Treatment of peri‐implantitis by local delivery of tetracycline
Identifieur interne : 004386 ( Istex/Corpus ); précédent : 004385; suivant : 004387Treatment of peri‐implantitis by local delivery of tetracycline
Auteurs : Andrea Mombelli ; Andreas Feloutzis ; Urs Br Gger ; Niklaus P. LangSource :
- Clinical Oral Implants Research [ 0905-7161 ] ; 2001-08.
English descriptors
- KwdEn :
- Actinobacillus actinomycetemcomitans, Actinomyces naeslundii, Actinomycetemcomitans, Anaerobic, Anaerobic rods, Bacterial contamination, Bacterial morphotypes, Bacteroides forsythus, Baseline, Bone density, Campylobacter rectus, Clin, Clinical outcome, Clinical parameters, Corrodens, Cultivable counts, Deepest site, Densitometric image analysis, Dental medicine, Digital image processing, Direct contact, Edentulous patients, Eikenella corrodens, Forsythus, Full body screws, Gingivalis, Impl, Implant, Implant score, Implant shoulder, Implant surface, Implant surfaces, Implants research, Lang, Liberation locale, Local delivery, Longitudinal, Longitudinal changes, Longitudinal development, Metres cliniques, Microbiological, Microbiological parameters, Microbiological procedures, Microorganism, Mombelli, Mpli, Oral impl, Other subjects, Periimplantitis, Periodontal, Periodontal research, Plaque index, Pocket depth, Polymeric tetracycline, Porphyromonas gingivalis, Positive effect, Positive values, Present study, Radiograph, Radiographic evidence, Radiological effects, Radiological results, Rectus, Target microorganisms, Tetracycline, Total cultivable counts, Vertical dimensions.
- Teeft :
- Actinobacillus actinomycetemcomitans, Actinomyces naeslundii, Actinomycetemcomitans, Anaerobic, Anaerobic rods, Bacterial contamination, Bacterial morphotypes, Bacteroides forsythus, Baseline, Bone density, Campylobacter rectus, Clin, Clinical outcome, Clinical parameters, Corrodens, Cultivable counts, Deepest site, Densitometric image analysis, Dental medicine, Digital image processing, Direct contact, Edentulous patients, Eikenella corrodens, Forsythus, Full body screws, Gingivalis, Impl, Implant, Implant score, Implant shoulder, Implant surface, Implant surfaces, Implants research, Lang, Liberation locale, Local delivery, Longitudinal, Longitudinal changes, Longitudinal development, Metres cliniques, Microbiological, Microbiological parameters, Microbiological procedures, Microorganism, Mombelli, Mpli, Oral impl, Other subjects, Periimplantitis, Periodontal, Periodontal research, Plaque index, Pocket depth, Polymeric tetracycline, Porphyromonas gingivalis, Positive effect, Positive values, Present study, Radiograph, Radiographic evidence, Radiological effects, Radiological results, Rectus, Target microorganisms, Tetracycline, Total cultivable counts, Vertical dimensions.
Abstract
Abstract: The purpose of this study was to investigate the clinical, microbiological and radiological effects of peri‐implantitis therapy by local delivery of tetracycline. In 25 partially edentulous patients, 30 implants with radiographic evidence of circumferential bone loss, and peri‐implant probing depths ≥5 mm were treated with polymeric tetracycline HCl‐containing fibers. Clinical and microbial parameters were recorded at baseline, and 1, 3, 6, and 12 months (M) after treatment. Standardized radiographs were obtained at baseline, M3, and one year after treatment. Two patients were discontinued from the study after 180 days because of persisting active peri‐implantitis with pus formation. The remaining subjects showed a significant decrease of mean peri‐implant probing depth from 6.0 to 4.1 mm (M1, P<0.001), which was maintained over 12 months. In comparison to baseline, the bleeding tendency was significantly reduced after one month, and thereafter (P<0.001). No significant recession of the mucosal margin was noted. The radiologically determined distance from the shoulder of the implant to the bottom of the bony defect decreased slightly, but not significantly, from 5.2 to 4.9 mm. At M1, M3 and M6, mean total anaerobic cultivable bacterial counts were significantly lower than at baseline (P<0.001). A significant decrease in frequency of detection was noted for Prevotella intermedia/nigrescens, Fusobacterium sp., Bacteroides forsythus, and Campylobacter rectus (P<0.01). Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Eikenella corrodens had very low baseline frequencies that could not be significantly suppressed further.
