.waal@umcg.nl</json:string></affiliations></json:item><json:item><name>Edwin G. Winkel</name><affiliations><json:string>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>Gerwin C. Raangs</name><affiliations><json:string>Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>Marleen L. van der Vusse</name><affiliations><json:string>Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>John W.A. 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Aim
<p>The aim of the study was to evaluate the effect of full‐mouth tooth extraction on the oral microflora, with emphasis on the presence and load of <hi rend="italic">Aggregatibacter actinomycetemcomitans</hi> and <hi rend="italic">Porphyromonas gingivalis</hi>.</p>
Material and methods
<p>Adult patients (<hi rend="italic">n</hi> = 30), with moderate to advanced periodontitis and scheduled for full‐mouth tooth extraction, were consecutively selected. Prior to and 1 and 3 months after full‐mouth tooth extraction saliva, tongue, buccal and gingival mucosa and subgingival plaque/prosthesis samples were obtained. Aerobic and anaerobic culture techniques and quantitative real‐time polymerase chain reaction (<hi rend="fc">qPCR</hi>) were employed for the detection of oral pathogens.</p>
Results
<p>Full‐mouth tooth extraction resulted in reduction below detection level of <hi rend="italic">A. actinomycetemcomitans</hi> and <hi rend="italic">P. gingivalis</hi> in 15 of 16 and 8 of 16 previously positive patients using culture techniques and <hi rend="fc">qPCR</hi>, respectively. Those patients remaining <hi rend="fc">qPCR</hi> positive showed a significant reduction in load of these bacteria.</p>
Conclusion
<p>Full‐mouth tooth extraction significantly changes the oral microflora. These changes include reduction of <hi rend="italic">A. actinomycetemcomitans</hi> and <hi rend="italic">P. gingivalis</hi>, frequently to levels below detection threshold. In some patients, <hi rend="italic">A. actinomycetemcomitans</hi> and <hi rend="italic">P. gingivalis</hi> can persist in the edentulous oral cavity up to 3 months after full‐mouth tooth extraction.</p></abstract><textClass><keywords><term xml:id="jcpe12297-kwd-0001">edentulous mouth</term><term xml:id="jcpe12297-kwd-0002">microbiology</term><term xml:id="jcpe12297-kwd-0003">periodontal diseases</term><term xml:id="jcpe12297-kwd-0004">tooth extraction</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Implant Therapy</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="jcpe12297" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-051X</doi><issn type="print">0303-6979</issn><issn type="electronic">1600-051X</issn><idGroup><id type="product" value="JCPE"></id></idGroup><titleGroup><title sort="JOURNAL OF CLINICAL PERIODONTOLOGY" type="main">Journal of Clinical Periodontology</title><title type="short">J Clin Periodontol</title></titleGroup></publicationMeta><publicationMeta level="part" position="100"><doi origin="wiley">10.1111/jcpe.2014.41.issue-10</doi><copyright ownership="publisher">Copyright © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</copyright><numberingGroup><numbering type="journalVolume" number="41">41</numbering><numbering type="journalIssue">10</numbering></numberingGroup><coverDate startDate="2014-10">October 2014</coverDate></publicationMeta><publicationMeta level="unit" position="60" status="forIssue" type="article"><doi>10.1111/jcpe.12297</doi><idGroup><id type="unit" value="JCPE12297"></id></idGroup><countGroup><count number="9" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Implant Therapy</title></titleGroup><copyright ownership="publisher">© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</copyright><eventGroup><event date="2014-07-22" type="manuscriptAccepted"></event><event agent="SPS" date="2014-08-02" type="xmlCreated"></event><event type="publishedOnlineAccepted" date="2014-07-26"></event><event type="publishedOnlineEarlyUnpaginated" date="2014-09-04"></event><event type="firstOnline" date="2014-09-04"></event><event type="publishedOnlineFinalForm" date="2014-09-22"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-07"></event></eventGroup><numberingGroup><numbering type="pageFirst">981</numbering><numbering type="pageLast">989</numbering></numberingGroup><correspondenceTo><lineatedText><line>Address:</line><line><i>Yvonne C.M. de Waal</i></line><line><i>University of Groningen</i></line><line><i>University Medical Center Groningen</i></line><line><i>Center for Dentistry and Oral Hygiene</i></line><line><i>Antonius Deusinglaan 1</i></line><line><i>9713 AV Groningen</i></line><line><i>The Netherlands</i></line><line><i>E‐mail: </i> <email>y.c.m.de.waal@umcg.nl</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="jcpe12297-cit-1001"><author><familyNamePrefix>de</familyNamePrefix> <familyName>Waal</familyName> <givenNames>YCM</givenNames></author>, <author><familyName>Winkel</familyName> <givenNames>EG</givenNames></author>, <author><familyName>Raangs</familyName> <givenNames>GC</givenNames></author>, <author><familyNamePrefix>van