Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP‐2/ACS or autogenous bone grafts: a proof‐of‐concept randomized clinical trial
Identifieur interne : 004980 ( Istex/Corpus ); précédent : 004979; suivant : 004981Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP‐2/ACS or autogenous bone grafts: a proof‐of‐concept randomized clinical trial
Auteurs : Rubens Moreno De Freitas ; Cristiano Susin ; Rubens Spin-Neto ; Claudio Marcantonio ; Ulf M. E. Wikesjö ; Luís Antônio Violin Dias Pereira ; Elcio Marcantonio JrSource :
- Journal of Clinical Periodontology [ 0303-6979 ] ; 2013-10.
English descriptors
- KwdEn :
- Alveolar, Alveolar bone, Alveolar crest, Alveolar ridge, Alveolar ridge augmentation, Alveolar ridge width, Analogue caliper, Anterior maxilla, Apical crestal levels, Augmentation, Autogenous, Autogenous bone graft, Autogenous bone graft group, Autogenous bone graft groups, Autogenous bone grafts, Baseline, Bone augmentation, Bone formation, Bone gain, Bone graft, Bone regeneration, Boyne, Case series, Clin periodontol, Clinical recordings, Clinical trial, Cochrane database, Collagen sponge, Complex extraction sites, Corresponding observations, Dental implant, Dental implant placement, Dental implant treatment, Dental implants, Dentistry, Edentulous, Elcio marcantonio, Experimental groups, Extraction socket augmentation, Feasibility study, Graft, Greater radiographic, Horizontal augmentation, Horizontal bone gain, Horizontal ridge augmentation, Immediate subcrestal level, Immediate subcrestal levels, Implant, Implant placement, Implants research, Incisive canal, International journal, John wiley sons, Mandibular retromolar region, Maxilla, Maxillary, Maxillary sinus, Maxillary sinus augmentation, Maxillofacial surgery, Midcrestal levels, Occlusal view, Optimal wound healing, Particulated autogenous bone, Periodontics, Primary intention healing, Primary stability, Prosthetic reconstruction, Radiographic, Radiographic alveolar ridge width gain, Radiographic bone gain, Radiographic recordings, Randomized, Realistic alternative, Recombinant, Restorative dentistry, Simple randomization, Sinus, Sinus augmentation, Susin, Titanium, Titanium mesh, Titanium screws, Unadjusted difference, Wikesj, Wound closure, Wound stability.
- Teeft :
- Alveolar, Alveolar bone, Alveolar crest, Alveolar ridge, Alveolar ridge augmentation, Alveolar ridge width, Analogue caliper, Anterior maxilla, Apical crestal levels, Augmentation, Autogenous, Autogenous bone graft, Autogenous bone graft group, Autogenous bone graft groups, Autogenous bone grafts, Baseline, Bone augmentation, Bone formation, Bone gain, Bone graft, Bone regeneration, Boyne, Case series, Clin periodontol, Clinical recordings, Clinical trial, Cochrane database, Collagen sponge, Complex extraction sites, Corresponding observations, Dental implant, Dental implant placement, Dental implant treatment, Dental implants, Dentistry, Edentulous, Elcio marcantonio, Experimental groups, Extraction socket augmentation, Feasibility study, Graft, Greater radiographic, Horizontal augmentation, Horizontal bone gain, Horizontal ridge augmentation, Immediate subcrestal level, Immediate subcrestal levels, Implant, Implant placement, Implants research, Incisive canal, International journal, John wiley sons, Mandibular retromolar region, Maxilla, Maxillary, Maxillary sinus, Maxillary sinus augmentation, Maxillofacial surgery, Midcrestal levels, Occlusal view, Optimal wound healing, Particulated autogenous bone, Periodontics, Primary intention healing, Primary stability, Prosthetic reconstruction, Radiographic, Radiographic alveolar ridge width gain, Radiographic bone gain, Radiographic recordings, Randomized, Realistic alternative, Recombinant, Restorative dentistry, Simple randomization, Sinus, Sinus augmentation, Susin, Titanium, Titanium mesh, Titanium screws, Unadjusted difference, Wikesj, Wound closure, Wound stability.
Abstract
To compare the effect of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) in an absorbable collagen sponge carrier (ACS) with autogenous bone graft for augmentation of the edentulous atrophic anterior maxilla.
