Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of Candida albicans, Salivary Flow, and Dry Mouth
Identifieur interne : 004095 ( Istex/Corpus ); précédent : 004094; suivant : 004096Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of Candida albicans, Salivary Flow, and Dry Mouth
Auteurs : Sandra Altarawneh ; Sompop Bencharit ; Luisito Mendoza ; Alice Curran ; David Barrow ; Silvana Barros ; John Preisser ; Zvi G. Loewy ; Linda Gendreau ; Steven OffenbacherSource :
- Journal of Prosthodontics [ 1059-941X ] ; 2013-01.
English descriptors
- KwdEn :
- Albicans, Albicans counts, Altarawneh, American college, Aust dent, Candida, Candida albicans, Candida species, Candidal, Candidiasis, Carolina school, Chapel hill, Control group, Control participants, Control patients, Cytology, Dent, Dentistry, Denture, Denture plaque, Denture stomatitis, Denture surfaces, Diseased, Diseased group, Etiological, Exfoliative, Exfoliative cytology, Fungal, Fungal forms, Healthy denture wearers, Healthy individuals, Healthy patients, Hypha, Kapur, Lateral force, Mucosal, Mucosal surface, Mucosal surfaces, Normal saliva, Oral candidiasis, Oral pathol, Oral surg, Palatal, Palatal mucosa, Participant, Prosthodontics, Prosthodontist, Prosthodontists altarawneh, Radiol endod, Saliva, Saliva rate, Salivary, Sample size, Smear, Stomatitis, Unaffected mucosa, Unstimulated, Vestibular area, Wearer, Whole saliva, Xerostomia, Xerostomia questionnaire.
- Teeft :
- Albicans, Albicans counts, Altarawneh, American college, Aust dent, Candida, Candida albicans, Candida species, Candidal, Candidiasis, Carolina school, Chapel hill, Control group, Control participants, Control patients, Cytology, Dent, Dentistry, Denture, Denture plaque, Denture stomatitis, Denture surfaces, Diseased, Diseased group, Etiological, Exfoliative, Exfoliative cytology, Fungal, Fungal forms, Healthy denture wearers, Healthy individuals, Healthy patients, Hypha, Kapur, Lateral force, Mucosal, Mucosal surface, Mucosal surfaces, Normal saliva, Oral candidiasis, Oral pathol, Oral surg, Palatal, Palatal mucosa, Participant, Prosthodontics, Prosthodontist, Prosthodontists altarawneh, Radiol endod, Saliva, Saliva rate, Salivary, Sample size, Smear, Stomatitis, Unaffected mucosa, Unstimulated, Vestibular area, Wearer, Whole saliva, Xerostomia, Xerostomia questionnaire.
Abstract
Purpose: Multifactorial etiological factors contribute to denture stomatitis (DS), a type of oral candidiasis; however, unlike other oral candidiasis, DS can occur in a healthy person wearing a denture. In this study, we therefore attempt to explore the association between candida, denture, and mucosal tissue using (1) exfoliative cytology, (2) the candidal levels present in saliva, on mucosal tissues and on denture surfaces, and (3) the salivary flow rate and xerostomic symptoms.
