Accuracy of quantitative digital subtraction radiography for determining changes in calcium mass in mandibular bone: an in vitro study
Identifieur interne : 004A23 ( Istex/Corpus ); précédent : 004A22; suivant : 004A24Accuracy of quantitative digital subtraction radiography for determining changes in calcium mass in mandibular bone: an in vitro study
Auteurs : M. Christgau ; K. Hiller ; G. Schmalz ; C. Kolbeck ; A. WenzelSource :
- Journal of Periodontal Research [ 0022-3484 ] ; 1998-04.
English descriptors
- KwdEn :
- Actual bone changes, Actual change, Actual changes, Alveolar bone, Alveolar bone loss, Bone, Bone changes, Bone chips, Bone density changes, Bone slice, Bone slices, Bone thickness, Bone type, Bone types, Buccal, Calcium, Calcium changes, Calcium loss, Calcium mass, Calcium mass changes, Cancellous, Cancellous bone, Cancellous bone slices, Christgau, Clin, Clin periodontol, Conventional radiography, Correlation coefficient, Correlation coefficients, Cortical, Cortical bone, Cortical bone slice, Cortical bone slices, Defect, Defect localization, Defect region, Density changes, Dental implants, Dentomaxillofac radiol, Detection limit, Digital subtraction, Digital subtraction radiography, Experimental region, Grey level, Grey level value, Grey levels, Hausmann, Hiller schmalz, Image pixel, Immediate interest, Implant, Individual jaws, Interproximal, Linear correlation, Mandible, Mandible segment, Median, Median value percentiles, Median values, Metal pins, Mineral content, Oral pathol, Oral surg, Periodont, Periodontal, Periodontol, Physical noise, Pixel, Present study, Previous studies, Projection geometry, Quantitative assessment, Quantitative evaluation, Radiograph, Radiographic, Radiographic density, Radiographic density changes, Radiographic density gain, Radiography, Regression function, Regression lines, Significant influence, Single values, Small changes, Southard, Standardized radiographs, Subtraction, Subtraction image, Subtraction images, Subtraction process, Subtraction radiography, Tooth roots, Total bone mass, Trabecular structure, Wenzel.
- Teeft :
- Actual bone changes, Actual change, Actual changes, Alveolar bone, Alveolar bone loss, Bone, Bone changes, Bone chips, Bone density changes, Bone slice, Bone slices, Bone thickness, Bone type, Bone types, Buccal, Calcium, Calcium changes, Calcium loss, Calcium mass, Calcium mass changes, Cancellous, Cancellous bone, Cancellous bone slices, Christgau, Clin, Clin periodontol, Conventional radiography, Correlation coefficient, Correlation coefficients, Cortical, Cortical bone, Cortical bone slice, Cortical bone slices, Defect, Defect localization, Defect region, Density changes, Dental implants, Dentomaxillofac radiol, Detection limit, Digital subtraction, Digital subtraction radiography, Experimental region, Grey level, Grey level value, Grey levels, Hausmann, Hiller schmalz, Image pixel, Immediate interest, Implant, Individual jaws, Interproximal, Linear correlation, Mandible, Mandible segment, Median, Median value percentiles, Median values, Metal pins, Mineral content, Oral pathol, Oral surg, Periodont, Periodontal, Periodontol, Physical noise, Pixel, Present study, Previous studies, Projection geometry, Quantitative assessment, Quantitative evaluation, Radiograph, Radiographic, Radiographic density, Radiographic density changes, Radiographic density gain, Radiography, Regression function, Regression lines, Significant influence, Single values, Small changes, Southard, Standardized radiographs, Subtraction, Subtraction image, Subtraction images, Subtraction process, Subtraction radiography, Tooth roots, Total bone mass, Trabecular structure, Wenzel.
