Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease
Identifieur interne : 004822 ( Istex/Corpus ); précédent : 004821; suivant : 004823Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease
Auteurs : Fabio José Persegani Olivar Fonseca ; Mario Moraes Junior ; Eduardo José Veras Lourenço ; Daniel De Moraes Teles ; Carlos Marcelo FigueredoSource :
- Clinical Oral Implants Research [ 0905-7161 ] ; 2014-02.
Abstract
This study aimed to measure the levels of GM‐CSF, IL‐1β, IL‐2, IL‐4, IL‐5, IL‐6, IL‐7, IL‐8, IL‐10, IL‐12, IFN‐γ and TNF‐α in peri‐implant crevicular fluid (PICF) and saliva from patients with peri‐implant disease.
Url:
DOI: 10.1111/clr.12052
Links to Exploration step
ISTEX:9098739419F81602C027659FC111A244C711CABELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease</title><author><name sortKey="Fonseca, Fabio Jose Persegani Olivar" sort="Fonseca, Fabio Jose Persegani Olivar" uniqKey="Fonseca F" first="Fabio José Persegani Olivar" last="Fonseca">Fabio José Persegani Olivar Fonseca</name><affiliation><mods:affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Junior, Mario Moraes" sort="Junior, Mario Moraes" uniqKey="Junior M" first="Mario Moraes" last="Junior">Mario Moraes Junior</name><affiliation><mods:affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Lourenco, Eduardo Jose Veras" sort="Lourenco, Eduardo Jose Veras" uniqKey="Lourenco E" first="Eduardo José Veras" last="Lourenço">Eduardo José Veras Lourenço</name><affiliation><mods:affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="De Moraes Teles, Daniel" sort="De Moraes Teles, Daniel" uniqKey="De Moraes Teles D" first="Daniel" last="De Moraes Teles">Daniel De Moraes Teles</name><affiliation><mods:affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Figueredo, Carlos Marcelo" sort="Figueredo, Carlos Marcelo" uniqKey="Figueredo C" first="Carlos Marcelo" last="Figueredo">Carlos Marcelo Figueredo</name><affiliation><mods:affiliation>Faculty of Odontology, Department of Periodontology, Rio de Janeiro State University, Rio de Janeiro, Brazil</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Periodontology, Faculty of OdontologyRio de Janeiro State UniversityBoulevard 28 de Setembro 157 ‐ Pavilhão de Pesquisa ‐Vila Isabel ‐ 20551‐030 Rio de Janeiro, BrasilTel./Fax: +55 21 2868 8642e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: cmfigueredo@hotmail.com</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9098739419F81602C027659FC111A244C711CABE</idno><date when="2014" year="2014">2014</date><idno type="doi">10.1111/clr.12052</idno><idno type="url">https://api.istex.fr/document/9098739419F81602C027659FC111A244C711CABE/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004822</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">004822</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease</title><author><name sortKey="Fonseca, Fabio Jose Persegani Olivar" sort="Fonseca, Fabio Jose Persegani Olivar" uniqKey="Fonseca F" first="Fabio José Persegani Olivar" last="Fonseca">Fabio José Persegani Olivar Fonseca</name><affiliation><mods:affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Junior, Mario Moraes" sort="Junior, Mario Moraes" uniqKey="Junior M" first="Mario Moraes" last="Junior">Mario Moraes Junior</name><affiliation><mods:affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Lourenco, Eduardo Jose Veras" sort="Lourenco, Eduardo Jose Veras" uniqKey="Lourenco E" first="Eduardo José Veras" last="Lourenço">Eduardo José Veras Lourenço</name><affiliation><mods:affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="De Moraes Teles, Daniel" sort="De Moraes Teles, Daniel" uniqKey="De Moraes Teles D" first="Daniel" last="De Moraes Teles">Daniel De Moraes Teles</name><affiliation><mods:affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Figueredo, Carlos Marcelo" sort="Figueredo, Carlos Marcelo" uniqKey="Figueredo C" first="Carlos Marcelo" last="Figueredo">Carlos Marcelo Figueredo</name><affiliation><mods:affiliation>Faculty of Odontology, Department of Periodontology, Rio de Janeiro State University, Rio de Janeiro, Brazil</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Periodontology, Faculty of OdontologyRio de Janeiro State UniversityBoulevard 28 de Setembro 157 ‐ Pavilhão de Pesquisa ‐Vila Isabel ‐ 