Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial
Identifieur interne : 004B57 ( Istex/Corpus ); précédent : 004B56; suivant : 004B58Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial
Auteurs : Niels Ulrich Hermund ; Andreas Stavropoulos ; Ole Donatsky ; Henrik Nielsen ; Christian Clausen ; Jesper Reibel ; Bente Pakkenberg ; Palle HolmstrupSource :
- Clinical Oral Implants Research [ 0905-7161 ] ; 2012-09.
English descriptors
- KwdEn :
- Arbitrary assumption, Augmentation, Autogenous, Autogenous bone, Autogenous bone cells, Autogenous cells, Biopsy, Bone biopsy, Bone cells, Bone density, Bone formation, Bone mineral, Bone substitute materials, Bovine bone mineral, Boyne james, Cawood class, Cell cultivation, Cell culture, Cell seeding, Clausen, Clin, Clinical examination, Clinical periodontology, Clinical trial, Composite dbbm, Control group, Control groups, Cylindrical biopsies, Dbbm, Dbbm particles, Dental implants, Expansion procedure, Experimental study, Geistlich biomaterials, Goldner trichrome staining, Graft, Hermund, Histologic observations, Histological results, Histomorphometric evaluation, Host bone, Human bone cells, Impl, Implant, Implant installation, Implant installation surgery, Implant site preparation, Implants osseointegrated, Implants research, International journal, John wiley sons, John wiley sons hermund, Larger amounts, Lateral osteotomy window, Limited amounts, Local anesthesia, Maxillary, Maxillary sinus, Maxillofacial surgery, Mineralized bone, Mineralized tissue, Months post implant surgery, Observation period, Observation periods, Oral impl, Oral surgery, Osteoblastic cells, Periodontology, Posterior maxilla, Power calculation, Present randomized, Present study, Pristine bone, Private dentist, Proprietary technology, Randomized, Relative bone density index, Sample size, Seeding, Several occasions, Silk sutures, Sinus, Sinus augmentation, Sinus cavity, Sinus mucosa, Stimulatory effect, Support implant placement, Suture removal, Systematic review, Test group, Tissue engineering, Total number, Treatment allocation, Tuberosity, Tuberosity area, Tuberosity region.
- Teeft :
- Arbitrary assumption, Augmentation, Autogenous, Autogenous bone, Autogenous bone cells, Autogenous cells, Biopsy, Bone biopsy, Bone cells, Bone density, Bone formation, Bone mineral, Bone substitute materials, Bovine bone mineral, Boyne james, Cawood class, Cell cultivation, Cell culture, Cell seeding, Clausen, Clin, Clinical examination, Clinical periodontology, Clinical trial, Composite dbbm, Control group, Control groups, Cylindrical biopsies, Dbbm, Dbbm particles, Dental implants, Expansion procedure, Experimental study, Geistlich biomaterials, Goldner trichrome staining, Graft, Hermund, Histologic observations, Histological results, Histomorphometric evaluation, Host bone, Human bone cells, Impl, Implant, Implant installation, Implant installation surgery, Implant site preparation, Implants osseointegrated, Implants research, International journal, John wiley sons, John wiley sons hermund, Larger amounts, Lateral osteotomy window, Limited amounts, Local anesthesia, Maxillary, Maxillary sinus, Maxillofacial surgery, Mineralized bone, Mineralized tissue, Months post implant surgery, Observation period, Observation periods, Oral impl, Oral surgery, Osteoblastic cells, Periodontology, Posterior maxilla, Power calculation, Present randomized, Present study, Pristine bone, Private dentist, Proprietary technology, Randomized, Relative bone density index, Sample size, Seeding, Several occasions, Silk sutures, Sinus, Sinus augmentation, Sinus cavity, Sinus mucosa, Stimulatory effect, Support implant placement, Suture removal, Systematic review, Test group, Tissue engineering, Total number, Treatment allocation, Tuberosity, Tuberosity area, Tuberosity region.
Abstract
The aim of the present randomized clinical study was to evaluate histologically whether the addition of cultivated, autogenous bone cells to a composite graft of deproteinized bovine bone mineral (DBBM) and autogenous bone (AB) for sinus floor augmentation (SFA) enhance bone formation compared with what achieved after SFA with DBBM + AB alone.