Abstract
The aim of this in vitro study was to determine the accuracy of digital subtraction radiography (DSR) to detect small changes in calcium mass in alveolar bone adjacent to tooth roots. In each of 4 dried porcine mandible segments, one interproximal and one buccal “defect” region was defined adjacent to a premolar root. A series of cortical and cancellous bone slices with a 50 μm‐stepwise increasing thickness (0‐5000 μm) were attached to the mandible segments covering the respective “defect” region. Standardized radiographs were quantitatively assessed for density changes using DSR. After dissolving each bone slice in hydrochloric acid, its calcium concentration was photometrically determined. For each bone slice, the mean calcium mass covering a single pixel of the subtraction image was calculated. The Wilcoxon signed‐rank test and the Mann‐Whitney U‐test were used for statistical analysis (α = 0.05). A strong linear correlation (r2 = 0.86‐1.00; p ≤ 0.001) was found between the thickness of the bone slices and their calcium mass. Cortical bone showed a 3.5 times higher mean calcium mass/pixel than cancellous bone. Furthermore, a strong linear correlation (r2 = 0.63‐1.00; p ≤ 0.001) was found between the mean calcium mass per image pixel and the radiographic density changes. Neither the bone type nor the “defect” localization had a significant influence on radiographic density changes caused by changes in calcium mass. A change in mean calcium mass per image pixel of 0.1‐0.15 mg was necessary to be detected by DSR. In conclusion, this study revealed a high accuracy of DSR to detect small changes in calcium mass in alveolar cortical and cancellous bone.
Url:
DOI: 10.1111/j.1600-0765.1998.tb02304.x
Links to Exploration step
ISTEX:94A60B1D5D9D5DE2BAFAD6098A0457DC8A5747A0Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Accuracy of quantitative digital subtraction radiography for determining changes in calcium mass in mandibular bone: an in vitro study</title><author><name sortKey="Christgau, M" sort="Christgau, M" uniqKey="Christgau M" first="M." last="Christgau">M. Christgau</name><affiliation><mods:affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: mchristg@mail.db.uth.tmc.edu</mods:affiliation></affiliation></author><author><name sortKey="Hiller, K" sort="Hiller, K" uniqKey="Hiller K" first="K." last="Hiller">K. Hiller</name><affiliation><mods:affiliation>University of Texas‐Houston, Department of Stomatology, Division of Periodontics, Houston, TX, USA</mods:affiliation></affiliation></author><author><name sortKey="Schmalz, G" sort="Schmalz, G" uniqKey="Schmalz G" first="G." last="Schmalz">G. Schmalz</name><affiliation><mods:affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kolbeck, C" sort="Kolbeck, C" uniqKey="Kolbeck C" first="C." last="Kolbeck">C. Kolbeck</name><affiliation><mods:affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wenzel, A" sort="Wenzel, A" uniqKey="Wenzel A" first="A." last="Wenzel">A. Wenzel</name><affiliation><mods:affiliation>Department of Oral Radiology, Royal Dental College, University of Aarhus, Aarhus, Denmark</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:94A60B1D5D9D5DE2BAFAD6098A0457DC8A5747A0</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1111/j.1600-0765.1998.tb02304.x</idno><idno type="url">https://api.istex.fr/document/94A60B1D5D9D5DE2BAFAD6098A0457DC8A5747A0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004A23</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">004A23</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Accuracy of quantitative digital subtraction radiography for determining changes in calcium mass in mandibular bone: an in vitro study</title><author><name sortKey="Christgau, M" sort="Christgau, M" uniqKey="Christgau M" first="M." last="Christgau">M. Christgau</name><affiliation><mods:affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: mchristg@mail.db.uth.tmc.edu</mods:affiliation></affiliation></author><author><name sortKey="Hiller, K" sort="Hiller, K" uniqKey="Hiller K" first="K." last="Hiller">K. Hiller</name><affiliation><mods:affiliation>University of Texas‐Houston, Department of Stomatology, Division of Periodontics, Houston, TX, USA</mods:affiliation></affiliation></author><author><name sortKey="Schmalz, G" sort="Schmalz, G" uniqKey="Schmalz G" first="G." last="Schmalz">G. Schmalz</name><affiliation><mods:affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kolbeck, C" sort="Kolbeck, C" uniqKey="Kolbeck C" first="C." last="Kolbeck">C. Kolbeck</name><affiliation><mods:affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wenzel, A" sort="Wenzel, A" uniqKey="Wenzel A" first="A." last="Wenzel">A. Wenzel</name><affiliation><mods:affiliation>Department of Oral Radiology, Royal Dental College, University of Aarhus, Aarhus, Denmark</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Periodontal Research</title><title level="j" type="alt">JOURNAL OF PERIODONTAL RESEARCH</title><idno type="ISSN">0022-3484</idno><idno type="eISSN">1600-0765</idno><imprint><biblScope unit="vol">33</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="138">138</biblScope><biblScope unit="page" to="149">149</biblScope><biblScope unit="page-count">12</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1998-04">1998-04</date></imprint><idno