Url:
DOI: 10.1111/j.1532-849X.2012.00906.x
Links to Exploration step
ISTEX:82D3D64B8AC68301566B6F73A5B7F770F303E925Le document en format XML
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In this study, we therefore attempt to explore the association between candida, denture, and mucosal tissue using (1) exfoliative cytology, (2) the candidal levels present in saliva, on mucosal tissues and on denture surfaces, and (3) the salivary flow rate and xerostomic symptoms.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>denture</json:string><json:string>candida</json:string><json:string>stomatitis</json:string><json:string>mucosal</json:string><json:string>albicans</json:string><json:string>denture stomatitis</json:string><json:string>salivary</json:string><json:string>cytology</json:string><json:string>palatal</json:string><json:string>denture surfaces</json:string><json:string>xerostomia</json:string><json:string>prosthodontist</json:string><json:string>prosthodontics</json:string><json:string>american college</json:string><json:string>candidiasis</json:string><json:string>unstimulated</json:string><json:string>exfoliative</json:string><json:string>altarawneh</json:string><json:string>candidal</json:string><json:string>wearer</json:string><json:string>saliva</json:string><json:string>candida albicans</json:string><json:string>healthy denture wearers</json:string><json:string>kapur</json:string><json:string>palatal mucosa</json:string><json:string>etiological</json:string><json:string>hypha</json:string><json:string>healthy patients</json:string><json:string>exfoliative cytology</json:string><json:string>fungal</json:string><json:string>chapel hill</json:string><json:string>oral candidiasis</json:string><json:string>carolina school</json:string><json:string>participant</json:string><json:string>control participants</json:string><json:string>oral pathol</json:string><json:string>dent</json:string><json:string>oral surg</json:string><json:string>aust dent</json:string><json:string>unaffected mucosa</json:string><json:string>control patients</json:string><json:string>healthy individuals</json:string><json:string>whole saliva</json:string><json:string>prosthodontists altarawneh</json:string><json:string>candida species</json:string><json:string>diseased</json:string><json:string>dentistry</json:string><json:string>normal saliva</json:string><json:string>diseased group</json:string><json:string>saliva rate</json:string><json:string>fungal forms</json:string><json:string>mucosal surface</json:string><json:string>mucosal surfaces</json:string><json:string>sample size</json:string><json:string>control group</json:string><json:string>vestibular area</json:string><json:string>albicans counts</json:string><json:string>denture plaque</json:string><json:string>lateral force</json:string><json:string>xerostomia questionnaire</json:string><json:string>radiol endod</json:string><json:string>smear</json:string><json:string>dryness</json:string></teeft></keywords><author><json:item><name>Sandra Altarawneh DDS, MS</name><affiliations><json:string>Department of Prosthdontics, University of North Carolina School of Dentistry, Chapel Hill, NC</json:string></affiliations></json:item><json:item><name>Sompop Bencharit DDS, MS, PhD</name><affiliations><json:string>Department of Prosthdontics, University of North Carolina School of Dentistry, Chapel Hill, NC</json:string></affiliations></json:item><json:item><name>Luisito Mendoza DDS</name><affiliations><json:string>Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC</json:string></affiliations></json:item><json:item><name>Alice Curran DMD, MS</name><affiliations><json:string>Department of Diagnostic Sciences & General Dentistry, University of North Carolina School of Dentistry, Chapel Hill, NC</json:string></affiliations></json:item><json:item><name>David Barrow</name><affiliations><json:string>Department of Dental Research, University of North Carolina School of Dentistry, Chapel Hill, NC</json:string></affiliations></json:item><json:item><name>Silvana Barros DDS, PhD</name><affiliations><json:string>Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC</json:string></affiliations></json:item><json:item><name>John Preisser PhD</name><affiliations><json:string>Department of Biostatistics, University of North Carolina School of Dentistry, Chapel Hill, NC</json:string></affiliations></json:item><json:item><name>Zvi G. Loewy PhD</name><affiliations><json:string>Department of Pharmaceutical & Biomedical Sciences, Touro College of Pharmacy, New York, NY</json:string></affiliations></json:item><json:item><name>Linda Gendreau DDS, MS</name><affiliations><json:string>GlaxoSmithKline, Parsippany, NJ</json:string></affiliations></json:item><json:item><name>Steven Offenbacher DDS, PhD, MMSc</name><affiliations><json:string>Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>C. albicans</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>denture</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hyposalivation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>stomatitis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>exfoliative cytology</value></json:item></subject><articleId><json:string>JOPR906</json:string></articleId><arkIstex>ark:/67375/WNG-14JLP07T-5</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Purpose: Multifactorial etiological factors contribute to denture stomatitis (DS), a type of oral candidiasis; however, unlike other oral candidiasis, DS can occur in a healthy person wearing a denture. In this study, we therefore attempt to explore the association between candida, denture, and mucosal tissue using (1) exfoliative cytology, (2) the candidal levels present in saliva, on mucosal tissues and on denture surfaces, and (3) the salivary flow rate and xerostomic symptoms.