Url:
DOI: 10.1034/j.1600-0501.2001.012004287.x
Links to Exploration step
ISTEX:88A2FE878CD6992FEAC118E763CE944D1151BD61Le document en format XML
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Lang</name><affiliation><mods:affiliation>School of Dental Medicine, University of Berne, Berne, Switzerland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Oral Implants Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="ISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><imprint><biblScope unit="vol">12</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="287">287</biblScope><biblScope unit="page" to="294">294</biblScope><biblScope unit="page-count">8</biblScope><publisher>Munksgaard International Publishers</publisher><pubPlace>Copenhagen</pubPlace><date type="published" when="2001-08">2001-08</date></imprint><idno type="ISSN">0905-7161</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0905-7161</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actinobacillus 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actinomycetemcomitans</term><term>Actinomyces naeslundii</term><term>Actinomycetemcomitans</term><term>Anaerobic</term><term>Anaerobic rods</term><term>Bacterial contamination</term><term>Bacterial morphotypes</term><term>Bacteroides forsythus</term><term>Baseline</term><term>Bone density</term><term>Campylobacter rectus</term><term>Clin</term><term>Clinical outcome</term><term>Clinical parameters</term><term>Corrodens</term><term>Cultivable counts</term><term>Deepest site</term><term>Densitometric image analysis</term><term>Dental medicine</term><term>Digital image processing</term><term>Direct contact</term><term>Edentulous patients</term><term>Eikenella corrodens</term><term>Forsythus</term><term>Full body screws</term><term>Gingivalis</term><term>Impl</term><term>Implant</term><term>Implant score</term><term>Implant shoulder</term><term>Implant surface</term><term>Implant surfaces</term><term>Implants research</term><term>Lang</term><term>Liberation locale</term><term>Local delivery</term><term>Longitudinal</term><term>Longitudinal changes</term><term>Longitudinal development</term><term>Metres cliniques</term><term>Microbiological</term><term>Microbiological parameters</term><term>Microbiological procedures</term><term>Microorganism</term><term>Mombelli</term><term>Mpli</term><term>Oral impl</term><term>Other subjects</term><term>Periimplantitis</term><term>Periodontal</term><term>Periodontal research</term><term>Plaque index</term><term>Pocket depth</term><term>Polymeric tetracycline</term><term>Porphyromonas gingivalis</term><term>Positive effect</term><term>Positive values</term><term>Present study</term><term>Radiograph</term><term>Radiographic evidence</term><term>Radiological effects</term><term>Radiological results</term><term>Rectus</term><term>Target microorganisms</term><term>Tetracycline</term><term>Total cultivable counts</term><term>Vertical dimensions</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Abstract: The purpose of this study was to investigate the clinical, microbiological and radiological effects of peri‐implantitis therapy by local delivery of tetracycline. In 25 partially edentulous patients, 30 implants with radiographic evidence of circumferential bone loss, and peri‐implant probing depths ≥5 mm were treated with polymeric tetracycline HCl‐containing fibers. Clinical and microbial parameters were recorded at baseline, and 1, 3, 6, and 12 months (M) after treatment. Standardized radiographs were obtained at baseline, M3, and one year after treatment. Two patients were discontinued from the study after 180 days because of persisting active peri‐implantitis with pus formation. The remaining subjects showed a significant decrease of mean peri‐implant probing depth from 6.0 to 4.1 mm (M1, P<0.001), which was maintained over 12 months. In comparison to baseline, the bleeding tendency was significantly reduced after one month, and thereafter (P<0.001). No significant recession of the mucosal margin was noted. The radiologically determined distance from the shoulder of the implant to the bottom of the bony defect decreased slightly, but not significantly, from 5.2 to 4.9 mm. At M1, M3 and M6, mean total anaerobic cultivable bacterial counts were significantly lower than at baseline (P<0.001). A significant decrease in frequency of detection was noted for Prevotella intermedia/nigrescens, Fusobacterium sp., Bacteroides forsythus, and Campylobacter rectus (P<0.01). Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Eikenella corrodens had very low baseline frequencies that could not be significantly suppressed further.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>implant</json:string><json:string>mombelli</json:string><json:string>baseline</json:string><json:string>microbiological</json:string><json:string>tetracycline</json:string><json:string>gingivalis</json:string><json:string>clin</json:string><json:string>impl</json:string><json:string>forsythus</json:string><json:string>rectus</json:string><json:string>oral impl</json:string><json:string>radiograph</json:string><json:string>mpli</json:string><json:string>periodontal</json:string><json:string>periimplantitis</json:string><json:string>actinomycetemcomitans</json:string><json:string>corrodens</json:string><json:string>local delivery</json:string><json:string>implants research</json:string><json:string>microbiological parameters</json:string><json:string>longitudinal development</json:string><json:string>target microorganisms</json:string><json:string>implant surfaces</json:string><json:string>lang</json:string><json:string>present study</json:string><json:string>clinical parameters</json:string><json:string>longitudinal</json:string><json:string>microorganism</json:string><json:string>anaerobic</json:string><json:string>longitudinal changes</json:string><json:string>bacteroides forsythus</json:string><json:string>bone density</json:string><json:string>positive effect</json:string><json:string>anaerobic rods</json:string><json:string>eikenella corrodens</json:string><json:string>dental medicine</json:string><json:string>campylobacter rectus</json:string><json:string>positive values</json:string><json:string>implant shoulder</json:string><json:string>porphyromonas gingivalis</json:string><json:string>implant score</json:string><json:string>total cultivable counts</json:string><json:string>microbiological procedures</json:string><json:string>pocket depth</json:string><json:string>actinomyces naeslundii</json:string><json:string>radiographic evidence</json:string><json:string>plaque index</json:string><json:string>polymeric tetracycline</json:string><json:string>full body