20551‐030 Rio de Janeiro, BrasilTel./Fax: +55 21 2868 8642e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: cmfigueredo@hotmail.com</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Oral Implants Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="ISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="e68">e68</biblScope><biblScope unit="page" to="e72">e72</biblScope><biblScope unit="page-count">5</biblScope><date type="published" when="2014-02">2014-02</date></imprint><idno type="ISSN">0905-7161</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0905-7161</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">This study aimed to measure the levels of GM‐CSF, IL‐1β, IL‐2, IL‐4, IL‐5, IL‐6, IL‐7, IL‐8, IL‐10, IL‐12, IFN‐γ and TNF‐α in peri‐implant crevicular fluid (PICF) and saliva from patients with peri‐implant disease.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Fabio José Persegani Olivar Fonseca</name><affiliations><json:string>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</json:string></affiliations></json:item><json:item><name>Mario Moraes Junior</name><affiliations><json:string>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</json:string></affiliations></json:item><json:item><name>Eduardo José Veras Lourenço</name><affiliations><json:string>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</json:string></affiliations></json:item><json:item><name>Daniel de Moraes Teles</name><affiliations><json:string>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</json:string></affiliations></json:item><json:item><name>Carlos Marcelo Figueredo</name><affiliations><json:string>Faculty of Odontology, Department of Periodontology, Rio de Janeiro State University, Rio de Janeiro, Brazil</json:string><json:string>Department of Periodontology, Faculty of OdontologyRio de Janeiro State UniversityBoulevard 28 de Setembro 157 ‐ Pavilhão de Pesquisa ‐Vila Isabel ‐ 20551‐030 Rio de Janeiro, BrasilTel./Fax: +55 21 2868 8642e‐mail:</json:string><json:string>E-mail: cmfigueredo@hotmail.com</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>cytokine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dental implants</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>IL‐1β</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mucositis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>peri‐implantitis</value></json:item></subject><articleId><json:string>CLR12052</json:string></articleId><arkIstex>ark:/67375/WNG-X1Q88RZ4-C</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>This study aimed to measure the levels of GM‐CSF, IL‐1β, IL‐2, IL‐4, IL‐5, IL‐6, IL‐7, IL‐8, IL‐10, IL‐12, IFN‐γ and TNF‐α in peri‐implant crevicular fluid (PICF) and saliva from patients with peri‐implant disease.</abstract><qualityIndicators><score>6.184</score><pdfWordCount>3788</pdfWordCount><pdfCharCount>26652</pdfCharCount><pdfVersion>1.7</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>33</abstractWordCount><abstractCharCount>214</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease</title><genre><json:string>article</json:string></genre><host><title>Clinical Oral Implants Research</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0501</json:string></doi><issn><json:string>0905-7161</json:string></issn><eissn><json:string>1600-0501</json:string></eissn><publisherId><json:string>CLR</json:string></publisherId><volume>25</volume><issue>2</issue><pages><first>e68</first><last>e72</last><total>5</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item></subject></host><ark><json:string>ark:/67375/WNG-X1Q88RZ4-C</json:string></ark><publicationDate>2014</publicationDate><copyrightDate>2014</copyrightDate><doi><json:string>10.1111/clr.12052</json:string></doi><id>9098739419F81602C027659FC111A244C711CABE</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/9098739419F81602C027659FC111A244C711CABE/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/9098739419F81602C027659FC111A244C711CABE/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/9098739419F81602C027659FC111A244C711CABE/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Publishing Ltd</publisher><availability><licence>© 2012 John Wiley & Sons A/S</licence></availability><date type="published" when="2014-02"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease</title><author