type="ISSN">0022-3484</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3484</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actual bone changes</term><term>Actual change</term><term>Actual changes</term><term>Alveolar bone</term><term>Alveolar bone loss</term><term>Bone</term><term>Bone changes</term><term>Bone chips</term><term>Bone density changes</term><term>Bone slice</term><term>Bone slices</term><term>Bone thickness</term><term>Bone type</term><term>Bone types</term><term>Buccal</term><term>Calcium</term><term>Calcium changes</term><term>Calcium loss</term><term>Calcium mass</term><term>Calcium mass changes</term><term>Cancellous</term><term>Cancellous bone</term><term>Cancellous bone slices</term><term>Christgau</term><term>Clin</term><term>Clin periodontol</term><term>Conventional radiography</term><term>Correlation coefficient</term><term>Correlation coefficients</term><term>Cortical</term><term>Cortical bone</term><term>Cortical bone slice</term><term>Cortical bone slices</term><term>Defect</term><term>Defect localization</term><term>Defect region</term><term>Density changes</term><term>Dental implants</term><term>Dentomaxillofac radiol</term><term>Detection limit</term><term>Digital subtraction</term><term>Digital subtraction radiography</term><term>Experimental region</term><term>Grey level</term><term>Grey level value</term><term>Grey levels</term><term>Hausmann</term><term>Hiller schmalz</term><term>Image pixel</term><term>Immediate interest</term><term>Implant</term><term>Individual jaws</term><term>Interproximal</term><term>Linear correlation</term><term>Mandible</term><term>Mandible segment</term><term>Median</term><term>Median value percentiles</term><term>Median values</term><term>Metal pins</term><term>Mineral content</term><term>Oral pathol</term><term>Oral surg</term><term>Periodont</term><term>Periodontal</term><term>Periodontol</term><term>Physical noise</term><term>Pixel</term><term>Present study</term><term>Previous studies</term><term>Projection geometry</term><term>Quantitative assessment</term><term>Quantitative evaluation</term><term>Radiograph</term><term>Radiographic</term><term>Radiographic density</term><term>Radiographic density changes</term><term>Radiographic density gain</term><term>Radiography</term><term>Regression function</term><term>Regression lines</term><term>Significant influence</term><term>Single values</term><term>Small changes</term><term>Southard</term><term>Standardized radiographs</term><term>Subtraction</term><term>Subtraction image</term><term>Subtraction images</term><term>Subtraction process</term><term>Subtraction radiography</term><term>Tooth roots</term><term>Total bone mass</term><term>Trabecular structure</term><term>Wenzel</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Actual bone changes</term><term>Actual change</term><term>Actual changes</term><term>Alveolar bone</term><term>Alveolar bone loss</term><term>Bone</term><term>Bone changes</term><term>Bone chips</term><term>Bone density changes</term><term>Bone slice</term><term>Bone slices</term><term>Bone thickness</term><term>Bone type</term><term>Bone types</term><term>Buccal</term><term>Calcium</term><term>Calcium changes</term><term>Calcium loss</term><term>Calcium mass</term><term>Calcium mass changes</term><term>Cancellous</term><term>Cancellous bone</term><term>Cancellous bone slices</term><term>Christgau</term><term>Clin</term><term>Clin periodontol</term><term>Conventional radiography</term><term>Correlation coefficient</term><term>Correlation coefficients</term><term>Cortical</term><term>Cortical bone</term><term>Cortical bone slice</term><term>Cortical bone slices</term><term>Defect</term><term>Defect localization</term><term>Defect region</term><term>Density changes</term><term>Dental implants</term><term>Dentomaxillofac radiol</term><term>Detection limit</term><term>Digital subtraction</term><term>Digital subtraction radiography</term><term>Experimental region</term><term>Grey level</term><term>Grey level value</term><term>Grey levels</term><term>Hausmann</term><term>Hiller schmalz</term><term>Image pixel</term><term>Immediate interest</term><term>Implant</term><term>Individual jaws</term><term>Interproximal</term><term>Linear correlation</term><term>Mandible</term><term>Mandible segment</term><term>Median</term><term>Median value percentiles</term><term>Median values</term><term>Metal pins</term><term>Mineral content</term><term>Oral pathol</term><term>Oral surg</term><term>Periodont</term><term>Periodontal</term><term>Periodontol</term><term>Physical noise</term><term>Pixel</term><term>Present study</term><term>Previous studies</term><term>Projection geometry</term><term>Quantitative assessment</term><term>Quantitative evaluation</term><term>Radiograph</term><term>Radiographic</term><term>Radiographic density</term><term>Radiographic density changes</term><term>Radiographic density gain</term><term>Radiography</term><term>Regression function</term><term>Regression lines</term><term>Significant influence</term><term>Single values</term><term>Small changes</term><term>Southard</term><term>Standardized radiographs</term><term>Subtraction</term><term>Subtraction image</term><term>Subtraction images</term><term>Subtraction