EdenteV2, Istex, Corpus, bibRecord, 004073

The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes

Identifieur interne : 004073 ( Istex/Corpus ); précédent : 004072; suivant : 004074

The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes

Auteurs : Svatava Lagronova-Churava ; Frantisek Spoutil ; Simona Vojtechova ; Herve Lesot ; Miroslav Peterka ; Ophir D. Klein ; Renata Peterkova

Source :

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution [ 1552-5007 ] ; 2013-07.

RBID : ISTEX:823EF7893D4D7B0C9AF7F9113489EDA34B066918

English descriptors

KwdEn :
- Adult mice, Anterior part, Anterior portion, Anteroconid, Apoptosis, Apoptotic, Biol, Biol peterkova, Body weight, Cheek region, Cobourne, Craniofac genet, Cusp, Cusp pattern, Czech, Czech republic, Dental epithelium, Dental measurements, Dentition, Diastema, Embryo, Enamel, Enamel knot, Enamel organ, Epithelium, Evol, Experimental medicine, Expression domains, Histological, Histological sections, Horizontal direction, Incisor, Jernvall, Klein, Larger size, Leica, Leica dmlb microscope, Leica microsystems gmbh, Lesot, Lower apoptosis, Lower molar, Mandible, Mitosis, Mitotic, Mitotic cells, Molar, Morphogenesis, Morphometric, Morphometric analysis, Mouse, Mouse embryos, Mouse molar morphogenesis, Mouse odontogenesis, Mutant, Mutant mice, Odontogenesis, Ohazama, Peterka, Peterkova, Posteriorly, Postnatal, Premolar, Prenatal, Prenatal stages, Present data, Primordium, Prochazka, Quadrant, Revitalization, Ruch, Rudiment, Rudimentary buds, Rudimentary tooth primordia, Rudiments, Scale bars, Sonic hedgehog, Spatial distribution, Sprouty, Sprouty genes, Sprouty mutants, Spry2, Spry2 mutants, Spry4, Spry4 mutants, Supernumerary, Supernumerary teeth, Supernumerary tooth, Supernumerary tooth development, Supernumerary tooth formation, Supernumerary tooth germs, Tooth, Tooth development, Tooth primordia, Tooth primordium, Total length, Viriot, Vonesch, Zool.
Teeft :
- Adult mice, Anterior part, Anterior portion, Anteroconid, Apoptosis, Apoptotic, Biol, Biol peterkova, Body weight, Cheek region, Cobourne, Craniofac genet, Cusp, Cusp pattern, Czech, Czech republic, Dental epithelium, Dental measurements, Dentition, Diastema, Embryo, Enamel, Enamel knot, Enamel organ, Epithelium, Evol, Experimental medicine, Expression domains, Histological, Histological sections, Horizontal direction, Incisor, Jernvall, Klein, Larger size, Leica, Leica dmlb microscope, Leica microsystems gmbh, Lesot, Lower apoptosis, Lower molar, Mandible, Mitosis, Mitotic, Mitotic cells, Molar, Morphogenesis, Morphometric, Morphometric analysis, Mouse, Mouse embryos, Mouse molar morphogenesis, Mouse odontogenesis, Mutant, Mutant mice, Odontogenesis, Ohazama, Peterka, Peterkova, Posteriorly, Postnatal, Premolar, Prenatal, Prenatal stages, Present data, Primordium, Prochazka, Quadrant, Revitalization, Ruch, Rudiment, Rudimentary buds, Rudimentary tooth primordia, Rudiments, Scale bars, Sonic hedgehog, Spatial distribution, Sprouty, Sprouty genes, Sprouty mutants, Spry2, Spry2 mutants, Spry4, Spry4 mutants, Supernumerary, Supernumerary teeth, Supernumerary tooth, Supernumerary tooth development, Supernumerary tooth formation, Supernumerary tooth germs, Tooth, Tooth development, Tooth primordia, Tooth primordium, Total length, Viriot, Vonesch, Zool.

Abstract

In mice, a toothless diastema separates the single incisor from the three molars in each dental quadrant. In the prospective diastema of the embryo, small rudimentary buds are found that are presumed to be rudiments of suppressed teeth. A supernumerary tooth occurs in the diastema of adult mice carrying mutations in either Spry2 or Spry4. In the case of Spry2 mutants, the origin of the supernumerary tooth involves the revitalization of a rudimentary tooth bud (called R2), whereas its origin in the Spry4 mutants is not known. In addition to R2, another rudimentary primordium (called MS) arises more anteriorly in the prospective diastema. We investigated the participation of both rudiments (MS and R2) in supernumerary tooth development in Spry2 and Spry4 mutants by comparing morphogenesis, proliferation, apoptosis, size and Shh expression in the dental epithelium of MS and R2 rudiments. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in Spry2−/− embryos. Apoptosis was also decreased in both rudiments in Spry4−/− embryos, but the proliferation was lower (similar to WT mice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Compared to Spry2−/− mice, a high number of Spry4−/− supernumerary tooth primordia degenerated after ED13.5, resulting in a low percentage of supernumerary teeth in adults. We propose that Sprouty genes were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution. J. Exp. Zool. (Mol. Dev. Evol.) 320B:307–320, 2013. © 2013 Wiley Periodicals, Inc.