</abstract><qualityIndicators><score>7.864</score><pdfWordCount>6266</pdfWordCount><pdfCharCount>40147</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>595.274 x 782.286 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>72</abstractWordCount><abstractCharCount>485</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of Candida albicans, Salivary Flow, and Dry Mouth</title><pmid><json:string>23107189</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Prosthodontics</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1532-849X</json:string></doi><issn><json:string>1059-941X</json:string></issn><eissn><json:string>1532-849X</json:string></eissn><publisherId><json:string>JOPR</json:string></publisherId><volume>22</volume><issue>1</issue><pages><first>13</first><last>22</last><total>10</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2013</json:string><json:string>1970s</json:string></date><geogName></geogName><orgName><json:string>University of North Carolina School of Dentistry</json:string><json:string>Ora Flow Inc.</json:string><json:string>Department of Dental Research, University of North Carolina School of Dentistry, Chapel Hill, NC</json:string><json:string>Affymetrix Inc., Santa Clara</json:string><json:string>Department of Diagnostic Sciences</json:string><json:string>American College of Prosthodontists</json:string><json:string>American College of Prosthodontists Educational Fund</json:string><json:string>Department of Biostatistics, University of North Carolina School of Dentistry, Chapel Hill, NC</json:string><json:string>Department of Prosthodontics, University of North Carolina School of Dentistry</json:string><json:string>Department of Pharmaceutical</json:string><json:string>Gender Male Female Race Caucasian African American Asian Kapur Index</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Alice Curran</json:string><json:string>Steven Offenbacher</json:string><json:string>Franklin Lakes</json:string><json:string>Sandra Altarawneh</json:string><json:string>Participants</json:string><json:string>In</json:string><json:string>C. R. Mack</json:string><json:string>John Preisser</json:string><json:string>Silvana Barros</json:string><json:string>G. Loewy</json:string><json:string>David Barrow</json:string><json:string>Linda Gendreau</json:string><json:string>Newton Classi</json:string></persName><placeName><json:string>Chapel Hill</json:string><json:string>NY</json:string><json:string>Eppendorf</json:string><json:string>NC</json:string><json:string>York</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Campisi et al</json:string><json:string>Model 6000</json:string><json:string>Beck et al.</json:string><json:string>Ritchie et al</json:string><json:string>Pereira-Cenci et al</json:string><json:string>Radford et al</json:string><json:string>Altarawneh et al</json:string><json:string>Torres et al</json:string><json:string>Barbeau et al</json:string><json:string>Hibino et al</json:string><json:string>Budtz-Jorgensen et al</json:string><json:string>Pires et al</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-14JLP07T-5</json:string></ark><categories><wos><json:string>1 - 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Dentistry</json:string></scopus></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1111/j.1532-849X.2012.00906.x</json:string></doi><id>82D3D64B8AC68301566B6F73A5B7F770F303E925</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/82D3D64B8AC68301566B6F73A5B7F770F303E925/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/82D3D64B8AC68301566B6F73A5B7F770F303E925/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/82D3D64B8AC68301566B6F73A5B7F770F303E925/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of <hi rend="italic">Candida albicans</hi>, Salivary Flow, and Dry Mouth</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><availability><licence>© 2012 by the American College of Prosthodontists</licence></availability><date type="published" when="2013-01"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of <hi rend="italic">Candida albicans</hi>, Salivary Flow, and Dry Mouth</title><title level="a" type="short">Role of C. albicans in Saliva, Mucosal and Denture Surfaces in DS</title><author xml:id="author-0000"><persName><forename type="first">Sandra</forename><surname>Altarawneh</surname><roleName type="degree">DDS, MS</roleName></persName><affiliation>Department of Prosthdontics, University of North Carolina School of Dentistry, Chapel Hill, NC<address><country key="US"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Sompop</forename><surname>Bencharit</surname><roleName type="degree">DDS, MS, PhD</roleName></persName><affiliation>Department of