EdenteV2, Istex, Corpus, bibRecord, 004B57

Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial

Identifieur interne : 004B57 ( Istex/Corpus ); précédent : 004B56; suivant : 004B58

Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial

Auteurs : Niels Ulrich Hermund ; Andreas Stavropoulos ; Ole Donatsky ; Henrik Nielsen ; Christian Clausen ; Jesper Reibel ; Bente Pakkenberg ; Palle Holmstrup

Source :

Clinical Oral Implants Research [ 0905-7161 ] ; 2012-09.

RBID : ISTEX:97767D67EEBB866DF5D2F84EDED569039D5EB9DA

English descriptors

Abstract

The aim of the present randomized clinical study was to evaluate histologically whether the addition of cultivated, autogenous bone cells to a composite graft of deproteinized bovine bone mineral (DBBM) and autogenous bone (AB) for sinus floor augmentation (SFA) enhance bone formation compared with what achieved after SFA with DBBM + AB alone.

Url:

https://api.istex.fr/document/97767D67EEBB866DF5D2F84EDED569039D5EB9DA/fulltext/pdf

DOI: 10.1111/j.1600-0501.2011.02251.x

Links to Exploration step

ISTEX:97767D67EEBB866DF5D2F84EDED569039D5EB9DA

Le document en format XML

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<front><div type="abstract">The aim of the present randomized clinical study was to evaluate histologically whether the addition of cultivated, autogenous bone cells to a composite graft of deproteinized bovine bone mineral (DBBM) and autogenous bone (AB) for sinus floor augmentation (SFA) enhance bone formation compared with what achieved after SFA with DBBM + AB alone.</div>
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<author xml:id="author-0000" role="corresp"><persName><forename type="first">Niels Ulrich</forename>
<surname>Hermund</surname>
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<affiliation><orgName>Department of Oral and Maxillofacial Surgery</orgName>
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<address><settlement type="city">Hilleroed</settlement>
<country key="DK">Denmark</country>
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<affiliation>Corresponding author: Niels Ulrich HermundDepartment of Oral and Maxillofacial SurgeryHilleroed Hospital/RigshospitaletBlegdamsvejDK‐2100 Copenhagen ØDenmarkTel.: 0045 35346356Fax: 0045 35452364e‐mail: nuhermund@hotmail.com</affiliation>
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<author xml:id="author-0001"><persName><forename type="first">Andreas</forename>
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<affiliation><orgName>Department of Periodontology</orgName>
<orgName>School of Dentistry</orgName>
<address><settlement type="city">Aarhus</settlement>
<country key="DK">Denmark</country>
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<author xml:id="author-0002"><persName><forename type="first">Ole</forename>
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<profileDesc><abstract style="main" xml:id="clr2251-abs-0001"><head>Abstract</head>

Objectives
<p>The aim of the present randomized clinical study was to evaluate histologically whether the addition of cultivated, autogenous bone cells to a composite graft of deproteinized bovine bone mineral (<hi rend="fc">DBBM</hi>
) and autogenous bone (<hi rend="fc">AB</hi>
) for sinus floor augmentation (<hi rend="fc">SFA</hi>
) enhance bone formation compared with what achieved after <hi rend="fc">SFA</hi>
 with <hi rend="fc">DBBM</hi>
 + <hi rend="fc">AB</hi>
 alone.</p>


Material and methods
<p>Twenty patients with remaining posterior maxillary alveolar crest height of less than 3 mm received <hi rend="fc">SFA</hi>
 after randomization either with an <hi rend="fc">DBBM</hi>
 and <hi rend="fc">AB</hi>
 composite in a 1 : 1 ratio or with <hi rend="fc">DBBM</hi>
 + <hi rend="fc">AB</hi>
 supplemented with autogenous bone cells, which were cultivated from a bone biopsy harvested earlier from the tuberosity area. Four months after <hi rend="fc">SFA</hi>
, two cylindrical biopsies were taken from the augmented sinuses concomitantly with the implant site preparation by means of a trephine bur. An additional biopsy was taken from the tuberosity area. Bone density at the augmented sinus and the tuberosity area and the height of augmentation were estimated on non‐decalcified histological sections prepared from the biopsies. A relative bone density index (<hi rend="fc">RBD</hi>
) was also calculated by dividing bone density at the augmented sinus with bone density at the tuberosity area.</p>