screws</json:string><json:string>deepest site</json:string><json:string>vertical dimensions</json:string><json:string>other subjects</json:string><json:string>edentulous patients</json:string><json:string>radiological effects</json:string><json:string>densitometric image analysis</json:string><json:string>cultivable counts</json:string><json:string>bacterial morphotypes</json:string><json:string>clinical outcome</json:string><json:string>implant surface</json:string><json:string>radiological results</json:string><json:string>bacterial contamination</json:string><json:string>liberation locale</json:string><json:string>metres cliniques</json:string><json:string>actinobacillus actinomycetemcomitans</json:string><json:string>direct contact</json:string><json:string>digital image processing</json:string><json:string>periodontal research</json:string></teeft></keywords><author><json:item><name>Andrea Mombelli</name><affiliations><json:string>School of Dental Medicine, University of Geneva, Geneva</json:string></affiliations></json:item><json:item><name>Andreas Feloutzis</name><affiliations><json:string>School of Dental Medicine, University of Berne, Berne, Switzerland</json:string></affiliations></json:item><json:item><name>Urs Brägger</name><affiliations><json:string>School of Dental Medicine, University of Berne, Berne, Switzerland</json:string></affiliations></json:item><json:item><name>Niklaus P. Lang</name><affiliations><json:string>School of Dental Medicine, University of Berne, Berne, Switzerland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Peri‐implantitis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tetracycline</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>microbiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>infection</value></json:item></subject><articleId><json:string>CLR120401</json:string></articleId><arkIstex>ark:/67375/WNG-J5KVLLGF-R</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Abstract: The purpose of this study was to investigate the clinical, microbiological and radiological effects of peri‐implantitis therapy by local delivery of tetracycline. In 25 partially edentulous patients, 30 implants with radiographic evidence of circumferential bone loss, and peri‐implant probing depths ≥5 mm were treated with polymeric tetracycline HCl‐containing fibers. Clinical and microbial parameters were recorded at baseline, and 1, 3, 6, and 12 months (M) after treatment. Standardized radiographs were obtained at baseline, M3, and one year after treatment. Two patients were discontinued from the study after 180 days because of persisting active peri‐implantitis with pus formation. The remaining subjects showed a significant decrease of mean peri‐implant probing depth from 6.0 to 4.1 mm (M1, P>0.001), which was maintained over 12 months. In comparison to baseline, the bleeding tendency was significantly reduced after one month, and thereafter (P>0.001). No significant recession of the mucosal margin was noted. The radiologically determined distance from the shoulder of the implant to the bottom of the bony defect decreased slightly, but not significantly, from 5.2 to 4.9 mm. At M1, M3 and M6, mean total anaerobic cultivable bacterial counts were significantly lower than at baseline (P>0.001). A significant decrease in frequency of detection was noted for Prevotella intermedia/nigrescens, Fusobacterium sp., Bacteroides forsythus, and Campylobacter rectus (P>0.01). Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Eikenella corrodens had very low baseline frequencies that could not be significantly suppressed further.</abstract><qualityIndicators><refBibsNative>true</refBibsNative><abstractWordCount>232</abstractWordCount><abstractCharCount>1673</abstractCharCount><keywordCount>4</keywordCount><score>9.023</score><pdfWordCount>4239</pdfWordCount><pdfCharCount>29075</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>595 x 794 pts</pdfPageSize></qualityIndicators><title>Treatment of peri‐implantitis by local delivery of tetracycline</title><pmid><json:string>11488856</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Clinical Oral Implants Research</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0501</json:string></doi><issn><json:string>0905-7161</json:string></issn><eissn><json:string>1600-0501</json:string></eissn><publisherId><json:string>CLR</json:string></publisherId><volume>12</volume><issue>4</issue><pages><first>287</first><last>294</last><total>8</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2001</json:string></date><geogName></geogName><orgName><json:string>University of Berne</json:string><json:string>University of Geneva School of Dental Medicine</json:string><json:string>Switzerland Correspondence</json:string><json:string>ALZA Corporation, Palo Alto</json:string><json:string>Switzerland Tel</json:string><json:string>Foundation</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Felouzis</json:string><json:string>Andrea Mombelli</json:string><json:string>Niklaus P. Lang</json:string><json:string>Dr</json:string><json:string>Marianne Weibel</json:string><json:string>Regula Hirschi-Jordi</json:string><json:string>Geneva Andreas</json:string></persName><placeName><json:string>USA</json:string><json:string>OH</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Fourmousis et al. 1994a</json:string><json:string>Syed et al. 1980</json:string><json:string>Rüttiman et al. 1986</json:string><json:string>Keller et al. (1998)</json:string><json:string>Mombelli et al</json:string><json:string>Mombelli et al. 1987</json:string><json:string>Ericsson et al. 1996</json:string><json:string>Brägger et al. 1988</json:string><json:string>Mombelli et al. 1997</json:string><json:string>Mombelli & Lang 1992</json:string><json:string>Fourmousis et al. 1994b</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-J5KVLLGF-R</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - engineering, biomedical</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Oral Surgery</json:string></scopus></categories><publicationDate>2001</publicationDate><copyrightDate>2001</copyrightDate><doi><json:string>10.1034/j.1600-0501.2001.012004287.x</json:string></doi><id>88A2FE878CD6992FEAC118E763CE944D1151BD61</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/88A2FE878CD6992FEAC118E763CE944D1151BD61/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/88A2FE878CD6992FEAC118E763CE944D1151BD61/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/88A2FE878CD6992FEAC118E763CE944D1151BD61/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Treatment of peri‐implantitis by local delivery of tetracycline</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Munksgaard International