A Randomized Controlled Clinical Trial of Edentulous Patients Treated with Immediately Loaded Implant‐Supported Mandibular Fixed Prostheses
Identifieur interne : 003574 ( Istex/Corpus ); précédent : 003573; suivant : 003575A Randomized Controlled Clinical Trial of Edentulous Patients Treated with Immediately Loaded Implant‐Supported Mandibular Fixed Prostheses
Auteurs : Sara Abdulaziz AlfaddaSource :
- Clinical Implant Dentistry and Related Research [ 1523-0899 ] ; 2014-12.
Abstract
A 1‐year blinded two‐arm parallel randomized controlled clinical trial was conducted to test the null hypothesis that immediate loading of four dental implants between the mental foramina with a fixed prosthesis has no benefits compared with the conventional loading technique in terms of implant success and clinical function.
Url:
DOI: 10.1111/cid.12057
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type="ISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="806">806</biblScope><biblScope unit="page" to="816">816</biblScope><biblScope unit="page-count">11</biblScope><date type="published" when="2014-12">2014-12</date></imprint><idno type="ISSN">1523-0899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1523-0899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">A 1‐year blinded two‐arm parallel randomized controlled clinical trial was conducted to test the null hypothesis that immediate loading of four dental implants between the mental foramina with a fixed prosthesis has no benefits compared with the conventional loading technique in terms of implant success and clinical function.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Sara Abdulaziz Alfadda BDS, MSc (Prosthodontics), PhD, FRCD(Canada)</name><affiliations><json:string>College of Dentistry, King Saud University, Riyadh, Saudi Arabia</json:string><json:string>E-mail: salfadda@gmail.com</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>edentulous mandible</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fixed implant prosthesis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>immediate loading</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>implant</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>randomized controlled 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Controlled Clinical Trial of Edentulous Patients Treated with Immediately Loaded Implant‐Supported Mandibular Fixed Prostheses</title><genre><json:string>article</json:string></genre><host><title>Clinical Implant Dentistry and Related 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Immediately Loaded Implant‐Supported Mandibular Fixed Prostheses</title><title level="a" type="short">RCT of Immediate Loading with Fixed Prostheses</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Sara Abdulaziz</forename><surname>Alfadda</surname><roleName type="degree">BDS, MSc (Prosthodontics), PhD, FRCD(Canada)</roleName></persName><affiliation><orgName>College of Dentistry</orgName><orgName>King Saud University</orgName><address><settlement type="city">Riyadh</settlement><country key="SA">Saudi Arabia</country></address></affiliation><affiliation>Reprint requests: Dr. Sara Abdulaziz Alfadda, College of Dentistry, King Saud University, Riyadh, Saudi Arabia, P.O. Box 1914, Riyadh 11441, Kingdom of Saudi Arabia; e‐mail: salfadda@gmail.com</affiliation></author><idno type="istex">6CB017F70E595C56AB7D8BCCB4A8511352253CCB</idno><idno type="ark">ark:/67375/WNG-811QL7RP-6</idno><idno type="DOI">10.1111/cid.12057</idno><idno type="unit">CID12057</idno><idno type="toTypesetVersion">file://CID.CID12057.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH</title><idno type="pISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><idno type="book-DOI">10.1111/(ISSN)1708-8208</idno><idno type="book-part-DOI">10.1111/cid.2014.16.issue-6</idno><idno type="product">CID</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="806">806</biblScope><biblScope unit="page" to="816">816</biblScope><biblScope unit="page-count">11</biblScope><date type="published" when="2014-12"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main"><head>Abstract</head>
Purpose
<p>A 1‐year blinded two‐arm parallel randomized controlled clinical trial was conducted to test the null hypothesis that immediate loading of four dental implants between the mental foramina with a fixed prosthesis has no benefits compared with the conventional loading technique in terms of implant success and clinical function.</p>
