Effect of cyclosporine‐A on orthodontic tooth movement in rats
Identifieur interne : 004262 ( Istex/Corpus ); précédent : 004261; suivant : 004263Effect of cyclosporine‐A on orthodontic tooth movement in rats
Auteurs : Ry Chen ; Mm Fu ; Yk Chih ; Ch Gau ; Cy Chiang ; S. Nieh ; Yd Hsieh ; E. FuSource :
- Orthodontics & Craniofacial Research [ 1601-6335 ] ; 2011-11.
English descriptors
- KwdEn :
- Acid phosphatase, Alveolar bone, Alveolar bone loss, Alveolar process, Animal groups, Animal studies, Apical, Apical zones, Bilateral maxillary, Body weight, Bone formation, Bone miner, Bone mineral metabolism, Bone resorption, Bone surface, Bone volume, Calcif tissue, Chen, Control group, Coronal, Craniofac, Cyclosporin, Cyclosporine, Daily dose, Dental alveoli, Dental alveolus, Dental medicine, Dentofacial, Experimental study, Experimental tooth movement, General anesthesia, General hospital, Gingival, Gingival enlargement, Gingival overgrowth, Harvard school, Higher serum level, Histological, Histological examination, Histological pictures, Histometric analysis, Histometric measurements, Hsieh, Intermolar, Intermolar distance, Intermolar distances, Marrow volume, Maxillary, Maxillary incisors, Maxillary right, Measures analysis, Molar, National defense, Negative control, Nieh, Organ transplantation, Orthod, Orthod craniofac, Orthod dentofacial orthop, Orthodontic, Orthodontic appliance, Orthodontic appliances, Orthodontic force, Orthodontic force application, Orthodontic movement, Orthodontic therapy, Orthodontic tooth movement, Orthodontic treatment, Orthop, Osteoblast differentiation, Osteoclast, Osteoclastic activity, Osteopenia, Other hand, Overgrowth, Present study, Previous study, Rat, Receptor activator, Resorption, Root resorption, Serum level, Serum levels, Spolidorio, Stainless steel ligature wires, Standard errors, Third molars, Tooth movement, Treatment factor.
- Teeft :
- Acid phosphatase, Alveolar bone, Alveolar bone loss, Alveolar process, Animal groups, Animal studies, Apical, Apical zones, Bilateral maxillary, Body weight, Bone formation, Bone miner, Bone mineral metabolism, Bone resorption, Bone surface, Bone volume, Calcif tissue, Chen, Control group, Coronal, Craniofac, Cyclosporin, Cyclosporine, Daily dose, Dental alveoli, Dental alveolus, Dental medicine, Dentofacial, Experimental study, Experimental tooth movement, General anesthesia, General hospital, Gingival, Gingival enlargement, Gingival overgrowth, Harvard school, Higher serum level, Histological, Histological examination, Histological pictures, Histometric analysis, Histometric measurements, Hsieh, Intermolar, Intermolar distance, Intermolar distances, Marrow volume, Maxillary, Maxillary incisors, Maxillary right, Measures analysis, Molar, National defense, Negative control, Nieh, Organ transplantation, Orthod, Orthod craniofac, Orthod dentofacial orthop, Orthodontic, Orthodontic appliance, Orthodontic appliances, Orthodontic force, Orthodontic force application, Orthodontic movement, Orthodontic therapy, Orthodontic tooth movement, Orthodontic treatment, Orthop, Osteoblast differentiation, Osteoclast, Osteoclastic activity, Osteopenia, Other hand, Overgrowth, Present study, Previous study, Rat, Receptor activator, Resorption, Root resorption, Serum level, Serum levels, Spolidorio, Stainless steel ligature wires, Standard errors, Third molars, Tooth movement, Treatment factor.
