Effect of cyclosporine‐A on orthodontic tooth movement in rats
Identifieur interne : 004262 ( Istex/Corpus ); précédent : 004261; suivant : 004263Effect of cyclosporine‐A on orthodontic tooth movement in rats
Auteurs : Ry Chen ; Mm Fu ; Yk Chih ; Ch Gau ; Cy Chiang ; S. Nieh ; Yd Hsieh ; E. FuSource :
- Orthodontics & Craniofacial Research [ 1601-6335 ] ; 2011-11.
English descriptors
- KwdEn :
- Acid phosphatase, Alveolar bone, Alveolar bone loss, Alveolar process, Animal groups, Animal studies, Apical, Apical zones, Bilateral maxillary, Body weight, Bone formation, Bone miner, Bone mineral metabolism, Bone resorption, Bone surface, Bone volume, Calcif tissue, Chen, Control group, Coronal, Craniofac, Cyclosporin, Cyclosporine, Daily dose, Dental alveoli, Dental alveolus, Dental medicine, Dentofacial, Experimental study, Experimental tooth movement, General anesthesia, General hospital, Gingival, Gingival enlargement, Gingival overgrowth, Harvard school, Higher serum level, Histological, Histological examination, Histological pictures, Histometric analysis, Histometric measurements, Hsieh, Intermolar, Intermolar distance, Intermolar distances, Marrow volume, Maxillary, Maxillary incisors, Maxillary right, Measures analysis, Molar, National defense, Negative control, Nieh, Organ transplantation, Orthod, Orthod craniofac, Orthod dentofacial orthop, Orthodontic, Orthodontic appliance, Orthodontic appliances, Orthodontic force, Orthodontic force application, Orthodontic movement, Orthodontic therapy, Orthodontic tooth movement, Orthodontic treatment, Orthop, Osteoblast differentiation, Osteoclast, Osteoclastic activity, Osteopenia, Other hand, Overgrowth, Present study, Previous study, Rat, Receptor activator, Resorption, Root resorption, Serum level, Serum levels, Spolidorio, Stainless steel ligature wires, Standard errors, Third molars, Tooth movement, Treatment factor.
- Teeft :
- Acid phosphatase, Alveolar bone, Alveolar bone loss, Alveolar process, Animal groups, Animal studies, Apical, Apical zones, Bilateral maxillary, Body weight, Bone formation, Bone miner, Bone mineral metabolism, Bone resorption, Bone surface, Bone volume, Calcif tissue, Chen, Control group, Coronal, Craniofac, Cyclosporin, Cyclosporine, Daily dose, Dental alveoli, Dental alveolus, Dental medicine, Dentofacial, Experimental study, Experimental tooth movement, General anesthesia, General hospital, Gingival, Gingival enlargement, Gingival overgrowth, Harvard school, Higher serum level, Histological, Histological examination, Histological pictures, Histometric analysis, Histometric measurements, Hsieh, Intermolar, Intermolar distance, Intermolar distances, Marrow volume, Maxillary, Maxillary incisors, Maxillary right, Measures analysis, Molar, National defense, Negative control, Nieh, Organ transplantation, Orthod, Orthod craniofac, Orthod dentofacial orthop, Orthodontic, Orthodontic appliance, Orthodontic appliances, Orthodontic force, Orthodontic force application, Orthodontic movement, Orthodontic therapy, Orthodontic tooth movement, Orthodontic treatment, Orthop, Osteoblast differentiation, Osteoclast, Osteoclastic activity, Osteopenia, Other hand, Overgrowth, Present study, Previous study, Rat, Receptor activator, Resorption, Root resorption, Serum level, Serum levels, Spolidorio, Stainless steel ligature wires, Standard errors, Third molars, Tooth movement, Treatment factor.
Abstract
To cite this article:
Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E:
Effect of cyclosporine‐A on orthodontic tooth movement in rats
Orthod Craniofac Res 2011;14:234–242
Url:
DOI: 10.1111/j.1601-6343.2011.01528.x
Links to Exploration step
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<term>Animal studies</term>
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<term>Harvard school</term>
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<term>Measures analysis</term>
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<term>Overgrowth</term>
<term>Present study</term>
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<term>Resorption</term>
<term>Root resorption</term>
<term>Serum level</term>
<term>Serum levels</term>
<term>Spolidorio</term>
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<front><div type="abstract">To cite this article:
Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E:
Effect of cyclosporine‐A on orthodontic tooth movement in rats
Orthod Craniofac Res 2011;14:234–242</div>
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<profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">To cite this article:</hi>
Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E:
Effect of cyclosporine‐A on orthodontic tooth movement in rats
<hi rend="italic">Orthod Craniofac Res</hi>
2011;<hi rend="bold">14</hi>
:234–242</p>
Structured Abstract
<p><hi rend="bold">Authors – </hi>
Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E</p>
<p><hi rend="bold">Objective – </hi>
The objective of this study is to examine the effect of cyclosporine‐A (CsA) on the rate of orthodontic tooth movement in rats.</p>
<p><hi rend="bold">Setting and Sample Population – </hi>
This is a randomized controlled trial with a split‐mouth design in Sprague–Dawley rats.</p>
<p><hi rend="bold">Material and Methods – </hi>
Eighteen rats, divided at random in two groups, were fed with 8 mg/kg CsA (experiment) or mineral oil (control) daily after initial healing of bilateral maxillary second molar removal. All rats received orthodontic coil springs (10 cN) secured to the maxillary incisors and first molars at the rights side, while no springs were placed at the left. Distances between first and third molars were measured on days 0, 3, 6, and 12. After sacrificing on day 12, the alveolar ridges of the maxillae were sectioned and blood samples were collected for serum tartrate‐resistant acid phosphatase (TRAP)‐5b level detection and for histology, respectively.</p>
<p><hi rend="bold">Results – </hi>