Results
<p>All patients but one could receive two implants after <hi rend="fc">SFA</hi>
; in one patient, only one implant could be placed. All implants were osseointegrated and could be loaded. Median bone density in the sinus was 30% and 25% in the cell seeded and no‐cells added <hi rend="fc">DBBM</hi>
 + <hi rend="fc">AB</hi>
 groups, respectively. Bone augmentation height averaged 6.0 and 5.4 mm and <hi rend="fc">RBD</hi>
 averaged 0.48 and 0.73 in the cell seeded and no‐cells added <hi rend="fc">DBBM</hi>
 + <hi rend="fc">AB</hi>
 groups, respectively. None of the differences between groups was statistically significant.</p>


Conclusions
<p>Cultivated autogenous bone cell seeded to a <hi rend="fc">DBBM</hi>
 + <hi rend="fc">AB</hi>
 composite did not significantly improve bone formation (density and height) after <hi rend="fc">SFA</hi>
, compared with what was achieved with <hi rend="fc">DBBM</hi>
 + <hi rend="fc">AB</hi>
 alone. Both approaches resulted into enough bone to support implant placement and osseointegration.</p>
</abstract>
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) and autogenous bone (<fc>AB</fc>
) for sinus floor augmentation (<fc>SFA</fc>
) enhance bone formation compared with what achieved after <fc>SFA</fc>
 with <fc>DBBM</fc>
 + <fc>AB</fc>
 alone.</p>
</section>
<section xml:id="clr2251-sec-0002"><title type="main">Material and methods</title>
<p>Twenty patients with remaining posterior maxillary alveolar crest height of less than 3 mm received <fc>SFA</fc>
 after randomization either with an <fc>DBBM</fc>
 and <fc>AB</fc>
 composite in a 1 : 1 ratio or with <fc>DBBM</fc>
 + <fc>AB</fc>
 supplemented with autogenous bone cells, which were cultivated from a bone biopsy harvested earlier from the tuberosity area. Four months after <fc>SFA</fc>
, two cylindrical biopsies were taken from the augmented sinuses concomitantly with the implant site preparation by means of a trephine bur. An additional biopsy was taken from the tuberosity area. Bone density at the augmented sinus and the tuberosity area and the height of augmentation were estimated on non‐decalcified histological sections prepared from the biopsies. A relative bone density index (<fc>RBD</fc>
) was also calculated by dividing bone density at the augmented sinus with bone density at the tuberosity area.</p>
</section>
<section xml:id="clr2251-sec-0003"><title type="main">Results</title>
<p>All patients but one could receive two implants after <fc>SFA</fc>
; in one patient, only one implant could be placed. All implants were osseointegrated and could be loaded. Median bone density in the sinus was 30% and 25% in the cell seeded and no‐cells added <fc>DBBM</fc>
 + <fc>AB</fc>
 groups, respectively. Bone augmentation height averaged 6.0 and 5.4 mm and <fc>RBD</fc>
 averaged 0.48 and 0.73 in the cell seeded and no‐cells added <fc>DBBM</fc>
 + <fc>AB</fc>
 groups, respectively. None of the differences between groups was statistically significant.</p>
</section>
<section xml:id="clr2251-sec-0004"><title type="main">Conclusions</title>
<p>Cultivated autogenous bone cell seeded to a <fc>DBBM</fc>
 + <fc>AB</fc>
 composite did not significantly improve bone formation (density and height) after <fc>SFA</fc>
, compared with what was achieved with <fc>DBBM</fc>
 + <fc>AB</fc>
 alone. Both approaches resulted into enough bone to support implant placement and osseointegration.</p>
</section>
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<mods version="3.6"><titleInfo lang="en"><title>Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial</title>
</titleInfo>
<name type="personal"><namePart type="given">Niels Ulrich</namePart>
<namePart type="family">Hermund</namePart>
<affiliation>Department of Oral and Maxillofacial Surgery, Hilleroed Hospital/Rigshospitalet, Hilleroed, Denmark</affiliation>
<affiliation>Niels Ulrich HermundDepartment of Oral and Maxillofacial SurgeryHilleroed Hospital/RigshospitaletBlegdamsvejDK‐2100 Copenhagen ØDenmarkTel.: 0045 35346356Fax: 0045 35452364e‐mail:</affiliation>
<affiliation>E-mail: nuhermund@hotmail.com</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Andreas</namePart>
<namePart type="family">Stavropoulos</namePart>
<affiliation>Department of Periodontology, School of Dentistry, Aarhus, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Ole</namePart>
<namePart type="family">Donatsky</namePart>
<affiliation>Department of Oral and Maxillofacial Surgery, Hilleroed Hospital/Rigshospitalet, Hilleroed, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Henrik</namePart>
<namePart type="family">Nielsen</namePart>
<affiliation>Department of Oral and Maxillofacial Surgery, Hilleroed Hospital/Rigshospitalet, Hilleroed, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Christian</namePart>
<namePart type="family">Clausen</namePart>