Url:
DOI: 10.1111/jcpe.12148
Links to Exploration step
ISTEX:93B8437DF9B0666D9A58569F214B1EC74C453FA3Le document en format XML
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healing</term><term>Primary stability</term><term>Prosthetic reconstruction</term><term>Radiographic</term><term>Radiographic alveolar ridge width gain</term><term>Radiographic bone gain</term><term>Radiographic recordings</term><term>Randomized</term><term>Realistic alternative</term><term>Recombinant</term><term>Restorative dentistry</term><term>Simple randomization</term><term>Sinus</term><term>Sinus augmentation</term><term>Susin</term><term>Titanium</term><term>Titanium mesh</term><term>Titanium screws</term><term>Unadjusted difference</term><term>Wikesj</term><term>Wound closure</term><term>Wound stability</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">To compare the effect of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) in an absorbable collagen sponge carrier (ACS) with autogenous bone graft for augmentation of the edentulous atrophic anterior 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augmentation</json:string></teeft></keywords><author><json:item><name>Rubens Moreno de Freitas</name><affiliations><json:string>Department of Diagnosis and Surgery – Periodontics, UNESP – Univ Estadual Paulista, Araraquara Dental School, Araraquara, SP, Brazil</json:string><json:string>Laboratory for Applied Periodontal & Craniofacial Regeneration, Departments of Periodontics and Oral Biology, College of Dental Medicine, GA, Augusta, USA</json:string></affiliations></json:item><json:item><name>Cristiano Susin</name><affiliations><json:string>Laboratory for Applied Periodontal & Craniofacial Regeneration, Departments of Periodontics and Oral Biology, College of Dental Medicine, Augusta, GA, USA</json:string><json:string>Department of Orthopedics, Medical College of Georgia, Georgia Regents University, GA, Augusta, USA</json:string></affiliations></json:item><json:item><name>Rubens Spin‐Neto</name><affiliations><json:string>Department of Diagnosis and Surgery – Periodontics, UNESP – Univ Estadual Paulista, Araraquara Dental School, Araraquara, SP, Brazil</json:string><json:string>Department of Dentistry, Oral Radiology, Aarhus University, Aarhus, Denmark</json:string></affiliations></json:item><json:item><name>Claudio Marcantonio</name><affiliations><json:string>Department of Diagnosis and Surgery – Periodontics, UNESP – Univ Estadual Paulista, Araraquara Dental School, SP, Araraquara, Brazil</json:string></affiliations></json:item><json:item><name>Ulf M. E. Wikesjö</name><affiliations><json:string>Laboratory for Applied Periodontal & Craniofacial Regeneration, Departments of Periodontics and Oral Biology, College of Dental Medicine, Augusta, GA, USA</json:string><json:string>Department of Orthopedics, Medical College of Georgia, Georgia Regents University, GA, Augusta, USA</json:string></affiliations></json:item><json:item><name>Luís Antônio Violin Dias Pereira</name><affiliations><json:string>Department of Histology and Embryology, UNICAMP – State University of Campinas, Institute of Biology, SP, Campinas, Brazil</json:string></affiliations></json:item><json:item><name>Elcio Marcantonio Jr</name><affiliations><json:string>Department of Diagnosis and Surgery – Periodontics, UNESP – Univ Estadual Paulista, Araraquara Dental School, SP, Araraquara, Brazil</json:string><json:string>Address:Elcio Marcantonio JrDepartment of Diagnosis and Surgery – PeriodonticsUNESP – Univ Estadual Paulista, Araraquara Dental SchoolRua Humaitá, 1680 – 2nd floorAraraquara, SP, Brazil 14801‐903E‐mail:</json:string><json:string>E-mail: elciojr@foar.unesp.br</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>alveolar ridge augmentation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>autogenous bone graft</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>randomized‐controlled trial</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>recombinant human bone morphogenetic protein</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rhBMP‐2</value></json:item></subject><articleId><json:string>JCPE12148</json:string></articleId><arkIstex>ark:/67375/WNG-TWX8H5K2-W</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>To compare the effect of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) in an absorbable collagen sponge carrier (ACS) with autogenous bone graft for augmentation of the edentulous atrophic anterior maxilla.