Publishers</publisher><pubPlace>Copenhagen</pubPlace><date type="published" when="2001-08"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Treatment of peri‐implantitis by local delivery of tetracycline</title><title level="a" type="sub">Clinical, microbiological and radiological results</title><title level="a" type="short">Treatment of peri‐implantitis</title><author xml:id="author-0000"><persName><forename type="first">Andrea</forename><surname>Mombelli</surname></persName><affiliation>School of Dental Medicine, University of Geneva, Geneva</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Andreas</forename><surname>Feloutzis</surname></persName><affiliation>School of Dental Medicine, University of Berne, Berne, Switzerland<address><country key="CH"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Urs</forename><surname>Brägger</surname></persName><affiliation>School of Dental Medicine, University of Berne, Berne, Switzerland<address><country key="CH"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Niklaus P.</forename><surname>Lang</surname></persName><affiliation>School of Dental Medicine, University of Berne, Berne, Switzerland<address><country key="CH"></country></address></affiliation></author><idno type="istex">88A2FE878CD6992FEAC118E763CE944D1151BD61</idno><idno type="ark">ark:/67375/WNG-J5KVLLGF-R</idno><idno type="DOI">10.1034/j.1600-0501.2001.012004287.x</idno><idno type="unit">CLR120401</idno><idno type="supplier">clr10o640</idno><idno type="toTypesetVersion">file:CLR.CLR120401.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Oral Implants Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="pISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><idno type="book-DOI">10.1111/(ISSN)1600-0501</idno><idno type="book-part-DOI">10.1111/clr.2001.12.issue-4</idno><idno type="product">CLR</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">12</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="287">287</biblScope><biblScope unit="page" to="294">294</biblScope><biblScope unit="page-count">8</biblScope><publisher>Munksgaard International Publishers</publisher><pubPlace>Copenhagen</pubPlace><date type="published" when="2001-08"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Abstract:</hi> The purpose of this study was to investigate the clinical, microbiological and radiological effects of peri‐implantitis therapy by local delivery of tetracycline. In 25 partially edentulous patients, 30 implants with radiographic evidence of circumferential bone loss, and peri‐implant probing depths ≥5 mm were treated with polymeric tetracycline HCl‐containing fibers. Clinical and microbial parameters were recorded at baseline, and 1, 3, 6, and 12 months (M) after treatment. Standardized radiographs were obtained at baseline, M3, and one year after treatment. Two patients were discontinued from the study after 180 days because of persisting active peri‐implantitis with pus formation. The remaining subjects showed a significant decrease of mean peri‐implant probing depth from 6.0 to 4.1 mm (M1, <hi rend="italic">P</hi><0.001), which was maintained over 12 months. In comparison to baseline, the bleeding tendency was significantly reduced after one month, and thereafter (<hi rend="italic">P</hi><0.001). No significant recession of the mucosal margin was noted. The radiologically determined distance from the shoulder of the implant to the bottom of the bony defect decreased slightly, but not significantly, from 5.2 to 4.9 mm. At M1, M3 and M6, mean total anaerobic cultivable bacterial counts were significantly lower than at baseline (<hi rend="italic">P</hi><0.001). A significant decrease in frequency of detection was noted for <hi rend="italic">Prevotella intermedia/nigrescens</hi>, <hi rend="italic">Fusobacterium</hi> sp., <hi rend="italic">Bacteroides forsythus,</hi> and <hi rend="italic">Campylobacter rectus</hi> (<hi rend="italic">P</hi><0.01). <hi rend="italic">Actinobacillus actinomycetemcomitans</hi>, <hi rend="italic">Porphyromonas gingivalis</hi>, and <hi rend="italic">Eikenella corrodens</hi> had very low baseline frequencies that could not be significantly suppressed further.</p><p>In conclusion, therapy of peri‐implantitis by local delivery of tetracycline had a positive effect on clinical and microbiological parameters.</p></abstract><abstract xml:lang="fr" style="main"><head>Résumé</head><p>Le but de cette étude a été d’analyser les effets cliniques, microbiologiques et radiologiques du traitement de la paroïmplantite par libération locale de tétracycline. Chez 25 patients partiellement édentés, trente implants avec une évidence radiologique de perte osseuse circonférencielle et des profondeurs au sondage autour de l’implant ≥5 mm ont été traités par des fibres contenant du HCL tétracycline polymérique. Les paramètres cliniques et microbiologiques ont été relevés lors de l’examen initial et après 1, 3, 6 et 12 mois (M) après le traitement. Des radiographies standards ont été obtenues lors de l’examen initial, à M3 et M12. Deux patients ont dû arrêter cette étude après 180 jours parce qu’une paroïmplantite persistante et active avec formation de pus avait été observée. Les sujets restants ont montré une diminution significative de la profondeur au sondage paroïmplantaire de 6.0 à 4.1 mm (M1: <hi rend="italic">P</hi><0.001) qui a été maintenue jusqu’à M12. En comparaison avec M0, la tendance au saignement était significativement réduite au M1 et après (<hi rend="italic">P</hi><0.001). Aucune récession significative de la muqueuse marginale n’a été notée. La distance déterminée par radiographie de l’épaule de l’imlant jusqu’au bas de la lésion osseuse diminuait faiblement mais pas significativement de 5.2 à 4.9 mm. A M1, M3 et M6 les comptages bactériens cultivables anaéraobies totaux étaient significativement inférieurs à ceux observés à M0 (<hi rend="italic">P</hi><0.001). Une diminution significative dans la fréquence de détection a été notée pour <hi rend="italic">Prevotella intermedia/nigrescens, Fusobacterium</hi> sp., <hi rend="italic">Bacteroides forsythus</hi> et <hi rend="italic">Campylobacter rectus</hi> (<hi rend="italic">P</hi><0.01). <hi rend="italic">Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis</hi> et <hi rend="italic">Eikenella corrodens</hi> se préentaient a de très basses fréquences au M0 qui n’ont pas pûêtre significativement supprimées par après. Le traitement de la paroïmplantite par libération locale de tétracycline a donc un effet positif tant sur les paramètres cliniques que microbiologiques.