Porphyromonas gingivalis promotes murine abdominal aortic aneurysms via matrix metalloproteinase‐2 induction
Identifieur interne : 003A71 ( Istex/Corpus ); précédent : 003A70; suivant : 003A72Porphyromonas gingivalis promotes murine abdominal aortic aneurysms via matrix metalloproteinase‐2 induction
Auteurs : N. Aoyama ; J. Suzuki ; D. Wang ; M. Ogawa ; N. Kobayashi ; T. Hanatani ; Y. Takeuchi ; Y. Izumi ; M. IsobeSource :
- Journal of Periodontal Research [ 0022-3484 ] ; 2011-04.
English descriptors
- KwdEn :
- Abdominal aortic aneurysm, Abdominal aortic aneurysms, Actinomycetemcomitans, Aggregatibacter, Aggregatibacter actinomycetemcomitans, Aneurysm, Aortic, Aortic aneurysms, Aortic diameter, Aortic tissue, Aortic wall, Cacl2, Cacl2 treatment, Cardiovascular, Cardiovascular disease, Clin, Clin microbiol, Dental university, Gingivalis, Gingivalis infection, Matrix, Mmps, Mouse, Murine, Nacl, Nacl treatment, Pathogen, Periodontal, Periodontal disease, Periodontal pathogens, Periodontitis, Periodontol, Periodontopathic, Periodontopathic bacteria, Plasma levels, Plasma samples, Porphyromonas, Porphyromonas gingivalis, Present study, Splenocytes, Uninfected mice, Vasc.
- Teeft :
- Abdominal aortic aneurysm, Abdominal aortic aneurysms, Actinomycetemcomitans, Aggregatibacter, Aggregatibacter actinomycetemcomitans, Aneurysm, Aortic, Aortic aneurysms, Aortic diameter, Aortic tissue, Aortic wall, Cacl2, Cacl2 treatment, Cardiovascular, Cardiovascular disease, Clin, Clin microbiol, Dental university, Gingivalis, Gingivalis infection, Matrix, Mmps, Mouse, Murine, Nacl, Nacl treatment, Pathogen, Periodontal, Periodontal disease, Periodontal pathogens, Periodontitis, Periodontol, Periodontopathic, Periodontopathic bacteria, Plasma levels, Plasma samples, Porphyromonas, Porphyromonas gingivalis, Present study, Splenocytes, Uninfected mice, Vasc.
Abstract
Aoyama N, Suzuki J, Wang D, Ogawa M, Kobayashi N, Hanatani T, Takeuchi Y, Izumi Y, Isobe M. Porphyromonas gingivalis promotes murine abdominal aortic aneurysms via matrix metalloproteinase‐2 induction. J Periodont Res 2011; 46: 176–183. © 2010 John Wiley & Sons A/S
Url:
DOI: 10.1111/j.1600-0765.2010.01326.x
Links to Exploration step
ISTEX:76E5742732168605CD97F2A0485B44A88BB30C16Le document en format XML
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Aoyama</name><affiliation><mods:affiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Suzuki, J" sort="Suzuki, J" uniqKey="Suzuki J" first="J." last="Suzuki">J. Suzuki</name><affiliation><mods:affiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Wang, D" sort="Wang, D" uniqKey="Wang D" first="D." last="Wang">D. Wang</name><affiliation><mods:affiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Periodontics and Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing, China</mods:affiliation></affiliation></author><author><name sortKey="Ogawa, M" sort="Ogawa, M" uniqKey="Ogawa M" first="M." last="Ogawa">M. Ogawa</name><affiliation><mods:affiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kobayashi, N" sort="Kobayashi, N" uniqKey="Kobayashi N" first="N." last="Kobayashi">N. 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Porphyromonas gingivalis promotes murine abdominal aortic aneurysms via matrix metalloproteinase‐2 induction. J Periodont Res 2011; 46: 176–183. © 2010 John Wiley & Sons A/S</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>gingivalis</json:string><json:string>aortic</json:string><json:string>actinomycetemcomitans</json:string><json:string>aneurysm</json:string><json:string>periodontal</json:string><json:string>cacl2</json:string><json:string>porphyromonas</json:string><json:string>periodontitis</json:string><json:string>nacl</json:string><json:string>mmps</json:string><json:string>porphyromonas gingivalis</json:string><json:string>matrix</json:string><json:string>periodontopathic</json:string><json:string>pathogen</json:string><json:string>aortic diameter</json:string><json:string>periodontal disease</json:string><json:string>cacl2 treatment</json:string><json:string>aggregatibacter</json:string><json:string>vasc</json:string><json:string>periodontol</json:string><json:string>periodontopathic bacteria</json:string><json:string>splenocytes</json:string><json:string>murine</json:string><json:string>aggregatibacter actinomycetemcomitans</json:string><json:string>clin</json:string><json:string>abdominal aortic aneurysm</json:string><json:string>abdominal aortic aneurysms</json:string><json:string>dental university</json:string><json:string>periodontal pathogens</json:string><json:string>gingivalis