Abstract
To cite this article:
Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E:
Effect of cyclosporine‐A on orthodontic tooth movement in rats
Orthod Craniofac Res 2011;14:234–242
Url:
DOI: 10.1111/j.1601-6343.2011.01528.x
Links to Exploration step
ISTEX:8636F77CD980F45F066D9B49D7BBD8779984E2A0Le document en format XML
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Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chih, Yk" sort="Chih, Yk" uniqKey="Chih Y" first="Yk" last="Chih">Yk Chih</name><affiliation><mods:affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. 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Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Nieh, S" sort="Nieh, S" uniqKey="Nieh S" first="S" last="Nieh">S. Nieh</name><affiliation><mods:affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Hsieh, Yd" sort="Hsieh, Yd" uniqKey="Hsieh Y" first="Yd" last="Hsieh">Yd Hsieh</name><affiliation><mods:affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Fu, E" sort="Fu, E" uniqKey="Fu E" first="E" last="Fu">E. Fu</name><affiliation><mods:affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8636F77CD980F45F066D9B49D7BBD8779984E2A0</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1111/j.1601-6343.2011.01528.x</idno><idno type="url">https://api.istex.fr/document/8636F77CD980F45F066D9B49D7BBD8779984E2A0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004262</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">004262</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Effect of cyclosporine‐A on orthodontic tooth movement in rats</title><author><name sortKey="Chen, Ry" sort="Chen, Ry" uniqKey="Chen R" first="Ry" last="Chen">Ry Chen</name></author><author><name sortKey="Fu, Mm" sort="Fu, Mm" uniqKey="Fu M" first="Mm" last="Fu">Mm Fu</name><affiliation><mods:affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chih, Yk" sort="Chih, Yk" uniqKey="Chih Y" first="Yk" last="Chih">Yk Chih</name><affiliation><mods:affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Gau, Ch" sort="Gau, Ch" uniqKey="Gau C" first="Ch" last="Gau">Ch Gau</name><affiliation><mods:affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chiang, Cy" sort="Chiang, Cy" uniqKey="Chiang C" first="Cy" last="Chiang">Cy Chiang</name><affiliation><mods:affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Nieh, S" sort="Nieh, S" uniqKey="Nieh S" first="S" last="Nieh">S. Nieh</name><affiliation><mods:affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Hsieh, Yd" sort="Hsieh, Yd" uniqKey="Hsieh Y" first="Yd" last="Hsieh">Yd Hsieh</name><affiliation><mods:affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Fu, E" sort="Fu, E" uniqKey="Fu E" first="E" last="Fu">E. Fu</name><affiliation><mods:affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Orthodontics & Craniofacial Research</title><title level="j" type="alt">ORTHODONTICS CRANIOFACIAL RESEARCH</title><idno type="ISSN">1601-6335</idno><idno type="eISSN">1601-6343</idno><imprint><biblScope unit="vol">14</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="234">234</biblScope><biblScope unit="page" to="242">242</biblScope><biblScope unit="page-count">9</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-11">2011-11</date></imprint><idno type="ISSN">1601-6335</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1601-6335</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acid phosphatase</term><term>Alveolar bone</term><term>Alveolar bone loss</term><term>Alveolar process</term><term>Animal groups</term><term>Animal studies</term><term>Apical</term><term>Apical zones</term><term>Bilateral maxillary</term><term>Body weight</term><term>Bone formation</term><term>Bone miner</term><term>Bone mineral metabolism</term><term>Bone resorption</term><term>Bone surface</term><term>Bone volume</term><term>Calcif tissue</term><term>Chen</term><term>Control group</term><term>Coronal</term><term>Craniofac</term><term>Cyclosporin</term><term>Cyclosporine</term><term>Daily dose</term><term>Dental alveoli</term><term>Dental alveolus</term><term>Dental medicine</term><term>Dentofacial</term><term>Experimental study</term><term>Experimental tooth movement</term><term>General anesthesia</term><term>General hospital</term><term>Gingival</term><term>Gingival enlargement</term><term>Gingival overgrowth</term><term>Harvard school</term><term>Higher serum level</term><term>Histological</term><term>Histological examination</term><term>Histological pictures</term><term>Histometric analysis</term><term>Histometric measurements</term><term>Hsieh</term><term>Intermolar</term><term>Intermolar distance</term><term>Intermolar distances</term><term>Marrow volume</term><term>Maxillary</term><term>Maxillary incisors</term><term>Maxillary right</term><term>Measures analysis</term><term>Molar</term><term>National defense</term><term>Negative control</term><term>Nieh</term><term>Organ transplantation</term><term>Orthod</term><term>Orthod craniofac</term><term>Orthod dentofacial orthop</term><term>Orthodontic</term><term>Orthodontic appliance</term><term>Orthodontic appliances</term><term>Orthodontic force</term><term>Orthodontic force application</term><term>Orthodontic movement</term><term>Orthodontic therapy</term><term>Orthodontic tooth movement</term><term>Orthodontic treatment</term><term>Orthop</term><term>Osteoblast differentiation</term><term>Osteoclast</term><term>Osteoclastic activity</term><term>Osteopenia</term><term>Other hand</term><term>Overgrowth</term><term>Present study</term><term>Previous