process</term><term>Subtraction radiography</term><term>Tooth roots</term><term>Total bone mass</term><term>Trabecular structure</term><term>Wenzel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this in vitro study was to determine the accuracy of digital subtraction radiography (DSR) to detect small changes in calcium mass in alveolar bone adjacent to tooth roots. In each of 4 dried porcine mandible segments, one interproximal and one buccal “defect” region was defined adjacent to a premolar root. A series of cortical and cancellous bone slices with a 50 μm‐stepwise increasing thickness (0‐5000 μm) were attached to the mandible segments covering the respective “defect” region. Standardized radiographs were quantitatively assessed for density changes using DSR. After dissolving each bone slice in hydrochloric acid, its calcium concentration was photometrically determined. For each bone slice, the mean calcium mass covering a single pixel of the subtraction image was calculated. The Wilcoxon signed‐rank test and the Mann‐Whitney U‐test were used for statistical analysis (α = 0.05). A strong linear correlation (r2 = 0.86‐1.00; p ≤ 0.001) was found between the thickness of the bone slices and their calcium mass. Cortical bone showed a 3.5 times higher mean calcium mass/pixel than cancellous bone. Furthermore, a strong linear correlation (r2 = 0.63‐1.00; p ≤ 0.001) was found between the mean calcium mass per image pixel and the radiographic density changes. Neither the bone type nor the “defect” localization had a significant influence on radiographic density changes caused by changes in calcium mass. A change in mean calcium mass per image pixel of 0.1‐0.15 mg was necessary to be detected by DSR. In conclusion, this study revealed a high accuracy of DSR to detect small changes in calcium mass in alveolar cortical and cancellous bone.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>calcium mass</json:string><json:string>radiographic</json:string><json:string>cancellous</json:string><json:string>pixel</json:string><json:string>cancellous bone</json:string><json:string>radiographic density changes</json:string><json:string>image pixel</json:string><json:string>buccal</json:string><json:string>subtraction radiography</json:string><json:string>radiography</json:string><json:string>radiograph</json:string><json:string>present study</json:string><json:string>mandible</json:string><json:string>periodontol</json:string><json:string>bone slice</json:string><json:string>periodont</json:string><json:string>interproximal</json:string><json:string>christgau</json:string><json:string>linear correlation</json:string><json:string>bone slices</json:string><json:string>cortical bone</json:string><json:string>cancellous bone slices</json:string><json:string>bone changes</json:string><json:string>digital subtraction radiography</json:string><json:string>periodontal</json:string><json:string>defect</json:string><json:string>southard</json:string><json:string>alveolar bone</json:string><json:string>bone type</json:string><json:string>hausmann</json:string><json:string>grey level</json:string><json:string>wenzel</json:string><json:string>density changes</json:string><json:string>correlation coefficients</json:string><json:string>bone thickness</json:string><json:string>clin</json:string><json:string>regression lines</json:string><json:string>cortical</json:string><json:string>oral surg</json:string><json:string>subtraction images</json:string><json:string>defect region</json:string><json:string>grey level value</json:string><json:string>experimental region</json:string><json:string>mineral content</json:string><json:string>grey levels</json:string><json:string>small changes</json:string><json:string>conventional radiography</json:string><json:string>oral pathol</json:string><json:string>immediate interest</json:string><json:string>mandible segment</json:string><json:string>clin periodontol</json:string><json:string>calcium</json:string><json:string>median</json:string><json:string>significant influence</json:string><json:string>metal pins</json:string><json:string>tooth roots</json:string><json:string>dental implants</json:string><json:string>radiographic density gain</json:string><json:string>bone chips</json:string><json:string>trabecular structure</json:string><json:string>quantitative evaluation</json:string><json:string>cortical bone slices</json:string><json:string>subtraction image</json:string><json:string>total bone mass</json:string><json:string>calcium mass changes</json:string><json:string>detection limit</json:string><json:string>calcium changes</json:string><json:string>correlation coefficient</json:string><json:string>median value percentiles</json:string><json:string>single values</json:string><json:string>individual jaws</json:string><json:string>bone density changes</json:string><json:string>previous studies</json:string><json:string>subtraction</json:string><json:string>implant</json:string><json:string>bone</json:string><json:string>actual bone changes</json:string><json:string>actual change</json:string><json:string>bone types</json:string><json:string>median values</json:string><json:string>cortical bone slice</json:string><json:string>calcium loss</json:string><json:string>quantitative