xml:id="author-0000"><persName><forename type="first">Fabio José Persegani Olivar</forename><surname>Fonseca</surname></persName><affiliation><orgName>Faculty of Odontology, Department of Prosthodontics</orgName><orgName>Rio de Janeiro State University</orgName><address><settlement type="city">Rio de Janeiro</settlement><country key="BR">Brazil</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Mario Moraes</forename><surname>Junior</surname></persName><affiliation><orgName>Faculty of Odontology, Department of Prosthodontics</orgName><orgName>Rio de Janeiro State University</orgName><address><settlement type="city">Rio de Janeiro</settlement><country key="BR">Brazil</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Eduardo José Veras</forename><surname>Lourenço</surname></persName><affiliation><orgName>Faculty of Odontology, Department of Prosthodontics</orgName><orgName>Rio de Janeiro State University</orgName><address><settlement type="city">Rio de Janeiro</settlement><country key="BR">Brazil</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Daniel</forename><surname>Moraes Teles</surname></persName><affiliation><orgName>Faculty of Odontology, Department of Prosthodontics</orgName><orgName>Rio de Janeiro State University</orgName><address><settlement type="city">Rio de Janeiro</settlement><country key="BR">Brazil</country></address></affiliation></author><author xml:id="author-0004" role="corresp"><persName><forename type="first">Carlos Marcelo</forename><surname>Figueredo</surname></persName><affiliation><orgName>Faculty of Odontology, Department of Periodontology</orgName><orgName>Rio de Janeiro State University</orgName><address><settlement type="city">Rio de Janeiro</settlement><country key="BR">Brazil</country></address></affiliation><affiliation>Corresponding author: Carlos Marcelo Figueredo Department of Periodontology, Faculty of Odontology Rio de Janeiro State University Boulevard 28 de Setembro 157 ‐ Pavilhão de Pesquisa ‐Vila Isabel ‐ 20551‐030 Rio de Janeiro, Brasil Tel./Fax: +55 21 2868 8642 e‐mail: cmfigueredo@hotmail.com</affiliation></author><idno type="istex">9098739419F81602C027659FC111A244C711CABE</idno><idno type="ark">ark:/67375/WNG-X1Q88RZ4-C</idno><idno type="DOI">10.1111/clr.12052</idno><idno type="unit">CLR12052</idno><idno type="toTypesetVersion">file:CLR.CLR12052.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Oral Implants Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="pISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><idno type="book-DOI">10.1111/(ISSN)1600-0501</idno><idno type="book-part-DOI">10.1111/clr.2014.25.issue-2</idno><idno type="product">CLR</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="e68">e68</biblScope><biblScope unit="page" to="e72">e72</biblScope><biblScope unit="page-count">5</biblScope><date type="published" when="2014-02"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="clr12052-abs-0001"><head>Abstract</head>
Objective
<p>This study aimed to measure the levels of <hi rend="fc">GM</hi>‐<hi rend="fc">CSF</hi>,<hi rend="fc"> IL</hi>‐1β, <hi rend="fc">IL</hi>‐2, <hi rend="fc">IL</hi>‐4, <hi rend="fc">IL</hi>‐5, <hi rend="fc">IL</hi>‐6, <hi rend="fc">IL</hi>‐7, <hi rend="fc">IL</hi>‐8, <hi rend="fc">IL</hi>‐10, <hi rend="fc">IL</hi>‐12, <hi rend="fc">IFN</hi>‐γ and <hi rend="fc">TNF</hi>‐α in peri‐implant crevicular fluid (<hi rend="fc">PICF</hi>) and saliva from patients with peri‐implant disease.</p>
Methods
<p>Twenty two total edentulous patients were divided into two groups: Mucositis (<hi rend="fc">MU</hi>) patients with bone loss around the implants until the first thread and pocket depth ≤3 mm, and Peri‐implantitis (<hi rend="fc">PI</hi>) patients with at least one implant with bone loss around two or more threads and pocket depth ≥4 mm. The clinical parameters evaluated were probing pocket depth, bleeding on probing, and percentage of plaque. <hi rend="fc">PICF</hi> samples were collected from <hi rend="fc">MU</hi> sites, and from shallow (<hi rend="fc">SPI</hi>) and deep (<hi rend="fc">DPI</hi>) sites in <hi rend="fc">PI</hi>. Unstimulated whole and parotid duct saliva was collected from all patients. The cytokines were measured by a multiplexed immunoassay.</p>
Results