der</familyNamePrefix> <familyName>Vusse</familyName> <givenNames>ML</givenNames></author>, <author><familyName>Rossen</familyName> <givenNames>JWA</givenNames></author>, <author><familyNamePrefix>van</familyNamePrefix> <familyName>Winkelhoff</familyName> <givenNames>AJ</givenNames></author>. <articleTitle>Changes in oral microflora after full‐mouth tooth extraction: a prospective cohort study</articleTitle>. <journalTitle>J Clin Periodontol</journalTitle> <pubYear year="2014">2014</pubYear>; <vol>41</vol>: <pageFirst>981</pageFirst>–<pageLast>989</pageLast>. doi: <accessionId ref="info:doi/10.1111/jcpe.12297">10.1111/jcpe.12297</accessionId>.</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:JCPE.JCPE12297.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Changes in oral microflora after full‐mouth tooth extraction: a prospective cohort study</title><title type="shortAuthors">de Waal et al.</title></titleGroup><creators><creator affiliationRef="#jcpe12297-aff-0001" corresponding="yes" creatorRole="author" xml:id="jcpe12297-cr-0001"><personName><givenNames>Yvonne C.M.</givenNames> <familyNamePrefix>de</familyNamePrefix><familyName>Waal</familyName></personName></creator><creator affiliationRef="#jcpe12297-aff-0001" creatorRole="author" xml:id="jcpe12297-cr-0002"><personName><givenNames>Edwin G.</givenNames> <familyName>Winkel</familyName></personName></creator><creator affiliationRef="#jcpe12297-aff-0002" creatorRole="author" xml:id="jcpe12297-cr-0003"><personName><givenNames>Gerwin C.</givenNames> <familyName>Raangs</familyName></personName></creator><creator affiliationRef="#jcpe12297-aff-0002" creatorRole="author" xml:id="jcpe12297-cr-0004"><personName><givenNames>Marleen L.</givenNames> <familyNamePrefix>van der</familyNamePrefix><familyName>Vusse</familyName></personName></creator><creator affiliationRef="#jcpe12297-aff-0002" creatorRole="author" xml:id="jcpe12297-cr-0005"><personName><givenNames>John W.A.</givenNames> <familyName>Rossen</familyName></personName></creator><creator affiliationRef="#jcpe12297-aff-0001 #jcpe12297-aff-0002" creatorRole="author" xml:id="jcpe12297-cr-0006"><personName><givenNames>Arie Jan</givenNames> <familyNamePrefix>van</familyNamePrefix> <familyName>Winkelhoff</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="NL" type="organization" xml:id="jcpe12297-aff-0001"><orgDiv>Center for Dentistry and Oral Hygiene</orgDiv> <orgName>University of Groningen</orgName> <orgDiv>University Medical Center Groningen</orgDiv> <address><city>Groningen</city> <country>The Netherlands</country></address></affiliation><affiliation countryCode="NL" type="organization" xml:id="jcpe12297-aff-0002"><orgDiv>Department of Medical Microbiology</orgDiv> <orgName>University of Groningen</orgName> <orgDiv>University Medical Center Groningen</orgDiv> <address><city>Groningen</city> <country>The Netherlands</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="jcpe12297-kwd-0001">edentulous mouth</keyword><keyword xml:id="jcpe12297-kwd-0002">microbiology</keyword><keyword xml:id="jcpe12297-kwd-0003">periodontal diseases</keyword><keyword xml:id="jcpe12297-kwd-0004">tooth extraction</keyword></keywordGroup><fundingInfo><fundingAgency>Dentaid SL</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:id="jcpe12297-abs-0001"><title type="main">Abstract</title><section xml:id="jcpe12297-sec-0001"><title type="main">Aim</title><p>The aim of the study was to evaluate the effect of full‐mouth tooth extraction on the oral microflora, with emphasis on the presence and load of <i>Aggregatibacter actinomycetemcomitans</i> and <i>Porphyromonas gingivalis</i>.</p></section><section xml:id="jcpe12297-sec-0002"><title type="main">Material and methods</title><p>Adult patients (<i>n</i> = 30), with moderate to advanced periodontitis and scheduled for full‐mouth tooth extraction, were consecutively selected. Prior to and 1 and 3 months after full‐mouth tooth extraction saliva, tongue, buccal and gingival mucosa and subgingival plaque/prosthesis samples were obtained. Aerobic and anaerobic culture techniques and quantitative real‐time polymerase chain reaction (<fc>qPCR</fc>) were employed for the detection of oral pathogens.</p></section><section xml:id="jcpe12297-sec-0003"><title type="main">Results</title><p>Full‐mouth tooth extraction resulted in reduction below detection level of <i>A. actinomycetemcomitans</i> and <i>P. gingivalis</i> in 15 of 16 and 8 of 16 previously positive patients using culture techniques and <fc>qPCR</fc>, respectively. Those patients remaining <fc>qPCR</fc> positive showed a significant reduction in load of these bacteria.