</p></abstract><abstract xml:lang="de" style="main"><head>Zusammenfassung</head><p>Es war das Ziel dieser Studie, die klinischen, mikrobiologischen und radiologischen Auswirkungen der Periimplantitistherapie mittels lokaler Applikation von Tetrazyklin zu untersuchen. Bei 25 Patienten wurden 30 Implantate, welche radiologisch sichtbaren zirkulären Knochenverlust und periimplantäre Sondierungstiefen von ≥5 mm aufwiesen, mit Fasern, welche polimeres Tetrazyklin‐HCI enthielten, behandelt. Klinische und mikrobiologische Parameter wurden bei der Ausgangsuntersuchung und nach 1, 3, 6 und 12 Monaten (M) nach der Behandlung aufgenommen. Standardisierte Röntgenbilder wurden bei der Ausgangsuntersuchung, bei M3 und ein Jahr nach der Behandlung angefertigt. Zwei Patienten mussten nach 180 Tagen wegen persistierender Periimplantitis mit Pusbildung aus der Untersuchung ausgeschlossen werden. Die verbliebenen Probanden zeigten eine signifikante Reduktion der mittleren periimplantären Sondierungstiefen von 6.0 auf 4.1 mm (M1, <hi rend="italic">P</hi><0.001), welche über 12 Monate erhalten blieb. Im Vergleich zur Ausgangsuntersuchung zeigte die Blutungstendenz nach einem Monat und auch in der Folge eine signifikante Reduktion (<hi rend="italic">P</hi><0.001). Es wurde keine signifikante Rezession des mukosalen Randes festgestellt. Die radiologisch bestimmte Distanz von der Implantatschulter zum Boden des Knochendefekts nahm von 5.2 auf 4.9 mm leicht, jedoch nicht signifikant ab. Bei M1, M3 und M6 war die mittlere totale Anzahl der kultivierbaren anaeroben Bakterien signifikant tiefer als bei der Ausgangsuntersuchung (<hi rend="italic">P</hi><0.001). Eine signifikante Abnahme in der Entdeckungsfrequenz wurde für <hi rend="italic">Prevotella intermedia/nigrescens, Fusobacterium</hi> sp., <hi rend="italic">Bacteroides forsythus</hi> und <hi rend="italic">Campylobacter rectus</hi> gefunden (<hi rend="italic">P</hi><0.01). <hi rend="italic">Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis</hi> und <hi rend="italic">Eikenella corrodens</hi> wiesen sehr tiefe Entdeckungsfrequenzen bei der Ausgangsuntersuchung auf, welche im Verlauf nicht signifikant weiter reduziert werden konnten. Es wird die Schlussfolgerung gezogen, dass die Behandlung der Periimplantitis mittels lokaler Applikation von Tetrazyklin einen positiven Effekt auf die klinischen und mikrobiologischen Parameter hatte.</p></abstract><abstract xml:lang="es" style="main"><head>Resumen</head><p>El propósito de este estudio fue investigar los efectos clínicos, microbiológicos y radiológicos de la terapia de periimplantitis por medio de liberación de tetraciclina. Se trataron 25 pacientes edéntulos con 30 implantes con evidencia radiográfica de perdida ósea circunferencial y profundidades de sondaje periimplantaria ≥5 mm con fibras conteniendo HCI de tetraciclina polimérica. Se registraron los parámetros clínicos y microbiológicos al inicio y a los 1, 3, 6 y 12 meses (M) tras el tratamiento. Se tomaron radiografias estandarizadas al inicio M3 y un año tras el tratamiento. Dos pacientes se fueron eliminados del estudio después de 180 días a causa de periimplantitis activa persistente con formación de pus. Los sujetos restantes mostraron una disminución significativa de la profundidad de sondaje media de 6.0 a 4.1 mm (M1, <hi rend="italic">P</hi><0.001), la cual se mantuvo a lo largo de 12 meses. En comparación con el inicio la tendencia al sangrado fue reducida significativamente tras un mes y posteriormente (<hi rend="italic">P</hi><0.001). No se notó recesión significativa del margen mucoso. La distancia determinada radiologicamente desde el hombro del implante al fondo del defecto óseo disminuyó ligeramente, pero no significativamente de 5.2 a 4.9 mm. Los recuentos bacterianos cultivables anaerobios totales medios en M1, M3 y M6 fueron significativamente menores que al inicio (<hi rend="italic">P</hi><0.001). Se notó una disminución significativa en la frecuencia de detección de <hi rend="italic">Prevotella intermedia/nigrescens, Fusobacterium</hi> sp., <hi rend="italic">Bacteroides forsythus,</hi> y <hi rend="italic">Campylobacter rectus</hi> (<hi rend="italic">P</hi><0.01). <hi rend="italic">Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis</hi> y <hi rend="italic">Eikenella corrodens</hi> tuvieron unas frecuencias gingivales muy bajas que no pudieron ser significativamente suprimidas posteriormente. En conclusión la terapia de periimplantitis por liberación local de tetraciclina tiene un efecto positivo en los parámetros clínicos y microbiológicos.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">Peri‐implantitis</term><term xml:id="k2">tetracycline</term><term xml:id="k3">microbiology</term><term xml:id="k4">infection</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/88A2FE878CD6992FEAC118E763CE944D1151BD61/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Munksgaard International Publishers</publisherName><publisherLoc>Copenhagen</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0501</doi><issn type="print">0905-7161</issn><issn type="electronic">1600-0501</issn><idGroup><id type="product" value="CLR"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="CLINICAL ORAL IMPLANTS RESEARCH">Clinical Oral Implants Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="08004"><doi origin="wiley">10.1111/clr.2001.12.issue-4</doi><numberingGroup><numbering type="journalVolume" number="12">12</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2001-08">August 2001</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0028700" status="forIssue"><doi origin="wiley">10.1034/j.1600-0501.2001.012004287.x</doi><idGroup><id type="unit" value="CLR120401"></id><id type="supplier" value="clr10o640"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><eventGroup><event type="firstOnline" date="2001-12-20"></event><event type="publishedOnlineFinalForm" date="2001-12-20"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-04"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="287">287</numbering><numbering type="pageLast" number="294">294</numbering></numberingGroup><correspondenceTo>
<i>Andrea Mombelli,
Prof. Dr. med. dent.</i>,
University of Geneva
School of Dental Medicine
19 rue Barthélemy‐Menn
CH‐1211 Geneva 4
Switzerland
Tel: +41 22 382 91 45
Fax: +41 22 382 99 92