infection</json:string><json:string>cardiovascular</json:string><json:string>aortic wall</json:string><json:string>cardiovascular disease</json:string><json:string>aortic aneurysms</json:string><json:string>nacl treatment</json:string><json:string>uninfected mice</json:string><json:string>clin microbiol</json:string><json:string>aortic tissue</json:string><json:string>plasma samples</json:string><json:string>present study</json:string><json:string>plasma levels</json:string><json:string>mouse</json:string></teeft></keywords><author><json:item><name>N. Aoyama</name><affiliations><json:string>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>J. Suzuki</name><affiliations><json:string>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</json:string><json:string>Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>D. Wang</name><affiliations><json:string>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</json:string><json:string>Department of Periodontics and Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing, China</json:string></affiliations></json:item><json:item><name>M. Ogawa</name><affiliations><json:string>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</json:string><json:string>Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>N. Kobayashi</name><affiliations><json:string>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>T. Hanatani</name><affiliations><json:string>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Y. Takeuchi</name><affiliations><json:string>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Y. Izumi</name><affiliations><json:string>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</json:string><json:string>Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>M. Isobe</name><affiliations><json:string>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>animal model</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>matrix metalloproteinase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>inflammation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Porphyromonas gingivalis</value></json:item></subject><articleId><json:string>JRE1326</json:string></articleId><arkIstex>ark:/67375/WNG-TNZRST69-D</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Aoyama N, Suzuki J, Wang D, Ogawa M, Kobayashi N, Hanatani T, Takeuchi Y, Izumi Y, Isobe M. Porphyromonas gingivalis promotes murine abdominal aortic aneurysms via matrix metalloproteinase‐2 induction. 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type="first">N.</forename><surname>Aoyama</surname></persName><affiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">J.</forename><surname>Suzuki</surname></persName><affiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan<address><country key="JP"></country></address></affiliation><affiliation>Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">D.</forename><surname>Wang</surname></persName><affiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan<address><country key="JP"></country></address></affiliation><affiliation>Department of Periodontics and Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing, China<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">M.</forename><surname>Ogawa</surname></persName><affiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan<address><country key="JP"></country></address></affiliation><affiliation>Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">N.</forename><surname>Kobayashi</surname></persName><affiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">T.</forename><surname>Hanatani</surname></persName><affiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Y.</forename><surname>Takeuchi</surname></persName><affiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Y.</forename><surname>Izumi</surname></persName><affiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan<address><country key="JP"></country></address></affiliation><affiliation>Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, Tokyo, Japan<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">M.</forename><surname>Isobe</surname></persName><affiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan<address><country key="JP"></country></address></affiliation></author><idno type="istex">76E5742732168605CD97F2A0485B44A88BB30C16</idno><idno type="ark">ark:/67375/WNG-TNZRST69-D</idno><idno type="DOI">10.1111/j.1600-0765.2010.01326.x</idno><idno type="unit">JRE1326</idno><idno type="toTypesetVersion">file:JRE.JRE1326.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Periodontal Research</title><title level="j" type="alt">JOURNAL OF PERIODONTAL RESEARCH</title><idno type="pISSN">0022-3484</idno><idno type="eISSN">1600-0765</idno><idno type="book-DOI">10.1111/(ISSN)1600-0765</idno><idno type="book-part-DOI">10.1111/jre.2011.46.issue-2</idno><idno type="product">JRE</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">46</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="176">176</biblScope><biblScope unit="page" to="183">183</biblScope><biblScope unit="page-count">8</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-04"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>