assessment</json:string><json:string>subtraction process</json:string><json:string>regression function</json:string><json:string>projection geometry</json:string><json:string>alveolar bone loss</json:string><json:string>standardized radiographs</json:string><json:string>actual changes</json:string><json:string>hiller schmalz</json:string><json:string>digital subtraction</json:string><json:string>radiographic density</json:string><json:string>physical noise</json:string><json:string>defect localization</json:string><json:string>dentomaxillofac radiol</json:string></teeft></keywords><author><json:item><name>M. Christgau</name><affiliations><json:string>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</json:string><json:string>E-mail: mchristg@mail.db.uth.tmc.edu</json:string></affiliations></json:item><json:item><name>K.‐A. Hiller</name><affiliations><json:string>University of Texas‐Houston, Department of Stomatology, Division of Periodontics, Houston, TX, USA</json:string></affiliations></json:item><json:item><name>G. Schmalz</name><affiliations><json:string>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</json:string></affiliations></json:item><json:item><name>C. Kolbeck</name><affiliations><json:string>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</json:string></affiliations></json:item><json:item><name>A. Wenzel</name><affiliations><json:string>Department of Oral Radiology, Royal Dental College, University of Aarhus, Aarhus, Denmark</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>subtraction radiography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>quantitative analysis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>calcium</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>alveolar bone</value></json:item></subject><articleId><json:string>JRE2304</json:string></articleId><arkIstex>ark:/67375/WNG-5FPL92V0-3</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The aim of this in vitro study was to determine the accuracy of digital subtraction radiography (DSR) to detect small changes in calcium mass in alveolar bone adjacent to tooth roots. In each of 4 dried porcine mandible segments, one interproximal and one buccal “defect” region was defined adjacent to a premolar root. A series of cortical and cancellous bone slices with a 50 μm‐stepwise increasing thickness (0‐5000 μm) were attached to the mandible segments covering the respective “defect” region. Standardized radiographs were quantitatively assessed for density changes using DSR. After dissolving each bone slice in hydrochloric acid, its calcium concentration was photometrically determined. For each bone slice, the mean calcium mass covering a single pixel of the subtraction image was calculated. The Wilcoxon signed‐rank test and the Mann‐Whitney U‐test were used for statistical analysis (α = 0.05). A strong linear correlation (r2 = 0.86‐1.00; p ≤ 0.001) was found between the thickness of the bone slices and their calcium mass. Cortical bone showed a 3.5 times higher mean calcium mass/pixel than cancellous bone. Furthermore, a strong linear correlation (r2 = 0.63‐1.00; p ≤ 0.001) was found between the mean calcium mass per image pixel and the radiographic density changes. Neither the bone type nor the “defect” localization had a significant influence on radiographic density changes caused by changes in calcium mass. A change in mean calcium mass per image pixel of 0.1‐0.15 mg was necessary to be detected by DSR. In conclusion, this study revealed a high accuracy of DSR to detect small changes in calcium mass in alveolar cortical and cancellous bone.</abstract><qualityIndicators><refBibsNative>true</refBibsNative><abstractWordCount>264</abstractWordCount><abstractCharCount>1678</abstractCharCount><keywordCount>4</keywordCount><score>10</score><pdfWordCount>6435</pdfWordCount><pdfCharCount>40242</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>12</pdfPageCount><pdfPageSize>612 x 791.759 pts</pdfPageSize></qualityIndicators><title>Accuracy of quantitative digital subtraction radiography for determining changes in calcium mass in mandibular bone: an in vitro study</title><genre><json:string>article</json:string></genre><host><title>Journal of Periodontal Research</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0765</json:string></doi><issn><json:string>0022-3484</json:string></issn><eissn><json:string>1600-0765</json:string></eissn><publisherId><json:string>JRE</json:string></publisherId><volume>33</volume><issue>3</issue><pages><first>138</first><last>149</last><total>12</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1998</json:string></date><geogName></geogName><orgName><json:string>Department of Oral Radiology, Royal Dental College, University of Aarhus, Aarhus, Denmark Christgau</json:string><json:string>Department of Stomatology, Division of Periodontics, University of Texas, Houston, TX, USA</json:string><json:string>University of Texas-Houston</json:string><json:string>Department of Stomatology, Division of Periodontics, Houston, TX,USA</json:string><json:string>Department of Operative Dentistry and Periodontology</json:string><json:string>University of Regensburg</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>G. Caffesse</json:string><json:string>A. Hiller</json:string><json:string>E. Leitz</json:string><json:string>Dr Thomas</json:string><json:string>Michael Christgau</json:string><json:string>C. Kolbeck</json:string><json:string>Med Dent</json:string><json:string>Dr Raul</json:string><json:string>A. Wenzel</json:string><json:string>E. Merck</json:string><json:string>G. Schmalz</json:string></persName><placeName><json:string>TX</json:string><json:string>Germany</json:string><json:string>Regensburg</json:string><json:string>Darmstadt</json:string><json:string>Houston</json:string><json:string>USA</json:string><json:string>Japan</json:string><json:string>Denmark</json:string><json:string>Wetzlar</json:string><json:string>France</json:string><json:string>Belgium</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Jeffcoat et al.