</abstract><qualityIndicators><score>6.6</score><pdfWordCount>4240</pdfWordCount><pdfCharCount>29443</pdfCharCount><pdfVersion>1.7</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>30</abstractWordCount><abstractCharCount>217</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP‐2/ACS or autogenous bone grafts: a proof‐of‐concept randomized clinical trial</title><pmid><json:string>23998375</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Clinical Periodontology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-051X</json:string></doi><issn><json:string>0303-6979</json:string></issn><eissn><json:string>1600-051X</json:string></eissn><publisherId><json:string>JCPE</json:string></publisherId><volume>40</volume><issue>10</issue><pages><first>968</first><last>975</last><total>8</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Randomized Clinical Trial</value></json:item></subject></host><namedEntities><unitex><date><json:string>2011</json:string><json:string>2002</json:string><json:string>2007</json:string><json:string>2013-07-26</json:string></date><geogName></geogName><orgName><json:string>Department of Histology and Embryology</json:string><json:string>Laboratory for Applied Periodontal</json:string><json:string>Imaging Sciences International</json:string><json:string>Brazil and CAPES, Brasilia, Brazil</json:string><json:string>Paulo Research Foundaa</json:string><json:string>Department of Dentistry, Oral Radiology, Aarhus University, Aarhus, Denmark</json:string><json:string>Department of Diagnosis and Oral Surgery</json:string><json:string>State University</json:string><json:string>Stata Corporation</json:string><json:string>Institute of Biology, Campinas, SP, Brazil</json:string><json:string>Department of Orthopedics, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Antonio Violin</json:string><json:string>M. E. Wikesjo</json:string><json:string>A. Schweickhardt</json:string><json:string>John Wiley</json:string><json:string>Daniel Duarte</json:string><json:string>Wikesj</json:string><json:string>Susin</json:string><json:string>Andreas Stavropoulos</json:string><json:string>W.L. Gore</json:string><json:string>Ann Wenzel</json:string><json:string>Rubens Spin-Neto</json:string><json:string>S. Published</json:string><json:string>Claudio Marcantonio</json:string></persName><placeName><json:string>TX</json:string><json:string>College Station</json:string><json:string>Germany</json:string><json:string>Korea</json:string><json:string>Seoul</json:string><json:string>Brazil</json:string><json:string>Curitiba</json:string><json:string>GA</json:string><json:string>Helsinki</json:string><json:string>Rio de Janeiro</json:string><json:string>USA</json:string><json:string>Herford</json:string><json:string>TN</json:string><json:string>Augusta</json:string><json:string>Memphis</json:string><json:string>Sweden</json:string><json:string>Campinas</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Triplett et al. 2009</json:string><json:string>McKay et al. 2007</json:string><json:string>Boyne et al. 2005</json:string><json:string>Boyne et al. 1997</json:string><json:string>Jung et al. 2003, 2009</json:string><json:string>Cochran et al. 2000</json:string><json:string>Carter et al. 2008</json:string><json:string>Fiorellini et al. 2005</json:string><json:string>de Freitas et al.</json:string><json:string>Kao et al. 2012</json:string><json:string>Spin-Neto et al. 2009</json:string><json:string>Lu et al. 2013</json:string><json:string>Esposito et al. 2009a,b</json:string><json:string>Lee et al.</json:string><json:string>Herford et al. 2007</json:string><json:string>Lee et al. 2013a,b</json:string><json:string>Howell et al. 1997</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-TWX8H5K2-W</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Periodontics</json:string></scopus></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1111/jcpe.12148</json:string></doi><id>93B8437DF9B0666D9A58569F214B1EC74C453FA3</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/93B8437DF9B0666D9A58569F214B1EC74C453FA3/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/93B8437DF9B0666D9A58569F214B1EC74C453FA3/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/93B8437DF9B0666D9A58569F214B1EC74C453FA3/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP‐2/ACS or autogenous bone grafts: a proof‐of‐concept randomized clinical trial</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Publishing Ltd</publisher><availability><licence>© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</licence></availability><date type="published" when="2013-10"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP‐2/ACS or autogenous bone grafts: a proof‐of‐concept randomized clinical trial</title><author xml:id="author-0000"><persName><forename type="first">Rubens Moreno</forename><surname>Freitas</surname></persName><affiliation><orgName>Department of Diagnosis and Surgery – Periodontics</orgName><orgName>UNESP – Univ Estadual Paulista, Araraquara Dental