Url:

https://api.istex.fr/document/823EF7893D4D7B0C9AF7F9113489EDA34B066918/fulltext/pdf

DOI: 10.1002/jez.b.22502

Links to Exploration step

ISTEX:823EF7893D4D7B0C9AF7F9113489EDA34B066918

Le document en format XML

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<affiliation><mods:affiliation>Correspondence to: Svatava Churava, Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v. v. i., Videnska 1083, 14220 Prague, Czech Republic.E‐mail:</mods:affiliation>
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<front><div type="abstract" xml:lang="en">In mice, a toothless diastema separates the single incisor from the three molars in each dental quadrant. In the prospective diastema of the embryo, small rudimentary buds are found that are presumed to be rudiments of suppressed teeth. A supernumerary tooth occurs in the diastema of adult mice carrying mutations in either Spry2 or Spry4. In the case of Spry2 mutants, the origin of the supernumerary tooth involves the revitalization of a rudimentary tooth bud (called R2), whereas its origin in the Spry4 mutants is not known. In addition to R2, another rudimentary primordium (called MS) arises more anteriorly in the prospective diastema. We investigated the participation of both rudiments (MS and R2) in supernumerary tooth development in Spry2 and Spry4 mutants by comparing morphogenesis, proliferation, apoptosis, size and Shh expression in the dental epithelium of MS and R2 rudiments. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in Spry2−/− embryos. Apoptosis was also decreased in both rudiments in Spry4−/− embryos, but the proliferation was lower (similar to WT mice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Compared to Spry2−/− mice, a high number of Spry4−/− supernumerary tooth primordia degenerated after ED13.5, resulting in a low percentage of supernumerary teeth in adults. We propose that Sprouty genes were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution. J. Exp. Zool. (Mol. Dev. Evol.) 320B:307–320, 2013. © 2013 Wiley Periodicals, Inc.</div>
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<abstract>In mice, a toothless diastema separates the single incisor from the three molars in each dental quadrant. In the prospective diastema of the embryo, small rudimentary buds are found that are presumed to be rudiments of suppressed teeth. A supernumerary tooth occurs in the diastema of adult mice carrying mutations in either Spry2 or Spry4. In the case of Spry2 mutants, the origin of the supernumerary tooth involves the revitalization of a rudimentary tooth bud (called R2), whereas its origin in the Spry4 mutants is not known. In addition to R2, another rudimentary primordium (called MS) arises more anteriorly in the prospective diastema. We investigated the participation of both rudiments (MS and R2) in supernumerary tooth development in Spry2 and Spry4 mutants by comparing morphogenesis, proliferation, apoptosis, size and Shh expression in the dental epithelium of MS and R2 rudiments. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in Spry2−/− embryos. Apoptosis was also decreased in both rudiments in Spry4−/− embryos, but the proliferation was lower (similar to WT mice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Compared to Spry2−/− mice, a high number of Spry4−/− supernumerary tooth primordia degenerated after ED13.5, resulting in a low percentage of supernumerary teeth in adults. We propose that Sprouty genes were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution. J. Exp. Zool. (Mol. Dev. Evol.) 320B:307–320, 2013. © 2013 Wiley Periodicals, Inc.</abstract>
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<profileDesc><abstract xml:lang="en" style="main"><head>ABSTRACT</head>
<p>In mice, a toothless diastema separates the single incisor from the three molars in each dental quadrant. In the prospective diastema of the embryo, small rudimentary buds are found that are presumed to be rudiments of suppressed teeth. A supernumerary tooth occurs in the diastema of adult mice carrying mutations in either <hi rend="italic">Spry2</hi>
 or <hi rend="italic">Spry4</hi>
. In the case of <hi rend="italic">Spry2</hi>
 mutants, the origin of the supernumerary tooth involves the revitalization of a rudimentary tooth bud (called R2), whereas its origin in the <hi rend="italic">Spry4</hi>
 mutants is not known. In addition to R2, another rudimentary primordium (called MS) arises more anteriorly in the prospective diastema. We investigated the participation of both rudiments (MS and R2) in supernumerary tooth development in <hi rend="italic">Spry2</hi>
 and <hi rend="italic">Spry4</hi>
 mutants by comparing morphogenesis, proliferation, apoptosis, size and <hi rend="italic">Shh</hi>