e‐mail: <email>andrea.mombelli@medecine.unige.ch</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CLR.CLR120401.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory><b>Date: </b> Accepted 17 July 2000</unparsedEditorialHistory><countGroup><count type="figureTotal" number="6"></count><count type="tableTotal" number="4"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="12"></count><count type="wordTotal" number="4582"></count><count type="linksPubMed" number="11"></count><count type="linksCrossRef" number="6"></count></countGroup><titleGroup><title type="main">Treatment of peri‐implantitis by local delivery of tetracycline</title><title type="subtitle">Clinical, microbiological and radiological results</title><title type="shortAuthors">Mombelli et al</title><title type="short">Treatment of peri‐implantitis</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Andrea</givenNames><familyName>Mombelli</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>Andreas</givenNames><familyName>Feloutzis</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>Urs</givenNames><familyName>Brägger</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>Niklaus P.</givenNames><familyName>Lang</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>School of Dental Medicine, University of Geneva, Geneva</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="CH"><unparsedAffiliation>School of Dental Medicine, University of Berne, Berne, Switzerland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Peri‐implantitis</keyword><keyword xml:id="k2">tetracycline</keyword><keyword xml:id="k3">microbiology</keyword><keyword xml:id="k4">infection</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Abstract:</b> The purpose of this study was to investigate the clinical, microbiological and radiological effects of peri‐implantitis therapy by local delivery of tetracycline. In 25 partially edentulous patients, 30 implants with radiographic evidence of circumferential bone loss, and peri‐implant probing depths ≥5 mm were treated with polymeric tetracycline HCl‐containing fibers. Clinical and microbial parameters were recorded at baseline, and 1, 3, 6, and 12 months (M) after treatment. Standardized radiographs were obtained at baseline, M3, and one year after treatment. Two patients were discontinued from the study after 180 days because of persisting active peri‐implantitis with pus formation. The remaining subjects showed a significant decrease of mean peri‐implant probing depth from 6.0 to 4.1 mm (M1, <i>P</i><0.001), which was maintained over 12 months. In comparison to baseline, the bleeding tendency was significantly reduced after one month, and thereafter (<i>P</i><0.001). No significant recession of the mucosal margin was noted. The radiologically determined distance from the shoulder of the implant to the bottom of the bony defect decreased slightly, but not significantly, from 5.2 to 4.9 mm. At M1, M3 and M6, mean total anaerobic cultivable bacterial counts were significantly lower than at baseline (<i>P</i><0.001). A significant decrease in frequency of detection was noted for <i>Prevotella intermedia/nigrescens</i>, <i>Fusobacterium</i> sp., <i>Bacteroides forsythus,</i> and <i>Campylobacter rectus</i> (<i>P</i><0.01). <i>Actinobacillus actinomycetemcomitans</i>, <i>Porphyromonas gingivalis</i>, and <i>Eikenella corrodens</i> had very low baseline frequencies that could not be significantly suppressed further.</p><p>In conclusion, therapy of peri‐implantitis by local delivery of tetracycline had a positive effect on clinical and microbiological parameters.</p></abstract><abstract type="main" xml:lang="fr"><title type="main">Résumé</title><p>Le but de cette étude a été d’analyser les effets cliniques, microbiologiques et radiologiques du traitement de la paroïmplantite par libération locale de tétracycline. Chez 25 patients partiellement édentés, trente implants avec une évidence radiologique de perte osseuse circonférencielle et des profondeurs au sondage autour de l’implant ≥5 mm ont été traités par des fibres contenant du HCL tétracycline polymérique. Les paramètres cliniques et microbiologiques ont été relevés lors de l’examen initial et après 1, 3, 6 et 12 mois (M) après le traitement. Des radiographies standards ont été obtenues lors de l’examen initial, à M3 et M12. Deux patients ont dû arrêter cette étude après 180 jours parce qu’une paroïmplantite persistante et active avec formation de pus avait été observée. Les sujets restants ont montré une diminution significative de la profondeur au sondage paroïmplantaire de 6.0 à 4.1 mm (M1: <i>P</i><0.001) qui a été maintenue jusqu’à M12. En comparaison avec M0, la tendance au saignement était significativement réduite au M1 et après (<i>P</i><0.001). Aucune récession significative de la muqueuse marginale n’a été notée. La distance déterminée par radiographie de l’épaule de l’imlant jusqu’au bas de la lésion osseuse diminuait faiblement mais pas significativement de 5.2 à 4.9 mm. A M1, M3 et M6 les comptages bactériens cultivables anaéraobies totaux étaient significativement inférieurs à ceux observés à M0 (<i>P</i><0.001). Une diminution significative dans la fréquence de détection a été notée pour <i>Prevotella intermedia/nigrescens, Fusobacterium</i> sp., <i>Bacteroides forsythus</i> et <i>Campylobacter rectus</i> (<i>P</i><0.01). <i>Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis</i> et <i>Eikenella corrodens</i> se préentaient a de très basses fréquences au M0 qui n’ont pas pûêtre significativement supprimées par après. Le traitement de la paroïmplantite par libération locale de tétracycline a donc un effet positif tant sur les paramètres cliniques que microbiologiques.</p></abstract><abstract type="main" xml:lang="de"><title type="main">Zusammenfassung</title><p>Es war das Ziel dieser Studie, die klinischen, mikrobiologischen und radiologischen Auswirkungen der Periimplantitistherapie mittels lokaler Applikation von Tetrazyklin zu untersuchen. Bei 25 Patienten wurden 30 Implantate, welche radiologisch sichtbaren zirkulären Knochenverlust und periimplantäre Sondierungstiefen von ≥5 mm aufwiesen, mit Fasern, welche polimeres Tetrazyklin‐HCI enthielten, behandelt. Klinische und mikrobiologische Parameter wurden bei der Ausgangsuntersuchung und nach 1, 3, 6 und 12 Monaten (M) nach der Behandlung aufgenommen. Standardisierte Röntgenbilder wurden bei der Ausgangsuntersuchung, bei M3 und ein Jahr nach der Behandlung angefertigt. Zwei Patienten mussten nach 180 Tagen wegen persistierender Periimplantitis mit Pusbildung aus der Untersuchung ausgeschlossen werden. Die verbliebenen Probanden zeigten eine signifikante Reduktion der mittleren periimplantären Sondierungstiefen von 6.0 auf 4.1 mm (M1, <i>P</i><0.001), welche über 12 Monate erhalten blieb. Im Vergleich zur Ausgangsuntersuchung zeigte die Blutungstendenz nach einem Monat und auch in der Folge eine signifikante Reduktion (<i>P</i><0.001). Es wurde keine signifikante Rezession des mukosalen Randes festgestellt. Die radiologisch bestimmte Distanz von der Implantatschulter zum Boden des Knochendefekts nahm von 5.2 auf 4.9 mm leicht, jedoch nicht signifikant ab. Bei M1, M3 und M6 war die mittlere totale Anzahl der kultivierbaren anaeroben Bakterien signifikant tiefer als bei der Ausgangsuntersuchung (<i>P</i><0.001). Eine signifikante Abnahme in der Entdeckungsfrequenz wurde für <i>Prevotella intermedia/nigrescens, Fusobacterium</i> sp., <i>Bacteroides forsythus</i> und <i>Campylobacter rectus</i> gefunden (<i>P</i><0.01). <i>Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis</i> und <i>Eikenella corrodens</i> wiesen sehr tiefe Entdeckungsfrequenzen bei der Ausgangsuntersuchung auf, welche im Verlauf nicht signifikant weiter reduziert werden konnten. Es wird die Schlussfolgerung gezogen, dass die Behandlung der Periimplantitis mittels lokaler Applikation von Tetrazyklin einen positiven Effekt auf die klinischen und mikrobiologischen Parameter hatte.