School</orgName><address><settlement type="city">Araraquara</settlement><region>SP</region><country key="BR">Brazil</country></address></affiliation><affiliation><orgName>Laboratory for Applied Periodontal & Craniofacial Regeneration</orgName><orgName>Departments of Periodontics and Oral Biology</orgName><orgName>College of Dental Medicine</orgName><address><settlement type="city">Augusta</settlement><region>GA</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Cristiano</forename><surname>Susin</surname></persName><affiliation><orgName>Laboratory for Applied Periodontal & Craniofacial Regeneration</orgName><orgName>Departments of Periodontics and Oral Biology</orgName><orgName>College of Dental Medicine</orgName><address><settlement type="city">Augusta</settlement><region>GA</region><country key="US">USA</country></address></affiliation><affiliation><orgName>Department of Orthopedics, Medical College of Georgia</orgName><orgName>Georgia Regents University</orgName><address><settlement type="city">Augusta</settlement><region>GA</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Rubens</forename><surname>Spin‐Neto</surname></persName><affiliation><orgName>Department of Diagnosis and Surgery – Periodontics</orgName><orgName>UNESP – Univ Estadual Paulista, Araraquara Dental School</orgName><address><settlement type="city">Araraquara</settlement><region>SP</region><country key="BR">Brazil</country></address></affiliation><affiliation><orgName>Department of Dentistry</orgName><orgName>Oral Radiology</orgName><orgName>Aarhus University</orgName><orgName>Aarhus</orgName><address><country key="DK">Denmark</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Claudio</forename><surname>Marcantonio</surname></persName><affiliation><orgName>Department of Diagnosis and Surgery – Periodontics</orgName><orgName>UNESP – Univ Estadual Paulista, Araraquara Dental School</orgName><address><settlement type="city">Araraquara</settlement><region>SP</region><country key="BR">Brazil</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Ulf M. E.</forename><surname>Wikesjö</surname></persName><affiliation><orgName>Laboratory for Applied Periodontal & Craniofacial Regeneration</orgName><orgName>Departments of Periodontics and Oral Biology</orgName><orgName>College of Dental Medicine</orgName><address><settlement type="city">Augusta</settlement><region>GA</region><country key="US">USA</country></address></affiliation><affiliation><orgName>Department of Orthopedics, Medical College of Georgia</orgName><orgName>Georgia Regents University</orgName><address><settlement type="city">Augusta</settlement><region>GA</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Luís Antônio Violin Dias</forename><surname>Pereira</surname></persName><affiliation><orgName>Department of Histology and Embryology</orgName><orgName>UNICAMP – State University of Campinas, Institute of Biology</orgName><address><settlement type="city">Campinas</settlement><region>SP</region><country key="BR">Brazil</country></address></affiliation></author><author xml:id="author-0006" role="corresp"><persName><genName>Jr</genName><forename type="first">Elcio</forename><surname>Marcantonio</surname></persName><affiliation><orgName>Department of Diagnosis and Surgery – Periodontics</orgName><orgName>UNESP – Univ Estadual Paulista, Araraquara Dental School</orgName><address><settlement type="city">Araraquara</settlement><region>SP</region><country key="BR">Brazil</country></address></affiliation><affiliation>Address: Elcio Marcantonio Jr Department of Diagnosis and Surgery – Periodontics UNESP – Univ Estadual Paulista, Araraquara Dental School Rua Humaitá, 1680 – 2nd floor Araraquara, SP, Brazil 14801‐903 E‐mail: elciojr@foar.unesp.br</affiliation></author><idno type="istex">93B8437DF9B0666D9A58569F214B1EC74C453FA3</idno><idno type="ark">ark:/67375/WNG-TWX8H5K2-W</idno><idno type="DOI">10.1111/jcpe.12148</idno><idno type="unit">JCPE12148</idno><idno type="toTypesetVersion">file:JCPE.JCPE12148.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Clinical Periodontology</title><title level="j" type="alt">JOURNAL OF CLINICAL PERIODONTOLOGY</title><idno type="pISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><idno type="book-DOI">10.1111/(ISSN)1600-051X</idno><idno type="book-part-DOI">10.1111/jcpe.2013.40.issue-10</idno><idno type="product">JCPE</idno><imprint><biblScope unit="vol">40</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="968">968</biblScope><biblScope unit="page" to="975">975</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2013-10"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="jcpe12148-abs-0001"><head>Abstract</head>
Aim