Url:
DOI: 10.1111/j.1600-0501.2011.02251.x
Links to Exploration step
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<term>Autogenous bone cells</term>
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<term>Bone biopsy</term>
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<term>Bone substitute materials</term>
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<term>Boyne james</term>
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<term>Cell culture</term>
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<term>Human bone cells</term>
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<term>Implant installation</term>
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<term>Maxillary sinus</term>
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<term>Present study</term>
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<term>Private dentist</term>
<term>Proprietary technology</term>
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<term>Bone biopsy</term>
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<term>Bone substitute materials</term>
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<term>Dbbm particles</term>
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<term>Histological results</term>
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<term>Human bone cells</term>
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<term>Implant</term>
<term>Implant installation</term>
<term>Implant installation surgery</term>
<term>Implant site preparation</term>
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<term>Implants research</term>
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<term>John wiley sons hermund</term>
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<term>Maxillofacial surgery</term>
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<term>Observation periods</term>
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<term>Oral surgery</term>
<term>Osteoblastic cells</term>
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<term>Present randomized</term>
<term>Present study</term>
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<term>Private dentist</term>
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<term>Support implant placement</term>
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<term>Systematic review</term>
<term>Test group</term>
<term>Tissue engineering</term>
<term>Total number</term>
<term>Treatment allocation</term>
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<front><div type="abstract">The aim of the present randomized clinical study was to evaluate histologically whether the addition of cultivated, autogenous bone cells to a composite graft of deproteinized bovine bone mineral (DBBM) and autogenous bone (AB) for sinus floor augmentation (SFA) enhance bone formation compared with what achieved after SFA with DBBM + AB alone.</div>
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<affiliation>Corresponding author: Niels Ulrich HermundDepartment of Oral and Maxillofacial SurgeryHilleroed Hospital/RigshospitaletBlegdamsvejDK‐2100 Copenhagen ØDenmarkTel.: 0045 35346356Fax: 0045 35452364e‐mail: nuhermund@hotmail.com</affiliation>
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<profileDesc><abstract style="main" xml:id="clr2251-abs-0001"><head>Abstract</head>
Objectives
<p>The aim of the present randomized clinical study was to evaluate histologically whether the addition of cultivated, autogenous bone cells to a composite graft of deproteinized bovine bone mineral (<hi rend="fc">DBBM</hi>
) and autogenous bone (<hi rend="fc">AB</hi>
) for sinus floor augmentation (<hi rend="fc">SFA</hi>
) enhance bone formation compared with what achieved after <hi rend="fc">SFA</hi>
with <hi rend="fc">DBBM</hi>
+ <hi rend="fc">AB</hi>
alone.</p>
Material and methods
<p>Twenty patients with remaining posterior maxillary alveolar crest height of less than 3 mm received <hi rend="fc">SFA</hi>
after randomization either with an <hi rend="fc">DBBM</hi>
and <hi rend="fc">AB</hi>
composite in a 1 : 1 ratio or with <hi rend="fc">DBBM</hi>
+ <hi rend="fc">AB</hi>
supplemented with autogenous bone cells, which were cultivated from a bone biopsy harvested earlier from the tuberosity area. Four months after <hi rend="fc">SFA</hi>
, two cylindrical biopsies were taken from the augmented sinuses concomitantly with the implant site preparation by means of a trephine bur. An additional biopsy was taken from the tuberosity area. Bone density at the augmented sinus and the tuberosity area and the height of augmentation were estimated on non‐decalcified histological sections prepared from the biopsies. A relative bone density index (<hi rend="fc">RBD</hi>
) was also calculated by dividing bone density at the augmented sinus with bone density at the tuberosity area.</p>
Results
<p>All patients but one could receive two implants after <hi rend="fc">SFA</hi>
; in one patient, only one implant could be placed. All implants were osseointegrated and could be loaded. Median bone density in the sinus was 30% and 25% in the cell seeded and no‐cells added <hi rend="fc">DBBM</hi>
+ <hi rend="fc">AB</hi>
groups, respectively. Bone augmentation height averaged 6.0 and 5.4 mm and <hi rend="fc">RBD</hi>
averaged 0.48 and 0.73 in the cell seeded and no‐cells added <hi rend="fc">DBBM</hi>
+ <hi rend="fc">AB</hi>
groups, respectively. None of the differences between groups was statistically significant.</p>