study</term><term>Rat</term><term>Receptor activator</term><term>Resorption</term><term>Root resorption</term><term>Serum level</term><term>Serum levels</term><term>Spolidorio</term><term>Stainless steel ligature wires</term><term>Standard errors</term><term>Third molars</term><term>Tooth movement</term><term>Treatment factor</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acid phosphatase</term><term>Alveolar bone</term><term>Alveolar bone loss</term><term>Alveolar process</term><term>Animal groups</term><term>Animal studies</term><term>Apical</term><term>Apical zones</term><term>Bilateral maxillary</term><term>Body weight</term><term>Bone formation</term><term>Bone miner</term><term>Bone mineral metabolism</term><term>Bone resorption</term><term>Bone surface</term><term>Bone volume</term><term>Calcif tissue</term><term>Chen</term><term>Control group</term><term>Coronal</term><term>Craniofac</term><term>Cyclosporin</term><term>Cyclosporine</term><term>Daily dose</term><term>Dental alveoli</term><term>Dental alveolus</term><term>Dental medicine</term><term>Dentofacial</term><term>Experimental study</term><term>Experimental tooth movement</term><term>General anesthesia</term><term>General hospital</term><term>Gingival</term><term>Gingival enlargement</term><term>Gingival overgrowth</term><term>Harvard school</term><term>Higher serum level</term><term>Histological</term><term>Histological examination</term><term>Histological pictures</term><term>Histometric analysis</term><term>Histometric measurements</term><term>Hsieh</term><term>Intermolar</term><term>Intermolar distance</term><term>Intermolar distances</term><term>Marrow volume</term><term>Maxillary</term><term>Maxillary incisors</term><term>Maxillary right</term><term>Measures analysis</term><term>Molar</term><term>National defense</term><term>Negative control</term><term>Nieh</term><term>Organ transplantation</term><term>Orthod</term><term>Orthod craniofac</term><term>Orthod dentofacial orthop</term><term>Orthodontic</term><term>Orthodontic appliance</term><term>Orthodontic appliances</term><term>Orthodontic force</term><term>Orthodontic force application</term><term>Orthodontic movement</term><term>Orthodontic therapy</term><term>Orthodontic tooth movement</term><term>Orthodontic treatment</term><term>Orthop</term><term>Osteoblast differentiation</term><term>Osteoclast</term><term>Osteoclastic activity</term><term>Osteopenia</term><term>Other hand</term><term>Overgrowth</term><term>Present study</term><term>Previous study</term><term>Rat</term><term>Receptor activator</term><term>Resorption</term><term>Root resorption</term><term>Serum level</term><term>Serum levels</term><term>Spolidorio</term><term>Stainless steel ligature wires</term><term>Standard errors</term><term>Third molars</term><term>Tooth movement</term><term>Treatment factor</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">To cite this article:
Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E:
Effect of cyclosporine‐A on orthodontic tooth movement in rats
Orthod Craniofac Res 2011;14:234–242</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>orthodontic tooth movement</json:string><json:string>orthod</json:string><json:string>osteopenia</json:string><json:string>cyclosporin</json:string><json:string>overgrowth</json:string><json:string>maxillary</json:string><json:string>gingival</json:string><json:string>intermolar</json:string><json:string>resorption</json:string><json:string>cyclosporine</json:string><json:string>orthop</json:string><json:string>osteoclast</json:string><json:string>craniofac</json:string><json:string>orthodontic force application</json:string><json:string>dentofacial</json:string><json:string>orthod craniofac</json:string><json:string>spolidorio</json:string><json:string>molar</json:string><json:string>histological</json:string><json:string>gingival overgrowth</json:string><json:string>orthodontic force</json:string><json:string>coronal</json:string><json:string>hsieh</json:string><json:string>apical</json:string><json:string>intermolar distances</json:string><json:string>nieh</json:string><json:string>orthod dentofacial orthop</json:string><json:string>orthodontic appliance</json:string><json:string>orthodontic treatment</json:string><json:string>tooth movement</json:string><json:string>orthodontic appliances</json:string><json:string>general hospital</json:string><json:string>negative control</json:string><json:string>apical zones</json:string><json:string>body weight</json:string><json:string>alveolar process</json:string><json:string>control group</json:string><json:string>osteoclastic activity</json:string><json:string>national defense</json:string><json:string>serum level</json:string><json:string>alveolar bone</json:string><json:string>bone formation</json:string><json:string>bone resorption</json:string><json:string>orthodontic</json:string><json:string>experimental tooth movement</json:string><json:string>orthodontic therapy</json:string><json:string>standard errors</json:string><json:string>marrow volume</json:string><json:string>bone surface</json:string><json:string>acid phosphatase</json:string><json:string>bone volume</json:string><json:string>orthodontic movement</json:string><json:string>intermolar distance</json:string><json:string>rat</json:string><json:string>chen</json:string><json:string>histometric measurements</json:string><json:string>dental alveoli</json:string><json:string>histological examination</json:string><json:string>histological pictures</json:string><json:string>higher