<affiliation>Interface Biotech A/S, Horsholm, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Jesper</namePart>
<namePart type="family">Reibel</namePart>
<affiliation>Department of Oral Pathology and Medicine, School of Dentistry, University of Copenhagen, Copenhagen, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Bente</namePart>
<namePart type="family">Pakkenberg</namePart>
<affiliation>Laboratory of Stereology, Bispebjerg University Hospital, Copenhagen, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Palle</namePart>
<namePart type="family">Holmstrup</namePart>
<affiliation>Department of Periodontology, School of Dentistry, University of Copenhagen, Copenhagen, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre>
<originInfo><publisher>Blackwell Publishing Ltd</publisher>
<dateIssued encoding="w3cdtf">2012-09</dateIssued>
<dateCreated encoding="w3cdtf">2011-06-28</dateCreated>
<dateValid encoding="w3cdtf">2011-05-23</dateValid>
<edition>Hermund NU, Stavropoulos A, Donatsky O, Nielsen, H, Clausen C, Reibel J, Pakkenberg B, Holmstrup P. Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial. Clin. Oral Impl. Res. 23 2012, 1031–1037.</edition>
<copyrightDate encoding="w3cdtf">2012</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<abstract>The aim of the present randomized clinical study was to evaluate histologically whether the addition of cultivated, autogenous bone cells to a composite graft of deproteinized bovine bone mineral (DBBM) and autogenous bone (AB) for sinus floor augmentation (SFA) enhance bone formation compared with what achieved after SFA with DBBM + AB alone.</abstract>
<abstract>Twenty patients with remaining posterior maxillary alveolar crest height of less than 3 mm received SFA after randomization either with an DBBM and AB composite in a 1 : 1 ratio or with DBBM + AB supplemented with autogenous bone cells, which were cultivated from a bone biopsy harvested earlier from the tuberosity area. Four months after SFA, two cylindrical biopsies were taken from the augmented sinuses concomitantly with the implant site preparation by means of a trephine bur. An additional biopsy was taken from the tuberosity area. Bone density at the augmented sinus and the tuberosity area and the height of augmentation were estimated on non‐decalcified histological sections prepared from the biopsies. A relative bone density index (RBD) was also calculated by dividing bone density at the augmented sinus with bone density at the tuberosity area.</abstract>
<abstract>All patients but one could receive two implants after SFA; in one patient, only one implant could be placed. All implants were osseointegrated and could be loaded. Median bone density in the sinus was 30% and 25% in the cell seeded and no‐cells added DBBM + AB groups, respectively. Bone augmentation height averaged 6.0 and 5.4 mm and RBD averaged 0.48 and 0.73 in the cell seeded and no‐cells added DBBM + AB groups, respectively. None of the differences between groups was statistically significant.</abstract>
<abstract>Cultivated autogenous bone cell seeded to a DBBM + AB composite did not significantly improve bone formation (density and height) after SFA, compared with what was achieved with DBBM + AB alone. Both approaches resulted into enough bone to support implant placement and osseointegration.</abstract>
<subject><genre>keywords</genre>
<topic>sinus floor augmentation</topic>
<topic>bovine bone</topic>
<topic>bone substitutes</topic>
<topic>cell culture</topic>
<topic>dental implant</topic>
<topic>tissue engineering</topic>
<topic>randomized clinical trial</topic>
<topic>histology</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Clinical Oral Implants Research</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Clin. Oral Impl. Res.</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<subject><genre>article-category</genre>
<topic>Original Article</topic>
</subject>
<identifier type="ISSN">0905-7161</identifier>
<identifier type="eISSN">1600-0501</identifier>
<identifier type="DOI">10.1111/(ISSN)1600-0501</identifier>
<identifier type="PublisherID">CLR</identifier>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>23</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>9</number>
</detail>
<extent unit="pages"><start>1031</start>
<end>1037</end>
<total>7</total>
</extent>
</part>
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<identifier type="ark">ark:/67375/WNG-T2C2CD2W-9</identifier>
<identifier type="DOI">10.1111/j.1600-0501.2011.02251.x</identifier>
<identifier type="ArticleID">CLR2251</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2012 John Wiley & Sons A/S© 2011 John Wiley & Sons A/S</accessCondition>
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Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial

Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial

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