Prosthdontics, University of North Carolina School of Dentistry, Chapel Hill, NC<address><country key="US"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Luisito</forename><surname>Mendoza</surname><roleName type="degree">DDS</roleName></persName><affiliation>Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC<address><country key="US"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Alice</forename><surname>Curran</surname><roleName type="degree">DMD, MS</roleName></persName><affiliation>Department of Diagnostic Sciences & General Dentistry, University of North Carolina School of Dentistry, Chapel Hill, NC<address><country key="US"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">David</forename><surname>Barrow</surname></persName><affiliation>Department of Dental Research, University of North Carolina School of Dentistry, Chapel Hill, NC<address><country key="US"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Silvana</forename><surname>Barros</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation>Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC<address><country key="US"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">John</forename><surname>Preisser</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Biostatistics, University of North Carolina School of Dentistry, Chapel Hill, NC<address><country key="US"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Zvi G.</forename><surname>Loewy</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Pharmaceutical & Biomedical Sciences, Touro College of Pharmacy, New York, NY<address><country key="US"></country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Linda</forename><surname>Gendreau</surname><roleName type="degree">DDS, MS</roleName></persName><affiliation>GlaxoSmithKline, Parsippany, NJ</affiliation></author><author xml:id="author-0009"><persName><forename type="first">Steven</forename><surname>Offenbacher</surname><roleName type="degree">DDS, PhD, MMSc</roleName></persName><affiliation>Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC<address><country key="US"></country></address></affiliation></author><idno type="istex">82D3D64B8AC68301566B6F73A5B7F770F303E925</idno><idno type="ark">ark:/67375/WNG-14JLP07T-5</idno><idno type="DOI">10.1111/j.1532-849X.2012.00906.x</idno><idno type="unit">JOPR906</idno><idno type="toTypesetVersion">file:JOPR.JOPR906.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Prosthodontics</title><title level="j" type="alt">JOURNAL OF PROSTHODONTICS</title><idno type="pISSN">1059-941X</idno><idno type="eISSN">1532-849X</idno><idno type="book-DOI">10.1111/(ISSN)1532-849X</idno><idno type="book-part-DOI">10.1111/jopr.2013.22.issue-1</idno><idno type="product">JOPR</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">22</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="13">13</biblScope><biblScope unit="page" to="22">22</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2013-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p><hi rend="bold">Purpose:</hi> Multifactorial etiological factors contribute to denture stomatitis (DS), a type of oral candidiasis; however, unlike other oral candidiasis, DS can occur in a healthy person wearing a denture. In this study, we therefore attempt to explore the association between candida, denture, and mucosal tissue using (1) exfoliative cytology, (2) the candidal levels present in saliva, on mucosal tissues and on denture surfaces, and (3) the salivary flow rate and xerostomic symptoms.</p><p><hi rend="bold">Materials and Methods:</hi> A cross‐sectional study enrolled 32 edentulous participants, 17 without DS as controls and 15 with DS (Newton's classification type II and III). Participants with systemic or other known oral conditions were excluded. Participants completed a xerostomia questionnaire, and salivary flow rates were measured. Samples of unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected. UWS was used for fungal culturing. Periodic acid‐Schiff (PAS) stain and quantitative exfoliative cytology were performed on samples from affected and unaffected mucosa from each participant. Levels of Candida species (<hi rend="italic">albicans</hi> and non‐<hi rend="italic">albicans</hi>) were determined in salivary samples (expressed as colony‐forming units, CFU), as well as from swab samples obtained from denture fitting surfaces, in addition to affected and unaffected mucosa.</p><p><hi rend="bold">Results:</hi> There were no significant differences in salivary flow rates, mucosal wetness, or frequency of reported dry mouth comparing participants with and without DS. Exfoliative cytology of mucosal smears demonstrated significantly higher (<hi rend="italic">p</hi>= 0.02) inflammatory cell counts in DS patients, as compared with smears of healthy denture‐wearers. <hi rend="italic">Candida albicans</hi> was significantly more prevalent in saliva (<hi rend="italic">p</hi>= 0.03) and on denture surfaces (<hi rend="italic">p</hi>= 0.002) of DS participants, whereas mucosal candidal counts and the presence of cytological hyphae did not show significant difference comparing DS to healthy participants.