serum level</json:string><json:string>histometric analysis</json:string><json:string>animal groups</json:string><json:string>maxillary right</json:string><json:string>stainless steel ligature wires</json:string><json:string>daily dose</json:string><json:string>general anesthesia</json:string><json:string>serum levels</json:string><json:string>other hand</json:string><json:string>previous study</json:string><json:string>animal studies</json:string><json:string>present study</json:string><json:string>measures analysis</json:string><json:string>third molars</json:string><json:string>gingival enlargement</json:string><json:string>osteoblast differentiation</json:string><json:string>maxillary incisors</json:string><json:string>organ transplantation</json:string><json:string>receptor activator</json:string><json:string>root resorption</json:string><json:string>bilateral maxillary</json:string><json:string>dental medicine</json:string><json:string>harvard school</json:string><json:string>treatment factor</json:string><json:string>alveolar bone loss</json:string><json:string>calcif tissue</json:string><json:string>experimental study</json:string><json:string>bone miner</json:string><json:string>bone mineral metabolism</json:string><json:string>dental alveolus</json:string></teeft></keywords><author><json:item><name>RY Chen</name></json:item><json:item><name>MM Fu</name><affiliations><json:string>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</json:string></affiliations></json:item><json:item><name>YK Chih</name><affiliations><json:string>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</json:string></affiliations></json:item><json:item><name>CH Gau</name><affiliations><json:string>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</json:string></affiliations></json:item><json:item><name>CY Chiang</name><affiliations><json:string>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</json:string></affiliations></json:item><json:item><name>S Nieh</name><affiliations><json:string>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</json:string></affiliations></json:item><json:item><name>YD Hsieh</name><affiliations><json:string>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</json:string></affiliations></json:item><json:item><name>E Fu</name><affiliations><json:string>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>cyclosporine‐A</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>orthodontics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>osteoclasts</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tooth movement</value></json:item></subject><articleId><json:string>OCR1528</json:string></articleId><arkIstex>ark:/67375/WNG-BMVJ01Q1-S</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>To cite this article: Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E:Effect of cyclosporine‐A on orthodontic tooth movement in ratsOrthod Craniofac Res 2011;14:234–242</abstract><qualityIndicators><score>6.614</score><pdfWordCount>4242</pdfWordCount><pdfCharCount>27713</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>31</abstractWordCount><abstractCharCount>190</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Effect of cyclosporine‐A on orthodontic tooth movement in rats</title><pmid><json:string>22008303</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Orthodontics & Craniofacial Research</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1601-6343</json:string></doi><issn><json:string>1601-6335</json:string></issn><eissn><json:string>1601-6343</json:string></eissn><publisherId><json:string>OCR</json:string></publisherId><volume>14</volume><issue>4</issue><pages><first>234</first><last>242</last><total>9</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>ORIGINAL ARTICLE</value></json:item></subject></host><namedEntities><unitex><date><json:string>2011</json:string><json:string>1991</json:string></date><geogName></geogName><orgName><json:string>Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan Authors</json:string><json:string>Department of Nursing, Kang-Ning Junior College of Medical Care and Management</json:string><json:string>Department of Oral Medicine, Infection and Immunity</json:string><json:string>National Defense Medical Center and Tri</json:string><json:string>Virbac Laboratories</json:string><json:string>National Defense Medical Center, Taiwan</json:string><json:string>Taiwan, Republic of China</json:string><json:string>Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA</json:string><json:string>Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri</json:string><json:string>Department of Periodontology, School of Dentistry National Defense Medical Center and Tri</json:string><json:string>Department of Pathology, National Defense Medical Center and Tri</json:string><json:string>Department of National Defence</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Studies</json:string><json:string>S. 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Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
M.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
Y.K. Chih, Private practice, HsinChu, Taiwan
C.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, Taiwan
C.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
S. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
Y.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation></author><author xml:id="author-0002"><persName><forename type="first">YK</forename><surname>Chih</surname></persName><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