<hi rend="italic">Aoyama N, Suzuki J, Wang D, Ogawa M, Kobayashi N, Hanatani T, Takeuchi Y, Izumi Y, Isobe M.</hi> Porphyromonas gingivalis <hi rend="italic">promotes murine abdominal aortic aneurysms via matrix metalloproteinase‐2 induction. J Periodont Res 2011; 46: 176–183. © 2010 John Wiley & Sons A/S</hi></p><p><hi rend="bold">Background and Objective: </hi> Abdominal aortic aneurysm (AAA) is a common and lethal disorder, and MMPs are highly expressed in AAA lesions. Large numbers of periodontopathic bacteria have been reported to be present in specimens obtained from the aortic walls of patients with an AAA. The purpose of this study was to analyze the influence of periodontopathic bacteria on AAA dilatation.</p><p><hi rend="bold">Material and Methods: </hi> AAAs were produced in mice by the periaortic application of 0.25 <hi rend="smallCaps">m</hi> CaCl<hi rend="subscript">2</hi>, and NaCl was used as a control. The mice were inoculated once weekly with live <hi rend="italic">Porphyromonas gingivalis</hi>, live <hi rend="italic">Aggregatibacter actinomycetemcomitans</hi> or vehicle.</p><p><hi rend="bold">Results: </hi> Four weeks after the periaortic application of either CaCl<hi rend="subscript">2</hi> or NaCl, a significant increase was observed in the aortic diameter of <hi rend="italic">P. gingivalis</hi>‐challenged mice compared with the vehicle control mice (<hi rend="italic">p </hi><<hi rend="italic"> </hi>0.05), whereas there was no statistically significant increase in the aortic diameter of the <hi rend="italic">A. actinomycetemcomitans</hi>‐challenged mice. Immunohistochemical analysis found significantly higher numbers of CD8‐positive and MOMA2‐positive cells and significantly higher levels of MMP‐2 in the aneurysmal samples of <hi rend="italic">P. gingivalis</hi>‐challenged mice compared with control mice. Live <hi rend="italic">P. gingivalis</hi> promoted a significant proliferation of splenocytes in comparison with <hi rend="italic">P. gingivalis</hi>‐lipopolysaccharide and live <hi rend="italic">A. actinomycetemcomitans</hi> (<hi rend="italic">p </hi>< 0.05).</p><p><hi rend="bold">Conclusion: </hi> These findings demonstrate that challenge with <hi rend="italic">P. gingivalis</hi>, but not with <hi rend="italic">A. actinomycetemcomitans</hi>, can accelerate, or even initiate, the progression of experimental AAA through the increased expression of MMPs.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">animal model</term><term xml:id="k2">matrix metalloproteinase</term><term xml:id="k3">inflammation</term><term xml:id="k4"><hi rend="italic">Porphyromonas gingivalis</hi></term></keywords><keywords rend="tocHeading1"><term>ORIGINAL ARTICLES</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/76E5742732168605CD97F2A0485B44A88BB30C16/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0765</doi><issn type="print">0022-3484</issn><issn type="electronic">1600-0765</issn><idGroup><id type="product" value="JRE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF PERIODONTAL RESEARCH">Journal of Periodontal Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="04102"><doi origin="wiley">10.1111/jre.2011.46.issue-2</doi><numberingGroup><numbering type="journalVolume" number="46">46</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="2011-04">April 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley">10.1111/j.1600-0765.2010.01326.x</doi><idGroup><id type="unit" value="JRE1326"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">ORIGINAL ARTICLES</title></titleGroup><copyright>© 2010 John Wiley & Sons A/S</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.4.7 mode:FullText" date="2011-02-23"></event><event type="publishedOnlineEarlyUnpaginated" date="2010-12-10"></event><event type="firstOnline" date="2010-12-10"></event><event type="publishedOnlineFinalForm" date="2011-02-23"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="176">176</numbering><numbering type="pageLast" number="183">183</numbering></numberingGroup><correspondenceTo>Mitsuaki Isobe, MD, PhD, Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1‐5‐45 Yushima, Bunkyo‐ku, Tokyo 113‐8549, Japan