Conclusions
<p>Cultivated autogenous bone cell seeded to a <hi rend="fc">DBBM</hi>
+ <hi rend="fc">AB</hi>
composite did not significantly improve bone formation (density and height) after <hi rend="fc">SFA</hi>
, compared with what was achieved with <hi rend="fc">DBBM</hi>
+ <hi rend="fc">AB</hi>
alone. Both approaches resulted into enough bone to support implant placement and osseointegration.</p>
</abstract>
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<affiliation countryCode="DK" type="organization" xml:id="clr2251-aff-0003"><orgName>Interface Biotech A/S</orgName>
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<country>Denmark</country>
</address>
</affiliation>
<affiliation countryCode="DK" type="organization" xml:id="clr2251-aff-0004"><orgDiv>Department of Oral Pathology and Medicine</orgDiv>
<orgDiv>School of Dentistry</orgDiv>
<orgName>University of Copenhagen</orgName>
<address><city>Copenhagen</city>
<country>Denmark</country>
</address>
</affiliation>
<affiliation countryCode="DK" type="organization" xml:id="clr2251-aff-0005"><orgDiv>Laboratory of Stereology</orgDiv>
<orgName>Bispebjerg University Hospital</orgName>
<address><city>Copenhagen</city>
<country>Denmark</country>
</address>
</affiliation>
<affiliation countryCode="DK" type="organization" xml:id="clr2251-aff-0006"><orgDiv>Department of Periodontology</orgDiv>
<orgDiv>School of Dentistry</orgDiv>
<orgName>University of Copenhagen</orgName>
<address><city>Copenhagen</city>
<country>Denmark</country>
</address>
</affiliation>
</affiliationGroup>
<keywordGroup type="author"><keyword xml:id="clr2251-kwd-0001">sinus floor augmentation</keyword>
<keyword xml:id="clr2251-kwd-0002">bovine bone</keyword>
<keyword xml:id="clr2251-kwd-0003">bone substitutes</keyword>
<keyword xml:id="clr2251-kwd-0004">cell culture</keyword>
<keyword xml:id="clr2251-kwd-0005">dental implant</keyword>
<keyword xml:id="clr2251-kwd-0006">tissue engineering</keyword>
<keyword xml:id="clr2251-kwd-0007">randomized clinical trial</keyword>
<keyword xml:id="clr2251-kwd-0008">histology</keyword>
</keywordGroup>
<abstractGroup><abstract type="main" xml:id="clr2251-abs-0001"><title type="main">Abstract</title>
<section xml:id="clr2251-sec-0001"><title type="main">Objectives</title>
<p>The aim of the present randomized clinical study was to evaluate histologically whether the addition of cultivated, autogenous bone cells to a composite graft of deproteinized bovine bone mineral (<fc>DBBM</fc>
) and autogenous bone (<fc>AB</fc>
) for sinus floor augmentation (<fc>SFA</fc>
) enhance bone formation compared with what achieved after <fc>SFA</fc>
with <fc>DBBM</fc>
+ <fc>AB</fc>
alone.</p>
</section>
<section xml:id="clr2251-sec-0002"><title type="main">Material and methods</title>
<p>Twenty patients with remaining posterior maxillary alveolar crest height of less than 3 mm received <fc>SFA</fc>
after randomization either with an <fc>DBBM</fc>
and <fc>AB</fc>
composite in a 1 : 1 ratio or with <fc>DBBM</fc>
+ <fc>AB</fc>
supplemented with autogenous bone cells, which were cultivated from a bone biopsy harvested earlier from the tuberosity area. Four months after <fc>SFA</fc>
, two cylindrical biopsies were taken from the augmented sinuses concomitantly with the implant site preparation by means of a trephine bur. An additional biopsy was taken from the tuberosity area. Bone density at the augmented sinus and the tuberosity area and the height of augmentation were estimated on non‐decalcified histological sections prepared from the biopsies. A relative bone density index (<fc>RBD</fc>
) was also calculated by dividing bone density at the augmented sinus with bone density at the tuberosity area.</p>
</section>
<section xml:id="clr2251-sec-0003"><title type="main">Results</title>
<p>All patients but one could receive two implants after <fc>SFA</fc>
; in one patient, only one implant could be placed. All implants were osseointegrated and could be loaded. Median bone density in the sinus was 30% and 25% in the cell seeded and no‐cells added <fc>DBBM</fc>
+ <fc>AB</fc>
groups, respectively. Bone augmentation height averaged 6.0 and 5.4 mm and <fc>RBD</fc>
averaged 0.48 and 0.73 in the cell seeded and no‐cells added <fc>DBBM</fc>
+ <fc>AB</fc>
groups, respectively. None of the differences between groups was statistically significant.</p>
</section>
<section xml:id="clr2251-sec-0004"><title type="main">Conclusions</title>
<p>Cultivated autogenous bone cell seeded to a <fc>DBBM</fc>
+ <fc>AB</fc>
composite did not significantly improve bone formation (density and height) after <fc>SFA</fc>
, compared with what was achieved with <fc>DBBM</fc>
+ <fc>AB</fc>
alone. Both approaches resulted into enough bone to support implant placement and osseointegration.</p>
</section>
</abstract>
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<mods version="3.6"><titleInfo lang="en"><title>Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial</title>
</titleInfo>
<name type="personal"><namePart type="given">Niels Ulrich</namePart>
<namePart type="family">Hermund</namePart>
<affiliation>Department of Oral and Maxillofacial Surgery, Hilleroed Hospital/Rigshospitalet, Hilleroed, Denmark</affiliation>
<affiliation>Niels Ulrich HermundDepartment of Oral and Maxillofacial SurgeryHilleroed Hospital/RigshospitaletBlegdamsvejDK‐2100 Copenhagen ØDenmarkTel.: 0045 35346356Fax: 0045 35452364e‐mail:</affiliation>