</json:string><json:string>Bragger et al.</json:string><json:string>M. Christgau et al.</json:string><json:string>Department of Stomatology, Division of Periodontics, 6516</json:string><json:string>Goodson et al.</json:string><json:string>Ortman et al.</json:string><json:string>Fourmousis et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-5FPL92V0-3</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Periodontics</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1998</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1111/j.1600-0765.1998.tb02304.x</json:string></doi><id>94A60B1D5D9D5DE2BAFAD6098A0457DC8A5747A0</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/94A60B1D5D9D5DE2BAFAD6098A0457DC8A5747A0/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/94A60B1D5D9D5DE2BAFAD6098A0457DC8A5747A0/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/94A60B1D5D9D5DE2BAFAD6098A0457DC8A5747A0/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Accuracy of quantitative digital subtraction radiography for determining changes in calcium mass in mandibular bone: an in vitro study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>1998 Munksgaard</licence></availability><date type="published" when="1998-04"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Accuracy of quantitative digital subtraction radiography for determining changes in calcium mass in mandibular bone: an in vitro study</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">M.</forename><surname>Christgau</surname></persName><affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany<address><country key="DE"></country></address></affiliation><affiliation>Michael Christgau, DMD, Dr Med Dent, University of Texas‐Houston, Department of Stomatology, Division of Periodontics, 6516 John Freeman Ave, Room 307, Houston, TX, USA Tel. (713) 500 4386 Fax. (713)500 4393 e‐mail: mchristg@mail.db.uth.tmc.edu</affiliation></author><author xml:id="author-0001"><persName><forename type="first">K.‐A.</forename><surname>Hiller</surname></persName><affiliation>University of Texas‐Houston, Department of Stomatology, Division of Periodontics, Houston, TX, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">G.</forename><surname>Schmalz</surname></persName><affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">C.</forename><surname>Kolbeck</surname></persName><affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">A.</forename><surname>Wenzel</surname></persName><affiliation>Department of Oral Radiology, Royal Dental College, University of Aarhus, Aarhus, Denmark<address><country key="DK"></country></address></affiliation></author><idno type="istex">94A60B1D5D9D5DE2BAFAD6098A0457DC8A5747A0</idno><idno type="ark">ark:/67375/WNG-5FPL92V0-3</idno><idno type="DOI">10.1111/j.1600-0765.1998.tb02304.x</idno><idno type="unit">JRE2304</idno><idno type="toTypesetVersion">file:JRE.JRE2304.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Periodontal Research</title><title level="j" type="alt">JOURNAL OF PERIODONTAL RESEARCH</title><idno type="pISSN">0022-3484</idno><idno type="eISSN">1600-0765</idno><idno type="book-DOI">10.1111/(ISSN)1600-0765</idno><idno type="book-part-DOI">10.1111/jre.1998.33.issue-3</idno><idno type="product">JRE</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">33</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="138">138</biblScope><biblScope unit="page" to="149">149</biblScope><biblScope unit="page-count">12</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1998-04"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>The aim of this <hi rend="italic">in vitro</hi> study was to determine the accuracy of digital subtraction radiography (DSR) to detect small changes in calcium mass in alveolar bone adjacent to tooth roots. In each of 4 dried porcine mandible segments, one interproximal and one buccal “defect” region was defined adjacent to a premolar root. A series of cortical and cancellous bone slices with a 50 μm‐stepwise increasing thickness (0‐5000 μm) were attached to the mandible segments covering the respective “defect” region. Standardized radiographs were quantitatively assessed for density changes using DSR. After dissolving each bone slice in hydrochloric acid, its calcium concentration was photometrically determined. For each bone slice, the mean calcium mass covering a single pixel of the subtraction image was calculated. The Wilcoxon signed‐rank test and the Mann‐Whitney <hi rend="italic">U</hi>‐test were used for