Tel: 81‐3‐5803‐5951
Fax: 81‐3‐5803‐0238
e‐mail: <email>isobemi.cvm@tmd.ac.jp</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JRE.JRE1326.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication September 29, 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="6"></count><count type="tableTotal" number="0"></count></countGroup><titleGroup><title type="main"><i>Porphyromonas gingivalis</i> promotes murine abdominal aortic aneurysms via matrix metalloproteinase‐2 induction</title><title type="shortAuthors"><i>Aoyama</i> et al.</title><title type="short"><i>Periodontitis promotes aneurysms</i></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>N.</givenNames><familyName>Aoyama</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2 #a3"><personName><givenNames>J.</givenNames><familyName>Suzuki</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2 #a4"><personName><givenNames>D.</givenNames><familyName>Wang</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2 #a3"><personName><givenNames>M.</givenNames><familyName>Ogawa</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>N.</givenNames><familyName>Kobayashi</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>T.</givenNames><familyName>Hanatani</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>Y.</givenNames><familyName>Takeuchi</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a1 #a5"><personName><givenNames>Y.</givenNames><familyName>Izumi</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a2"><personName><givenNames>M.</givenNames><familyName>Isobe</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="JP"><unparsedAffiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="JP"><unparsedAffiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="JP"><unparsedAffiliation>Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="CN"><unparsedAffiliation>Department of Periodontics and Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing, China</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="JP"><unparsedAffiliation>Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, Tokyo, Japan</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">animal model</keyword><keyword xml:id="k2">matrix metalloproteinase</keyword><keyword xml:id="k3">inflammation</keyword><keyword xml:id="k4"><i>Porphyromonas gingivalis</i></keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p> <i>Aoyama N, Suzuki J, Wang D, Ogawa M, Kobayashi N, Hanatani T, Takeuchi Y, Izumi Y, Isobe M.</i> Porphyromonas gingivalis <i>promotes murine abdominal aortic aneurysms via matrix metalloproteinase‐2 induction. J Periodont Res 2011; 46: 176–183. © 2010 John Wiley & Sons A/S</i></p><p><b>Background and Objective: </b> Abdominal aortic aneurysm (AAA) is a common and lethal disorder, and MMPs are highly expressed in AAA lesions. Large numbers of periodontopathic bacteria have been reported to be present in specimens obtained from the aortic walls of patients with an AAA. The purpose of this study was to analyze the influence of periodontopathic bacteria on AAA dilatation.</p><p><b>Material and Methods: </b> AAAs were produced in mice by the periaortic application of 0.25 <sc>m</sc> CaCl<sub>2</sub>, and NaCl was used as a control. The mice were inoculated once weekly with live <i>Porphyromonas gingivalis</i>, live <i>Aggregatibacter actinomycetemcomitans</i> or vehicle.</p><p><b>Results: </b> Four weeks after the periaortic application of either CaCl<sub>2</sub> or NaCl, a significant increase was observed in the aortic diameter of <i>P. gingivalis</i>‐challenged mice compared with the vehicle control mice (<i>p </i><<i> </i>0.05), whereas there was no statistically significant increase in the aortic diameter of the <i>A. actinomycetemcomitans</i>‐challenged mice. Immunohistochemical analysis found significantly higher numbers of CD8‐positive and MOMA2‐positive cells and significantly higher levels of MMP‐2 in the aneurysmal samples of <i>P. gingivalis</i>‐challenged mice compared with control mice. Live <i>P. gingivalis</i> promoted a significant proliferation of splenocytes in comparison with <i>P. gingivalis</i>‐lipopolysaccharide and live <i>A. actinomycetemcomitans</i> (<i>p </i>< 0.05).</p><p><b>Conclusion: </b> These findings demonstrate that challenge with <i>P. gingivalis</i>, but not with <i>A. actinomycetemcomitans</i>, can accelerate, or even initiate, the progression of experimental AAA through the increased expression of MMPs.