<affiliation>E-mail: nuhermund@hotmail.com</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Andreas</namePart>
<namePart type="family">Stavropoulos</namePart>
<affiliation>Department of Periodontology, School of Dentistry, Aarhus, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Ole</namePart>
<namePart type="family">Donatsky</namePart>
<affiliation>Department of Oral and Maxillofacial Surgery, Hilleroed Hospital/Rigshospitalet, Hilleroed, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Henrik</namePart>
<namePart type="family">Nielsen</namePart>
<affiliation>Department of Oral and Maxillofacial Surgery, Hilleroed Hospital/Rigshospitalet, Hilleroed, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Christian</namePart>
<namePart type="family">Clausen</namePart>
<affiliation>Interface Biotech A/S, Horsholm, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Jesper</namePart>
<namePart type="family">Reibel</namePart>
<affiliation>Department of Oral Pathology and Medicine, School of Dentistry, University of Copenhagen, Copenhagen, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Bente</namePart>
<namePart type="family">Pakkenberg</namePart>
<affiliation>Laboratory of Stereology, Bispebjerg University Hospital, Copenhagen, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Palle</namePart>
<namePart type="family">Holmstrup</namePart>
<affiliation>Department of Periodontology, School of Dentistry, University of Copenhagen, Copenhagen, Denmark</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
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<dateIssued encoding="w3cdtf">2012-09</dateIssued>
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<edition>Hermund NU, Stavropoulos A, Donatsky O, Nielsen, H, Clausen C, Reibel J, Pakkenberg B, Holmstrup P. Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial. Clin. Oral Impl. Res. 23 2012, 1031–1037.</edition>
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<abstract>The aim of the present randomized clinical study was to evaluate histologically whether the addition of cultivated, autogenous bone cells to a composite graft of deproteinized bovine bone mineral (DBBM) and autogenous bone (AB) for sinus floor augmentation (SFA) enhance bone formation compared with what achieved after SFA with DBBM + AB alone.</abstract>
<abstract>Twenty patients with remaining posterior maxillary alveolar crest height of less than 3 mm received SFA after randomization either with an DBBM and AB composite in a 1 : 1 ratio or with DBBM + AB supplemented with autogenous bone cells, which were cultivated from a bone biopsy harvested earlier from the tuberosity area. Four months after SFA, two cylindrical biopsies were taken from the augmented sinuses concomitantly with the implant site preparation by means of a trephine bur. An additional biopsy was taken from the tuberosity area. Bone density at the augmented sinus and the tuberosity area and the height of augmentation were estimated on non‐decalcified histological sections prepared from the biopsies. A relative bone density index (RBD) was also calculated by dividing bone density at the augmented sinus with bone density at the tuberosity area.</abstract>
<abstract>All patients but one could receive two implants after SFA; in one patient, only one implant could be placed. All implants were osseointegrated and could be loaded. Median bone density in the sinus was 30% and 25% in the cell seeded and no‐cells added DBBM + AB groups, respectively. Bone augmentation height averaged 6.0 and 5.4 mm and RBD averaged 0.48 and 0.73 in the cell seeded and no‐cells added DBBM + AB groups, respectively. None of the differences between groups was statistically significant.</abstract>
<abstract>Cultivated autogenous bone cell seeded to a DBBM + AB composite did not significantly improve bone formation (density and height) after SFA, compared with what was achieved with DBBM + AB alone. Both approaches resulted into enough bone to support implant placement and osseointegration.</abstract>
<subject><genre>keywords</genre>
<topic>sinus floor augmentation</topic>
<topic>bovine bone</topic>
<topic>bone substitutes</topic>
<topic>cell culture</topic>
<topic>dental implant</topic>
<topic>tissue engineering</topic>
<topic>randomized clinical trial</topic>
<topic>histology</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Clinical Oral Implants Research</title>
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<titleInfo type="abbreviated"><title>Clin. Oral Impl. Res.</title>
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<subject><genre>article-category</genre>
<topic>Original Article</topic>
</subject>
<identifier type="ISSN">0905-7161</identifier>
<identifier type="eISSN">1600-0501</identifier>
<identifier type="DOI">10.1111/(ISSN)1600-0501</identifier>
<identifier type="PublisherID">CLR</identifier>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>23</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>9</number>
</detail>
<extent unit="pages"><start>1031</start>
<end>1037</end>
<total>7</total>
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<identifier type="DOI">10.1111/j.1600-0501.2011.02251.x</identifier>
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<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2012 John Wiley & Sons A/S© 2011 John Wiley & Sons A/S</accessCondition>
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