statistical analysis (α = 0.05). A strong linear correlation (<hi rend="italic">r</hi><hi rend="superscript">2</hi> = 0.86‐1.00; p ≤ 0.001) was found between the thickness of the bone slices and their calcium mass. Cortical bone showed a 3.5 times higher mean calcium mass/pixel than cancellous bone. Furthermore, a strong linear correlation (<hi rend="italic">r</hi><hi rend="superscript">2</hi> = 0.63‐1.00; p ≤ 0.001) was found between the mean calcium mass per image pixel and the radiographic density changes. Neither the bone type nor the “defect” localization had a significant influence on radiographic density changes caused by changes in calcium mass. A change in mean calcium mass per image pixel of 0.1‐0.15 mg was necessary to be detected by DSR. In conclusion, this study revealed a high accuracy of DSR to detect small changes in calcium mass in alveolar cortical and cancellous bone.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">subtraction radiography</term><term xml:id="k2">quantitative analysis</term><term xml:id="k3">calcium</term><term xml:id="k4">alveolar bone</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/94A60B1D5D9D5DE2BAFAD6098A0457DC8A5747A0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0765</doi><issn type="print">0022-3484</issn><issn type="electronic">1600-0765</issn><idGroup><id type="product" value="JRE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF PERIODONTAL RESEARCH">Journal of Periodontal Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="04003"><doi origin="wiley">10.1111/jre.1998.33.issue-3</doi><numberingGroup><numbering type="journalVolume" number="33">33</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="1998-04">April 1998</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="2" status="forIssue"><doi origin="wiley">10.1111/j.1600-0765.1998.tb02304.x</doi><idGroup><id type="unit" value="JRE2304"></id></idGroup><countGroup><count type="pageTotal" number="12"></count></countGroup><copyright>1998 Munksgaard</copyright><eventGroup><event type="firstOnline" date="2010-06-14"></event><event type="publishedOnlineFinalForm" date="2010-06-14"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.9 mode:FullText source:HeaderRef result:HeaderRef" date="2010-06-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="138">138</numbering><numbering type="pageLast" number="149">149</numbering></numberingGroup><correspondenceTo>Michael Christgau, DMD, Dr Med Dent, University of Texas‐Houston, Department of Stomatology, Division of Periodontics, 6516 John Freeman Ave, Room 307, Houston, TX, USA Tel. (713) 500 4386 Fax. (713)500 4393 e‐mail: <email>mchristg@mail.db.uth.tmc.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JRE.JRE2304.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>January 8,1998</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="41"></count><count type="linksCrossRef" number="6"></count></countGroup><titleGroup><title type="main">Accuracy of quantitative digital subtraction radiography for determining changes in calcium mass in mandibular bone: an in vitro study</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>M.</givenNames><familyName>Christgau</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>K.‐A.</givenNames><familyName>Hiller</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>G.</givenNames><familyName>Schmalz</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>C.</givenNames><familyName>Kolbeck</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a3"><personName><givenNames>A.</givenNames><familyName>Wenzel</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="DE"><unparsedAffiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation>University of Texas‐Houston, Department of Stomatology, Division of Periodontics, Houston, TX, USA</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="DK"><unparsedAffiliation>Department of Oral Radiology, Royal Dental College, University of Aarhus, Aarhus, Denmark</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">subtraction radiography</keyword><keyword xml:id="k2">quantitative analysis</keyword><keyword xml:id="k3">calcium</keyword><keyword xml:id="k4">alveolar bone</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>The aim of this <i>in vitro</i> study was to determine the accuracy of digital subtraction radiography (DSR) to detect small changes in calcium mass in alveolar bone adjacent to tooth roots. In each of 4 dried porcine mandible segments, one interproximal and one buccal “defect” region was defined adjacent to a premolar root. A series of cortical and cancellous bone slices with a 50 μm‐stepwise increasing thickness (0‐5000 μm) were attached to the mandible segments covering the respective “defect” region. Standardized radiographs were quantitatively assessed for density changes using DSR. After dissolving each bone slice in hydrochloric acid, its calcium concentration was photometrically determined. For each bone slice, the mean calcium mass covering a single pixel of the subtraction image was calculated. The Wilcoxon signed‐rank test and the Mann‐Whitney <i>U</i>‐test were used for statistical analysis (α = 0.05). A strong linear correlation (<i>r</i><sup>2</sup> = 0.86‐1.00; p ≤ 0.001) was found between the thickness of the bone slices and their calcium mass. Cortical bone showed a 3.5 times higher mean calcium mass/pixel than cancellous bone. Furthermore, a strong linear correlation (<i>r</i><sup>2</sup> = 0.63‐1.00; p ≤ 0.001) was found between the mean calcium mass per image pixel and the radiographic density changes. Neither the bone type nor the “defect” localization had a significant influence on radiographic density changes caused by changes in calcium mass. A change in mean calcium mass per image pixel of 0.1‐0.15 mg was necessary to be detected by DSR. In conclusion, this study revealed a high accuracy of DSR to detect small changes in calcium mass in alveolar cortical and cancellous bone.