<p><hi rend="fc">PI</hi> patients had a higher percentage of plaque compared with <hi rend="fc">MU</hi> (<hi rend="italic">P</hi> = 0.02). <hi rend="fc">MU</hi> sites had lower pocket depth compared to <hi rend="fc">SPI</hi> (<hi rend="italic">P</hi> = 0.001) and to <hi rend="fc">DPI</hi> (<hi rend="italic">P</hi> ≤ 0.001). In <hi rend="fc">PICF</hi>, the levels of <hi rend="fc">IL</hi>‐1β were significantly higher in <hi rend="fc">SPI</hi> sites compared to <hi rend="fc">MU</hi> (<hi rend="italic">P</hi> = 0.03). In the saliva from parotid, <hi rend="fc">IL</hi>‐8 and <hi rend="fc">IL</hi>‐12 were significantly higher in patients with <hi rend="fc">PI</hi> (<hi rend="italic">P</hi> = 0.04).</p>
Conclusion
<p>Elevated levels of <hi rend="fc">IL</hi>‐1β in <hi rend="fc">PICF</hi> seem to be a characteristic trait of patients with peri‐implantitis. The parotid duct saliva showed a significant increase in expression of <hi rend="fc">IL</hi>‐8, which might be related to a systemic response.</p></abstract><textClass><keywords><term xml:id="clr12052-kwd-0001">cytokine</term><term xml:id="clr12052-kwd-0002">dental implants</term><term xml:id="clr12052-kwd-0003"><hi rend="fc">IL</hi>‐1β</term><term xml:id="clr12052-kwd-0004">mucositis</term><term xml:id="clr12052-kwd-0005">peri‐implantitis</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="clr12052" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0501</doi><issn type="print">0905-7161</issn><issn type="electronic">1600-0501</issn><idGroup><id type="product" value="CLR"></id></idGroup><titleGroup><title sort="CLINICAL ORAL IMPLANTS RESEARCH" type="main">Clinical Oral Implants Research</title><title type="short">Clin. Oral Impl. Res.</title></titleGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley">10.1111/clr.2014.25.issue-2</doi><copyright ownership="publisher">Copyright © 2014 John Wiley & Sons Ltd</copyright><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2014-02">February 2014</coverDate></publicationMeta><publicationMeta level="unit" position="270" status="forIssue" type="article"><doi>10.1111/clr.12052</doi><idGroup><id type="unit" value="CLR12052"></id></idGroup><countGroup><count number="5" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">© 2012 John Wiley & Sons A/S</copyright><eventGroup><event date="2012-09-08" type="manuscriptAccepted"></event><event agent="SPS" date="2012-09-23" type="xmlCreated"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.2.9 mode:FullText" date="2014-01-09"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-10-29"></event><event type="firstOnline" date="2012-10-29"></event><event type="publishedOnlineFinalForm" date="2014-01-09"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-06"></event></eventGroup><numberingGroup><numbering type="pageFirst">e68</numbering><numbering type="pageLast">e72</numbering></numberingGroup><correspondenceTo><lineatedText><line><b>Corresponding author:</b></line><line><i>Carlos Marcelo Figueredo</i></line><line>Department of Periodontology, Faculty of Odontology</line><line>Rio de Janeiro State University</line><line>Boulevard 28 de Setembro 157 ‐ Pavilhão de Pesquisa ‐Vila Isabel ‐ 20551‐030 Rio de Janeiro, Brasil</line><line>Tel./Fax: +55 21 2868 8642</line><line>e‐mail: <email>cmfigueredo@hotmail.com</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="clr12052-cit-1001"><author><familyName>Fonseca</familyName> <givenNames>FJPO</givenNames></author>, <author><familyName>Moraes Junior</familyName> <givenNames>M</givenNames></author>, <author><familyName>Lourenço</familyName> <givenNames>EJV</givenNames></author>, <author><familyName>Teles</familyName> <givenNames>DM</givenNames></author>, <author><familyName>Figueredo</familyName> <givenNames>CM</givenNames></author>. <articleTitle>Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease</articleTitle>. <journalTitle>Clin. Oral Impl. Res.</journalTitle> <vol>25</vol>, <pubYear year="2014">2014</pubYear>; <pageFirst>e68</pageFirst>–<pageLast>e72</pageLast>.</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:CLR.CLR12052.