 expression in the dental epithelium of MS and R2 rudiments. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in <hi rend="italic">Spry2</hi>
<hi rend="superscript"><hi rend="italic">−/−</hi>
</hi>
 embryos. Apoptosis was also decreased in both rudiments in <hi rend="italic">Spry4</hi>
<hi rend="superscript"><hi rend="italic">−/−</hi>
</hi>
 embryos, but the proliferation was lower (similar to WT mice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Compared to <hi rend="italic">Spry2</hi>
<hi rend="superscript"><hi rend="italic">−/−</hi>
</hi>
 mice, a high number of <hi rend="italic">Spry4</hi>
<hi rend="superscript"><hi rend="italic">−/−</hi>
</hi>
 supernumerary tooth primordia degenerated after ED13.5, resulting in a low percentage of supernumerary teeth in adults. We propose that Sprouty genes were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution. J. Exp. Zool. (Mol. Dev. Evol.) 320B:307–320, 2013. © 2013 Wiley Periodicals, Inc.</p>
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 <givenNames>S</givenNames>
</author>, 
<author><familyName>Spoutil</familyName>
 <givenNames>F</givenNames>
</author>, 
<author><familyName>Vojtechova</familyName>
 <givenNames>S</givenNames>
</author>, 
<author><familyName>Lesot</familyName>
 <givenNames>H</givenNames>
</author>, 
<author><familyName>Peterka</familyName>
 <givenNames>M</givenNames>
</author>, 
<author><familyName>Klein</familyName>
 <givenNames>OD</givenNames>
</author>, 
<author><familyName>Peterkova</familyName>
 <givenNames>R</givenNames>
</author>. 
<pubYear year="2013">2013</pubYear>. 
<articleTitle>The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes</articleTitle>. 
<journalTitle>J. Exp. Zool. (Mol. Dev. Evol.)</journalTitle> 
<vol>320B</vol>
:<pageFirst>307</pageFirst>
–<pageLast>320</pageLast>.
</citation>
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<contentMeta><titleGroup><title type="main">The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes</title>
<title type="short">SUPERNUMERARY TOOTH DEVELOPMENT IN SPROUTY MUTANTS</title>
<title type="shortAuthors">LAGRONOVA‐CHURAVA ET AL.</title>
</titleGroup>
<creators><creator xml:id="jezb22502-cr-0001" creatorRole="author" affiliationRef="#jezb22502-aff-0001 #jezb22502-aff-0002" corresponding="yes"><personName><givenNames>SVATAVA</givenNames>
 <familyName>LAGRONOVA‐CHURAVA</familyName>
</personName>
</creator>
<creator xml:id="jezb22502-cr-0002" creatorRole="author" affiliationRef="#jezb22502-aff-0001"><personName><givenNames>FRANTISEK</givenNames>
 <familyName>SPOUTIL</familyName>
</personName>
</creator>
<creator xml:id="jezb22502-cr-0003" creatorRole="author" affiliationRef="#jezb22502-aff-0001"><personName><givenNames>SIMONA</givenNames>
 <familyName>VOJTECHOVA</familyName>
</personName>
</creator>
<creator xml:id="jezb22502-cr-0004" creatorRole="author" affiliationRef="#jezb22502-aff-0003"><personName><givenNames>HERVE</givenNames>
 <familyName>LESOT</familyName>
</personName>
</creator>
<creator xml:id="jezb22502-cr-0005" creatorRole="author" affiliationRef="#jezb22502-aff-0001"><personName><givenNames>MIROSLAV</givenNames>
 <familyName>PETERKA</familyName>
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<creator xml:id="jezb22502-cr-0006" creatorRole="author" affiliationRef="#jezb22502-aff-0004"><personName><givenNames>OPHIR D.</givenNames>
 <familyName>KLEIN</familyName>
</personName>
</creator>
<creator xml:id="jezb22502-cr-0007" creatorRole="author" affiliationRef="#jezb22502-aff-0001"><personName><givenNames>RENATA</givenNames>
 <familyName>PETERKOVA</familyName>
</personName>
</creator>
</creators>
<affiliationGroup><affiliation xml:id="jezb22502-aff-0001" countryCode="CZ"><orgDiv>Department of Teratology</orgDiv>
<orgName>Institute of Experimental Medicine AS CR</orgName>
<address><city>Prague</city>
<country>Czech Republic</country>
</address>
</affiliation>
<affiliation xml:id="jezb22502-aff-0002" countryCode="CZ"><orgDiv>Department of Anthropology and Human Genetics</orgDiv>
<orgName>Faculty of Science, Charles University</orgName>
<address><city>Prague</city>
<country>Czech Republic</country>
</address>
</affiliation>
<affiliation xml:id="jezb22502-aff-0003" countryCode="FR"><orgDiv>INSERM UMR 1109, Team “Osteoarticular and Dental Regenerative NanoMedicine”, and Dental School</orgDiv>
<orgName>Université de Strasbourg</orgName>
<address><city>Strasbourg</city>
<country>France</country>
</address>
</affiliation>
<affiliation xml:id="jezb22502-aff-0004" countryCode="US"><orgDiv>Departments of Orofacial Sciences and Pediatrics and Program in Craniofacial and Mesenchymal Biology</orgDiv>
<orgName>University of California San Francisco</orgName>
<address><city>San Francisco, California</city>
</address>
</affiliation>
</affiliationGroup>