<p>To compare the effect of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) in an absorbable collagen sponge carrier (ACS) with autogenous bone graft for augmentation of the edentulous atrophic anterior maxilla.</p>
Methods
<p>Twenty‐four subjects were enrolled in a randomized, controlled, parallel‐group, open‐label clinical trial. Subjects either received rhBMP‐2/ACS (1.5 mg/ml) or particulated autogenous bone harvested from the mandibular retromolar region. A titanium‐mesh was used to provide space and wound stability. A guide was used to standardize clinical recordings using an analogue caliper. Alveolar ridge width was also assessed using cone‐beam computed tomography.</p>
Results
<p>rhBMP‐2/ACS yielded significantly greater radiographic horizontal bone gain compared with autogenous bone graft at immediate subcrestal levels (1.5 ± 0.7 <hi rend="italic">versus</hi> 0.5 ± 0.9 mm; <hi rend="italic">p</hi> = 0.01); non‐significant differences were observed at mid‐ (2.9 ± 0.8 <hi rend="italic">versus</hi> 2.9 ± 0.9 mm; <hi rend="italic">p</hi> = 0.98) and apical (1.7 ± 0.9 <hi rend="italic">versus</hi> 1.8 ± 1.1 mm; <hi rend="italic">p</hi> = 0.85) crestal levels. No significant differences in clinical horizontal bone gain were observed at 6 months between rhBMP‐2/ACS and autogenous bone graft (3.2 ± 0.9 mm <hi rend="italic">versus</hi> 3.7 ± 1.4 mm; <hi rend="italic">p</hi> = 0.31). Sixty‐two implants were placed after 6 month of healing with no significant differences between groups for number of implants, implant size, primary stability and survival.</p>
Conclusions
<p>rhBMP‐2/ACS appears a realistic alternative for augmentation of the edentulous atrophic anterior maxilla.</p></abstract><abstract style="short"><p>View the pubcast on this paper at <ref type="url">http://www.scivee.tv/journalnode/60739</ref></p></abstract><textClass><keywords><term xml:id="jcpe12148-kwd-0001">alveolar ridge augmentation</term><term xml:id="jcpe12148-kwd-0002">autogenous bone graft</term><term xml:id="jcpe12148-kwd-0003">randomized‐controlled trial</term><term xml:id="jcpe12148-kwd-0004">recombinant human bone morphogenetic protein</term><term xml:id="jcpe12148-kwd-0005">rhBMP‐2</term></keywords><keywords rend="articleCategory"><term>Randomized Clinical Trial</term></keywords><keywords rend="tocHeading1"><term>Implant Therapy</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/93B8437DF9B0666D9A58569F214B1EC74C453FA3/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="jcpe12148" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-051X</doi><issn type="print">0303-6979</issn><issn type="electronic">1600-051X</issn><idGroup><id type="product" value="JCPE"></id></idGroup><titleGroup><title sort="JOURNAL OF CLINICAL PERIODONTOLOGY" type="main">Journal of Clinical Periodontology</title><title type="short">J Clin Periodontol</title></titleGroup></publicationMeta><publicationMeta level="part" position="100"><doi origin="wiley">10.1111/jcpe.2013.40.issue-10</doi><copyright ownership="publisher">Copyright © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</copyright><numberingGroup><numbering number="40" type="journalVolume">40</numbering><numbering type="journalIssue">10</numbering></numberingGroup><coverDate startDate="2013-10">October 2013</coverDate></publicationMeta><publicationMeta level="unit" position="90" status="forIssue" type="article"><doi>10.1111/jcpe.12148</doi><idGroup><id type="unit" value="JCPE12148"></id></idGroup><countGroup><count number="8" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Randomized Clinical Trial</title><title type="tocHeading1">Implant Therapy</title></titleGroup><copyright ownership="publisher">© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</copyright><eventGroup><event date="2013-07-16" type="manuscriptAccepted"></event><event agent="SPS" date="2013-07-26" type="xmlCreated"></event><event agent="SPS" date="2013-10-24" type="xmlCorrected"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.2.6 mode:FullText" date="2013-10-24"></event><event type="publishedOnlineAccepted" date="2013-07-22"></event><event type="publishedOnlineFinalForm" date="2013-09-02"></event><event type="firstOnline" date="2013-09-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-01"></event></eventGroup><numberingGroup><numbering type="pageFirst">968</numbering><numbering type="pageLast">975</numbering></numberingGroup><correspondenceTo><lineatedText><line>Address:</line><line>Elcio Marcantonio Jr</line><line>Department of Diagnosis and Surgery – Periodontics</line><line>UNESP – Univ Estadual Paulista, Araraquara Dental School</line><line>Rua Humaitá, 1680 – 2nd floor</line><line>Araraquara, SP, Brazil 14801‐903</line><line>E‐mail: <email>elciojr@foar.unesp.br</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="jcpe12148-cit-1001"><author><familyNamePrefix>de</familyNamePrefix> <familyName>Freitas</familyName> <givenNames>RM</givenNames></author>, <author> <familyName>Susin</familyName> <givenNames>C</givenNames></author>, <author><familyName>Spin‐Neto</familyName> <givenNames>R</givenNames></author>, <author><familyName>Marcantonio</familyName> <givenNames>C</givenNames></author>, <author><familyName>Wikesjö</familyName> <givenNames>UME</givenNames></author>, <author><familyName>Pereira</familyName> <givenNames>LAVD</givenNames></author>, <author><familyName>Marcantonio</familyName> <givenNames>E</givenNames> <nameSuffix>Jr</nameSuffix></author>. <articleTitle>Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP‐2/ACS or autogenous bone grafts: a proof‐of‐concept randomized clinical trial</articleTitle>. <journalTitle>J Clin Periodontol</journalTitle> <pubYear year="2013">2013</pubYear>; <vol>40</vol>: <pageFirst>968</pageFirst>–<pageLast>976</pageLast>. doi: <accessionId ref="info:doi/10.1111/jcpe.12148">10.1111/jcpe.12148</accessionId></citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:JCPE.JCPE12148.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP‐2/ACS or autogenous bone grafts: a proof‐of‐concept randomized clinical trial</title><title type="shortAuthors">de Freitas <i>et al</i>.</title></titleGroup><creators><creator affiliationRef="#jcpe12148-aff-0001 #jcpe12148-aff-0002" creatorRole="author" xml:id="jcpe12148-cr-0001"><personName><givenNames>Rubens Moreno</givenNames> <familyNamePrefix>de</familyNamePrefix> <familyName>Freitas</familyName></personName></creator><creator affiliationRef="#jcpe12148-aff-0002 #jcpe12148-aff-0003" creatorRole="author" xml:id="jcpe12148-cr-0002"><personName><givenNames>Cristiano</givenNames> <familyName>Susin</familyName></personName></creator><creator affiliationRef="#jcpe12148-aff-0001 #jcpe12148-aff-0004" creatorRole="author" xml:id="jcpe12148-cr-0003"><personName><givenNames>Rubens</givenNames> <familyName>Spin‐Neto</familyName></personName></creator><creator affiliationRef="#jcpe12148-aff-0001" creatorRole="author" xml:id="jcpe12148-cr-0004"><personName><givenNames>Claudio</givenNames> <familyName>Marcantonio</familyName></personName></creator><creator affiliationRef="#jcpe12148-aff-0002 #jcpe12148-aff-0003" creatorRole="author" xml:id="jcpe12148-cr-0005"><personName><givenNames>Ulf M. E.</givenNames> <familyName>Wikesjö</familyName></personName></creator><creator affiliationRef="#jcpe12148-aff-0005" creatorRole="author" xml:id="jcpe12148-cr-0006"><personName><givenNames>Luís Antônio Violin Dias</givenNames> <familyName>Pereira</familyName></personName></creator><creator affiliationRef="#jcpe12148-aff-0001" corresponding="yes" creatorRole="author" xml:id="jcpe12148-cr-0007"><personName><givenNames>Elcio</givenNames> <familyName>Marcantonio</familyName> <nameSuffix>Jr</nameSuffix></personName></creator></creators><affiliationGroup><affiliation countryCode="BR" type="organization" xml:id="jcpe12148-aff-0001"><orgDiv>Department of Diagnosis and Surgery – Periodontics</orgDiv> <orgName>UNESP – Univ Estadual Paulista, Araraquara Dental School</orgName> <address><city>Araraquara</city> <countryPart>SP</countryPart> <country>Brazil</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="jcpe12148-aff-0002"><orgDiv>Laboratory for Applied Periodontal & Craniofacial Regeneration</orgDiv> <orgDiv>Departments of Periodontics and Oral Biology</orgDiv> <orgName>College of Dental Medicine</orgName> <address><city>Augusta</city> <countryPart>GA</countryPart> <country>USA</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="jcpe12148-aff-0003"><orgDiv>Department of Orthopedics, Medical College of Georgia</orgDiv> <orgName>Georgia Regents University</orgName> <address><city>Augusta</city> <countryPart>GA</countryPart> <country>USA</country></address></affiliation><affiliation countryCode="DK" type="organization" xml:id="jcpe12148-aff-0004"><orgDiv>Department of Dentistry</orgDiv> <orgName>Oral Radiology</orgName> <orgName>Aarhus University</orgName> <orgName>Aarhus</orgName> <address><country>Denmark</country></address></affiliation><affiliation countryCode="BR" type="organization" xml:id="jcpe12148-aff-0005"><orgDiv>Department of Histology and Embryology</orgDiv> <orgName>UNICAMP – State University of Campinas, Institute of Biology</orgName> <address><city>Campinas</city> <countryPart>SP</countryPart><country>Brazil</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="jcpe12148-kwd-0001">alveolar ridge augmentation</keyword><keyword xml:id="jcpe12148-kwd-0002">autogenous bone graft</keyword><keyword xml:id="jcpe12148-kwd-0003">randomized‐controlled trial</keyword><keyword xml:id="jcpe12148-kwd-0004">recombinant human bone morphogenetic protein</keyword><keyword xml:id="jcpe12148-kwd-0005">rhBMP‐2</keyword></keywordGroup><fundingInfo><fundingAgency>São Paulo Research Foundation</fundingAgency><fundingNumber>2009/16016‐8</fundingNumber></fundingInfo><fundingInfo><fundingAgency>3M Non‐Tenured Faculty</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Nobel Biocare AB</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:id="jcpe12148-abs-0001"><title type="main">Abstract</title><section xml:id="jcpe12148-sec-0001"><title type="main">Aim</title><p>To compare the effect of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) in an absorbable collagen sponge carrier (ACS) with autogenous bone graft for augmentation of the edentulous atrophic anterior maxilla.