</p><p><hi rend="bold">Conclusions:</hi> In this investigation, we presented a unique group of healthy edentulous patients. This population may reflect the general DS population without systemic or other oral diseases. The prominent etiological factor for DS in this population is the presence of candida in denture and saliva. We found that other factors such as saliva flow/xerostomia, fitting of the denture, and the presence of candida in the mucosa, are less important in this population. Therefore, DS treatments in healthy patients should first focus on sanitization of an existing denture and/or fabrication of a new denture.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1"><hi rend="italic">C. albicans</hi></term><term xml:id="k2">denture</term><term xml:id="k3">hyposalivation</term><term xml:id="k4">stomatitis</term><term xml:id="k5">exfoliative cytology</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/82D3D64B8AC68301566B6F73A5B7F770F303E925/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Inc</publisherName><publisherLoc>Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1532-849X</doi><issn type="print">1059-941X</issn><issn type="electronic">1532-849X</issn><idGroup><id type="product" value="JOPR"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF PROSTHODONTICS">Journal of Prosthodontics</title><title type="subtitle">Implant, Esthetic and Reconstructive Dentistry</title></titleGroup></publicationMeta><publicationMeta level="part" position="01101"><doi origin="wiley">10.1111/jopr.2013.22.issue-1</doi><numberingGroup><numbering type="journalVolume" number="22">22</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="2013-01">January 2013</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="3" status="forIssue"><doi origin="wiley">10.1111/j.1532-849X.2012.00906.x</doi><idGroup><id type="unit" value="JOPR906"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2012 by the American College of Prosthodontists</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.1.9 mode:FullText" date="2013-01-08"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-10-25"></event><event type="firstOnline" date="2012-10-25"></event><event type="publishedOnlineFinalForm" date="2013-01-08"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-03"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="13">13</numbering><numbering type="pageLast" number="22">22</numbering></numberingGroup><correspondenceTo>Sandra Altarawneh, Department of Prosthodontics, University of North Carolina School of Dentistry, 330 Brauer Hall, CB# 7450, Chapel Hill, NC 27599. E‐mail: <email>altaraws@dentistry.unc.edu</email></correspondenceTo><objectNameGroup><objectName elementName="appendix">Appendix</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:JOPR.JOPR906.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted March 24, 2012</unparsedEditorialHistory><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="6"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="48"></count><count type="linksCrossRef" number="60"></count></countGroup><titleGroup><title type="main">Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of <i>Candida albicans</i>, Salivary Flow, and Dry Mouth</title><title type="shortAuthors">Altarawneh <i>et al</i></title><title type="short">Role of <i>C. albicans</i> in Saliva, Mucosal and Denture Surfaces in DS</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Sandra</givenNames><familyName>Altarawneh</familyName><degrees>DDS, MS</degrees></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Sompop</givenNames><familyName>Bencharit</familyName><degrees>DDS, MS, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>Luisito</givenNames><familyName>Mendoza</familyName><degrees>DDS</degrees></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>Alice</givenNames><familyName>Curran</familyName><degrees>DMD, MS</degrees></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>David</givenNames><familyName>Barrow</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2"><personName><givenNames>Silvana</givenNames><familyName>Barros</familyName><degrees>DDS, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a5"><personName><givenNames>John</givenNames><familyName>Preisser</familyName><degrees>PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a6"><personName><givenNames>Zvi G.</givenNames><familyName>Loewy</familyName><degrees>PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a7"><personName><givenNames>Linda</givenNames><familyName>Gendreau</familyName><degrees>DDS, MS</degrees></personName></creator><creator creatorRole="author" xml:id="cr10" affiliationRef="#a2"><personName><givenNames>Steven</givenNames><familyName>Offenbacher</familyName><degrees>DDS, PhD, MMSc</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Department of Prosthdontics, University of North Carolina School of Dentistry, Chapel Hill, NC</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation>Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="US"><unparsedAffiliation>Department of Diagnostic Sciences & General Dentistry, University of North Carolina School of Dentistry, Chapel Hill, NC</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="US"><unparsedAffiliation>Department of Dental Research, University of North Carolina School of Dentistry, Chapel