Materials and Methods
<p>Forty‐five patients, completely edentulous in the mandibles seeking implant‐supported prostheses at the <hi rend="fc">F</hi>aculty of <hi rend="fc">D</hi>entistry, <hi rend="fc">U</hi>niversity of <hi rend="fc">T</hi>oronto, were recruited. Four <hi rend="fc">TiU</hi>nite dental implants (<hi rend="fc">NobelBiocare</hi>®, <hi rend="fc">G</hi>öteborg, <hi rend="fc">S</hi>weden) were placed following the one‐stage surgical protocol. Immediately after surgery, the patients were randomly assigned to either study arms by a third independent party. In the experimental arm (<hi rend="fc">EA</hi>), existing mandibular denture was converted into an interim implant‐supported fixed bridge (<hi rend="fc">ISFB</hi>) on the same day of surgery. In the control arm (<hi rend="fc">CA</hi>), the mandibular denture was hollowed out and relined with a soft tissue reline. The implants were loaded with the permanent <hi rend="fc">ISFB</hi> at least 3 months postsurgery. Patients were assessed by a calibrated independent investigator at 2, 6, and 12 months following completion of treatment.</p>
Results
<p>A total of one hundred sixty implants were placed. Due to anatomical limitations, one patient was excluded from the study. Four patients in the <hi rend="fc">EA</hi> did not receive intervention as allocated and were transferred to the <hi rend="fc">CA</hi>. Implant success rate was comparable between the two arms and exceeded 96%. Marginal bone loss was statistically significantly more in the immediate loading arm, −0.296 mm versus −0.037 mm (intention to treat: <hi rend="italic">p</hi> = .002; per protocol: <hi rend="italic">p</hi> = .021). The relatively early intervention and insertion of the final prosthesis in the immediate arm, when bone healing and remodeling process had not yet been completed, might explain the difference in the amount of bone loss.</p>
Conclusion
<p>Immediate loading of four dental implants with a fixed prosthesis in the edentulous mandible is a feasible treatment option and leads to a substantial improvement in perceived oral health status.</p></abstract><textClass><keywords><term xml:id="cid12057-kwd-0001">edentulous mandible</term><term xml:id="cid12057-kwd-0002">fixed implant prosthesis</term><term xml:id="cid12057-kwd-0003">immediate loading</term><term xml:id="cid12057-kwd-0004">implant</term><term xml:id="cid12057-kwd-0005">randomized controlled trial</term></keywords><keywords rend="tocHeading1"><term>ARTICLES</term></keywords><keywords rend="articleCategory"><term>ARTICLE</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body" wicri:toSee="Element #text"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="cid12057" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley">10.1111/(ISSN)1708-8208</doi><issn type="print">1523-0899</issn><issn type="electronic">1708-8208</issn><idGroup><id type="product" value="CID"></id></idGroup><titleGroup><title sort="CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH" type="main">Clinical Implant Dentistry and Related Research</title><title type="short">Clinical Implant Dentistry and Related Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="12106"><doi>10.1111/cid.2014.16.issue-6</doi><copyright ownership="publisher">Copyright © 2014 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering number="16" type="journalVolume">16</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="2014-12">December 2014</coverDate></publicationMeta><publicationMeta level="unit" status="forIssue" type="article" position="30"><doi>10.1111/cid.12057</doi><idGroup><id type="unit" value="CID12057"></id></idGroup><countGroup><count number="11" type="pageTotal"></count></countGroup><titleGroup><title type="tocHeading1">ARTICLES</title><title type="articleCategory">ARTICLE</title></titleGroup><copyright ownership="publisher">© 2013 Wiley Periodicals, Inc.</copyright><eventGroup><event agent="bestset" date="2013-02-25" type="xmlCreated"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-03-18"></event><event type="firstOnline" date="2013-03-18"></event><event type="publishedOnlineFinalForm" date="2014-12-29"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-06"></event></eventGroup><numberingGroup><numbering type="pageFirst">806</numbering><numbering type="pageLast">816</numbering></numberingGroup><correspondenceTo>Reprint requests: Dr. Sara Abdulaziz Alfadda, College of Dentistry, King Saud University, Riyadh, Saudi Arabia, P.O. Box 1914, Riyadh 11441, Kingdom of Saudi Arabia; e‐mail: <email>salfadda@gmail.com</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file://CID.CID12057.