</p></section><section xml:id="jcpe12148-sec-0002"><title type="main">Methods</title><p>Twenty‐four subjects were enrolled in a randomized, controlled, parallel‐group, open‐label clinical trial. Subjects either received rhBMP‐2/ACS (1.5 mg/ml) or particulated autogenous bone harvested from the mandibular retromolar region. A titanium‐mesh was used to provide space and wound stability. A guide was used to standardize clinical recordings using an analogue caliper. Alveolar ridge width was also assessed using cone‐beam computed tomography.</p></section><section xml:id="jcpe12148-sec-0003"><title type="main">Results</title><p>rhBMP‐2/ACS yielded significantly greater radiographic horizontal bone gain compared with autogenous bone graft at immediate subcrestal levels (1.5 ± 0.7 <i>versus</i> 0.5 ± 0.9 mm; <i>p</i> = 0.01); non‐significant differences were observed at mid‐ (2.9 ± 0.8 <i>versus</i> 2.9 ± 0.9 mm; <i>p</i> = 0.98) and apical (1.7 ± 0.9 <i>versus</i> 1.8 ± 1.1 mm; <i>p</i> = 0.85) crestal levels. No significant differences in clinical horizontal bone gain were observed at 6 months between rhBMP‐2/ACS and autogenous bone graft (3.2 ± 0.9 mm <i>versus</i> 3.7 ± 1.4 mm; <i>p</i> = 0.31). Sixty‐two implants were placed after 6 month of healing with no significant differences between groups for number of implants, implant size, primary stability and survival.</p></section><section xml:id="jcpe12148-sec-0004"><title type="main">Conclusions</title><p>rhBMP‐2/ACS appears a realistic alternative for augmentation of the edentulous atrophic anterior maxilla.</p></section></abstract><abstract type="short"><p>View the pubcast on this paper at <url href="http://www.scivee.tv/journalnode/60739">http://www.scivee.tv/journalnode/60739</url></p></abstract></abstractGroup></contentMeta><noteGroup xml:id="jcpe12148-ntgp-0001"><note numbered="no" xml:id="jcpe12148-note-0001"><p><b>Conflict of interest and source of funding statement</b></p><p>The authors declare no conflict of interest for this study. Research funding was provided from the São Paulo Research Foundation (FAPESP – grant number 2009/16016‐8), São Paulo, Brazil and CAPES, Brasilia, Brazil. Dr. Susin was supported in part by a 3M Non‐Tenured Faculty Grant, St Paul, MN, USA. Drs Wikesjö and Susin were supported in part by a grant from Nobel Biocare AB, Göteborg, Sweden.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP‐2/ACS or autogenous bone grafts: a proof‐of‐concept randomized clinical trial</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP‐2/ACS or autogenous bone grafts: a proof‐of‐concept randomized clinical trial</title></titleInfo><name type="personal"><namePart type="given">Rubens Moreno</namePart><namePart type="family">de Freitas</namePart><affiliation>Department of Diagnosis and Surgery – Periodontics, UNESP – Univ Estadual Paulista, Araraquara Dental School, Araraquara, SP, Brazil</affiliation><affiliation>Laboratory for Applied Periodontal & Craniofacial Regeneration, Departments of Periodontics and Oral Biology, College of Dental Medicine, GA, Augusta, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cristiano</namePart><namePart type="family">Susin</namePart><affiliation>Laboratory for Applied Periodontal & Craniofacial Regeneration, Departments of Periodontics and Oral Biology, College of Dental Medicine, Augusta, GA, USA</affiliation><affiliation>Department of Orthopedics, Medical College of Georgia, Georgia Regents University, GA, Augusta, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rubens</namePart><namePart type="family">Spin‐Neto</namePart><affiliation>Department of Diagnosis and Surgery – Periodontics, UNESP – Univ Estadual Paulista, Araraquara Dental School, Araraquara, SP, Brazil</affiliation><affiliation>Department of Dentistry, Oral Radiology, Aarhus University, Aarhus, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claudio</namePart><namePart type="family">Marcantonio</namePart><affiliation>Department of Diagnosis and Surgery – Periodontics, UNESP – Univ Estadual Paulista, Araraquara Dental School, SP, Araraquara, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ulf M. E.