M.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
Y.K. Chih, Private practice, HsinChu, Taiwan
C.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, Taiwan
C.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
S. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
Y.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation></author><author xml:id="author-0003"><persName><forename type="first">CH</forename><surname>Gau</surname></persName><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
M.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
Y.K. Chih, Private practice, HsinChu, Taiwan
C.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, Taiwan
C.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
S. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
Y.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation></author><author xml:id="author-0004"><persName><forename type="first">CY</forename><surname>Chiang</surname></persName><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
M.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
Y.K. Chih, Private practice, HsinChu, Taiwan
C.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, Taiwan
C.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
S. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
Y.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation></author><author xml:id="author-0005"><persName><forename type="first">S</forename><surname>Nieh</surname></persName><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
M.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
Y.K. Chih, Private practice, HsinChu, Taiwan
C.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, Taiwan
C.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
S. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
Y.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation></author><author xml:id="author-0006"><persName><forename type="first">YD</forename><surname>Hsieh</surname></persName><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
M.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
Y.K. Chih, Private practice, HsinChu, Taiwan
C.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, Taiwan
C.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
S. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
Y.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation></author><author xml:id="author-0007"><persName><forename type="first">E</forename><surname>Fu</surname></persName><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
M.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
Y.K. Chih, Private practice, HsinChu, Taiwan
C.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, Taiwan
C.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
S. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
Y.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation></author><idno type="istex">8636F77CD980F45F066D9B49D7BBD8779984E2A0</idno><idno type="ark">ark:/67375/WNG-BMVJ01Q1-S</idno><idno type="DOI">10.1111/j.1601-6343.2011.01528.x</idno><idno type="unit">OCR1528</idno><idno type="toTypesetVersion">file:OCR.OCR1528.pdf</idno></analytic><monogr><title level="j" type="main">Orthodontics & Craniofacial Research</title><title level="j" type="alt">ORTHODONTICS CRANIOFACIAL RESEARCH</title><idno type="pISSN">1601-6335</idno><idno type="eISSN">1601-6343</idno><idno type="book-DOI">10.1111/(ISSN)1601-6343</idno><idno type="book-part-DOI">10.1111/ocr.2011.14.issue-4</idno><idno type="product">OCR</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">14</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="234">234</biblScope><biblScope unit="page" to="242">242</biblScope><biblScope unit="page-count">9</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-11"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">To cite this article:</hi>
Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E:
Effect of cyclosporine‐A on orthodontic tooth movement in rats
<hi rend="italic">Orthod Craniofac Res</hi> 2011;<hi rend="bold">14</hi>:234–242</p>
Structured Abstract
<p><hi rend="bold">Authors – </hi> Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E</p><p><hi rend="bold">Objective – </hi> The objective of this study is to examine the effect of cyclosporine‐A (CsA) on the rate of orthodontic tooth movement in rats.</p><p><hi rend="bold">Setting and Sample Population – </hi> This is a randomized controlled trial with a split‐mouth design in Sprague–Dawley rats.</p><p><hi rend="bold">Material and Methods – </hi> Eighteen rats, divided at random in two groups, were fed with 8 mg/kg CsA (experiment) or mineral oil (control) daily after initial healing of bilateral maxillary second molar removal. All rats received orthodontic coil springs (10 cN) secured to the maxillary incisors and first molars at the rights side, while no springs were placed at the left. Distances between first and third molars were measured on days 0, 3, 6, and 12. After sacrificing on day 12, the alveolar ridges of the maxillae were sectioned and blood samples were collected for serum tartrate‐resistant acid phosphatase (TRAP)‐5b level detection and for histology, respectively.</p><p><hi rend="bold">Results – </hi> Significantly larger changes in intermolar distances were found after orthodontic force application in the CsA group at days 3 and 12 when compared with the control group. The inter‐radicular dental alveolus of CSA‐fed rats was osteopenic. Significantly increased TRAP‐5b serum level was noted in the CsA group when compared with the control group.