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="n-fnt-1" numbered="no"><p>The authors wish to thank Dr Thomas Reitinger (Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany) for his helpful instructions for the determination of the calcium concentrations. Furthermore, we are grateful to Dr Raul G. CarTesse (Department of Stomatology, Division of Periodontics, University of Texas, Houston, TX, USA) for reviewing this manuscript.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Accuracy of quantitative digital subtraction radiography for determining changes in calcium mass in mandibular bone: an in vitro study</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Accuracy of quantitative digital subtraction radiography for determining changes in calcium mass in mandibular bone: an in vitro study</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Christgau</namePart><affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</affiliation><affiliation>E-mail: mchristg@mail.db.uth.tmc.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.‐A.</namePart><namePart type="family">Hiller</namePart><affiliation>University of Texas‐Houston, Department of Stomatology, Division of Periodontics, Houston, TX, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Schmalz</namePart><affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Kolbeck</namePart><affiliation>Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Wenzel</namePart><affiliation>Department of Oral Radiology, Royal Dental College, University of Aarhus, Aarhus, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1998-04</dateIssued><edition>January 8,1998</edition><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">41</extent><extent unit="linksCrossRef">6</extent></physicalDescription><abstract lang="en">The aim of this in vitro study was to determine the accuracy of digital subtraction radiography (DSR) to detect small changes in calcium mass in alveolar bone adjacent to tooth roots. In each of 4 dried porcine mandible segments, one interproximal and one buccal “defect” region was defined adjacent to a premolar root. A series of cortical and cancellous bone slices with a 50 μm‐stepwise increasing thickness (0‐5000 μm) were attached to the mandible segments covering the respective “defect” region. Standardized radiographs were quantitatively assessed for density changes using DSR. After dissolving each bone slice in hydrochloric acid, its calcium concentration was photometrically determined. For each bone slice, the mean calcium mass covering a single pixel of the subtraction image was calculated. The Wilcoxon signed‐rank test and the Mann‐Whitney U‐test were used for statistical analysis (α = 0.05). A strong linear correlation (r2 = 0.86‐1.00; p ≤ 0.001) was found between the thickness of the bone slices and their calcium mass. Cortical bone showed a 3.5 times higher mean calcium mass/pixel than cancellous bone. Furthermore, a strong linear correlation (r2 = 0.63‐1.00; p ≤ 0.001) was found between the mean calcium mass per image pixel and the radiographic density changes. Neither the bone type nor the “defect” localization had a significant influence on radiographic density changes caused by changes in calcium mass. A change in mean calcium mass per image pixel of 0.1‐0.15 mg was necessary to be detected by DSR. In conclusion, this study revealed a high accuracy of DSR to detect small changes in calcium mass in alveolar cortical and cancellous bone.</abstract><subject lang="en"><genre>keywords</genre><topic>subtraction radiography</topic><topic>quantitative analysis</topic><topic>calcium</topic><topic>alveolar bone</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Periodontal Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0022-3484</identifier><identifier type="eISSN">1600-0765</identifier><identifier type="DOI">10.1111/(ISSN)1600-0765</identifier><identifier type="PublisherID">JRE</identifier><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>138</start><end>149</end><total>12</total></extent></part></relatedItem><identifier type="istex">94A60B1D5D9D5DE2BAFAD6098A0457DC8A5747A0</identifier><identifier type="ark">ark:/67375/WNG-5FPL92V0-3</identifier><identifier type="DOI">10.1111/j.1600-0765.1998.tb02304.x</identifier><identifier type="ArticleID">JRE2304</identifier><accessCondition type="use and reproduction" contentType="copyright">1998 Munksgaard</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/94A60B1D5D9D5DE2BAFAD6098A0457DC8A5747A0/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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