</namePart><namePart type="family">Wikesjö</namePart><affiliation>Laboratory for Applied Periodontal & Craniofacial Regeneration, Departments of Periodontics and Oral Biology, College of Dental Medicine, Augusta, GA, USA</affiliation><affiliation>Department of Orthopedics, Medical College of Georgia, Georgia Regents University, GA, Augusta, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luís Antônio Violin Dias</namePart><namePart type="family">Pereira</namePart><affiliation>Department of Histology and Embryology, UNICAMP – State University of Campinas, Institute of Biology, SP, Campinas, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elcio</namePart><namePart type="family">Marcantonio Jr</namePart><affiliation>Department of Diagnosis and Surgery – Periodontics, UNESP – Univ Estadual Paulista, Araraquara Dental School, SP, Araraquara, Brazil</affiliation><affiliation>Address:Elcio Marcantonio JrDepartment of Diagnosis and Surgery – PeriodonticsUNESP – Univ Estadual Paulista, Araraquara Dental SchoolRua Humaitá, 1680 – 2nd floorAraraquara, SP, Brazil 14801‐903E‐mail:</affiliation><affiliation>E-mail: elciojr@foar.unesp.br</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-10</dateIssued><dateCreated encoding="w3cdtf">2013-07-26</dateCreated><dateValid encoding="w3cdtf">2013-07-16</dateValid><edition>de Freitas RM, Susin C, Spin‐Neto R, Marcantonio C, Wikesjö UME, Pereira LAVD, Marcantonio E Jr. Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP‐2/ACS or autogenous bone grafts: a proof‐of‐concept randomized clinical trial. J Clin Periodontol 2013; 40: 968–976. doi: 10.1111/jcpe.12148</edition><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>To compare the effect of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) in an absorbable collagen sponge carrier (ACS) with autogenous bone graft for augmentation of the edentulous atrophic anterior maxilla.</abstract><abstract>Twenty‐four subjects were enrolled in a randomized, controlled, parallel‐group, open‐label clinical trial. Subjects either received rhBMP‐2/ACS (1.5 mg/ml) or particulated autogenous bone harvested from the mandibular retromolar region. A titanium‐mesh was used to provide space and wound stability. A guide was used to standardize clinical recordings using an analogue caliper. Alveolar ridge width was also assessed using cone‐beam computed tomography.</abstract><abstract>rhBMP‐2/ACS yielded significantly greater radiographic horizontal bone gain compared with autogenous bone graft at immediate subcrestal levels (1.5 ± 0.7 versus 0.5 ± 0.9 mm; p = 0.01); non‐significant differences were observed at mid‐ (2.9 ± 0.8 versus 2.9 ± 0.9 mm; p = 0.98) and apical (1.7 ± 0.9 versus 1.8 ± 1.1 mm; p = 0.85) crestal levels. No significant differences in clinical horizontal bone gain were observed at 6 months between rhBMP‐2/ACS and autogenous bone graft (3.2 ± 0.9 mm versus 3.7 ± 1.4 mm; p = 0.31). Sixty‐two implants were placed after 6 month of healing with no significant differences between groups for number of implants, implant size, primary stability and survival.</abstract><abstract>rhBMP‐2/ACS appears a realistic alternative for augmentation of the edentulous atrophic anterior maxilla.</abstract><abstract type="short">View the pubcast on this paper at http://www.scivee.tv/journalnode/60739</abstract><note type="funding">São Paulo Research Foundation - No. 2009/16016‐8; </note><note type="funding">3M Non‐Tenured Faculty</note><note type="funding">Nobel Biocare AB</note><subject><genre>keywords</genre><topic>alveolar ridge augmentation</topic><topic>autogenous bone graft</topic><topic>randomized‐controlled trial</topic><topic>recombinant human bone morphogenetic protein</topic><topic>rhBMP‐2</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Clinical Periodontology</title></titleInfo><titleInfo type="abbreviated"><title>J Clin Periodontol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Randomized Clinical Trial</topic></subject><identifier type="ISSN">0303-6979</identifier><identifier type="eISSN">1600-051X</identifier><identifier type="DOI">10.1111/(ISSN)1600-051X</identifier><identifier type="PublisherID">JCPE</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>968</start><end>975</end><total>8</total></extent></part></relatedItem><identifier type="istex">93B8437DF9B0666D9A58569F214B1EC74C453FA3</identifier><identifier type="ark">ark:/67375/WNG-TWX8H5K2-W</identifier><identifier type="DOI">10.1111/jcpe.12148</identifier><identifier type="ArticleID">JCPE12148</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 John Wiley & Sons A/S. 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