</p><p><hi rend="bold">Conclusions – </hi> We suggest that CsA enhanced the rate of orthodontic tooth movement. The osteopenia and the increased osteoclastic activity could be the underlying factors.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">cyclosporine‐A</term><term xml:id="k2">orthodontics</term><term xml:id="k3">osteoclasts</term><term xml:id="k4">tooth movement</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords><keywords rend="articleCategory"><term>ORIGINAL ARTICLE</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/8636F77CD980F45F066D9B49D7BBD8779984E2A0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1601-6343</doi><issn type="print">1601-6335</issn><issn type="electronic">1601-6343</issn><idGroup><id type="product" value="OCR"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ORTHODONTICS CRANIOFACIAL RESEARCH">Orthodontics & Craniofacial Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="11104"><doi origin="wiley">10.1111/ocr.2011.14.issue-4</doi><numberingGroup><numbering type="journalVolume" number="14">14</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2011-11">November 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="6" status="forIssue"><doi origin="wiley">10.1111/j.1601-6343.2011.01528.x</doi><idGroup><id type="unit" value="OCR1528"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title><title type="articleCategory">ORIGINAL ARTICLE</title></titleGroup><copyright>© 2011 John Wiley & Sons A/S</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.10 mode:FullText" date="2011-10-18"></event><event type="firstOnline" date="2011-10-18"></event><event type="publishedOnlineFinalForm" date="2011-10-18"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-06"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-03"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="234">234</numbering><numbering type="pageLast" number="242">242</numbering></numberingGroup><correspondenceTo><i>Dr Earl Fu</i>
Department of Periodontology, School of Dentistry
National Defense Medical Center and Tri‐Service General Hospital
PO Box 90048‐507
Taipei
Taiwan
E‐mail: <email>dentalab@tpts5.seed.net.tw</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:OCR.OCR1528.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory><b>Dates:</b> Accepted 15 September 2011</unparsedEditorialHistory><countGroup><count type="figureTotal" number="6"></count><count type="tableTotal" number="0"></count></countGroup><titleGroup><title type="main">Effect of cyclosporine‐A on orthodontic tooth movement in rats</title><title type="shortAuthors">Chen et al.</title><title type="short">Effect of cyclosporine‐A on orthodontic tooth movement</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" noteRef="#fn1"><personName><givenNames>RY</givenNames><familyName>Chen</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>MM</givenNames><familyName>Fu</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#aff-1-1"><personName><givenNames>YK</givenNames><familyName>Chih</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#aff-1-1"><personName><givenNames>CH</givenNames><familyName>Gau</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#aff-1-1"><personName><givenNames>CY</givenNames><familyName>Chiang</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#aff-1-1"><personName><givenNames>S</givenNames><familyName>Nieh</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#aff-1-1"><personName><givenNames>YD</givenNames><familyName>Hsieh</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#aff-1-1"><personName><givenNames>E</givenNames><familyName>Fu</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1"><unparsedAffiliation><i>R.Y. Chen</i>, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
<i>M.M. Fu</i>, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
<i>Y.K. Chih</i>, Private practice, HsinChu, Taiwan
<i>C.H. Gau</i>, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, Taiwan
<i>C.Y. Chiang</i>, <i>Y.D. Hsieh</i>, <i>E. Fu</i>, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
<i>S. Nieh</i>, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
<i>Y.D. Hsieh</i>, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">cyclosporine‐A</keyword><keyword xml:id="k2">orthodontics</keyword><keyword xml:id="k3">osteoclasts</keyword><keyword xml:id="k4">tooth movement</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><section xml:id="sec-sum-1"><p><b>To cite this article:</b>
Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E:
Effect of cyclosporine‐A on orthodontic tooth movement in rats
<i>Orthod Craniofac Res</i> 2011;<b>14</b>:234–242</p></section><section xml:id="abs1-1"><title type="main">Structured Abstract</title><p><b>Authors – </b> Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E</p><p><b>Objective – </b> The objective of this study is to examine the effect of cyclosporine‐A (CsA) on the rate of orthodontic tooth movement in rats.</p><p><b>Setting and Sample Population – </b> This is a randomized controlled trial with a split‐mouth design in Sprague–Dawley rats.</p><p><b>Material and Methods – </b> Eighteen rats, divided at random in two groups, were fed with 8 mg/kg CsA (experiment) or mineral oil (control) daily after initial healing of bilateral maxillary second molar removal. All rats received orthodontic coil springs (10 cN) secured to the maxillary incisors and first molars at the rights side, while no springs were placed at the left. Distances between first and third molars were measured on days 0, 3, 6, and 12. After sacrificing on day 12, the alveolar ridges of the maxillae were sectioned and blood samples were collected for serum tartrate‐resistant acid phosphatase (TRAP)‐5b level detection and for histology, respectively.