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="short">RCT of Immediate Loading with Fixed Prostheses</title><title type="main">A Randomized Controlled Clinical Trial of Edentulous Patients Treated with Immediately Loaded Implant‐Supported Mandibular Fixed Prostheses</title></titleGroup><creators><creator affiliationRef="#cid12057-aff-0001" corresponding="yes" creatorRole="author" xml:id="cid12057-cr-0001"><personName><givenNames>Sara Abdulaziz</givenNames><familyName>Alfadda</familyName><degrees>BDS, MSc (Prosthodontics), PhD, FRCD(Canada)</degrees></personName><jobTitle>Assistant professor</jobTitle></creator></creators><affiliationGroup><affiliation countryCode="SA" xml:id="cid12057-aff-0001"><orgDiv>College of Dentistry</orgDiv><orgName>King Saud University</orgName><address><city>Riyadh</city><country>Saudi Arabia</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="cid12057-kwd-0001">edentulous mandible</keyword><keyword xml:id="cid12057-kwd-0002">fixed implant prosthesis</keyword><keyword xml:id="cid12057-kwd-0003">immediate loading</keyword><keyword xml:id="cid12057-kwd-0004">implant</keyword><keyword xml:id="cid12057-kwd-0005">randomized controlled trial</keyword></keywordGroup><fundingInfo><fundingAgency>Nobel Biocare® Graduate Students Grant</fundingAgency></fundingInfo><abstractGroup><abstract type="main"><title type="main">Abstract</title><section xml:id="cid12057-sec-0001"><title type="main">Purpose</title><p>A 1‐year blinded two‐arm parallel randomized controlled clinical trial was conducted to test the null hypothesis that immediate loading of four dental implants between the mental foramina with a fixed prosthesis has no benefits compared with the conventional loading technique in terms of implant success and clinical function.</p></section><section xml:id="cid12057-sec-0002"><title type="main">Materials and Methods</title><p>Forty‐five patients, completely edentulous in the mandibles seeking implant‐supported prostheses at the <fc>F</fc>aculty of <fc>D</fc>entistry, <fc>U</fc>niversity of <fc>T</fc>oronto, were recruited. Four <fc>TiU</fc>nite dental implants (<fc>NobelBiocare</fc>®, <fc>G</fc>öteborg, <fc>S</fc>weden) were placed following the one‐stage surgical protocol. Immediately after surgery, the patients were randomly assigned to either study arms by a third independent party. In the experimental arm (<fc>EA</fc>), existing mandibular denture was converted into an interim implant‐supported fixed bridge (<fc>ISFB</fc>) on the same day of surgery. In the control arm (<fc>CA</fc>), the mandibular denture was hollowed out and relined with a soft tissue reline. The implants were loaded with the permanent <fc>ISFB</fc> at least 3 months postsurgery. Patients were assessed by a calibrated independent investigator at 2, 6, and 12 months following completion of treatment.</p></section><section xml:id="cid12057-sec-0003"><title type="main">Results</title><p>A total of one hundred sixty implants were placed. Due to anatomical limitations, one patient was excluded from the study. Four patients in the <fc>EA</fc> did not receive intervention as allocated and were transferred to the <fc>CA</fc>. Implant success rate was comparable between the two arms and exceeded 96%. Marginal bone loss was statistically significantly more in the immediate loading arm, −0.296 mm versus −0.037 mm (intention to treat: <i>p</i> = .002; per protocol: <i>p</i> = .021). The relatively early intervention and insertion of the final prosthesis in the immediate arm, when bone healing and remodeling process had not yet been completed, might explain the difference in the amount of bone loss.</p></section><section xml:id="cid12057-sec-0004"><title type="main">Conclusion</title><p>Immediate loading of four dental implants with a fixed prosthesis in the edentulous mandible is a feasible treatment option and leads to a substantial improvement in perceived oral health status.</p></section></abstract></abstractGroup></contentMeta><noteGroup><note numbered="no" xml:id="cid12057-note-0001">Conflict of interest: No conflict of interest.