<fundingInfo><fundingAgency>Grant Agency of the Czech Republic</fundingAgency>
<fundingNumber>CZ:GA ČR:GAP305/12/1766</fundingNumber>
</fundingInfo>
<abstractGroup><abstract type="main" xml:lang="en"><title type="main">ABSTRACT</title>
<section xml:id="jezb22502-sec-0001"><p>In mice, a toothless diastema separates the single incisor from the three molars in each dental quadrant. In the prospective diastema of the embryo, small rudimentary buds are found that are presumed to be rudiments of suppressed teeth. A supernumerary tooth occurs in the diastema of adult mice carrying mutations in either <i>Spry2</i>
 or <i>Spry4</i>
. In the case of <i>Spry2</i>
 mutants, the origin of the supernumerary tooth involves the revitalization of a rudimentary tooth bud (called R2), whereas its origin in the <i>Spry4</i>
 mutants is not known. In addition to R2, another rudimentary primordium (called MS) arises more anteriorly in the prospective diastema. We investigated the participation of both rudiments (MS and R2) in supernumerary tooth development in <i>Spry2</i>
 and <i>Spry4</i>
 mutants by comparing morphogenesis, proliferation, apoptosis, size and <i>Shh</i>
 expression in the dental epithelium of MS and R2 rudiments. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in <i>Spry2</i>
<sup><i>−/−</i>
</sup>
 embryos. Apoptosis was also decreased in both rudiments in <i>Spry4</i>
<sup><i>−/−</i>
</sup>
 embryos, but the proliferation was lower (similar to WT mice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Compared to <i>Spry2</i>
<sup><i>−/−</i>
</sup>
 mice, a high number of <i>Spry4</i>
<sup><i>−/−</i>
</sup>
 supernumerary tooth primordia degenerated after ED13.5, resulting in a low percentage of supernumerary teeth in adults. We propose that Sprouty genes were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution. J. Exp. Zool. (Mol. Dev. Evol.) 320B:307–320, 2013. © 2013 Wiley Periodicals, Inc.</p>
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<titleInfo type="abbreviated" lang="en"><title>SUPERNUMERARY TOOTH DEVELOPMENT IN SPROUTY MUTANTS</title>
</titleInfo>
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<name type="personal"><namePart type="given">SVATAVA</namePart>
<namePart type="family">LAGRONOVA‐CHURAVA</namePart>
<affiliation>Department of Teratology, Institute of Experimental Medicine AS CR, Prague, Czech Republic</affiliation>
<affiliation>Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Prague, Czech Republic</affiliation>
<affiliation>Correspondence to: Svatava Churava, Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v. v. i., Videnska 1083, 14220 Prague, Czech Republic.E‐mail:</affiliation>
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<name type="personal"><namePart type="given">OPHIR D.</namePart>
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<role><roleTerm type="text">author</roleTerm>
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<abstract lang="en">In mice, a toothless diastema separates the single incisor from the three molars in each dental quadrant. In the prospective diastema of the embryo, small rudimentary buds are found that are presumed to be rudiments of suppressed teeth. A supernumerary tooth occurs in the diastema of adult mice carrying mutations in either Spry2 or Spry4. In the case of Spry2 mutants, the origin of the supernumerary tooth involves the revitalization of a rudimentary tooth bud (called R2), whereas its origin in the Spry4 mutants is not known. In addition to R2, another rudimentary primordium (called MS) arises more anteriorly in the prospective diastema. We investigated the participation of both rudiments (MS and R2) in supernumerary tooth development in Spry2 and Spry4 mutants by comparing morphogenesis, proliferation, apoptosis, size and Shh expression in the dental epithelium of MS and R2 rudiments. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in Spry2−/− embryos. Apoptosis was also decreased in both rudiments in Spry4−/− embryos, but the proliferation was lower (similar to WT mice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Compared to Spry2−/− mice, a high number of Spry4−/− supernumerary tooth primordia degenerated after ED13.5, resulting in a low percentage of supernumerary teeth in adults. We propose that Sprouty genes were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution. J. Exp. Zool. (Mol. Dev. Evol.) 320B:307–320, 2013. © 2013 Wiley Periodicals, Inc.</abstract>
<note type="funding">Grant Agency of the Czech Republic - No. CZ:GA ČR:GAP305/12/1766; </note>
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The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes

The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes

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