</p></abstract><abstract type="main" xml:lang="es"><title type="main">Resumen</title><p>El propósito de este estudio fue investigar los efectos clínicos, microbiológicos y radiológicos de la terapia de periimplantitis por medio de liberación de tetraciclina. Se trataron 25 pacientes edéntulos con 30 implantes con evidencia radiográfica de perdida ósea circunferencial y profundidades de sondaje periimplantaria ≥5 mm con fibras conteniendo HCI de tetraciclina polimérica. Se registraron los parámetros clínicos y microbiológicos al inicio y a los 1, 3, 6 y 12 meses (M) tras el tratamiento. Se tomaron radiografias estandarizadas al inicio M3 y un año tras el tratamiento. Dos pacientes se fueron eliminados del estudio después de 180 días a causa de periimplantitis activa persistente con formación de pus. Los sujetos restantes mostraron una disminución significativa de la profundidad de sondaje media de 6.0 a 4.1 mm (M1, <i>P</i><0.001), la cual se mantuvo a lo largo de 12 meses. En comparación con el inicio la tendencia al sangrado fue reducida significativamente tras un mes y posteriormente (<i>P</i><0.001). No se notó recesión significativa del margen mucoso. La distancia determinada radiologicamente desde el hombro del implante al fondo del defecto óseo disminuyó ligeramente, pero no significativamente de 5.2 a 4.9 mm. Los recuentos bacterianos cultivables anaerobios totales medios en M1, M3 y M6 fueron significativamente menores que al inicio (<i>P</i><0.001). Se notó una disminución significativa en la frecuencia de detección de <i>Prevotella intermedia/nigrescens, Fusobacterium</i> sp., <i>Bacteroides forsythus,</i> y <i>Campylobacter rectus</i> (<i>P</i><0.01). <i>Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis</i> y <i>Eikenella corrodens</i> tuvieron unas frecuencias gingivales muy bajas que no pudieron ser significativamente suprimidas posteriormente. En conclusión la terapia de periimplantitis por liberación local de tetraciclina tiene un efecto positivo en los parámetros clínicos y microbiológicos.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Treatment of peri‐implantitis by local delivery of tetracycline</title><subTitle>Clinical, microbiological and radiological results</subTitle></titleInfo><titleInfo type="abbreviated" lang="en"><title>Treatment of peri‐implantitis</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Treatment of peri‐implantitis by local delivery of tetracycline</title></titleInfo><name type="personal"><namePart type="given">Andrea</namePart><namePart type="family">Mombelli</namePart><affiliation>School of Dental Medicine, University of Geneva, Geneva</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andreas</namePart><namePart type="family">Feloutzis</namePart><affiliation>School of Dental Medicine, University of Berne, Berne, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Urs</namePart><namePart type="family">Brägger</namePart><affiliation>School of Dental Medicine, University of Berne, Berne, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Niklaus P.</namePart><namePart type="family">Lang</namePart><affiliation>School of Dental Medicine, University of Berne, Berne, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Munksgaard International Publishers</publisher><place><placeTerm type="text">Copenhagen</placeTerm></place><dateIssued encoding="w3cdtf">2001-08</dateIssued><edition>Date: Accepted 17 July 2000</edition><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">6</extent><extent unit="tables">4</extent><extent unit="formulas">0</extent><extent unit="references">12</extent><extent unit="linksCrossRef">6</extent><extent unit="words">4582</extent></physicalDescription><abstract>Abstract: The purpose of this study was to investigate the clinical, microbiological and radiological effects of peri‐implantitis therapy by local delivery of tetracycline. In 25 partially edentulous patients, 30 implants with radiographic evidence of circumferential bone loss, and peri‐implant probing depths ≥5 mm were treated with polymeric tetracycline HCl‐containing fibers. Clinical and microbial parameters were recorded at baseline, and 1, 3, 6, and 12 months (M) after treatment. Standardized radiographs were obtained at baseline, M3, and one year after treatment. Two patients were discontinued from the study after 180 days because of persisting active peri‐implantitis with pus formation. The remaining subjects showed a significant decrease of mean peri‐implant probing depth from 6.0 to 4.1 mm (M1, P<0.001), which was maintained over 12 months. In comparison to baseline, the bleeding tendency was significantly reduced after one month, and thereafter (P<0.001). No significant recession of the mucosal margin was noted. The radiologically determined distance from the shoulder of the implant to the bottom of the bony defect decreased slightly, but not significantly, from 5.2 to 4.9 mm. At M1, M3 and M6, mean total anaerobic cultivable bacterial counts were significantly lower than at baseline (P<0.001). A significant decrease in frequency of detection was noted for Prevotella intermedia/nigrescens, Fusobacterium sp., Bacteroides forsythus, and Campylobacter rectus (P<0.01). Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Eikenella corrodens had very low baseline frequencies that could not be significantly suppressed further.</abstract><abstract>In conclusion, therapy of peri‐implantitis by local delivery of tetracycline had a positive effect on clinical and microbiological parameters.