Hill, NC</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="US"><unparsedAffiliation>Department of Biostatistics, University of North Carolina School of Dentistry, Chapel Hill, NC</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="US"><unparsedAffiliation>Department of Pharmaceutical & Biomedical Sciences, Touro College of Pharmacy, New York, NY</unparsedAffiliation></affiliation><affiliation xml:id="a7"><unparsedAffiliation>GlaxoSmithKline, Parsippany, NJ</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1"><i>C. albicans</i></keyword><keyword xml:id="k2">denture</keyword><keyword xml:id="k3">hyposalivation</keyword><keyword xml:id="k4">stomatitis</keyword><keyword xml:id="k5">exfoliative cytology</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><b>Purpose:</b> Multifactorial etiological factors contribute to denture stomatitis (DS), a type of oral candidiasis; however, unlike other oral candidiasis, DS can occur in a healthy person wearing a denture. In this study, we therefore attempt to explore the association between candida, denture, and mucosal tissue using (1) exfoliative cytology, (2) the candidal levels present in saliva, on mucosal tissues and on denture surfaces, and (3) the salivary flow rate and xerostomic symptoms.</p><p><b>Materials and Methods:</b> A cross‐sectional study enrolled 32 edentulous participants, 17 without DS as controls and 15 with DS (Newton's classification type II and III). Participants with systemic or other known oral conditions were excluded. Participants completed a xerostomia questionnaire, and salivary flow rates were measured. Samples of unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected. UWS was used for fungal culturing. Periodic acid‐Schiff (PAS) stain and quantitative exfoliative cytology were performed on samples from affected and unaffected mucosa from each participant. Levels of Candida species (<i>albicans</i> and non‐<i>albicans</i>) were determined in salivary samples (expressed as colony‐forming units, CFU), as well as from swab samples obtained from denture fitting surfaces, in addition to affected and unaffected mucosa.</p><p><b>Results:</b> There were no significant differences in salivary flow rates, mucosal wetness, or frequency of reported dry mouth comparing participants with and without DS. Exfoliative cytology of mucosal smears demonstrated significantly higher (<i>p</i>= 0.02) inflammatory cell counts in DS patients, as compared with smears of healthy denture‐wearers. <i>Candida albicans</i> was significantly more prevalent in saliva (<i>p</i>= 0.03) and on denture surfaces (<i>p</i>= 0.002) of DS participants, whereas mucosal candidal counts and the presence of cytological hyphae did not show significant difference comparing DS to healthy participants.</p><p><b>Conclusions:</b> In this investigation, we presented a unique group of healthy edentulous patients. This population may reflect the general DS population without systemic or other oral diseases. The prominent etiological factor for DS in this population is the presence of candida in denture and saliva. We found that other factors such as saliva flow/xerostomia, fitting of the denture, and the presence of candida in the mucosa, are less important in this population. Therefore, DS treatments in healthy patients should first focus on sanitization of an existing denture and/or fabrication of a new denture.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="n-fnt-1"><p><i>This work was supported by NIH research grants UL‐1‐RR025746 and R21HL092338, GSK Consumer Healthcare, and the American College of Prosthodontists Educational Fund</i>.</p></note><note xml:id="n-fnt-2"><p><i>The funder had no role in manuscript preparation or submission of the manuscript; however, Authors ZGL and LG are, respectively, former and current employees of GSK, one of the funders</i>.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of Candida albicans, Salivary Flow, and Dry Mouth</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Role of C. albicans in Saliva, Mucosal and Denture Surfaces in DS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of Candida albicans, Salivary Flow, and Dry Mouth</title></titleInfo><name type="personal"><namePart type="given">Sandra</namePart><namePart type="family">Altarawneh</namePart><namePart type="termsOfAddress">DDS, MS</namePart><affiliation>Department of Prosthdontics, University of North Carolina School of Dentistry, Chapel Hill, NC</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sompop</namePart><namePart type="family">Bencharit</namePart><namePart type="termsOfAddress">DDS, MS, PhD</namePart><affiliation>Department of Prosthdontics, University of North Carolina School of Dentistry, Chapel Hill, NC</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luisito</namePart><namePart type="family">Mendoza</namePart><namePart type="termsOfAddress">DDS</namePart><affiliation>Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alice</namePart><namePart type="family">Curran</namePart><namePart type="termsOfAddress">DMD, MS</namePart><affiliation>Department of Diagnostic Sciences & General Dentistry, University of North Carolina School of Dentistry, Chapel Hill, NC</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David</namePart><namePart type="family">Barrow</namePart><affiliation>Department of Dental Research, University of North Carolina School of Dentistry, Chapel Hill, NC</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Silvana</namePart><namePart type="family">Barros</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John</namePart><namePart type="family">Preisser</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Biostatistics, University of North Carolina School of Dentistry, Chapel Hill, NC</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Zvi G.