</note></noteGroup></header> </component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A Randomized Controlled Clinical Trial of Edentulous Patients Treated with Immediately Loaded Implant‐Supported Mandibular Fixed Prostheses</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>RCT of Immediate Loading with Fixed Prostheses</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A Randomized Controlled Clinical Trial of Edentulous Patients Treated with Immediately Loaded Implant‐Supported Mandibular Fixed Prostheses</title></titleInfo><name type="personal"><namePart type="given">Sara Abdulaziz</namePart><namePart type="family">Alfadda</namePart><namePart type="termsOfAddress">BDS, MSc (Prosthodontics), PhD, FRCD(Canada)</namePart><affiliation>College of Dentistry, King Saud University, Riyadh, Saudi Arabia</affiliation><affiliation>E-mail: salfadda@gmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role><description>Assistant professor</description></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-12</dateIssued><dateCreated encoding="w3cdtf">2013-02-25</dateCreated><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>A 1‐year blinded two‐arm parallel randomized controlled clinical trial was conducted to test the null hypothesis that immediate loading of four dental implants between the mental foramina with a fixed prosthesis has no benefits compared with the conventional loading technique in terms of implant success and clinical function.</abstract><abstract>Forty‐five patients, completely edentulous in the mandibles seeking implant‐supported prostheses at the Faculty of Dentistry, University of Toronto, were recruited. Four TiUnite dental implants (NobelBiocare®, Göteborg, Sweden) were placed following the one‐stage surgical protocol. Immediately after surgery, the patients were randomly assigned to either study arms by a third independent party. In the experimental arm (EA), existing mandibular denture was converted into an interim implant‐supported fixed bridge (ISFB) on the same day of surgery. In the control arm (CA), the mandibular denture was hollowed out and relined with a soft tissue reline. The implants were loaded with the permanent ISFB at least 3 months postsurgery. Patients were assessed by a calibrated independent investigator at 2, 6, and 12 months following completion of treatment.</abstract><abstract>A total of one hundred sixty implants were placed. Due to anatomical limitations, one patient was excluded from the study. Four patients in the EA did not receive intervention as allocated and were transferred to the CA. Implant success rate was comparable between the two arms and exceeded 96%. Marginal bone loss was statistically significantly more in the immediate loading arm, −0.296 mm versus −0.037 mm (intention to treat: p = .002; per protocol: p = .021). The relatively early intervention and insertion of the final prosthesis in the immediate arm, when bone healing and remodeling process had not yet been completed, might explain the difference in the amount of bone loss.</abstract><abstract>Immediate loading of four dental implants with a fixed prosthesis in the edentulous mandible is a feasible treatment option and leads to a substantial improvement in perceived oral health status.</abstract><note type="funding">Nobel Biocare® Graduate Students Grant</note><subject><genre>keywords</genre><topic>edentulous mandible</topic><topic>fixed implant prosthesis</topic><topic>immediate loading</topic><topic>implant</topic><topic>randomized controlled trial</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Implant Dentistry and Related Research</title></titleInfo><titleInfo type="abbreviated"><title>Clinical Implant Dentistry and Related Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>ARTICLE</topic></subject><identifier type="ISSN">1523-0899</identifier><identifier type="eISSN">1708-8208</identifier><identifier type="DOI">10.1111/(ISSN)1708-8208</identifier><identifier type="PublisherID">CID</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>806</start><end>816</end><total>11</total></extent></part></relatedItem><identifier type="istex">6CB017F70E595C56AB7D8BCCB4A8511352253CCB</identifier><identifier type="ark">ark:/67375/WNG-811QL7RP-6</identifier><identifier type="DOI">10.1111/cid.12057</identifier><identifier type="ArticleID">CID12057</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2014 Wiley Periodicals, Inc.© 2013 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/6CB017F70E595C56AB7D8BCCB4A8511352253CCB/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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