</p><p><b>Results – </b> Significantly larger changes in intermolar distances were found after orthodontic force application in the CsA group at days 3 and 12 when compared with the control group. The inter‐radicular dental alveolus of CSA‐fed rats was osteopenic. Significantly increased TRAP‐5b serum level was noted in the CsA group when compared with the control group.</p><p><b>Conclusions – </b> We suggest that CsA enhanced the rate of orthodontic tooth movement. The osteopenia and the increased osteoclastic activity could be the underlying factors.</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>
Present address: Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effect of cyclosporine‐A on orthodontic tooth movement in rats</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Effect of cyclosporine‐A on orthodontic tooth movement</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effect of cyclosporine‐A on orthodontic tooth movement in rats</title></titleInfo><name type="personal"><namePart type="given">RY</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MM</namePart><namePart type="family">Fu</namePart><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YK</namePart><namePart type="family">Chih</namePart><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CH</namePart><namePart type="family">Gau</namePart><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CY</namePart><namePart type="family">Chiang</namePart><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Nieh</namePart><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YD</namePart><namePart type="family">Hsieh</namePart><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Fu</namePart><affiliation>R.Y. Chen, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanM.M. Fu, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USAY.K. Chih, Private practice, HsinChu, TaiwanC.H. Gau, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, TaiwanC.Y. Chiang, Y.D. Hsieh, E. Fu, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanS. Nieh, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, TaiwanY.D. Hsieh, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-11</dateIssued><edition>Dates: Accepted 15 September 2011</edition><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">6</extent><extent unit="tables">0</extent></physicalDescription><abstract>To cite this article:
Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E:
Effect of cyclosporine‐A on orthodontic tooth movement in rats
Orthod Craniofac Res 2011;14:234–242</abstract><abstract>Authors – Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E Objective – The objective of this study is to examine the effect of cyclosporine‐A (CsA) on the rate of orthodontic tooth movement in rats. Setting and Sample Population – This is a randomized controlled trial with a split‐mouth design in Sprague–Dawley rats. Material and Methods – Eighteen rats, divided at random in two groups, were fed with 8 mg/kg CsA (experiment) or mineral oil (control) daily after initial healing of bilateral maxillary second molar removal. All rats received orthodontic coil springs (10 cN) secured to the maxillary incisors and first molars at the rights side, while no springs were placed at the left. Distances between first and third molars were measured on days 0, 3, 6, and 12. After sacrificing on day 12, the alveolar ridges of the maxillae were sectioned and blood samples were collected for serum tartrate‐resistant acid phosphatase (TRAP)‐5b level detection and for histology, respectively. Results – Significantly larger changes in intermolar distances were found after orthodontic force application in the CsA group at days 3 and 12 when compared with the control group. The inter‐radicular dental alveolus of CSA‐fed rats was osteopenic. Significantly increased TRAP‐5b serum level was noted in the CsA group when compared with the control group. Conclusions – We suggest that CsA enhanced the rate of orthodontic tooth movement. The osteopenia and the increased osteoclastic activity could be the underlying factors.</abstract><subject lang="en"><genre>keywords</genre><topic>cyclosporine‐A</topic><topic>orthodontics</topic><topic>osteoclasts</topic><topic>tooth movement</topic></subject><relatedItem type="host"><titleInfo><title>Orthodontics & Craniofacial Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>ORIGINAL ARTICLE</topic></subject><identifier type="ISSN">1601-6335</identifier><identifier type="eISSN">1601-6343</identifier><identifier type="DOI">10.1111/(ISSN)1601-6343</identifier><identifier type="PublisherID">OCR</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>234</start><end>242</end><total>9</total></extent></part></relatedItem><identifier type="istex">8636F77CD980F45F066D9B49D7BBD8779984E2A0</identifier><identifier type="ark">ark:/67375/WNG-BMVJ01Q1-S</identifier><identifier type="DOI">10.1111/j.1601-6343.2011.01528.x</identifier><identifier type="ArticleID">OCR1528</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2011 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/8636F77CD980F45F066D9B49D7BBD8779984E2A0/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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