Significantly larger changes in intermolar distances were found after orthodontic force application in the CsA group at days 3 and 12 when compared with the control group. The inter‐radicular dental alveolus of CSA‐fed rats was osteopenic. Significantly increased TRAP‐5b serum level was noted in the CsA group when compared with the control group.</p>
<p><hi rend="bold">Conclusions – </hi>
We suggest that CsA enhanced the rate of orthodontic tooth movement. The osteopenia and the increased osteoclastic activity could be the underlying factors.</p>
</abstract>
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<correspondenceTo><i>Dr Earl Fu</i>
Department of Periodontology, School of Dentistry
National Defense Medical Center and Tri‐Service General Hospital
PO Box 90048‐507
Taipei
Taiwan
E‐mail: <email>dentalab@tpts5.seed.net.tw</email>
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<titleGroup><title type="main">Effect of cyclosporine‐A on orthodontic tooth movement in rats</title>
<title type="shortAuthors">Chen et al.</title>
<title type="short">Effect of cyclosporine‐A on orthodontic tooth movement</title>
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<affiliationGroup><affiliation xml:id="aff-1-1"><unparsedAffiliation><i>R.Y. Chen</i>
, Department of Pediatric Dentistry and Orthodontics, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
<i>M.M. Fu</i>
, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
<i>Y.K. Chih</i>
, Private practice, HsinChu, Taiwan
<i>C.H. Gau</i>
, Department of Nursing, Kang‐Ning Junior College of Medical Care and Management, Taipei, Taiwan
<i>C.Y. Chiang</i>
, <i>Y.D. Hsieh</i>
, <i>E. Fu</i>
, Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
<i>S. Nieh</i>
, Department of Pathology, National Defense Medical Center and Tri‐Service General Hospital, Taipei, Taiwan
<i>Y.D. Hsieh</i>
, Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan</unparsedAffiliation>
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<abstractGroup><abstract type="main" xml:lang="en"><section xml:id="sec-sum-1"><p><b>To cite this article:</b>
Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E:
Effect of cyclosporine‐A on orthodontic tooth movement in rats
<i>Orthod Craniofac Res</i>
2011;<b>14</b>
:234–242</p>
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<section xml:id="abs1-1"><title type="main">Structured Abstract</title>
<p><b>Authors – </b>
Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E</p>
<p><b>Objective – </b>
The objective of this study is to examine the effect of cyclosporine‐A (CsA) on the rate of orthodontic tooth movement in rats.</p>
<p><b>Setting and Sample Population – </b>
This is a randomized controlled trial with a split‐mouth design in Sprague–Dawley rats.</p>
<p><b>Material and Methods – </b>
Eighteen rats, divided at random in two groups, were fed with 8 mg/kg CsA (experiment) or mineral oil (control) daily after initial healing of bilateral maxillary second molar removal. All rats received orthodontic coil springs (10 cN) secured to the maxillary incisors and first molars at the rights side, while no springs were placed at the left. Distances between first and third molars were measured on days 0, 3, 6, and 12. After sacrificing on day 12, the alveolar ridges of the maxillae were sectioned and blood samples were collected for serum tartrate‐resistant acid phosphatase (TRAP)‐5b level detection and for histology, respectively.</p>
<p><b>Results – </b>
Significantly larger changes in intermolar distances were found after orthodontic force application in the CsA group at days 3 and 12 when compared with the control group. The inter‐radicular dental alveolus of CSA‐fed rats was osteopenic. Significantly increased TRAP‐5b serum level was noted in the CsA group when compared with the control group.</p>
<p><b>Conclusions – </b>
We suggest that CsA enhanced the rate of orthodontic tooth movement. The osteopenia and the increased osteoclastic activity could be the underlying factors.</p>
</section>
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Present address: Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA.</p>
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Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E:
Effect of cyclosporine‐A on orthodontic tooth movement in rats
Orthod Craniofac Res 2011;14:234–242</abstract>
<abstract>Authors – Chen RY, Fu MM, Chih YK, Gau CH, Chiang CY, Nieh S, Hsieh YD, Fu E Objective – The objective of this study is to examine the effect of cyclosporine‐A (CsA) on the rate of orthodontic tooth movement in rats. Setting and Sample Population – This is a randomized controlled trial with a split‐mouth design in Sprague–Dawley rats. Material and Methods – Eighteen rats, divided at random in two groups, were fed with 8 mg/kg CsA (experiment) or mineral oil (control) daily after initial healing of bilateral maxillary second molar removal. All rats received orthodontic coil springs (10 cN) secured to the maxillary incisors and first molars at the rights side, while no springs were placed at the left. Distances between first and third molars were measured on days 0, 3, 6, and 12. After sacrificing on day 12, the alveolar ridges of the maxillae were sectioned and blood samples were collected for serum tartrate‐resistant acid phosphatase (TRAP)‐5b level detection and for histology, respectively. Results – Significantly larger changes in intermolar distances were found after orthodontic force application in the CsA group at days 3 and 12 when compared with the control group. The inter‐radicular dental alveolus of CSA‐fed rats was osteopenic. Significantly increased TRAP‐5b serum level was noted in the CsA group when compared with the control group. Conclusions – We suggest that CsA enhanced the rate of orthodontic tooth movement. The osteopenia and the increased osteoclastic activity could be the underlying factors.</abstract>
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