</p></section><section xml:id="jcpe12297-sec-0004"><title type="main">Conclusion</title><p>Full‐mouth tooth extraction significantly changes the oral microflora. These changes include reduction of <i>A. actinomycetemcomitans</i> and <i>P. gingivalis</i>, frequently to levels below detection threshold. In some patients, <i>A. actinomycetemcomitans</i> and <i>P. gingivalis</i> can persist in the edentulous oral cavity up to 3 months after full‐mouth tooth extraction.</p></section></abstract></abstractGroup></contentMeta><noteGroup xml:id="jcpe12297-ntgp-0001"><note numbered="no" xml:id="jcpe12297-note-0001"><p><b>Conflict of interest and source of funding statement</b></p><p>Co‐authors E. G. Winkel and A. J. van Winkelhoff declare stock ownership of LabOral International and LabOral Diagnostics, service laboratories for microbial diagnostics in dentistry. The other authors declare no potential conflict of interest. The study was supported by a grant of Dentaid SL (Cerdanyola, Spain).</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Changes in oral microflora after full‐mouth tooth extraction: a prospective cohort study</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Changes in oral microflora after full‐mouth tooth extraction: a prospective cohort study</title></titleInfo><name type="personal"><namePart type="given">Yvonne C.M.</namePart><namePart type="family">de Waal</namePart><affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><affiliation>Address:</affiliation><affiliation>E-mail: y.c.m.de.waal@umcg.nl</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Edwin G.</namePart><namePart type="family">Winkel</namePart><affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gerwin C.</namePart><namePart type="family">Raangs</namePart><affiliation>Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marleen L.</namePart><namePart type="family">van der Vusse</namePart><affiliation>Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John W.A.</namePart><namePart type="family">Rossen</namePart><affiliation>Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arie Jan</namePart><namePart type="family">van Winkelhoff</namePart><affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><affiliation>Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-10</dateIssued><dateCreated encoding="w3cdtf">2014-08-02</dateCreated><dateValid encoding="w3cdtf">2014-07-22</dateValid><edition>de Waal YCM, Winkel EG, Raangs GC, van der Vusse ML, Rossen JWA, van Winkelhoff AJ. Changes in oral microflora after full‐mouth tooth extraction: a prospective cohort study. J Clin Periodontol 2014; 41: 981–989. doi: 10.1111/jcpe.12297.</edition><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>The aim of the study was to evaluate the effect of full‐mouth tooth extraction on the oral microflora, with emphasis on the presence and load of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis.</abstract><abstract>Adult patients (n = 30), with moderate to advanced periodontitis and scheduled for full‐mouth tooth extraction, were consecutively selected. Prior to and 1 and 3 months after full‐mouth tooth extraction saliva, tongue, buccal and gingival mucosa and subgingival plaque/prosthesis samples were obtained. Aerobic and anaerobic culture techniques and quantitative real‐time polymerase chain reaction (qPCR) were employed for the detection of oral pathogens.</abstract><abstract>Full‐mouth tooth extraction resulted in reduction below detection level of A. actinomycetemcomitans and P. gingivalis in 15 of 16 and 8 of 16 previously positive patients using culture techniques and qPCR, respectively. Those patients remaining qPCR positive showed a significant reduction in load of these bacteria.</abstract><abstract>Full‐mouth tooth extraction significantly changes the oral microflora. These changes include reduction of A. actinomycetemcomitans and P. gingivalis, frequently to levels below detection threshold. In some patients, A. actinomycetemcomitans and P. gingivalis can persist in the edentulous oral cavity up to 3 months after full‐mouth tooth extraction.</abstract><note type="funding">Dentaid SL</note><subject><genre>keywords</genre><topic>edentulous mouth</topic><topic>microbiology</topic><topic>periodontal diseases</topic><topic>tooth extraction</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Clinical Periodontology</title></titleInfo><titleInfo type="abbreviated"><title>J Clin Periodontol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0303-6979</identifier><identifier type="eISSN">1600-051X</identifier><identifier type="DOI">10.1111/(ISSN)1600-051X</identifier><identifier type="PublisherID">JCPE</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>981</start><end>989</end><total>9</total></extent></part></relatedItem><identifier type="istex">A196D7C98AF137086AE62112A4BAE80F28236DA0</identifier><identifier type="ark">ark:/67375/WNG-4PZS40NV-K</identifier><identifier type="DOI">10.1111/jcpe.12297</identifier><identifier type="ArticleID">JCPE12297</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2014 John Wiley & Sons A/S. 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