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Porphyromonas gingivalis promotes murine abdominal aortic aneurysms via matrix metalloproteinase‐2 induction</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Periodontitis promotes aneurysms</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Porphyromonas gingivalis promotes murine abdominal aortic aneurysms via matrix metalloproteinase‐2 induction</title></titleInfo><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Aoyama</namePart><affiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Suzuki</namePart><affiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</affiliation><affiliation>Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Wang</namePart><affiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</affiliation><affiliation>Department of Periodontics and Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Ogawa</namePart><affiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</affiliation><affiliation>Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Kobayashi</namePart><affiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Hanatani</namePart><affiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Takeuchi</namePart><affiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Izumi</namePart><affiliation>Section of Periodontology, Department of Hard Tissue Engineering, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan</affiliation><affiliation>Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Isobe</namePart><affiliation>Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-04</dateIssued><edition>Accepted for publication September 29, 2010</edition><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">6</extent><extent unit="tables">0</extent></physicalDescription><abstract>Aoyama N, Suzuki J, Wang D, Ogawa M, Kobayashi N, Hanatani T, Takeuchi Y, Izumi Y, Isobe M. Porphyromonas gingivalis promotes murine abdominal aortic aneurysms via matrix metalloproteinase‐2 induction. J Periodont Res 2011; 46: 176–183. © 2010 John Wiley & Sons A/S</abstract><abstract>Background and Objective: Abdominal aortic aneurysm (AAA) is a common and lethal disorder, and MMPs are highly expressed in AAA lesions. Large numbers of periodontopathic bacteria have been reported to be present in specimens obtained from the aortic walls of patients with an AAA. The purpose of this study was to analyze the influence of periodontopathic bacteria on AAA dilatation.</abstract><abstract>Material and Methods: AAAs were produced in mice by the periaortic application of 0.25 m CaCl2, and NaCl was used as a control. The mice were inoculated once weekly with live Porphyromonas gingivalis, live Aggregatibacter actinomycetemcomitans or vehicle.</abstract><abstract>Results: Four weeks after the periaortic application of either CaCl2 or NaCl, a significant increase was observed in the aortic diameter of P. gingivalis‐challenged mice compared with the vehicle control mice (p < 0.05), whereas there was no statistically significant increase in the aortic diameter of the A. actinomycetemcomitans‐challenged mice. Immunohistochemical analysis found significantly higher numbers of CD8‐positive and MOMA2‐positive cells and significantly higher levels of MMP‐2 in the aneurysmal samples of P. gingivalis‐challenged mice compared with control mice. Live P. gingivalis promoted a significant proliferation of splenocytes in comparison with P. gingivalis‐lipopolysaccharide and live A. actinomycetemcomitans (p < 0.05).</abstract><abstract>Conclusion: These findings demonstrate that challenge with P. gingivalis, but not with A. actinomycetemcomitans, can accelerate, or even initiate, the progression of experimental AAA through the increased expression of MMPs.</abstract><subject lang="en"><genre>keywords</genre><topic>animal model</topic><topic>matrix metalloproteinase</topic><topic>inflammation</topic><topic>Porphyromonas gingivalis</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Periodontal Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0022-3484</identifier><identifier type="eISSN">1600-0765</identifier><identifier type="DOI">10.1111/(ISSN)1600-0765</identifier><identifier type="PublisherID">JRE</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>176</start><end>183</end><total>8</total></extent></part></relatedItem><identifier type="istex">76E5742732168605CD97F2A0485B44A88BB30C16</identifier><identifier type="ark">ark:/67375/WNG-TNZRST69-D</identifier><identifier type="DOI">10.1111/j.1600-0765.2010.01326.x</identifier><identifier type="ArticleID">JRE1326</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/76E5742732168605CD97F2A0485B44A88BB30C16/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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