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease</title><title type="shortAuthors">Fonseca et al</title></titleGroup><creators><creator affiliationRef="#clr12052-aff-0001" creatorRole="author" xml:id="clr12052-cr-0001"><personName><givenNames>Fabio José Persegani Olivar</givenNames> <familyName>Fonseca</familyName></personName></creator><creator affiliationRef="#clr12052-aff-0001" creatorRole="author" xml:id="clr12052-cr-0002"><personName><givenNames>Mario Moraes</givenNames> <familyName>Junior</familyName></personName></creator><creator affiliationRef="#clr12052-aff-0001" creatorRole="author" xml:id="clr12052-cr-0003"><personName><givenNames>Eduardo José Veras</givenNames> <familyName>Lourenço</familyName></personName></creator><creator affiliationRef="#clr12052-aff-0001" creatorRole="author" xml:id="clr12052-cr-0004"><personName><givenNames>Daniel</givenNames> <familyNamePrefix>de</familyNamePrefix> <familyName>Moraes Teles</familyName></personName></creator><creator affiliationRef="#clr12052-aff-0002" corresponding="yes" creatorRole="author" xml:id="clr12052-cr-0005"><personName><givenNames>Carlos Marcelo</givenNames> <familyName>Figueredo</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="BR" type="organization" xml:id="clr12052-aff-0001"><orgDiv>Faculty of Odontology, Department of Prosthodontics</orgDiv> <orgName>Rio de Janeiro State University</orgName> <address><city>Rio de Janeiro</city> <country>Brazil</country></address></affiliation><affiliation countryCode="BR" type="organization" xml:id="clr12052-aff-0002"><orgDiv>Faculty of Odontology, Department of Periodontology</orgDiv> <orgName>Rio de Janeiro State University</orgName> <address><city>Rio de Janeiro</city> <country>Brazil</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="clr12052-kwd-0001">cytokine</keyword><keyword xml:id="clr12052-kwd-0002">dental implants</keyword><keyword xml:id="clr12052-kwd-0003"><fc>IL</fc>‐1β</keyword><keyword xml:id="clr12052-kwd-0004">mucositis</keyword><keyword xml:id="clr12052-kwd-0005">peri‐implantitis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:id="clr12052-abs-0001"><title type="main">Abstract</title><section xml:id="clr12052-sec-0001"><title type="main">Objective</title><p>This study aimed to measure the levels of <fc>GM</fc>‐<fc>CSF</fc>,<fc> IL</fc>‐1β, <fc>IL</fc>‐2, <fc>IL</fc>‐4, <fc>IL</fc>‐5, <fc>IL</fc>‐6, <fc>IL</fc>‐7, <fc>IL</fc>‐8, <fc>IL</fc>‐10, <fc>IL</fc>‐12, <fc>IFN</fc>‐γ and <fc>TNF</fc>‐α in peri‐implant crevicular fluid (<fc>PICF</fc>) and saliva from patients with peri‐implant disease.</p></section><section xml:id="clr12052-sec-0002"><title type="main">Methods</title><p>Twenty two total edentulous patients were divided into two groups: Mucositis (<fc>MU</fc>) patients with bone loss around the implants until the first thread and pocket depth ≤3 mm, and Peri‐implantitis (<fc>PI</fc>) patients with at least one implant with bone loss around two or more threads and pocket depth ≥4 mm. The clinical parameters evaluated were probing pocket depth, bleeding on probing, and percentage of plaque. <fc>PICF</fc> samples were collected from <fc>MU</fc> sites, and from shallow (<fc>SPI</fc>) and deep (<fc>DPI</fc>) sites in <fc>PI</fc>. Unstimulated whole and parotid duct saliva was collected from all patients. The cytokines were measured by a multiplexed immunoassay.</p></section><section xml:id="clr12052-sec-0003"><title type="main">Results</title><p><fc>PI</fc> patients had a higher percentage of plaque compared with <fc>MU</fc> (<i>P</i> = 0.02). <fc>MU</fc> sites had lower pocket depth compared to <fc>SPI</fc> (<i>P</i> = 0.001) and to <fc>DPI</fc> (<i>P</i> ≤ 0.001). In <fc>PICF</fc>, the levels of <fc>IL</fc>‐1β were significantly higher in <fc>SPI</fc> sites compared to <fc>MU</fc> (<i>P</i> = 0.03). In the saliva from parotid, <fc>IL</fc>‐8 and <fc>IL</fc>‐12 were significantly higher in patients with <fc>PI</fc> (<i>P</i> = 0.04).</p></section><section xml:id="clr12052-sec-0004"><title type="main">Conclusion</title><p>Elevated levels of <fc>IL</fc>‐1β in <fc>PICF</fc> seem to be a characteristic trait of patients with peri‐implantitis. The parotid duct saliva showed a significant increase in expression of <fc>IL</fc>‐8, which might be related to a systemic response.