</namePart><namePart type="family">Loewy</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Pharmaceutical & Biomedical Sciences, Touro College of Pharmacy, New York, NY</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Linda</namePart><namePart type="family">Gendreau</namePart><namePart type="termsOfAddress">DDS, MS</namePart><affiliation>GlaxoSmithKline, Parsippany, NJ</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Steven</namePart><namePart type="family">Offenbacher</namePart><namePart type="termsOfAddress">DDS, PhD, MMSc</namePart><affiliation>Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2013-01</dateIssued><edition>Accepted March 24, 2012</edition><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">3</extent><extent unit="tables">6</extent><extent unit="formulas">0</extent><extent unit="references">48</extent><extent unit="linksCrossRef">60</extent></physicalDescription><abstract>Purpose: Multifactorial etiological factors contribute to denture stomatitis (DS), a type of oral candidiasis; however, unlike other oral candidiasis, DS can occur in a healthy person wearing a denture. In this study, we therefore attempt to explore the association between candida, denture, and mucosal tissue using (1) exfoliative cytology, (2) the candidal levels present in saliva, on mucosal tissues and on denture surfaces, and (3) the salivary flow rate and xerostomic symptoms.</abstract><abstract>Materials and Methods: A cross‐sectional study enrolled 32 edentulous participants, 17 without DS as controls and 15 with DS (Newton's classification type II and III). Participants with systemic or other known oral conditions were excluded. Participants completed a xerostomia questionnaire, and salivary flow rates were measured. Samples of unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected. UWS was used for fungal culturing. Periodic acid‐Schiff (PAS) stain and quantitative exfoliative cytology were performed on samples from affected and unaffected mucosa from each participant. Levels of Candida species (albicans and non‐albicans) were determined in salivary samples (expressed as colony‐forming units, CFU), as well as from swab samples obtained from denture fitting surfaces, in addition to affected and unaffected mucosa.</abstract><abstract>Results: There were no significant differences in salivary flow rates, mucosal wetness, or frequency of reported dry mouth comparing participants with and without DS. Exfoliative cytology of mucosal smears demonstrated significantly higher (p= 0.02) inflammatory cell counts in DS patients, as compared with smears of healthy denture‐wearers. Candida albicans was significantly more prevalent in saliva (p= 0.03) and on denture surfaces (p= 0.002) of DS participants, whereas mucosal candidal counts and the presence of cytological hyphae did not show significant difference comparing DS to healthy participants.</abstract><abstract>Conclusions: In this investigation, we presented a unique group of healthy edentulous patients. This population may reflect the general DS population without systemic or other oral diseases. The prominent etiological factor for DS in this population is the presence of candida in denture and saliva. We found that other factors such as saliva flow/xerostomia, fitting of the denture, and the presence of candida in the mucosa, are less important in this population. Therefore, DS treatments in healthy patients should first focus on sanitization of an existing denture and/or fabrication of a new denture.</abstract><subject lang="en"><genre>keywords</genre><topic>C. albicans</topic><topic>denture</topic><topic>hyposalivation</topic><topic>stomatitis</topic><topic>exfoliative cytology</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Prosthodontics</title><subTitle>Implant, Esthetic and Reconstructive Dentistry</subTitle></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1059-941X</identifier><identifier type="eISSN">1532-849X</identifier><identifier type="DOI">10.1111/(ISSN)1532-849X</identifier><identifier type="PublisherID">JOPR</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>13</start><end>22</end><total>10</total></extent></part></relatedItem><identifier type="istex">82D3D64B8AC68301566B6F73A5B7F770F303E925</identifier><identifier type="ark">ark:/67375/WNG-14JLP07T-5</identifier><identifier type="DOI">10.1111/j.1532-849X.2012.00906.x</identifier><identifier type="ArticleID">JOPR906</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2012 by the American College of Prosthodontists</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/82D3D64B8AC68301566B6F73A5B7F770F303E925/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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