</abstract><abstract lang="fr">Le but de cette étude a été d’analyser les effets cliniques, microbiologiques et radiologiques du traitement de la paroïmplantite par libération locale de tétracycline. Chez 25 patients partiellement édentés, trente implants avec une évidence radiologique de perte osseuse circonférencielle et des profondeurs au sondage autour de l’implant ≥5 mm ont été traités par des fibres contenant du HCL tétracycline polymérique. Les paramètres cliniques et microbiologiques ont été relevés lors de l’examen initial et après 1, 3, 6 et 12 mois (M) après le traitement. Des radiographies standards ont été obtenues lors de l’examen initial, à M3 et M12. Deux patients ont dû arrêter cette étude après 180 jours parce qu’une paroïmplantite persistante et active avec formation de pus avait été observée. Les sujets restants ont montré une diminution significative de la profondeur au sondage paroïmplantaire de 6.0 à 4.1 mm (M1: P<0.001) qui a été maintenue jusqu’à M12. En comparaison avec M0, la tendance au saignement était significativement réduite au M1 et après (P<0.001). Aucune récession significative de la muqueuse marginale n’a été notée. La distance déterminée par radiographie de l’épaule de l’imlant jusqu’au bas de la lésion osseuse diminuait faiblement mais pas significativement de 5.2 à 4.9 mm. A M1, M3 et M6 les comptages bactériens cultivables anaéraobies totaux étaient significativement inférieurs à ceux observés à M0 (P<0.001). Une diminution significative dans la fréquence de détection a été notée pour Prevotella intermedia/nigrescens, Fusobacterium sp., Bacteroides forsythus et Campylobacter rectus (P<0.01). Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis et Eikenella corrodens se préentaient a de très basses fréquences au M0 qui n’ont pas pûêtre significativement supprimées par après. Le traitement de la paroïmplantite par libération locale de tétracycline a donc un effet positif tant sur les paramètres cliniques que microbiologiques.</abstract><abstract lang="de">Es war das Ziel dieser Studie, die klinischen, mikrobiologischen und radiologischen Auswirkungen der Periimplantitistherapie mittels lokaler Applikation von Tetrazyklin zu untersuchen. Bei 25 Patienten wurden 30 Implantate, welche radiologisch sichtbaren zirkulären Knochenverlust und periimplantäre Sondierungstiefen von ≥5 mm aufwiesen, mit Fasern, welche polimeres Tetrazyklin‐HCI enthielten, behandelt. Klinische und mikrobiologische Parameter wurden bei der Ausgangsuntersuchung und nach 1, 3, 6 und 12 Monaten (M) nach der Behandlung aufgenommen. Standardisierte Röntgenbilder wurden bei der Ausgangsuntersuchung, bei M3 und ein Jahr nach der Behandlung angefertigt. Zwei Patienten mussten nach 180 Tagen wegen persistierender Periimplantitis mit Pusbildung aus der Untersuchung ausgeschlossen werden. Die verbliebenen Probanden zeigten eine signifikante Reduktion der mittleren periimplantären Sondierungstiefen von 6.0 auf 4.1 mm (M1, P<0.001), welche über 12 Monate erhalten blieb. Im Vergleich zur Ausgangsuntersuchung zeigte die Blutungstendenz nach einem Monat und auch in der Folge eine signifikante Reduktion (P<0.001). Es wurde keine signifikante Rezession des mukosalen Randes festgestellt. Die radiologisch bestimmte Distanz von der Implantatschulter zum Boden des Knochendefekts nahm von 5.2 auf 4.9 mm leicht, jedoch nicht signifikant ab. Bei M1, M3 und M6 war die mittlere totale Anzahl der kultivierbaren anaeroben Bakterien signifikant tiefer als bei der Ausgangsuntersuchung (P<0.001). Eine signifikante Abnahme in der Entdeckungsfrequenz wurde für Prevotella intermedia/nigrescens, Fusobacterium sp., Bacteroides forsythus und Campylobacter rectus gefunden (P<0.01). Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis und Eikenella corrodens wiesen sehr tiefe Entdeckungsfrequenzen bei der Ausgangsuntersuchung auf, welche im Verlauf nicht signifikant weiter reduziert werden konnten. Es wird die Schlussfolgerung gezogen, dass die Behandlung der Periimplantitis mittels lokaler Applikation von Tetrazyklin einen positiven Effekt auf die klinischen und mikrobiologischen Parameter hatte.</abstract><abstract lang="es">El propósito de este estudio fue investigar los efectos clínicos, microbiológicos y radiológicos de la terapia de periimplantitis por medio de liberación de tetraciclina. Se trataron 25 pacientes edéntulos con 30 implantes con evidencia radiográfica de perdida ósea circunferencial y profundidades de sondaje periimplantaria ≥5 mm con fibras conteniendo HCI de tetraciclina polimérica. Se registraron los parámetros clínicos y microbiológicos al inicio y a los 1, 3, 6 y 12 meses (M) tras el tratamiento. Se tomaron radiografias estandarizadas al inicio M3 y un año tras el tratamiento. Dos pacientes se fueron eliminados del estudio después de 180 días a causa de periimplantitis activa persistente con formación de pus. Los sujetos restantes mostraron una disminución significativa de la profundidad de sondaje media de 6.0 a 4.1 mm (M1, P<0.001), la cual se mantuvo a lo largo de 12 meses. En comparación con el inicio la tendencia al sangrado fue reducida significativamente tras un mes y posteriormente (P<0.001). No se notó recesión significativa del margen mucoso. La distancia determinada radiologicamente desde el hombro del implante al fondo del defecto óseo disminuyó ligeramente, pero no significativamente de 5.2 a 4.9 mm. Los recuentos bacterianos cultivables anaerobios totales medios en M1, M3 y M6 fueron significativamente menores que al inicio (P<0.001). Se notó una disminución significativa en la frecuencia de detección de Prevotella intermedia/nigrescens, Fusobacterium sp., Bacteroides forsythus, y Campylobacter rectus (P<0.01). Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis y Eikenella corrodens tuvieron unas frecuencias gingivales muy bajas que no pudieron ser significativamente suprimidas posteriormente. En conclusión la terapia de periimplantitis por liberación local de tetraciclina tiene un efecto positivo en los parámetros clínicos y microbiológicos.</abstract><subject lang="en"><genre>keywords</genre><topic>Peri‐implantitis</topic><topic>tetracycline</topic><topic>microbiology</topic><topic>infection</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Oral Implants Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0905-7161</identifier><identifier type="eISSN">1600-0501</identifier><identifier type="DOI">10.1111/(ISSN)1600-0501</identifier><identifier type="PublisherID">CLR</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>287</start><end>294</end><total>8</total></extent></part></relatedItem><identifier type="istex">88A2FE878CD6992FEAC118E763CE944D1151BD61</identifier><identifier type="ark">ark:/67375/WNG-J5KVLLGF-R</identifier><identifier type="DOI">10.1034/j.1600-0501.2001.012004287.x</identifier><identifier type="ArticleID">CLR120401</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Munksgaard International Publishers</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/88A2FE878CD6992FEAC118E763CE944D1151BD61/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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