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease</title></titleInfo><name type="personal"><namePart type="given">Fabio José Persegani Olivar</namePart><namePart type="family">Fonseca</namePart><affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mario Moraes</namePart><namePart type="family">Junior</namePart><affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eduardo José Veras</namePart><namePart type="family">Lourenço</namePart><affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniel</namePart><namePart type="family">de Moraes Teles</namePart><affiliation>Faculty of Odontology, Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlos Marcelo</namePart><namePart type="family">Figueredo</namePart><affiliation>Faculty of Odontology, Department of Periodontology, Rio de Janeiro State University, Rio de Janeiro, Brazil</affiliation><affiliation>Department of Periodontology, Faculty of OdontologyRio de Janeiro State UniversityBoulevard 28 de Setembro 157 ‐ Pavilhão de Pesquisa ‐Vila Isabel ‐ 20551‐030 Rio de Janeiro, BrasilTel./Fax: +55 21 2868 8642e‐mail:</affiliation><affiliation>E-mail: cmfigueredo@hotmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-02</dateIssued><dateCreated encoding="w3cdtf">2012-09-23</dateCreated><dateValid encoding="w3cdtf">2012-09-08</dateValid><edition>Fonseca FJPO, Moraes Junior M, Lourenço EJV, Teles DM, Figueredo CM. Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease. Clin. Oral Impl. Res. 25, 2014; e68–e72.</edition><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>This study aimed to measure the levels of GM‐CSF, IL‐1β, IL‐2, IL‐4, IL‐5, IL‐6, IL‐7, IL‐8, IL‐10, IL‐12, IFN‐γ and TNF‐α in peri‐implant crevicular fluid (PICF) and saliva from patients with peri‐implant disease.</abstract><abstract>Twenty two total edentulous patients were divided into two groups: Mucositis (MU) patients with bone loss around the implants until the first thread and pocket depth ≤3 mm, and Peri‐implantitis (PI) patients with at least one implant with bone loss around two or more threads and pocket depth ≥4 mm. The clinical parameters evaluated were probing pocket depth, bleeding on probing, and percentage of plaque. PICF samples were collected from MU sites, and from shallow (SPI) and deep (DPI) sites in PI. Unstimulated whole and parotid duct saliva was collected from all patients. The cytokines were measured by a multiplexed immunoassay.</abstract><abstract>PI patients had a higher percentage of plaque compared with MU (P = 0.02). MU sites had lower pocket depth compared to SPI (P = 0.001) and to DPI (P ≤ 0.001). In PICF, the levels of IL‐1β were significantly higher in SPI sites compared to MU (P = 0.03). In the saliva from parotid, IL‐8 and IL‐12 were significantly higher in patients with PI (P = 0.04).</abstract><abstract>Elevated levels of IL‐1β in PICF seem to be a characteristic trait of patients with peri‐implantitis. The parotid duct saliva showed a significant increase in expression of IL‐8, which might be related to a systemic response.</abstract><subject><genre>keywords</genre><topic>cytokine</topic><topic>dental implants</topic><topic>IL‐1β</topic><topic>mucositis</topic><topic>peri‐implantitis</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Oral Implants Research</title></titleInfo><titleInfo type="abbreviated"><title>Clin. Oral Impl. Res.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0905-7161</identifier><identifier type="eISSN">1600-0501</identifier><identifier type="DOI">10.1111/(ISSN)1600-0501</identifier><identifier type="PublisherID">CLR</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>e68</start><end>e72</end><total>5</total></extent></part></relatedItem><identifier type="istex">9098739419F81602C027659FC111A244C711CABE</identifier><identifier type="ark">ark:/67375/WNG-X1Q88RZ4-C</identifier><identifier type="DOI">10.1111/clr.12052</identifier><identifier type="ArticleID">CLR12052</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2014 John Wiley & Sons Ltd© 2012 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/9098739419F81602C027659FC111A244C711CABE/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004822 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 004822 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:9098739419F81602C027659FC111A244C711CABE
|texte= Cytokines expression in saliva and peri‐implant crevicular fluid of patients with peri‐implant disease
}}
| This area was generated with Dilib version V0.6.32. |  |